a muscle can actively generate via the sliding filament mechanism Active strength of a muscles contraction is based on the number of cross-bridges that exist between myosin and actin filaments If the number of cross-bridges were to decrease, the strength of the muscles contraction would decrease If the strength of a muscles contraction decreases sufficiently, the muscle could be said to be insufficient in strength Actively insufficient muscle is a muscle that cannot generate sufficient strength actively via the sliding filament mechanism Active insufficiency is the term used to describe a muscle that is weak because of a decrease in the number of myosin-actin crossbridges during the sliding filament mechanism. Shortened active insufficiency of a muscle occurs when a muscle is shorter than its resting length and weak because of a decrease in myosin-actin cross-bridges o At rest, we see that every myosin head is able to form a cross-bridge by binding to the adjacent actin filament. Given this maximal number of cross-bridge formation, the sarcomere at rest can generate maximal pulling force and is therefore strong. o In a shortened sarcomere, the actin filaments overlap one another in such a way that some of the binding (active) sites on one of the actin filaments are blocked by the other actin filament (and some of the binding sites of the actin filament that is overlapping the other are too close toward the center and also not
accessible by the myosin
heads). o Myosin heads that would normally form cross-bridges by attaching to those binding sites are unable to do so. This results in fewer cross-bridges. A sarcomere that forms fewer crossbridges cannot generate as much pulling force, and its strength is diminished o Because a shortened muscle is composed of shortened sarcomeres, a shortened muscle exhibits shortened active insufficiency and is weaker because it forms fewer myosin-actin cross-bridges Lengthened active insufficiency of a muscle occurs when a muscle is longer than its resting length and weak because of a decrease in myosin-actin cross-bridges. o A sarcomere at rest in which every myosin head is able to form a cross-bridge by binding to the adjacent actin filament. Given this maximal number of crossbridge formation, the sarcomere at rest can generate maximal pulling force and is therefore strong o In a lengthened sarcomere, the actin filaments are pulled so far from the center of the sarcomere that many of the myosin heads cannot reach the actin filaments to form cross-bridge o Therefore many of the myosin heads that would normally form cross-bridges are unable to do so. This results in fewer crossbridges o Because a lengthened muscle is composed of lengthened sarcomeres, a lengthened muscle exhibits lengthened active insufficiency and is weaker
because it forms fewer
myosin-actin cross-bridges When a person makes a fist, the muscles that make the fist are the flexors of the fingers and thumb, and the specific muscles responsible for this action are primarily the extrinsic flexors that attach proximally in the arm/forearm (flexor digitorum superficialis, flexor digitorum profundus, flexor pollicis longus). These extrinsic flexors cross the wrist joint anteriorly to enter the hand; then they cross the metacarpophalangeal (MCP) and interphalangeal (IP) joints to enter the fingers If the wrist joint is flexed, these extrinsic muscles would shorten across the wrist joint, and because of shortened active insufficiency, would be unable to generate sufficient strength to move the fingers and make a strong fist If the wrist joint is extended instead, these muscles would be stretched longer across the wrist joint and, because of lengthened
active insufficiency, would be
unable to generate sufficient strength to move the fingers and make a strong fist Another classic example that demonstrates shortened active insufficiency is abdominal curlups (i.e., crunches). o The reason for bending the hip joint is to shorten the iliopsoas by bringing its attachments closer together (flexing the thigh at the hip joint brings the lesser trochanter closer to the pelvis and spine) o By doing this, the iliopsoas becomes shortened and actively insufficient; therefore it is not as readily recruited during the curl-up and is not strengthened as much (SOURCE: Kinesiology: The Skeletal System and Muscle Function by Joseph Muscolino)