Brain Health Guide

The
BRAIN
HEALTH
Guide
third edition
Produced by Quincy Bioscience
Copyright 2012 Quincy Bioscience
*These statements have not been evaluated by the Food and

Drug Administration. This product is not intended to diagnose,
treat, cure or prevent any disease.
The personal experiences related herein are from actual

Prevagen users and were received as a text, audio or video
submission. They are not from employees, friends or any
party where compensation was offered as an inducement
for providing a personal experience with Prevagen. The
testimonials are displayed as received except for possible
editing to correct grammar or spelling errors. Some may have
been shortened if the original was lengthy or not appropriate
for the general public.
ii
CONTENTS
Table of Contents
Chapter 1:

Americas State of Brain Health
Chapter 2:

Nutrition Tips for Memory Fitness
Chapter 3:

Lifestyle Tips for Memory Fitness
Jellyfish and the Nobel Prize

Whats the Connection?
13
What is Prevagen?
15
The Latest Science
18
What People are Saying
26
Researchers Discover
A Gift From The Sea
31
Chapter 4:

Chapter 5:

Chapter 6:

Chapter 7:

Epilogue:

Appendix I:

Memory Test
33
Appendix II:
Madison Memory Study
35
iii
Foreword
~
Did you hear about the elderly woman who was pulled over
for speeding? She explained to the young officer, I had to
hurry up before I forgot where I was going.
Memory lapses like these can produce some amusing

situations. We can laugh knowing that often senior
moments are fairly harmless. However, mild memory
problems can also have consequences that negatively affect
our lives.
The Brain Health Guide is a tool to help keep your brain as

sharp as possible so that any memory lapses that do occur
are the laughable kind.
Heres to good brain health!

iv
Foreword
THE BRAIN HEALTH GUIDE
Chapter 1
America's State of Brain Health
here is good news and bad news when it comes to brain health.
The good news is that people are living longer than any other
time in history. Major nutritional and medical advancements have
been made to help keep the body physically healthy. The bad news is
we are seeing an unprecedented number of mild brain health issues
affecting our families and our friends. When life spans were shorter,
people simply were not living long enough to see the effects of natural
brain aging that are
common today.
Scientists estimate
we lose between
30,000 and 50,000
brain cells every
single day. This leads
not only to common
occurrences like the
misplacement
of
car keys and reading
glasses, but difficulty with management of our time and household
tasks. A recent study by the Natural Marketing Institute ranked
healthy mental function as the number one health concern among
those over 60 years old.
As we age, mild memory problems result in more than difficulty
remembering. It also leads to an inability to focus, pay attention
or stay on task. With increasing age comes increasing stress that
can affect the brain. The health of the brain is arguably the most
important part of overall health because it controls all organ systems
in the body.
The problems with mild memory problems in the United States are
mainly due to the aging of our society. In the year 1900, the average
Chapter 1
QUINCY BIOSCIENCE
life expectancy was 47 years. In the year 2012, life expectancy

has risen to nearly 80 years. While this increase reflects positive
improvements in health care, it has led to an increase in the wear
and tear on our bodies, including our brains.
Caring for the brain requires an understanding of its needs. The
brain is a demanding organ. Despite comprising just 2% of the
average adult body weight, the brain requires 20% of the bodys
energy and up to 25% of the hearts blood flow. In each of the
100 billion neurons in the brain are energy factories known as the
mitochondria; the neuronal mitochondria turn glucose into chemical
energy in the form of adenosine triphosphate (ATP). Feeding your
brain the right nutrients becomes more important as we age.
~~
Chapter 1
Chapter 2
Nutrition Tips for Memory Fitness
f were honest with ourselves, when we self-assess our overall

health, the brain is not usually considered. The parts of the body
giving us the most feedback get the most attention. Because of our
improving longevity, this is a major oversight, as the brain controls
everything the body does. We all know the brain controls cognitive
areas like memory, thinking, and focus. When these functions are
strongly supported, the implications on our lives are tremendous!
Julian Allan, lead researcher and health psychologist, concluded,
A person with less efficient executive function is less likely to resist
temptation and stick with what they had planned on any given day,
than someone with excellent executive function.
Executive function will be discussed
more later in the book but suffice to
say here that a properly supported
brain through proper nutrition,
lifestyle, and supplementation will
lead to a healthier more productive
life!
Unfortunately, the normal process
of aging can negatively affect brain
performance. The next several pages will give you valuable tips to
improve not only your executive function but the overall health of
your brain.
Tip #1 - Eat The Right Kind Of Fat:
Research suggests that a healthy diet can help keep your major
organs functioning at a high level. A diet consisting of the right
blend of proteins and complex carbohydrates has proven to be the
most beneficial. The brain and nervous system are comprised of
60% fat, so ensure your diet is rich in the Omega 3 essential fatty
Chapter 2
QUINCY BIOSCIENCE
acids found in cold water fish, fish

oil and flax oil.
Foods high in saturated fat, such as
fried and overly processed foods,
not only increase body mass but can
disrupt the natural function of the
brain. Poor diet can also affect your
cholesterol levels and blood pressure.
People with high cholesterol and
blood pressure are several more
times likely to experience age-related
mild memory problems. A good rule of thumb is skip the chips!
Tip #2 - Water, Water:
Heres an anti-aging tip so obvious we shouldnt have to mention

it: Water. Were bringing it up
because water doesnt get the credit
it deserves.
Used properly, water helps us look,
feel and act younger than we are
keeping healthy and enjoying life
to the fullest. If youre not already
doing it, drinking 8-12 eight ounce
glasses per day is the guideline. If
you prefer it bottled, four per day
would do the trick.
But dont cheat. Tea, coffee and soft drinks dont count. Substituting
these for water will actually dehydrate yousomething you dont need
and dont want.
Since it has zero calories, drinking water helps you lose weight and
keeps skin looking healthier. It keeps you more productive, regulates
body temps and helps in digestion. In general, consuming enough
water helps keep you in a good mood.
If you want to feel better, knock back at least 8 glasses of water a day.
You cant live without it, so drink up!
4
Chapter 2
Tip #3 - Eat Your Vegetables:
New research has found that to retain the health benefits associated
with eating broccoli or other cruciferous veggies (like cabbage,
turnips, cauliflower, kale and broccoli), you must consume the real
thingbecause of a phytochemical inside them thats missing in
supplements.
The study, published by the Pauling
Institute at Oregon State University and
supported by the National Institutes of
Health, is one of the first of its type
to determine whether the healthy
compounds found in cruciferous
vegetables can be just as easily obtained
through supplements.
The answer is no.
You need the whole foods and must go easy on cooking them. While
some nutrients, like folic acid, can be better absorbed via supplement,
the compounds that give vegetables like broccoli their health value
comes from the real thing.
The reason is that an enzyme that must be there to provide the
maximum nutrient kick is absent in supplements of this type.
Without these enzymes, the absorption rate is five to eight times less.
Intensive cooking also impedes delivery. If broccoli is cooked until
it's mushy, its health value plummets.
Instead, cook for 2-3 minutes, or steam until it's still a little crunchy.
(Broccoli was highlighted because it contains the highest levels of a
class of phytochemicals that may reduce the risk of prostate, breast,
lung and colorectal cancer.)
Bottom line: Eat your vegetables! And consume the real thing, prepared
correctly.
Tip #4 - Try Coconut Oil:
Coconut oil has been consumed for thousands of years in tropical

cultures. However, its health benefits have only recently been
Chapter 2
QUINCY BIOSCIENCE
acknowledged in the United States.

