ASTHMA

Extrinsic Intrinsic
(Allergy) (Idiosyncrotic)

Inhaled allergens: Viral infection, physical exertion,

Pollen, dander, etc. aspirin, smoke fumes,
(Antigens) psychologic stress

Sensitization of bronchial mucosa Most cell stabilizers

by tissue specific antibodies Increase stimulus level
(Immunoglobulin of the IgE type 1 class) of the irritant receptors in the
Chemical mediators trancheobronchial tree
-Histamines (Antihistamines)
IgE mediators are affixed -Leukotrines (Leukotrine modifiers)
To the most cells of the -Prostaglandins Hyperactivity nonspecific
tracheobronchial tree -Bradykinin (Antiinflammatory) stimuli triggers activation
of most cells

Reflex stimulation of Increase vascular permeability Smooth muscle relaxation

parasympathetic nervous system receptors causing leakage of proteins Reflex stimulation of
in bronchial mucosa and fluid into tissue produce early and late-phase tracheobronchial receptors
bronchoconstriction

Vagal stimulation of bronchial

Tissue changes smooth muscle contraction
Increase in serum
(Methylxanthine derivatives)
(Bronchial wall response) (B-adrenergic)
(Anticholinergic)

Vasodilators with mucosal edema Smooth muscle contraction Increase mucous secretion
-Mucolytics
-Expectorants
Prolonged expiration
Dyspnea Cough Wheezing
-Eosinophilia
-Non productive cough (steroids)

Stimulate the beta receptors

within smooth muscle of the
tracheobronchial tree

Opening airway passages to greater volumes of air Regulate fat and carbohydrate metabolism
WRITTEN OUTPUT
(Asthma)
Submitted by:

BSN3O1

Argente, Maria Angelica

Bercasio, Kristine
Castañeda, Ma. Angelica
Estepa, Ana Marie
Labrada, Maydean
Libao, Riola
Mendoza, Angeli
Mendoza, Ma. Allyza
Tuazon, Rachel Ann
Barangan, Victor Emmanuel
Barreda, Michael
Seña, Christopher Jello

Submitted to:

Dr. Jahnen I. Calugan-Tanamal, R.N., M.D.

(NCM-102 Lecturer)