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PHARMACEUTICAL CHEMISTRY
BPH 1133
ASSIGNMENT TITLE: ASTRINGENT
NAME
ID NUMBER
1134150714847
I/C NUMBER
960809-06-5828
LECTURER NAME :
BATCH
3RD BATCH
Astringent is one of the topical agents. It is the substances that bring about
protein precipitation.
It has low cell permeability due to the protein precipitation action. Hence, the
action is limited to the cell surface and the interstitial surface. It actions are by
contraction, wrinkling of tissues and by blanching (?)
The protein precipitation brought about by astringent is ascribed to the
presence of metallic ions having large charge/radius ratio or strong
electrostatic fields. The metal would form complex with various polar groups
present on the protein or an enzyme. This complexation of important
functional group at the active site of protein or an enzyme causes a drastic
changes in the properties of the protein.
Usually applied on damaged skin topically or to the mucous membrane of the
GIT (?) includes mouth. The precipitated protein and astringent form a
protective layer on the surface.
Astringent are used in forming protective layer, control bleeding, reduce
inflammation, and promote healing. However, many astringents are irritants or
caustics (?) in high doses and can cause redness, pain and ulceration.
Adverse(?) Viable(?) Ascribed (?)
Astringent also known to inhibit the transcapillary movement of plasma
proteins. (?) This help to reduce local edema, exudation and inflammation.
When applied topically in a low concentration, astringents will stimulate the
growth of new tissues. In a high concentration, astringents will have corrosive
effect on contact tissue.
Can be divide into metallic astringent and vegetable astringent.
Metallic astringents such as aluminium compounds (Al acetate, Al chloride),
zinc compound (Zn oxide, Zn chloride), calamine (Iron oxide with zn oxide)
and etc ( silver nitrate, potassium permanganate). Example of vegetable
astringents is tannic acid.
Astringent is basically a substance that causes body tissues such as skin to
tighten and helps in controlling bleeding or other secretion. Astringent is
derived from the Latin word which is adstringere. It means to bind fast.
It can usually divide into 3 groups based on their mode of action.
i. Those that decrease the blood supply by narrowing the blood vessels
such as epinephrine and cocaine.
ii. Those that abstract water from tissue like glycerol and alcohol.
iii. Those that coagulate the superficial tissue layers into a crust. For
example, metallic astringents such as calamine or alum.
Exhibit:
i. Styptic action (stopping bleeding by coagulation of blood and
constriction of blood capillary)
ii. Antiperspirant by decreasing secretion of perspiration by reducing pore
size of skin
iii. Anti-inflammatory (by decreasing supply of blood to the tissues)
iv. Antimicrobial (by protein precipitation mechanism)
v. Used to treat diarrhoea
vi. Possess deodorant properties
vii. Decrease sweating and make skin toughter
viii.
Promote healing process
In medicine, astringent is used to make the mucous membrane or exposed
tissues shrink. It also mainly used internally to check the secretion of blood
serum or mucous. If astringent is used externally, it will cause mild
coagulation of skin proteins, dry, harden, and protect the skin.
Astringent usually prepared as hydrosols for inclusion in facial toners.
*HYDROSOLS?
3. Describe:
SO 4 3 . x H 2 O
a) Aluminium Sulphate,(
)
Al 2
i. Preparation:
By interaction of freshly precipitated aluminium hydroxide with sufficient
amount of sulphuric acid
ii.
iii.
iv.
Pharmaceutical uses:
Use internally
Acts as an emetic acting upon the vomiting reflex (actions are rapid
and not cause local irritation to gastric mucosa)
Externally, it is used in solutions and powders of astringent
0.25% solution is employed for ophthalmic purpose
Aqueous solution of zinc sulphate is employed for protein precipitation
Zn CO 3 ZnO +CO 2
An accurate amount of substance of about 1 g is dissolved in 100 ml of
water
Then, it is heated at 90
With constant stirring, solution of sodium carbonate is added until
complete precipitation of zinc carbonate is formed
Caution not to add excess sodium carbonate
The precipitate of zinc carbonate solution is boiled for few minutes
Then, it is filtered through Gooch crucible (?), which is washed with hot
water until free from alkali
The residue is dried, ignited and weight
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