Coconut oil provides a variety of health
benefits. Coconut oil can make your skin
and hair healthier, with many people
reporting that it has even made their
wrinkles disappear! Coconut oil also
has benefits for the brain. People who
consume coconut oil daily report that
it helps with their short-term memory
and allows them to think clearly, stay
focused, and have better concentration. Researchers believe this
most likely comes from the medium chain triglycerides in coconut
oil which are converted by the liver into fat called ketones. Ketones
are a great source of energy for brain cells.
Coconut oil users love that it is so easy to useyou can cook and
bake with it, spread it on toast, eat it plain, and even smooth it on
your skin. Make sure the coconut oil you buy is non-hydrogenated
and contains no trans-fat.
Tip #5 Balance your Diet and Supplements:
Eating a well-balanced diet is the best way to get the important

nutrients our bodies and brains need. Sometimes it is hard for
people to get enough of the nutrients they need through diet alone,
so supplements can help to ensure the right balance is achieved. But
supplements should not be used to replace a healthy diet.
An article appeared recently in a national magazine, about a
writer who after realizing that the taking of vitamin supplements
was something hed been missing out on, went on a self-imposed
five month regimen as recommended by a respected supplement
manufacturerand reported his experience.
This writer was about 30 years old and had been doing a good job of
taking care of himselfeating right and getting the proper amount
of exercisebut was lacking in supplement savvy.
6
Chapter 2
Soon after beginning (and logging) his daily dosage, he began to feel
much better, and found himself waking up feeling more vigorous,
armed with a greater confidence in facing the challenges ahead.
Supported by the supplements, and without realizing it fully, he
began changing his eating habitsgoing off his low in calorie/
high in protein diet to one including junk food, causing an 8-pound
weight gain over the five month test.
At the end of his singular study, the physicians who examined him
said that his vitamin-induced euphoria and subsequent straying from
making good lifestyle choices was a form of compensation, but poor
excuse for falling off the food wagon. And their advice?
Dont do that.
Like every other life plan, moderation and balance should be the key,
and while its okay to over-indulge now and then, staying on course,
eating right and exercising to fit your age and general health, then
backing things up with a realistic daily dosage of vitamins, minerals,
(and supplements) is the prescription for success.
Tip #6 Practice Moderation
Everybody likes a salty snack or a sweet treat. It is hard to say no

to ice cream on a hot day or chips and dip while watching the big
game.
But just as excess salt and diets high in sugar are bad for our bodies,
eating too much of these can also be harmful for our brains. Many
people have experienced the crash after a sugar buzz, which can
leave them feeling tired, sluggish, and not able to think clearly. The
long-term effects of consuming too much sugar could leave you
feeling like you do after a sugar buzz all the time.
The best way to approach food items like French fries and cookies
are to eat them in moderation. Once in a while they are a great treat,
but eating them on a regular basis not only can cause harm to our
bodies and brains, but it can take the enjoyment out of indulging
every once in a while.
Anyone who has ever been on a diet can attest to the fact that
nutritional changes can be hard to stick to long-term. But a healthy
Chapter 2
QUINCY BIOSCIENCE
diet is important when it comes to brain health. Of course, change

doesnt happen overnight. If youre not following the nutrition tips
for better brain health already, try incorporating them one at a time
over the course of a few months. You may be surprised at the positive
changes you see!
~~
Chapter 2
Chapter 3
Lifestyle Tips for Memory Fitness
n Chapter 2 we gave you a few nutritional tips to follow to

improve your brain health and memory. Maintaining a healthy
diet is an important part of brain health, but it isnt the only way
to better memory. There are also many lifestyle changes you can to
incorporate into your routine.
Tip #1 - Physical Exercise:
A great way to improve the health of

your entire body, including your brain, is
through physical exercise. Committing to
a regular form of exercise is one of the
most difficult things to do. It requires a
time commitment and dedication. The
good news is that an hour in a gym every
day is not a requirement for good health.
Consistent, low stress workouts, like a brisk
walk a few times a week or yoga, can be enough. Even everyday activities
like gardening and cleaning promote good brain health. The normal
process of aging can put stress on your brain, but regular exercise can
help by maintaining fine motor skills, improving concentration skills,
and support mental health.
Tip #2 - Mental Exercise:
Just as proper diet and physical exercise

are important, so is directly stimulating
your brain with mental exercises. Activities
such as crossword puzzles, word games and
math problems are not only fun, but also
strengthen connections within your brain.
If you continue to challenge your brain,
you may be able to curb mild memory
problems, and become a better problem
Chapter 3
QUINCY BIOSCIENCE
solver. Increasing scientific evidence is showing that you can fight aging
by challenging your mind.
Tip #3 - Embrace Technology
Many new technologies exist today that

allow people to communicate with a
variety of people instantaneously. By
using these new communication tools
in the right way, networks of people can
learn to collaborate globally, discussing
ideas and arriving at possible solutions.
You might seize on a problem, learn about it, and find what others are
thinking. Many decry that Facebook, Twitter, Linkedin and others are
a waste of time, keeping us from communicating properly with each
other. But maybe they deserve a deeper look into whats possible if we
use these new technologies to better ourselves and our world. Strange
as it may seem, indulging yourself in these possibilities builds a sense of
communityone that goes well beyond the neighborhood.
Tip #4 Balance Technology with

