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Practice Series in Medicine: Basic & Clinical Sciences

MEDICINE Pre-MD MCQ Practice Series

UMMECLCH-20150921-2

Topic: Clinical Pharmacology

umh - 21 September 2015
Teacher: Chatterjee
TotalQuestions:
Questions:100
100
Total

Marks:
Marks:200
200

Time: 1 hr

Name:
Objective type practice series designed for students appearing for Medicine PGI Entrance examinations. This practice series contains
questions from basic medical and clinical sciences; subjects include: Anatomy, Physiology, Biochemistry, and Microbiology. There
Student id:
is a Negative marking of -2 for each incorrect response. Figures in the margin indicate marks for each question.
Class:
Author Email: sidharta123@yahoo.com
MCQ
After
taking the test, you may check with the answers given at the end.

Question
1
(1)
A
B
C
D

(alpha) blockers induce all of the following physiological effects except-

Question
2
(1)
A
B
C
D
E

Which of the following oils are used as a carminative: for explusion of gas
from the stomach?

Question
3
(1)
A
B
C
D

Which of the following is not a selective PDE3 phosphodiesterase inhibitor?

Question
4
(1)
A
B
C
D
E

Vitamin synthesized by the human body from choline-

Question
5
(1)

All of the following drugs can damage esophageal mucosa except-

cardiac output
reflex bradycardia
bronchodilatation
reflex tachycardia

oil of eucalyptus
oil of wintergreen
castor oil
peppermint oil
asafoetida oil

cilostazol
milrinone
vinpocetine
pimobendane

Biotin
Vitamin B8
Vitamin B16
dimethylglycine (DMG)
Vitamin B4

A
B
C
D

potassium chloride
iron salts
erythromycin
doxycycline

Question
6
(1)
A
B
C
D

An example of Cataplerotic enzyme-

Question
7
(1)
A
B
C

What is not true regarding the law of mass action which governs interaction
of drugs with their receptors?

Question
8
(1)
A
B
C
D

Which of the following is not a characteristic of essential oils?

Question
9
(1)
A
B
C
D
E

Glycoside that yields glucose on acid hydrolysis:

Question
10
(1)
A
B
C
D

Which of the following agents is nephrotoxic?

Question
11
(1)
A
B
C

Which of the following is a selective 5-HT1B agonist?

pyruvate carboxylase
aspartate transaminase
adenylosuccinate lyase
glutamate dehydrogenase

relationship between receptor occupany and drug response is linear

depends on concentration of both receptors and ligand
relationship between receptor occupany and drug response is nonlinear

used as carminatives and antiseptics

formed by oxidation or polymerization of resins
essential oils do not have any caloric value
may contain hydrocarbon terpene

Salicin
strophanthin
laevomandelonitrile
amygdalin
Urushiol

capreomycin
carbamazapine
methyldopa
carmustine

buspirone
psilocin
lorcaserin

D
E

rizatriptan
DMT

Question
12
(1)
A
B
C
D

Placebo may include all of the following except-

Question
13
(1)
A
B
C
D

Drug whose intramuscular absorption is slower when compared to its oral

absorption-

Question
14
(1)
A
B
C
D

Amount of fluid administered during evacuant enema

Question
15
(1)
A
B
C
D

An example of negative acute phase protein:

naloxone
Vitamin B1
lactose
distilled water injections

buspirone
amitriptyline
diazepam
nortriptyline

600
300
450
150

ml
ml
ml
ml

Creactive protein
C-

albumin
1acid glycoprotein
2macroglobulin

Question
16
(1)
A
B
C
D

Vaccine which is administered intradermally:

Question
17
(1)
A
B
C
D

Strength of electrostatic interaction in drug-receptor bonding-

Question

The innermost layer of the epidermis is-

Hepatitis A vaccine
Rabies vaccine
BCG vaccine
Influenza vaccine

57 kcal/mol
510 kcal/mol
58 kcal/mol
0.51 kcal/mol

18
(1)
A
B
C
D
E

stratum
stratum
stratum
stratum
stratum

basale
corneum
lucidum
spinosum
granulosum

Question
19
(1)
A
B
C
D
E

Which of the following drug can be used by retrobulbar injection?

