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LECTURE 8
Lipids: a family of compounds not soluble in water
1. phospholipids (lecithin - egg yolks have lecithin)
foods with lecithin are used to help keep certain things mixed
2. sterols (cholesterol)
3. triglycerides (fats and oils; glycerol)
structure of Phospholipid: glycerol, two fatty heads
the polar head attracts water and the non-polar tail repels
phospholipid's role in cell membranes:
1. can serve as emulsifiers in the body
2. joining with both water and fat
3. used in foods such as salad dressings to keep the fats dispersed
Sterols: cholesterol - a soft, waxy substance made in the body; found in animal-derivative foods
cholesterol can be:
testosterone),
incorporated of cell membranes
made into Vitamin D
used to make bile
deposited in the artery walls, leading to
used to make sex hormones (estrogen and
plaque buildup and heart disease
Dietary cholesterol vs. Blood cholesterol
Do you need to eat cholesterol? No, because the liver produces it already.
Fat: about 95% of the lipids in foods and in the human body are triglycerides
A closer view of fats: triglycerides are the major class of lipids including fats and oils; made up of three
fatty acids and one glycerol
Fatty acids - basic units; chains of carbon atoms with an acid group at one end
1. saturated - carbon partners; carbons all have paired hydrogens; (butter)
2. mono-unsaturated - there is one double bond; (canola oil)
3. poly-unsaturated - have more than one double bonds; (nuts, vegetable oil, soy-bean)
Saturated - stacks up better; contains the maximum possible number of hydrogen atoms
Unsaturated fatty acid: one or more points of unsaturation
Saturated vs. Unsaturated Fatty Acids:
degree of saturation - affects the temperature at which the fat melts
in general, the more unsaturated the fatty acids the more liquid the fat is at room temperature
fatty acids help shape foods
Hydrogenated Vegetable Oil - solidified, otherwise liquid, oils by adding hydrogens to the unpaired
carbons (hydrogenated); this increased shelf life, easier to spread
Trans Fatty Acid:
created when an unsaturated fat is hydrogenated;
changing the conformation of the acid from cis (hydrogens are on the same side of the double bond)
to trans (hydrogens are one opposite sides of the double bond); trans fats lowers the good cholesterol
and raises the bad cholesterol (unlike butter, which doesn't touch the good cholesterol)
found primarily in margarines, shortenings, commercials frying fats, and baked goods
LDL
HDL
<200
ideal
<100
ideal
<40
low
200-239
borderline high
100-129
>60
ideal
240
high
130-159
borderline high
160-189
high
Recommendations Applied:
Daily fat caloric intake should be 20-35%
Keep saturated fats and trans fats below 10% of caloric intake
Substitute saturated or trans fats with monounsaturated or polyunsaturated fats
Lower daily cholesterol to less than 300 mg daily [one egg a day does not increase risk of CVD]
Omega-3: they decrease risk of arrhythmia, blood triglycerides, growth rate of atherosclerosis, blood
pressure
Source: fatty fish, salmon, and other fish
Recommended: 0.5 grams daily
you want two fish meals a week (particularly fatty fish); 8 oz. of fatty fish a week
Alternatives to salmon - tuna and pinked/canned salmon
Issue of methylmercury: bioaccumulation of methylmercury in shark, swordfish, king macarel, and
tilefish (golden bass/snapper)
Proteins
9 essential amino acids: can get from any animal source or soy
Alcohol
Salt
Mechanical Force
Making marang (air inside)
Cant store unlimited amino acids: i.e. we need to replenish supply every day
Collagen meant for structure and support in ligaments, hair, skin, RBC, etc.
Enzymes are catalysts that speed up reactions
Effect of Proteins on fluid balance
Traps fluid from intercellular space to keep in balanced
Too much fluid/water in blood high blood pressure
o Put them on diuretic to get the fluid out (i.e. edema)
Chylomicron
Lipoprotein
Doesn't like water (protein on outer edge with phosphate and fat on the inside) globular micelle
that brings fat throughout body
High Density Lipoprotein has more protein to bring it to liver to get rid of it
LECTURE 13
(Proteins continued)
Energy
Carbohydrates and Fat = $
Protein = $$$; should spread out daily intake of protein throughout the day than banking it at night or
in the morning
Low Protein Diet: low protein diets associated with loss of bone mass
Protein Energy Malnutrition (PEM): inadequate calories and/or protein; factors - poverty, poor food
quality, insufficient food, unsanitary living conditions, ignorance, stop nursing too early
Kwashiorkor - caused by inadequate protein but adequate calories;
Edema - swelling of the body tissue cause by leakage of fluid from cells
Marasmus - emaciated appearance
How much protein do you need? 10-35% protein, 20-35% fat, 45-65% carbohydrates
To individualize protein need: (weight/2.2)*0.8 = grams of protein you need daily
Jeopardy:
Fruits do not provide a significant amount of proteins
proteins help to maintain the pH of your body by functioning as buffers
Vegetarians can meet protein needs by consuming: variety of plant foods, and some animal products
protein-rich meat alternative: soy, dried beans and other legumes, nuts, eggs, dairy (lacto-ovovegetarians)
Advantages/Benefits of soy:
high quality protein source,