Real Life Interactions
While many, regardless of age, use todays
communications tools to share information
or to be aware of where theyre supposed
to be next Thursday at 9:00some have
made social networking a way of life.
And while much of this new order in our

lives is good, research is showing many are
spending too much of their time making use of the sophisticated tools
at their disposal. And a significant percentage is also attempting to work
more than one program at a time, an effort that can be both seen as
both negative and positive.
Multi-tasking involves that part of the brain that governs social and
reasoning behavior and could be detrimental to cognitive reasoning.
Visual and motor skills might be improved, but the loss of the ability to
focus and think things through in an orderly way is also possible.
10
Chapter 3
One way to use social technologies such as facebook to our advantage

is to use it as a planning tool. Join a local group and attend an event, or
schedule a get together with family and friends. Interacting with people
face-to-face is another great way to keep your brain in top shape.
Tip #5 Engage with People
Actively engaging with others requires using different regions of

the brain. The unpredictability of conversation requires you to pay
attention in order to follow along and contribute to a dialogue. This is
called active listening. The opposite, passive listening, offers little
help for brain development. Socializing has a positive effect on the brain
because of the mental exercise involved. Research has shown having
a limited social network is associated with many health problems.
Scientists do not completely understand how social interactions improve
mental function. One theory is our social networks help manage stress
by allowing us to share our struggles and deal with stress, and giving us
a sense of purpose and well-being.
Tip #6 - Change your Routine and Try Something New
Stimulate your sensory side by breaking routine; shave or brush your

teeth with your non-dominant hand, take a shower and/or get dressed
with your eyes closed, and learn new skills. This could include taking
a course on a subject about which you know little, learning a new
language or preparing a dish from unfamiliar recipes. The key is to
choose something that really interests you.
In addition to challenging your brain with new experiences, here are
some memory improvement ideas you might try on sometime: Pay
attention. Focus on something for 8-10 seconds and process it in
your memory. Apply your best learning style. Do you pick up on
things best by reading, or by listening? Go with your strength. Involve
your senses. Relate things to color, texture, taste and smell if you can.
Organize information. Write things down, take notes regarding
complex material, then organize and study them. Interpret complex
material. Focus on the basics rather than memorizing myriad details.
Be able to explain it to someone else in your own words.
Finally, Be Motivated and Positive. Declare to yourself that you not
Chapter 3
11
QUINCY BIOSCIENCE
only want to remember what youve learned, youre able to do both.
Tip #7 Find Something to Love
Recent research on the phenomenon

of aging has found that having a stable
relationship and clearly defined goals
in life have as much to do with growing
older as an active, vibrant person as being
blessed with good genes.
If you take the steps to care for your
physical self by eating the right foods,
exercising regularly, getting enough sleep
the critical factor remaining is lovewhich encompasses not only your
feelings about the living beings around you, but the great things you can
do in your lifelike being persistent, curious, having a sense of humor,
and caring about what you do.
Having love in your life is in itself a source of energyhelping provide
reason, purpose, and direction. Generating, building, and maintaining
social connections are not only of immense help mentally, possessing
these traits bring physical support too. Having these attitudes percolating
from within not only brightens outlook, they strengthen overall wellbeing. Not all of us are lucky enough to be equipped with the full array
of genetic longevity, excellent physical and mental health, and lots of
love in our lives, but we can still do best with what we have. Maximizing
the efforts over that in which you have control gives you the best shot of
coming out on top. Then when you face life head-on, youll be making
the most of its positives and dealing firmly with its challenges.
It is important to recognize you can play an active role in the health
of your brain. Scientists have demonstrated that connections between
brain cells are constantly changing. A lack of attention to brain activities
will cause disconnections, while active care of the brain will promote
greater mental acuity.
~~
12
Chapter 3
Chapter 4
Jellyfish & the Nobel Prize...
What's the Connection?
n addition to nutrition and lifestyle changes to support your brain

health, the addition of key supplements can play a key role in
addressing specific functions in the brain. Here we will explain how
the jellyfish and the Nobel prize played a role in the discovery of a
new tool that has researchers, physicians,
and consumers excited about the
prospects for better brain health in aging.
In 1961 a group of researchers from
Princeton University studied a specific
species of jellyfish called Aequorea
victoria to determine what caused them
to glow. Led by Osamu Shimomura,
PhD, they packed up their Plymouth
station wagon and drove to Friday
Harbor on San Juan Island near
Seattle, Washington. A constant stream
of glowing jellyfish floated by their
laboratory each day. They developed
an extraction process and eventually
obtained enough luminescent fluid for
study. The researchers discovered the cause of the glowing jellyfish
was a specific protein. Upon binding with calcium, this protein
triggered a small amount of light. Initially, this was a great discovery
of a novel aspect to this species of jellyfish called Aequorea victoria.
Later, a technique to manufacture this protein without harvesting
jellyfish was discovered, and a research purpose evolved from the
jellyfish protein.
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 4
13
QUINCY BIOSCIENCE
Researchers began using the protein in experiments. Under a

microscope, they could track where calcium traveled in the body
because of the glow that occurred when this protein bound to
calcium--a biological flashlight! This jellyfish protein allowed
researchers to better understand the function of calcium in the body.
The pioneering discovery and the decades of research that followed
led to a 2008 Nobel Prize in chemistry for Drs. Shimomura, Martin
Chalfie, and Roger Y. Tsien.
Research conducted at the University of Wisconsin-Milwaukee in the
early 2000s helped determine that the jellyfish protein, apoaequorin,
could play a useful role in supporting brain performance in humans.
This discovery resulted in the formation of Quincy Bioscience, a
biotechnology company in Madison, Wisconsin, that develops
products and technologies based on apoaequorin to help support
brain function in aging.* The first product developed was Prevagen,
a supplement that has demonstrated an ability to improve memory.*
~~
14
Chapter 4
ChapTer 5
WhaT is prevagen?
f you could help support the health of your brain, what kind of
health impact would that have on the rest of your body? How
would thinking and decision-making abilities improve? Would the
quality of your life improve also? Quincy
Bioscience has seen first-hand how the
daily use of Prevagen has helped the
lives of many people (if youre eager to see
how, jump ahead to Chapter 7).
As we established earlier, when your

brain is not functioning properly,
everything in the body can be affected,
which in turn negatively affects your
quality of life. In order to stay healthy,
the brain has specific proteins which
help support brain cell function.* Like
other physiological processes in normal aging, the brains level of
these proteins decrease as we grow older. In the progression of
normal aging, signs of forgetfulness become more obvious in our
50s. What was once easy to recall now takes a little longer to retrieve.
how oFten do theSe oCCur? you may want to aSk

a loved one to help you anSwer the QueStionS!
1.
2.
3.
4.
5.
Forget words you want to use in a conversation.