Question
20
(1)
A
B
C
D

The type of chemical bonding that alters enzyme chemically following its
binding with irreversible inhibitior-

Question
21
(1)
A
B
C
D

Which of the following is a short acting NSAID anti-inflammatory agent?

Question
22
(1)
A
B
C
D

Not true about the composition of Lactated Ringer's solution-

Question
23
(1)
A
B
C
D

An example of an enzyme catalyzing anaplerotic reaction in the

mitochondrial matrix of the liver-

Question
24
(1)

Which of the following statements is not true about fixed oils?

epinephrine
Hyaluronidase
lidocaine
hydrocortisone acetate
all of the above

ionic bonding
hydrogen bonding
covalent bonding
van der Waals forces

ibuprofen
naproxen
meloxicab
celecoxib

4 mmol/L potassium
109 mmol/L sodium
28 mmol/L lactate
1.5 mmol/L Calcium

Glutamate dehydrogenase
-ketoglutarate dehydrogenase
Pyruvate dehydrogenase
Pyruvate carboxylase

A
B
C
D
E

they posses aromas and contain hydrocarbon terpene

they do not have any food (caloric) value
include oleoresins that are mixtures of fixed oils and resins
they are glycerides of oleic and palmitic acids
include castor oil and coconut oil

Question
25
(1)
A
B
C
D

Drugs which are extensively bound (>90%) to plasma proteins-

Question
26
(1)
A
B
C
D

All of the following are positive acute phase proteins except:

Question
27
(1)
A
B
C
D

Following agents are not an alpha 1 selective blockers-

Question
28
(1)
A
B
C
D

The effects of placebo may be modified by all of the following factors except-

Question
29
(1)
A
B
C
D

Regarding bioavailability, what is not true?

Question
30
(1)
A
B

Not true regarding placebo-

furosemide
fluconazole
lisinopril
metoprolol

Haptoglobin
Alpha 1-antitrypsin
transferrin
Ceruloplasmin

terazosin
betaxolol
prazosin
phentolamine

personality of the physician

form of administration
potency of the preparation
personality of the patient

achlorhydria may affect drug bioavailability

AUC is the most reliable measure of a drug's bioavailability
highly ionized and polar drugs have high bioavailability
highly ionized and polar drugs have low bioavailability

generally used in phase 2 and phase 3 clinical studies

generally used in phase 1 and phase 2 clinical studies

C
D
E

consists of inactive, inert preparations

used as a control device in clinical drug trials
may induce release of endorphins

Question
31
(1)
A
B
C
D

Which of the following is not a mitochondrial enzyme?

Question
32
(1)
A
B
C
D
E

Tendency of a drug binding to the receptors is governed by-

Question
33
(1)
A
B
C
D

Contraindications to digoxin therapy includes all of the following except-

Question
34
(1)
A
B
C
D

The first pharmacology institute was created by

Question
35
(1)
A
B
C
D

Which of the following condition is a contraindication for beta blocker

administration?

Question
36
(1)
A
B
C

Calcium dependent clotting factors includes all of the following except-

Sialyltransferases
Monoamine oxidases
Carnitine acetyltransferase
Choline dehydrogenase

its
its
its
its
its

concentration
potency
efficacy
affinity
specificity

acute myocarditis
congestive heart failure
hypokalemia
ventricular tachycardia

Rudolf Virchow
Friedrich Sertrner
Sir Bernard Katz
Rudolf Buchheim

hypertension
tachycardia
cardiac arrhythmias
bradycardia

Factor IV
Factor VII
Factor XII

D
E
Question
37
(1)
A
B
C
D

Factor IX
Factor X
The first pass metabolism of which of the following agents is less in the
liver?
propanolol
codeine
midazolam
s
verapamil

Question
38
(1)
A
B
C
D

Severe bradycardia may occur when propanolol is concurrently taken with

all of the following except

Question
39
(1)
A
B
C
D
E

Which of the following agent is highly ototoxic capable of causing hearing

impairment/loss?

