1

17
29
32
43

Leo Kanner 1943

8 3

sameness

Early Infantile Autism

Bleuler
1950-19701930

Diagnostic and Statistic Manual of Mental DisordersDSMDSM-I1952

DSM-II1968Childhood
SchizophreniaInternational Classification of
Diseases and Injuries, ICDICD-9WHO, 1977

1970

RutterSchopler1978Kanner
DSM-III1980
Pervasive Developmental

Disorders,PDD

DSM-III-R(1987) DSM-IV(1994) Autistic Disorder ICD-10

WHO,1992Childhood Autism

PDDICD-10DSM-IV
comorbidityPDD

ICD-10WHO, 1993A.B.C

1.
2.
3. DSM-IV
1.2.3.61.22.3.1
1.

a.
b.
c.

d.

2
e.

f.
g.
h.

3
a.
b.
c.
d.
C

DSM-IV

B
1.2.3 1

3~51

3 1

1. Atypical Autism
A B
A
B 6 1. 2 2. 3.

B 3.
B 1.
B 2.

ICD-10
DSM-IV
PDD PDD PDDNOS
2. Retts Disorder

5 30
5 48

3. Disintegrative Disorder

4. Aspergers Disorder
1944

8 1

1.

85%
TEACCH

theory of mind

executivefunction

central coherence
deficit

2.

10~37%

200 450
1%

17~61% 1~14%
15 15

3.

1980

1985 1986

CT(MRI)

MRI

1995 2 102 112

MRI

MRI MRI

4.

X X X

80%
X

X
Bregman 532 X
122 (23%) 594 50 (8.4%)
X X
X
X
1214 20 19 XY
15X71016 17
75~150
60~90%
0~10% 91~93%

2 10 3
7

1.

dopomine

haloperidol pimozide
pimozide haloperidol
haloperidal

serotonin

10

risperidoneolanzapine clozaril
clozaril

clomipramine

clomipremine

clomipramine

fluvoxaminefluoxetinesertraline
paroxetine citalopram

fenfluramine secretin
30~40%

11

fluramine
1997 Secretin 1998
1998

1999 secretin

clomipramine
fluvoxaminefluoxetine
halopeidal

Ritalin methyphenidate
imipramineclonidine haloperidol

carbamazepine

12

lamotrigene

haloperidol
propranolol
naltrexone haloperidol

ticsGilles de la Tourette disorder

haloperidol clonidine

70%
halopenidal

13

2.

3.

1994

1982 1992

1985

deep pressure

14

4.

auditory trainingRimland
auditory integration training

48

5.

90~1200 2~4

15

B6
X
X

3~5%

16

1960

1970

1.

2%

17

()
2
6
8
12
18
24
36

48

60

()

()
12

()

18

18
24

36

48

60

(
)

()
;

18-20

19

1
2
3
4

2.

20

()
2
6
8

12

(
)

18

3~5

24

36

48

1000

()

60

21

22

3.

23

1.
1970 Rutter

70%

24

generalization

2.

3.

25

4.

26

10~37%

1.

1/5

1/4

2.

3 %

3.

4.

27

5.

6.

28

29

30

1.

2.

3.

31

1.

32

2.

3.

1.

33

2.

3.

1.

prompt-fading technique

2.

34

3.

4.

5.

35

36

20%

30%
50%

37

1.

2.

3.

1.

2.

3.

4.

1.

38

39

40

1.
2.

3.

4.
5.

41

1.

2.

50% 60%

42

TEACCH
Lovaas

43