Set items down and then forget where you placed them.
Repeat tasks that you already completed previously.
Forget details of what you did or what happened to you yesterday.
Ask someone the same question twice or telling the same story.
ChapTer 5
15
QUINCY BIOSCIENCE
Prevagen may help you improve your memory.*
Breakthrough Brain Health Supplement*
Prevagen is a safe and effective brain health supplement shown to

improve memory.* Prevagen supports brain function by using the
protein apoaequorin to supplement the proteins that are diminished
as we age.* Supplementing with Prevagen has also shown to support
the performance of the brain as demonstrated in cognitive testing
(more on this in the next chapter).*
More than ever, people are beginning to understand its possible to
support the health and function of your brain.* The brain is not
unlike other organs in the body, such as the heart, which is capable
of improving its function even as you get older with good choices!
Lifestyle adjustments such as daily 30-minute walks, diet changes
like incorporating more fish (not fried!) into your week will make a
difference.
Adding Prevagen to your brain health regimen promotes better
brain function as you age.* As time goes on, this reduction in
naturally occurring proteins can gradually become more significant.
Prevagen supplements these proteins that time
takes away.*
What is the main ingredient in

Prevagen?
Prevagen contains only one main ingredient

apoaequorin. Other memory supplements
contain vitamins, minerals, and amino acids
that can be obtained by eating a good diet.
Prevagen is the only supplement that contains
the brain supporting power of apoaequorin.*
16
Chapter 5
Quincy Bioscience has been on the cutting edge of the research and the
development of Prevagen for years. It has taken the original research to
its next logical level--application. By supplementing our proteins with
Prevagen, we may be able to support our brain function, as demonstrated
in the research.* The replenishment of these proteins supports healthy
brain function, a sharper mind and clearer thinking.*
Visit
www.freeonlinememorytest.com
to evaluate and track your memory.
~~
Chapter 5
17
QUINCY BIOSCIENCE
ChapTer 6
The laTesT sCienCe
revagen was developed by scientists and University researchers

in Madison, Wisconsin, and has been put through rigorous
scientific testing. In this chapter, a concise summary of this research
will be discussed.
aging and prevagen
It is clear when looking at the aging demographics in the United

States that supporting brain cell function needs to be a top priority!
Beginning January 1, 2011, the oldest members of the baby boomer
generation turned 65 years old. Since that day, and every day for the
next 19 years, 10,000 baby boomers will celebrate their 65th birthday.
Gray hair may look distinguished, but other consequences of aging
may not be as appreciated, such as mild memory problems.*
The supporting research behind Prevagen suggests that those who
are experiencing the beginnings of normal age-related mild memory
problems, as well as those who are not yet affected by memory lapses,
can benefit from Prevagen.*
prevagen improveS memory*
In 2010, Quincy Bioscience set out to

build on the strong evidence that had
been gathered on ability of apoaequorin
to improve memory.* The Madison
Memory Study was launched with
an ambitious goal to recruit over 200
people into a computer-based trial. The
participants were to have mild memory
18
ChapTer 6
concerns but be undiagnosed with any type of memory disorder. For

the next year-and-a-half, participants recruited for the study were
evaluated using a set of timed computer tasks.
The goal of the Madison Memory Study was to measure Prevagens
ability to improve brain function using computer software in people
experiencing normal age-related mild memory difficulties.*
Cogstate, Ltd., the worlds leading cognitive testing software
company, provided the testing protocol, which is the specific plan
for how the study was to be conducted. Computers were used in this
setting to objectively measure changes in cognition.
Prevagen Reduces Errors*

Change in Errors
0%
-1.50%
% Change in Total Errors
-4.60%
-5%
-6.59%
-10.59%
-10%
-9.84%
-15%
-18.81%
-20%
30
*
90
Testing Day
Apoaequorin
Placebo
p< .05
In 90 days, the Prevagen group significantly reduced the number of errors that were
made compared to placebo in the Groton Maze. This task measures executive function,
learning and memory.
Chapter 6
19
QUINCY BIOSCIENCE
The trial enrolled participants assigned to either Prevagen or placebo

for ninety days. Neither the people in the study, nor the researchers,
knew which capsule the participants were taking. This is known as
a randomized, double-blind, placebo-controlled study--the gold
standard for measuring the effect of a compound.
A total of 218 adults aged 40 to 91 years, were tested at predetermined
one-month time intervals and changes on specific assessments of
cognitive function were measured at various time points during the
study. The final results of the study were very encouraging. The
data showed that people on Prevagen had statistically significant
improvement in several areas of memory compared to baseline and
to placebo.*
The Prevagen group improved their scores in executive function,
learning, memory, and word recall.*
Lets take a look at these areas of cognitive function more closely:
Short-Term Memory
Quick questionwhat is on your mental to do list, right now? Can

you recall them all?
The One Card Learning Task, is a part of the Madison Memory
Study that measures a participants ability to identify and compile
information on short-term memory.
The simplest definition of short-term memory is the state of being
currently aware of something and creating an action around it.
Like making and holding in your mind a small handful of to dos.
Or preparing a short list of prioritized tasksand remembering
to refer to it as you work through your day. Short-term memory is
used when meeting someone new, while reading a book, and during
conversation.
A fleeting thing, short-term memories are information that exits
quickly from your mind unless you make an attempt to keep it on
20
Chapter 6
file. If you repeat an action, youre storing (or re-storing) it mentally,

providing greater meaning and association.
Short-term memory is just that, short. The average time a thought
can be retained is 30 seconds, but can be less. And the number of
bits and pieces we can hold in our brain varies. Most scientists agree
that 7 is a decent average number.
The One Card Learning task, sort of a sophisticated version of
the childhood card game Concentration, observes and analyzes a
subjects short-term memory skills. Participants taking Prevagen
scored highestanother indication it was supporting brain function.
From making your way through that small list of daily responsibilities,
to communicating effectively, short-term memory is a lifestrengthener.
Executive Function
Have you ever made a plan? You used your Executive Function,
which loosely means your brains ability to put an order to the things
in your world. You use it to do things like setting goals and priorities,
and identifying what to accomplish during our day.
Executive function is an extremely important function of the brain.
Should it falter, tasks become more difficult.
One of the tests in the Madison Memory Study is the Groton Maze
Learning (GML) task, used to measure participants executive
function. Looking at a tile-like grid on a computer screen, subjects
repeatedly learn to work their way through a maze that takes them
from an identified start to a marked ending. Errors are expected, but
if executive function is present, each time its taken, mistakes are
fewer. Those on Prevagen showed an almost double decrease in
errors over a specific time than those on the placebo.
So if setting goals or prioritization is a problem for you, thats likely
Chapter 6
21
QUINCY BIOSCIENCE
a normal problem associated with aging. Results from the Madison

Memory Study suggest you try one capsule of Prevagen per day.
Employing this regimen might then serve you better in situations
such as making plans, formulating a to-do list, and accomplishing
your goals.
Delayed Recall
We exercise the function of delayed recall constantly. Have you ever

thought of something you wanted to accomplish at a later point in
time? Maybe you just read of a great vacation destination, and want
to remember it next summer.
Simple as it sounds, the ability to recall is one of the basic and most
important processes of memory. But the act of recollection can be
a tough chore.
One way to discover an individuals level of acuity in conjuring up
the recent past is to test their cognitive function. Part of the Madison
Memory Study does just that.
A critical part of the Study is the Groton Maze Recall task, or GMR.
It asks participants to reproduce the maze-like pathway (remember
the tile grid?) they were introduced to during the earlier, learning
task phase. Subjects taking Prevagen performed excellentlywith
a dramatic 29% reduction in errors over the 90-day study. Compare
this to the placebo group which only showed a 4.4% improvement,
and you have a compelling reason to take Prevagen!
Our almost constant need for being able to recall someone or
something is what makes it so essential.
If Prevagen aids in helping you zip through a maze of tiles on a
computer screen, chances are itll help in other ways too.
22
Chapter 6
Youll know the next time you try to think of the name of someone
who figures in your thoughts. If it comes to you quickly, then
everythings clicking.
A Life of Quality
Have you ever heard something, and it made an impression on you?