Question
40
(1)
A
B
C
D

Clinical pharmacology includes the study of all of the following except-

Question
41
(1)
A
B
C
D

Not correct regarding the composition of Ringer's Lactate-

Question
42
(1)
A
B
C
D

Regarding transdermal therapeutic system (TTS), which of the following

statements is not true?

digitalis
calcium channel blockers
indomethacin
adrenaline

vancomycin
ethambutol
gentamicin
dantrolene
neomycin

determination of ideal dosage regimens

cost-benefit and risk-benefit ratio analysis
qualitative and quantitative evaluation of drug activities
therapeutic evaluation of a drug in human subjects

sodium 130 mmol/L

chloride 109 mmol/L
glucose 185 mmol/L
sodium 154 mmol/L

drug is subjected to first pass metabolism

percutaneous absorption into circulation
constant and predictable rate of drug delivery
absorbed via the stratum corneum

Question
43
(1)
A
B
C
D

All of the following drugs can cause abscess following intramuscular

injection except-

Question
44
(1)
A
B
C
D
E

Vitamin produced in the human body from glucose-

Question
45
(1)
A
B
C

Which of the following statements regarding dose-response curve is not

true?

diclofenac
procaine penicillin
quinine
moclobemide

nicotinic acid
Vitamin B8
thiamine
riboflavin
niacin

used to measure the affinity of agonist drugs for their receptors

used to estimate the maximal response of a drug (Emax)
estimation of concentration needed to produce a 50% maximal response
(EC50)
used for comparing the potencies of different drugs

Question
46
(1)
A
B
C
D
E

Following is not a characteristic of agonists-

Question
47
(1)
A
B
C
D

Why binding curves with agonists are difficult to interpret?

Question
48
(1)
A
B
C
D

Leptin mediates the activation of all of the following except-

Question

Pharmacokinetics concerns with all of the following except-

have affinity and maximal intrinsic activity

have affinity but negative intrinsic activity
potency of agonist is inversely related to its EC50 value
have affinity but no intrinsic activity
potency of agonist is inversely related to its ED50 value

due
due
due
due

to
to
to
to

apparent heterogeneity among receptors

apparent homogeneity among receptors
secondary event of G-protein coupling
lack of secondary event of G-protein coupling

protein kinase B
phosphodiesterase 3B
cAMP
phosphatidylinositol 3-kinase (PI3K)

49
(1)
A
B
C
D

what the body does to the drug

what the drug does to the body
binding and distribution
biotransformation

Question
50
(1)
A
B
C
D
E

Nonabsorbable drug given orally which is extremely nephrotoxic-

Question
51
(1)
A
B
C
D
E

Which of the following do not belong to G-protein coupled receptor family?

Question
52
(1)
A
B
C
D

Plasma protein binding of nortriptyline is-

Question
53
(1)
A
B
C
D

Denervation in skeletal muscles results in-

Question
54
(1)
A
B
C
D

Pick out the incorrect statements regarding the composition of normal

saline-

Question
55
(1)

Collagens employ ========= as an intermediate in extracellular signal

transduction mechanism.

kaolin
aluminium hydroxide
neomycin
kanamycin
Chlorpromazine

insulin receptor
integrin
adrenergic 1
histamine H2
angiotensin AT1

96%
9296%
93%
9395%
-

a decrease in the number of receptors in the target cell

an increase in the number of receptors in the target cell
a phenomenon called denervation insensitivity
all of the above

glucose 185 mmol/L

chloride 154 mmol/L
sodium 130 mmol/L
sodium 154 mmol/L

A
B
C
D

Gprotein coupled receptor

tyrosine kinase
JAKSTAT pathway
integrins

Question
56
(1)
A
B
C
D

Plasma protein binding of digoxin is-

Question
57
(1)
A
B
C
D

The rates of absorption following intramuscular injection-

Question
58
(1)
A
B
C
D
E

Which of the following agents is not categorized as an Orphan drug?