lowers blood cholesterol levels,
low in saturated fat contains isofavones
may reduce the risk of heart disease
(phytoestrogens), which may have
anticancer functions,
Disadvantage: does not have B12 (a vitamin in animal products) that helps in nerve health
Many Faces of Vegetarians: vegan, lacto-vegetarian, lacto-ovo-vegetarian, semi-vegetarian
Vegetarian diets: decrease obesity, heart disease rates, high blood pressure rates, and cancer rates
MIA nutrients: iron, zinc, calcium, vitamin D, B12, and omega-3 fatty acids
can be found in oat bran or soymilks that are enforced with the vitamins
LECTURE 14
Vitamins: organic compounds, vital to life, and indispensable to body functions, needed in minute
amounts, no caloric essential nutrients
Two classes of vitamins: fat-soluble vitamins (need fat to absorb them and can be stored in the fat as
well) and water soluble-vitamins (does not need fat to absorb but cannot be absorbed like fat can)
without the vitamin, they cannot differentiate and then lose a formidable immune system
Accutane is a source of vitamin A (ingested and used to help protect epithelial cells)
When deficient in Vitamin A, skin is unable to repair itself
Beta-carotene (in orange and green vegetables and fruits) - most abundant of the carotenoid Vitamin
A activity; meaning it can be taken from these sources and then converted into Vitamin A; it is also an
antioxidant
Upper Level (UL) for Vitamin A: 3000g
10
only refers to preformed vitamin A from animals and supplements; not from the beta-carotene source
(beta-carotene is stored under the skin and only used when needed; thus non-toxic)
Toxicity from preformed Vitamin A: too much can lead to weakened bones and may affect pregnancy
Excess beta-carotene may not cause toxicity, but it may cause carotenodermia (orange pigmentation
of the skin - not harmful)
Eat foods and not supplements (found to have increased risk of cancer)
Carotenoids and Diseases:
Age related - Macular degeneration: progressive loss of function of the part of the retina most crucial
to vision
age related (loss of central vision) or cataracts (cloudy vision); approximately 7mil Americans are at
risk for AMD, which is the leading cause of central blindness
What you eat may help what you see
Lutein and zeaxanthin-rich: green leafy
vegies (spinach, kale, broccoli) and oranges
exercise
Vitamin D: body can make all it need with the help of the sun
How: UV exposure to a cholesterol compound can convert into active form
Vitamin D:
1. functions as a hormone - regulation of blood calcium and phosphorus;
2. acts to raise blood calcium levels
[otherwise: will draw calcium from bones, promotes calcium absorption and retention]
Older individuals may have painful joints and muscles due to low Vitamin D levels: osteomalacia
New RDA for Vitamin D - 600 IU: can come from either milk or yogurt fortified in vitamin D
Exposure to sun of about 15 min a day may be sufficient for Vitamin D production
Too much vitamin D - a danger to soft tissues
Upper Level (UL) for Vitamin D: 4000IU
11
LECTURE 15
12
adequate folate consumption lowers chances of birth defects, neural tube birth defects: range from
slight problems in the spinal cord to mental retardation, severely diminished brain size, or even death
after birth
FDA: women who can conceive must consume at lease 400g daily
Neural tube birth defects: arise a few days or weeks of pregnancy
50% of US pregnancies are unplanned; gov't solution - fortified all grains with folic acid
as a result - birth defects decreased
Toxicity: can mask a Vitamin B12 deficiency
Upper Limit (UL): 1000g from supplements and fortified foods; none from naturally occurring
foods
Vitamin B12: maintains the sheaths that surround and protect nerve fiber; works with folate
Deficiency: damaged nerve sheaths, creeping paralysis, and malfunctioning of nerves and muscles
Intrinsic factor needed to absorb Vitamin B12
found in all animal products and lesser in dairy, which is bad for vegetarians
Pernicious anemia the deformation in blood cell shape
AT RISK: vegetarians, older people (>50) [solution: use synthetic form]
When meeting vitamin needs, it is best to incorporate plant foods because they provide
phytochemicals, antioxidants, and fiber. Fortified foods are sufficient, but usually focus on one
vitamin rather than an umber of them. (c.f. page 9 of notes) Supplements should only be used in old
age or prescription.
14
required: 1000mg of calcium for ages 19-50, and 1300mg for 14-18
sources: salmon
Suggested: 3 servings (1 serving - 300 mg); although actual intake is 1.7 servings
Supplements: you want less than 500mg at a time; no bone meal, oyster shells, or dolomite unless
USP symbol
Upper Level: 2000 to 3000 mg; too much can cause kidney stones
Sodium
Sodium: fluid balance, electrolyte balance, maintain extracellular fluid, acid-base balance, muscle
contraction, and nerve transmission
Recommended: 1500mg; BUT for the sheets use 2300mg a day
Blood pressure is measured at the moment of heart beat (systolic over diastolic)
reduce blood pressure: reduce sodium and alcohol consumption
DASH: dietary approaches to stop hypertension [read about this in the book: important]
Comes from: processed foods, adding during cooking/eating, and natural [ranked from highest to
lowest]
Equivalent to beta-blockers: reduce sodium, lose weight, stop drinking, exercise, and DASH diet
Potassium