That is verbal learning. The act of remembering is primal. And
the ability to summon information previously heard or seen is at
our core. Being able to recall (and repeat) something that occurred
earlier gives our lives greater meaning and purpose.
An example might be experiencing something someone saidwords
from a colleague or an actor in a film. Those wordsanything from
something profound and memorable to a joke, made an impression.
You wanted to remember what you had just heard so you could
relate it to others. Still another example might be hearing of a new
book, and wanting to recall its title so you could later find out more.
Both exhibit verbal learning, an essential brain activity that helps us
retain information.
When the International Shopping Recall List test was presented
in the Madison Memory Study, the list was read aloud to subjects
three times in succession. Then the other tests were taken. When
completed, testers asked each subject to recall verbally what was on
the shopping list. The results were significant. Over the 90-day run
of the study, subjects within a normal cognitive range and those with
mild to moderate impairment fared well. Both groups had taken
Prevagen during the three-month study period.
While little in this world is perfect, research, executed properly,
uncovers ways that can improve the quality of our lives as we age.
And being able to remember and repeat something verbally to others
is an example of that quality.
Chapter 6
23
QUINCY BIOSCIENCE
In the Madison Memory Study, the Prevagen arm significantly

improved all of the above mentioned areas. For more about the
study, see the appendix.
In an earlier trial, The Prevagen Quality of Life Study tracked

generally healthy participants over a 90-day period measuring
changes in overall cognition, quality of sleep, energy, mood, and
general health. Changes in performance were measured, through
self-assessment, utilizing a standardized battery of questions.
Prevagen was taken daily by 56 participants. The study showed a
statistically significant improvement in memory after 30 days. 57%
of participants reported improvement in general memory, 51% in
retaining information, 84% in remembering driving directions and
66% in word recall.*
24
ChapTer 6
The combination of these trials has given Quincy Bioscience, as well

as tens of thousands of satisfied consumers, the confidence to say
Prevagen can support healthy brain function, sharper mind, and
clearer thinking!*
Visit
~~
Chapter 6
25
QUINCY BIOSCIENCE
Chapter 7
What People Are Saying
ince the availability of Prevagen in the fall of 2007, several hundred

testimonials have been received from customers and physicians related
to the benefits that people experience. Not all people have the same results
in the same period of time. Here are a few of our most recent stories, in
their own words
From the Healthcare Providers
When people are experiencing the start of memory problems

such as having difficulty remembering why they walked from one
room to the next, I suggest they take Prevagen.
~ Henry Matick, M.D., Matick Neurology Clinic
Thanks to Prevagen my memory, and worries about those

"frightening" moments are fairly significantly improved, and have
been telling all, both young and older, about Prevagen supplement
... the response has been very positive.
~ Thomas G. Morelli, M.D.
Prevagen is my first choice supplement. My patients say that

Prevagen also helps them to think clearly and be more effective in
their daily lives.
~ Sarah Amy Thorson, Licensed Acupuncturist
26
Chapter 7
He Feels Like Himself Again

Jim Pease
"I initially heard about Prevagen from
my neighbor. We happened to have a
little card party that we get together
occasionally. Some of the memory
issues that I had were: Did I take my
pill? Have I set my alarm? Did I turn
the water off when I started the water to run in the sink? When I
turned on the pot to boil water on the stove, do I remember its there,
or do I go off and watch television, or a computer? Before I started
taking Prevagen, I was concerned about my memory.
Prevagen has given me the ability to feel actually getting back to what
I would consider normal for me. And thats very comforting for me.
It relieves a lot of stress. Whether it works on everybody, I dont know,
but I had such a positive experience from it that I would urge anybody
to at least try it and see if itll work for you, because it sure helped me."
She Recommends Prevagen

Ginny Marino
"Because of family history I called and
asked if they were having some kind of
a program that that I would qualify for.
With Prevagen I think I became sharper.
And I think that with Prevagen my
memory is better. When I take Prevagen
I have a tendency to remember lists better. My recall is better. As far
as where I have to go, even if I have it on my calendar, I don't have to
look at the calendar. The recall is much clearer.
Chapter 7
27
QUINCY BIOSCIENCE
I absolutely would recommend Prevagen to my friends, absolutely,

especially if theyre my age and older. I think Ive seen improvement
in myself since I started using it, and I would definitely recommend
Prevagen to my friends and family. I would really encourage them to
use Prevagen for three or four months, initially, and to keep going,
because I think the longer you use it the more progress you see in your
memory and your energy."
She Has Better Memory

Sue Baumer
"I dont think you really know that
youre forgetting things. And we have
a tendency to try to cover it. Since Ive
been on Prevagen, I dont have that
kind of problem with stuff anymore.
In fact, everyone says to me, how do
you remember that stuff ? Are you a private detective or something?
It really does work well. It was about three weeks when the product
began to work for me, and its just getting better. I think its important
to optimally age, because theres no such thing as anti-aging. Were all
going to age. So for me, this has been optimal because I remember
stuff other people dont. Its wonderful."
Here are a Few More Great Prevagen Stories. Enjoy!

"I got Prevagen originally for my mother and for myself. I started
using the product, and I also saw excellent results with my mother.
She had been having problems remembering little things. It was
not severe, but it was just little day-to-day things that she would
forget. Within two months, her memory vastly improved. She was
remembering things that I couldnt remember. Her personality
28
Chapter 7
perked up. Prevagen does improve your memory. I didnt realize

at the time I was having trouble recalling words, but things
became easier to recall. There wasnt any effort there. I was able
to do things quicker. I mean, as far as paying bills, reading books, I
was picking up more information and being able to process it quicker."