Question
59
(1)
A
B
C
D
E

Following are not responses mediated by leptin-

Question
60
(1)
A
B
C
D

Regarding essential drug concept laid down by the WHO, not true is-

Question
61
(1)
A

Drugs that increase gastric emptying includes all of the following except-

70%
20%
35%
25%

thigh>arm>buttocks
thigh>buttocks>arm
arm>thigh>buttocks
arm>buttocks>thigh

ketokonazole HRA
vigabatrin
pulmozyme
defifrobate
vidarabine

minimizes use of endogenous reserves of energy

leptin minimizes energy expenditure
maximizes use of endogenous reserves of energy
leptin maximizes energy expenditure
triggers decrease production of thyroid hormones

should be of fixed ratio combination

choice depends on relative efficacy, price
safety from clinical studies
depend upon pattern of prevalent diseases

acetylcholine

B
C
D
E

cisapride
Metoclopramide
erythromycin
mitemcinal

Question
62
(1)
A
B
C
D

What is not true about tannins?

Question
63
(1)
A
B
C
D

Which of the following is an Uncoupling protein (UCP)?

Question
64
(1)
A
B
C
D

All of the following agents are nonselective NSAIDs that inhibit both COX-1
and COX-2 except:

Question
65
(1)
A
B
C
D

Continuous infusion pumps consists of-

Question
66
(1)
A
B
C
D

Which of the following is not a lipid soluble drug?

Question
67
(1)
A
B
C

- blockers include all of the following except-

non-nitrogenous plant constituents

nitrogenous plant constituents
is an astringent, plant polyphenolic compound
precipitate proteins from cells of the mucous membranes

leptin
thermogenin
adiponectin
ubiquitin

ibuprofen
naproxen
indometacin
celecoxib

high infusion rate used to administer antibiotic

method of choice for patient-controlled analgesia (PCA)
small pulses for repeated small doses of opioid analgesics
small pulses to administer medications

clonidine
fentanyl
scopolamine
terazosin

Phenoxybenzamine
butaxamine
sotalol

metoprolol

Question
68
(1)
A
B
C
D

Which of the following alkaloid is a pyridine derivative?

Question
69
(1)
A
B
C
D

Regarding intravenous colloids, true is-

Question
70
(1)
A
B
C
D

Which of the following agents is toxic to osteoclasts?

Question
71
(1)
A
B
C
D
E
F

Regarding Ringers Lactate/Lactated Ringers solution, all of the following

statements are true except-

Question
72
(1)
A
B
C
D

Antihypertensive that is primarily used in patients who develop bradycardia

with propanolol-

Question
73
(1)
A
B
C
D

A prototype of cardioselective blocker-

anabasine
emetine
ibotenic acid
quinidine

increase intravascular volume

increase intracellular volume
cheaper than crystalloids
increase interstitial volume

estrogen
methotrexate
parathyroid hormone (PTH)
bisphosphonates

has a pH of 7.45
contain potassium
conrain crystalloids
contain colloids
contain lactate
contain NaCl

labetalol
atenolol
pindolol
metoprolol

metoprolol
propanolol
labetalol
pindolol

Question
74
(1)
A
B
C
D
E

Which of the following is not an action mediated by leptin?

Question
75
(1)
A
B
C
D

Which of the following drugs have the lowest therapeutic index?

Question
76
(1)
A
B
C
D

-adrenergic agent with least oral bioavailability-

Question
77
(1)
A
B
C
D

Drug-receptor system that can display the phenomenon of "hormesis"-

Question
78
(1)
A
B
C
D

Drugs having flow-dependent clearence thus high hepatic extraction ratios-

Question
79
(1)
A
B
C
D
E

Which of the following mechanism is not involved in drug absorption?

Question
80

Arsenical compounds for treating syphilis was discovered by-

activates AMP-dependent protein kinase (AMPK)

leptin inhibits insulin release
leptin acts on hypothalamic receptors to stimulate appetite
leptin acts on hypothalamic receptors to curtail appetite
leptin stimulates insulin release

remifentanyl
diazepam
morphine
dimercaprol

pindolol
labetolol
sotalol
timolol

prostaglandins
serotonergic agonists
serotonergic antagonists
all of the following

alfentanyl
profofol
methadone
Both A & C

facilitated osmosis
filtration
active transport
passive diffusion
osmosis

(1)
A
B
C
D
E

Ulf von Euler

Jack Strominger
John Newport Langley
Paul Ehrlich
Gerhard Domagk

Question
81
(1)
A
B
C
D

All of the following drugs are capable of causing esophageal damage/ulcer

except-

Question
82
(1)
A
B
C
D

Bioequivalence:

Question
83
(1)
A
B
C
D

Which of the following adrenergic blocking agents have the highest oral
bioavailibility?