~ Donna F., Baton Rouge LA
"I started having problems and it really concerned me, so I figured

Prevagen sounded like a good deal. So I tried it and I noticed an
improvement within the first two weeks. I have noticed a marked
improvement in my overall memory. I can recall facts that before I
know I couldnt recall. They just come to the forefront in my brain.
My memory has definitely improved. I can recall facts and names of
people. I firmly believe Prevagen has made a difference in my life;
without a shadow of a doubt."
~ Herbert L., Great View WA
"Im very handy, and I would try to do things around the house. I
would measure the door opening, come back, measure my cut and go
take it back and it would be wrong. My memory and concentration
was terrible. I started taking the Prevagen and I would say within a
week it turned my life completely around. My day now with taking
Prevagen, Im up at 7:15-7:30 and I go all day. I have so much drive
and my mind is so clear, its incredible. I just cant say enough good
stuff about Prevagen."
~ William B., Union Bridge MD
"Remembering names is very important in my job. After I had
taken Prevagen for two to three weeks, I started seeing a change,
and Ive been on it ever since. I find that my memory of names is
much better than it was before. When Im in conversations with
Chapter 7
29
QUINCY BIOSCIENCE
customers on particular products that I sell, I find that I retain

knowledge of the product better than what I had in the past.
It has been a tremendous help with my product line and me.
Anybody thats contemplating taking Prevagen, Id highly
recommend the product, simply because Ive seen the results with
myself, my daughter, my wife and now my mom, which is the biggest
testimony of all."
~ Michael B., Lafayette LA
Visit
~~
30
Chapter 7
Epilogue
Researchers Discover Key to Brain Health
Mark Underwood, President and Co-Founder
Quincy Bioscience
ne evening I came across a very interesting article in a scientific publication.

It stopped me in my tracks. It said that an Australian swimmer who had
been stung by a jellyfish suddenly developed neurological symptoms. This
really piqued my interest.
How could the jellyfish have this poison inside of it, without
suffering from any effects? What was it in the jellyfish, could this
jellyfish protein help to protect support our brains in the same way
as the jellyfish? This sounded a lot like the snake and its venomwhy
doesnt the snake get killed by its own bite?
The brain and how it works became a topic of interest to me at a
young age because I was forced to face what happens when the brain
doesnt work. A family history of memory problems has led me to a
lifelong study of the brain and how we can help to keep it working.
In college, as a student at the University of Wisconsin at Milwaukee,
I focused my studies on neurochemistry and neuropsychology. What
I found was really exciting. Extensive research on a rare species
of jellyfish had been done and the amazing properties a protein
produced in its body gave it its ability to glow in the dark.
Recently, this experience inspired me to write a book titled, Gift from
the Sea How a Protein from Jellyfish Fights the Aging Process. I hope that
people will find the connection between our brain health and these
unique sea creatures that glow in the dark to be as fascinating as I do.
Together with Mike Beaman we founded Quincy Bioscience in 2004
to further develop the jellyfish technology to be used for supporting
the brain.*
The great secret unlocked through the study of this rare protein,
Epilogue
31
QUINCY BIOSCIENCE
apoaequorin, . We have plenty of these proteins in our bodies in our

20s and 30s, but they begin to diminish in the human brain as we
age.
It is amazing that the jellyfish, one of the simplest creatures on earth,
could help the health of most complex creature on earth. Who
would ever have imagined that such a powerful protein was locked
inside of a jellyfish?!
My goal is to help as many people as we can through the further
development of Prevagen, by educating people on brain health, and
by providing the public with a supplement that has been shown to
work and is safe and scientifically sound.
Today I live in Madison, Wisconsin, with my beautiful wife and our
two lovely daughters. I feel great knowing that this work could help
many other families keep their memories and change their lives.
32
~~
Epilogue
Appendix I
Take this short Memory Test to see how
Your brain is performing.
The following statements describe everyday life situations. Please

rate how common each situation is for you by selecting one of
the following: Daily, Regularly, Occasionally, Rarely, Never.
Circle the corresponding number for each rating.
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Forgetting where you have put something. Losing things

around the house.
Failing to recognize places that you have been before.
Finding a television story difficult to follow.
Not remembering a change in your daily routine, such
as a change in the place where something is kept, or a
change in the time something happens. Following your
old routine by mistake.
Having to go back to check whether you have done
something that you meant to do.
Completely forgetting to take things with you, or leaving
things behind and having to go back fetch them.
Forgetting that you were told something yesterday or a
few days ago, and having to be reminded about it.
Starting to read something (book, newspaper, magazine)
without realizing you have already read it before.
Having difficulty picking up a new skill. For example,
finding it hard to learn a new game or to work a new
gadget after you have practiced it once or twice.
Finding that a word is on the tip of your tongue. You
know what it is but you cannot quite find it.
Da
ily
Re
gu
lar
ly
Oc
ca
sio
Ra
na
re
lll
y
Ne ly
ve
r
Visit www.freeonlinememorytest.com to track your progress.
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
Memory test continued on next page...

Appendix I
33
Da
ily
Re
gu
lar
ly
Oc
ca
sio
Ra
na
re
lll
y
Ne ly
ve
r
QUINCY BIOSCIENCE
Memory test continued...

11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
Forgetting important details of what you did or what

happened to you the day before.
When talking to someone, forgetting what you have just
said. Maybe saying What was I talking about?
When reading a newspaper or magazine, being unable
to follow the thread of a story, losing track of what it is
about.
Getting the details of what someone has told you mixed
up and confused.
Telling someone a story or joke that you have told them
already.
Forgetting details of things you do regularly, whether at
home or work, for example, forgetting details of what to
do or what time it is.
Forgetting where things are normally kept, or looking for
them in the wrong place.
Getting lost or turning in the wrong direction on a
journey, on a walk, or in a building where you have been
before.
Repeating to someone what you have just told them or
asking them the same question twice.
Doing some routine thing twice by mistake. For example
putting two bags of tea in the teapot, or going to brush/
comb your hair when you have just done so.
34
88
30's
82
40's
78
50's
70
60's
62
70's
60
80's
45
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
Your Total
Score
Age range Ave. score

20's
1 2 3 4 5
To track your progress visit

Appendix I
Appendix II
The Effects of the Calcium Binding Protein
Apoaequorin on Memory and Cognitive
Functioning in Older Adults
Mark Y. Underwood, Peggy A. Sivesind, Taylor A. Gabourie, Kenneth C. Lerner
Quincy Bioscience, LLC, Madison, WI, USA
QUINCY BIOSCIENCE
http://www.quincybioscience.com/research
Copyright Quincy Bioscience 2012,

301 S Westeld Road, Suite 200
Madison, Wisconsin, USA
The Effects of the Calcium Binding Protein Apoaequorin

on Memory and Cognitive Functioning in Older Adults
SUMMARY
Background
We report here on a double-blind, placebo-controlled study designed to

assess the effect of an apoaequorin supplement, compared to placebo, on
specific areas of cognitive functioning using quantitative, computerized
assessments. In a recent double-blind, placebo-controlled trial, older adults
taking an apoaequorin supplement reported improvements in cognitive
functioning. Apoaequorin, a calcium-binding protein, is a unique main
ingredient originally isolated from the jellyfish, Aequorea victoria.
Appendix II
35
QUINCY BIOSCIENCE
Methods
A total of 218 adults, aged 40 to 91 years, who had self-reported mild

memory concerns were randomly assigned to receive a 90 day supply of
either apoaequorin 10 mg daily or a matched placebo. Participants were
tested at predetermined time points using computer-based assessments
from CogState Ltd (www.cogstate.com). Changes on specific assessments
of cognitive function were measured at various time points during the
study.
Results
The apoaequorin arm showed a significant improvement in scores of

executive functioning on the Groton Maze Learning task over the 90day study period. In measures of learning, study participants given
apoaequorin demonstrated significantly improved recall performance at
Day 90 compared to Baseline.
In an assessment of short-term memory and learning, the apoaequorin
arm saw significant improvement at Day 90 compared to baseline in the
One Card Learning task. The apoaequorin group also improved their
ability to recall shopping list items from a previously presented list in
the International Shopping Recall List test. Apoaequorin was very welltolerated in this study.
Conclusion
These results indicated a strong relationship between apoaequorin and

improvements on several quantitative measures of cognitive function.
Apoaequorin has been shown to be a well-tolerated and effective
supplement for use by adults as they age. These results suggest an important
role for apoaequorin in improving cognitive functioning problems that are
associated with aging.
Methods
All participants completed the AD8 Screening Interview (AD8) prior to

their baseline cognitive testing. Participants were additionally required to
complete five (5) cognitive testing sessions. The CogState Research Battery
36
Appendix II
(CogState Ltd.) was utilized and included measures of executive function,

speed of visual processing, psychomotor function, attention, verbal learning,
delayed recall, and simple and complex working memory. Cognitive testing
sessions lasted between 35 to 60 minutes depending on the participant,
and were administered by a trained researcher at predetermined intervals
throughout the three (3) month study.
Methods
The primary efficacy variable measured the change from the Baseline/
Day 0 to Day 90 as recorded by the CogState software. The measurements
included speed of performance, total number of correct moves per second,
total errors, and the accuracy of performance. The secondary efficacy
variables were self-reported improvements defined by positive changes
from Baseline/Day 0 to Day 90 on the qualitative survey instruments.
Data Analysis: Analysis was conducted using the IBM Statistical Package
for the Social Sciences (SPSS) version 19 (IBM, Inc.). Data from all 218
participants were included in the analysis. The qualitative survey data
were analyzed to find descriptive statistics, the Mann-Whitney U Test and
the Wilcoxon Signed Rank Test. Group means and standard deviations
were found for each cognitive assessment. Each cognitive assessment was
analyzed using paired and independent t-tests, and the Mixed-Model
Repeated Measures Analysis of Covariance (ANCOVA). The Baseline/
Day 0 test scores served as the covariate for the Mixed-Model Repeated
Measure ANCOVA. Participant data was segregated for analysis based
upon self-reported level of impairment as measured by the AD8 score prior
to Baseline/Day 0.
Participants: The Madison Memory Study sample was comprised of
218 participants (148 females and 70 males) aged 40 to 91 (= 62.48) years.
Eligible participants were randomized, by a 2:3 ratio, into the Placebo arm
(n=92) or the Apoaequorin arm (n=126) respectively.
Inclusion Criteria:
Healthy males and females that were not excluded by the
predetermined exclusion criteria
Appendix II
37
QUINCY BIOSCIENCE
Age between 40 to 95 on Baseline/Day 0 testing

Concerns related to memory difficulties
Ability to comply with study protocol and complete periodic
computerized cognitive testing
Exclusion Criteria:

A history of uncontrolled hypertension

Untreated psychotic or major depressive disorder
A significant neurological disease
Inability to adhere to study protocol or complete computerized
testing
Methods
P articipant Characteristics
nA
ge Range
Group Characteristics
218 (70 male)
Apoaequorin arm
126 (43 male)
40 - 90
62.54 1
92 (27 male)
40 - 91
62.39
Placebo arm
40 - 91
62.48 1
SD
1.43
1.79
10.98
Study Design: The Madison Memory Study was a double-blind,

placebo-controlled study. Participants were randomized into the Control
arm or the Experimental arm with a random number generator using
a 2:3 ratio. In the Control, or Placebo arm, participants received a
supply of capsules containing only white rice flour. Participants in the
Experimental, or Apoaequorin arm, received a supply of capsules
containing 10 mg of Apoaequorin in addition to the white rice flour.
Placebo capsules were size and color matched to the Apoaequorin
capsules. Participants were required to take one (1) capsule daily for the
entire duration of the three (3) month study.
38
Appendix II
Primary Objective: To compare and assess the effectiveness

of Apoaequorin (10 mg daily) for improvement of memory
and cognitive functioning. Secondary Objective: To assess the
effectiveness of Apoaequorin in areas including, but not limited to,
measures of sleep quality, energy levels, and participants quality of
life.
Groton Maze Learning Results (Figure 1)
The Groton Maze Learning (GML) and the Groton Maze Recall
(GMR) cognitive tasks measured participants executive function
and delayed recall. The GML task reported the total number of
errors participants made repeating the same maze five (5) times.
Whereas, the GMR task reported the total number of errors made
during the participants recall of the same maze seen previously in
the GML.
Figure 1: Groton Maze Learning

0%
-1.50%
-4.60%
-5%
-6.59%
-10.59%
-10%
-9.84%
-15%
-18.81%
-20%
30
*
90
Testing Day
Apoaequorin
Placebo
p< .05
There was not a significant change over time between arms

when looking at the complete study sample on the GML.
However, there was a significant change over time between
Baseline/Day 0 and , SD= 5.63), t126 = 2.09, p< .001,
Appendix II
39
QUINCY BIOSCIENCE
with a decrease in total errors by 18.81% (Figure 1).