Question
84
(1)
A
B
C
D
E

Pick the incorrect statements regarding drug absoption:

Question
85
(1)
A
B
C
D

Orphan drugs includes all of the following except-

Question
86
(1)
A

Which of the following agents is hepatotoxic?

doxycycline
alendronate
Vitamin C
clopidogrel

contain the same active compound in the same amount

result in more adverse effect but less efficacy
have the same therapeutic and adverse effects
result in equivalent concentrations of drug in plasma and tissues

terazosin
prazosin
bisoprolol
nadolol

ionized form of drug is usually water soluble

unionized form of drug is usually lipid soluble
ionized form of drug penetrate cell membrane easily
unionized form of drug penetrate cell membrane easily
water soluble drugs have low electrical resistance

baclofen
acetylcysteine
desmopressin
acetyl salicylic acid

Cisplatin

B
C
D

cisplatin
vancomycin
demeclocycline
naltrexone

Question
87
(1)
A
B
C
D
E

1-selective agonist agents include-

Question
88
(1)
A
B
C
D

Pick among the following oils that have no food value:

Question
89
(1)
A
B
C
D

An estimation of non-specific binding can be measured by-

Question
90
(1)
A
B
C
D

Which of the following are competitive antagonists?

Question
91
(1)
A
B
C
D
E

Which of the following statements is not true regarding drug-receptor

interactions?

Question
92
(1)
A

All of the following agents are Selective serotonin reuptake inhibitor (SSRIs)
except-

propanolol
labetolol
nadolol
atenolol
timilol

oil of wintergreen
castor oil
sweet almond oil
mustard oil

measuring
measuring
measuring
measuring

the
the
the
the

binding of the radioactive drug to the receptors

radioactivity taken up in presence of a non-radioactive ligand
radioactivity taken up in absence of a non-radioactive ligand
radioactivity of the unbound drug to its receptors

isoproterenol
propanolol
pentazocine
morphine

interaction with ligandactivated ion channel

interaction with intracellular nuclear receptor
receptoractivated tyrosine kinase
interaction with cAMPcoupled receptor
interaction with Gprotein coupled receptor

linezolid

B
C
D
E

sertraline
fluvoxamine
selegiline
paroxetine

Question
93
(1)
A
B
C
D
E

Which of the following drugs is not included in WHO essential drug concept
classification?

Question
94
(1)
A
B
C
D
E

Which of the following statements is not true about natural resins?

Question
95
(1)
A
B
C
D

Which of the following agents is a nonselective 1 and

beta1 blocker?

Question
96
(1)
A
B
C
D

Therapeutic index of diazepam is about

Question
97
(1)
A
B
C
D

What is true about therapeutic index in human?

Question
98
(1)
A

Which of the following statements regarding action of digoxin is not true?

ketoconazole
neomycin
amidopyrine
carbamazepine
procarbazine

natural resins contain tannins

insoluble in alcohol but soluble in water
soluble in alcohol but insoluble in water
shellac
natural resins contain terpenes

metoprolol
atenolol
metoprolol
esmolol
timolol

15 : 1
100 : 1
1000 : 1
10 : 1

TD50/ED50
LD50/ED50
LD50/EC50
TD50/EC50

positive chronotropic effect

B
C
D

positive inotropic effect

reduces AV conduction
negative chronotropic effect

Question
99
(1)
A
B
C
D

Antihypertensive agent with intrinsic sympathomimetic activities-

Question
100
(1)
A
B
C
D

Examples of alkaloids are-

bisoprolol
pindolol
atenolol
propanolol

strophanthin
oleoresins
atrophine
digoxin

Every attempt has been made to validate each and every answer. Please consult standard textbooks given in
the reference section for any discrepancy. Any remaining error is regreted.
Please Note: Usual disclaimer applies to this series and all other accompanying / previous test banks designed
by the author. Students should note that the questions included in the practice sets are not selected from any
previous exams / PGI tests, but meticulously designed by the author to enhance the skills of students and
recap quick essential facts.