Additionally, participants in the Apoaequorin arm within the
normal cognitive range (0 to 1) on the AD8 showed significant
change over time on the GML from Baseline/Day 0 to Day 90, (=
12.81, SD= 18.47), t36= 4.29, p< .000, Cohens d= 1.00. There
was a decrease in total errors by 22.88% over the course of the
study.
Groton Maze Recall Results (Figure 2)
Figure 2: Groton Maze Recall

15%
5.76%
10%
8.15%
5%
0%
-4.35%
-5%
-10%
-15%
-15.31%
-20%
-18.09%
-25%
-30%
-29.12%
-35%
30
90
Testing Day
Apoaequorin AD8 0-1
Placebo AD8 0-1
p< .001
There was a significant difference over time in the total number

of errors reported on the GMR between the Apoaequorin arm
and the Placebo arm for participants who were considered within
the range of normal to mild cognitive impairment (0 to 2) on the
AD8, F1, 90= 4.22, p< .05. A significant effect was seen within the
Apoaequorin arm from Baseline/Day 0 to Day 90, (= 1.71, SD=
5.06), t57= 2.57, p< .05, with total errors decreasing on the GMR
by 19.42%.
40
Appendix II
A significant difference was seen over time between the

Apoaequorin arm and the Placebo arm in the total number of
errors made on the GMR for participants who scored within
the normal cognitive range (0 to 1) on the AD8, F1, 54 = 7.19,
p< .01. Additionally there was a significant effect seen within
the Apoaequorin arm when comparing the Baseline/ Day 0
and Day 90 results, (= 8.92, SD= 20.33), t36= 3.67, p< .001,
Cohens d= 0.8.
The total errors in the Apoaequorin arm for participants who
scored within the normal cognitive range (0 to 1) on the AD8,
between Baseline/ Day 0 and Day 90, decreased by 29.12% on
the GMR compared to only 4.35% in the Placebo arm (Figure
2).
One Card Learning Results (Figure 3)
One Card Learning:
The One Card Learning (OCL) test measured the proportion of correct
responses during the entire duration of the test. Participants were required
to remember each card that was shown in addition to responding correctly
as to whether a card was new or had been seen previously.
Figure 3: One Card Learning

1.03
Accuracy of Performance
1.02
1.01
1.00
0.99
0.98
0.97
0.96
0.95
30
90
Testing Day
Apoaequorin
Placebo
p< .05
Appendix II
41
QUINCY BIOSCIENCE
The Apoaequorin arm saw a significant change from Baseline/Day

0 to Day 90, (= -0.03, SD= 0.14), t126 = -2.08, p< .05, with 61.47%
of participants showing an improvement from the Baseline/Day 0 to
Day 90 as measured by the accuracy of performance (Figure 3). The
accuracy of performance is the arcsine transformation of the square
root of the proportion of correct responses.
International Shopping Recall List Results (Figure 4)
The International Shopping Recall List:
The International Shopping Recall List (ISRL) measures the number
of correct shopping list items the participant can recall from a
previously presented list of items. Verbal learning and delayed recall
are cognitive functions specifically measured by the ISRL.
Figure 4: International Shopping Recall List

9.4
Mean of Correct Responses
9.2
9.0
8.8
8.6
8.4
8.2
8.0
7.8
30
90
Testing Day
Apoaequorin AD8 0-1
Apoaequorin AD8 2-5
42
p< .05
Appendix II
There was a significant difference over time between the

total number of correct responses on the ISRL for participants
who were within the normal cognitive range (0 to 1) on the
AD8, (= -2.81, SD= 4.94), t36= -3.46, p< .001 (Figure 4).
A significant effect was also seen over time on the ISRL for
participants within the mild to moderate cognitive range (2 to
5) on the AD8 in the Apoaequorin arm, (= -2.76, SD= 5.41),
t67= 2.40, p< .05 (Figure 4).
Summary
Overall, participants in the Apoaequorin arm and within the
normal to mild cognitive range on the AD8 saw a significant
positive change over the three (3) month study period in:
Verbal Learning (ISRL)
Memory (OCL)
Delayed recall (GMR and ISRL)
Executive Function (GML)
Conclusion
This study establishes a relationship between Apoaequorin and improvements
on quantitative measures of cognitive function. These results show statistical
significance between Prevagen and improvements on several quantitative
measures of cognitive function. Prevagen has been shown to be a well-tolerated
and effective dietary supplement for use by adults as they age. These results
suggest an important role for Prevagen in improving cognitive functioning
associated with aging.
Appendix II
43
QUINCY BIOSCIENCE
Notes:
Notes
Notes:
Notes
Quincy Bioscience
~
301 S Westfield Road Suite 200
Madison, Wisconsin 53717
1.888.814.0814

Brain Health Guide

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Brain Health Guide

Uploaded by

Copyright:

Available Formats

The

Produced by Quincy Bioscience

Copyright 2012 Quincy Bioscience

*These statements have not been evaluated by the Food and

The personal experiences related herein are from actual

Americas State of Brain Health

Nutrition Tips for Memory Fitness

Lifestyle Tips for Memory Fitness

Jellyfish and the Nobel Prize

The Latest Science

What People are Saying

Memory lapses like these can produce some amusing

The Brain Health Guide is a tool to help keep your brain as

Heres to good brain health!

THE BRAIN HEALTH GUIDE

life expectancy was 47 years. In the year 2012, life expectancy

THE BRAIN HEALTH GUIDE

f were honest with ourselves, when we self-assess our overall

acids found in cold water fish, fish

Heres an anti-aging tip so obvious we shouldnt have to mention

THE BRAIN HEALTH GUIDE

Tip #3 - Eat Your Vegetables:

Coconut oil has been consumed for thousands of years in tropical

acknowledged in the United States.

Eating a well-balanced diet is the best way to get the important

THE BRAIN HEALTH GUIDE

Everybody likes a salty snack or a sweet treat. It is hard to say no

diet is important when it comes to brain health. Of course, change

THE BRAIN HEALTH GUIDE

n Chapter 2 we gave you a few nutritional tips to follow to

Tip #1 - Physical Exercise:

A great way to improve the health of

Tip #2 - Mental Exercise:

Just as proper diet and physical exercise

Tip #3 - Embrace Technology

Many new technologies exist today that

Tip #4 Balance Technology with

And while much of this new order in our

THE BRAIN HEALTH GUIDE

One way to use social technologies such as facebook to our advantage

Tip #5 Engage with People

Actively engaging with others requires using different regions of

Tip #6 - Change your Routine and Try Something New

Stimulate your sensory side by breaking routine; shave or brush your

only want to remember what youve learned, youre able to do both.

Tip #7 Find Something to Love

Recent research on the phenomenon

THE BRAIN HEALTH GUIDE

n addition to nutrition and lifestyle changes to support your brain

Researchers began using the protein in experiments. Under a

THE BRAIN HEALTH GUIDE

As we established earlier, when your

how oFten do theSe oCCur? you may want to aSk

Forget words you want to use in a conversation.

Prevagen may help you improve your memory.*

Breakthrough Brain Health Supplement*

Prevagen is a safe and effective brain health supplement shown to

What is the main ingredient in

Prevagen contains only one main ingredient

THE BRAIN HEALTH GUIDE

revagen was developed by scientists and University researchers

aging and prevagen

It is clear when looking at the aging demographics in the United

prevagen improveS memory*