Answers MEDICINE Pre-MD MCQ Practice Series

umh - 21 September 2015
Teacher: Chatterjee

UMMECLCH-20150921-2

Question Points Answer

1

reflex bradycardia; bronchodilatation

oil of eucalyptus; asafoetida oil

C - vinpocetine

Vitamin B16; dimethylglycine (DMG)

C - erythromycin

D - glutamate dehydrogenase

A - relationship between receptor occupany and drug response is linear

B - formed by oxidation or polymerization of resins

B - strophanthin

10

A - capreomycin

11

D - rizatriptan

12

A - naloxone

13

C - diazepam

14

A - 600 ml

15

B - albumin

16

C - BCG vaccine

17

B - 510 kcal/mol

18

A - stratum basale

19

E - all of the above

20

C - covalent bonding

21

B - naproxen

22

B - 109 mmol/L sodium

23

D - Pyruvate carboxylase

24

they posses aromas and contain hydrocarbon terpene; they do not have
any food (caloric) value; include oleoresins that are mixtures of fixed oils
and resins

25

A - furosemide

26

C - transferrin

27

betaxolol; phentolamine

28

C - potency of the preparation

29

C - highly ionized and polar drugs have high bioavailability

30

B - generally used in phase 1 and phase 2 clinical studies

31

A - Sialyltransferases

32

D - its affinity

33

B - congestive heart failure

34

A - Rudolf Virchow

35

D - bradycardia

36

C - Factor XII

37

B - codeine

38

C - indomethacin

39

E - neomycin

40

C - qualitative and quantitative evaluation of drug activities

41

glucose 185 mmol/L; sodium 154 mmol/L

42

A - drug is subjected to first pass metabolism

43

D - moclobemide

44

B - Vitamin B8

45

A - used to measure the affinity of agonist drugs for their receptors

46

have affinity but negative intrinsic activity; have affinity but no intrinsic
activity; potency of agonist is inversely related to its ED50 value

47

due to apparent heterogeneity among receptors; due to secondary event

of G-protein coupling

48

C - cAMP

49

B - what the drug does to the body

50

C - neomycin

51

insulin receptor; integrin

52

D - 9395%

53

B - an increase in the number of receptors in the target cell

54

glucose 185 mmol/L; sodium 130 mmol/L

55

D - integrins

56

D - 25%

57

C - arm>thigh>buttocks

58

E - vidarabine

59

minimizes use of endogenous reserves of energy; leptin maximizes

energy expenditure

60

A - should be of fixed ratio combination

61

C - Metoclopramide

62

B - nitrogenous plant constituents

63

B - thermogenin

64

D - celecoxib

65

D - small pulses to administer medications

66

D - terazosin

67

A - Phenoxybenzamine

68

A - anabasine

69

A - increase intravascular volume

70

D - bisphosphonates

71

has a pH of 7.45; contain colloids

72

C - pindolol

73

A - metoprolol

74

leptin acts on hypothalamic receptors to stimulate appetite; leptin

stimulates insulin release

75

D - dimercaprol

76

B - labetolol

77

prostaglandins; serotonergic agonists

78

B - profofol

79

A - facilitated osmosis

80

D - Paul Ehrlich

81

D - clopidogrel

82

D - result in equivalent concentrations of drug in plasma and tissues

83

A - terazosin

84

ionized form of drug penetrate cell membrane easily; water soluble

drugs have low electrical resistance

85

D - acetyl salicylic acid

86

D - naltrexone

87

D - atenolol

88

oil of wintergreen; castor oil

89

B - measuring the radioactivity taken up in presence of a non-radioactive

ligand

90

B - propanolol

91

D - interaction with cAMPcoupled receptor

92

A - linezolid

93

C - amidopyrine

94

natural resins contain tannins; insoluble in alcohol but soluble in water

95

D - timolol

96

B - 100 : 1

97

A - TD50/ED50

98

A - positive chronotropic effect

99

B - pindolol

100

C - atrophine

Reference Textbooks:
1. Essentials of Medical Pharmacology, KD Tripathi, 7th Edition
2. Basic and Clinical Pharmacology, Katzung 13E