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Jamilah Meghji
C
Robert F Miller
Abstract
Respiratory disease remains a common cause of morbidity and mortality
in HIV-infected patients. The spectrum of disease is broad and includes
infection, malignancy, airway, parenchymal, pleural, and vascular pathology. The pattern of disease has changed markedly in populations where
combination antiretroviral therapy (cART) is available; the incidence of
many opportunistic infections and malignancies has fallen, although
rates remain higher than in the general population, and conditions such
as chronic obstructive pulmonary disease and lung cancer are increasing
as life expectancies rise. Controversies still remain over the timing of cART
in relation to the treatment of opportunistic infections such as tuberculosis, and the diagnosis and treatment of the immune reconstitution inflammatory syndrome (IRIS).
In populations with access to combination antiretroviral therapy (cART) there has been a marked reduction in the incidence
of many HIV-associated infectious and malignant pulmonary
diseases
Immune reconstitution inflammatory syndrome (IRIS) is more
widely recognized as a cause of paradoxical disease exacerbation on initiation of cART
Despite cART, bacterial pulmonary infections continue to be
more common in HIV-infected individuals than in the general
population
Non-infectious respiratory complications of HIV, such as chronic
obstructive airways disease and lung cancer, are increasingly
recognized in an ageing population
Bacterial infections
Upper respiratory tract infections, acute bronchitis and acute
sinusitis occur more commonly in HIV-infected patients than in
the general population. Symptomatic chronic sinusitis affects
more than 15% of HIV-infected individuals, particularly those
with CD4 counts less than 200/ml (normal count is 470e1450/ml).
Introduction
Bronchiectasis: bronchiectasis is increasingly recognized among
HIV-infected adults. It is probably due to recurrent bacterial,
mycobacterial and P. jirovecii infections. Management is as for
adults bronchiectasis unassociated with cystic fibrosis. Among
those with vertically acquired HIV infection who survive to late
adolescence/early childhood (with or without cART), bronchiectasis probably occurs secondary to lymphocytic interstitial
pneumonitis or to obliterative bronchiolitis.
Infection
HIV directly impairs innate and adaptive immune responses
leaving the respiratory tract vulnerable to infection. Treatment
with cART does not fully restore immune function.2
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Non-malignant disease
Fixed obstructive airways disease
C
Interstitial lung disease
Non-specific interstitial pneumonitis
Lymphoid interstitial pneumonitis
Sarcoidosis
C
Pulmonary arterial hypertension
C
Pneumothorax
C
Reactions to HIV therapy
Immune reconstitution inflammatory syndrome
C
a
b
AIDS-defining illness.
AIDS-defining illness if recurrent episode within 1 year.
Table 1
Fungal infections
Pneumocystis pneumonia: P. jirovecii (previously known as
Pneumocystis carinii) is the cause of Pneumocystis pneumonia
(PCP). In the post-cART era, PCP is seen mainly among those
presenting with a new diagnosis of HIV, and those not receiving
cART and/or prophylaxis due to poor adherence or limited
access to treatment.
The clinical presentation is sub-acute with several days to weeks
of non-productive cough and progressive exertional dyspnoea,
with or without fever. Chest auscultation may be normal or reveals
end-inspiratory crackles. Cyanosis may be detected in severe
(hypoxaemic) disease. The most common chest radiograph finding
is of bilateral perihilar infiltrates (Figure 2).
Atypical findings, such as upper zone infiltrates, hilar/mediastinal lymphadenopathy, lobar consolidation, and nodules, are
seen in up to 20%. A normal chest radiograph occurs in 10%,
particularly in those with early presentations, and does not
exclude the diagnosis, but the absence of ground-glass change on
CT makes PCP unlikely.
The gold standard for diagnosis is bronchoalveolar lavage
(BAL) with or without transbronchial biopsy. Sputum induction
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(a) Chest radiograph showing diffuse, bilateral infiltrates
mimicking Pneumocystis jirovecii pneumonia. The cause was
Streptococcus pneumoniae . (b) Chest radiograph showing lobar
consolidation. The cause was Staphylococcus aureus.
Figure 1
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Other fungal infections: Cryptococcus neoformans causes pulmonary infection when the CD4 count is below 200/ml. This can
pulmonary Kaposis sarcoma, and the presence of medical comorbidity, such as pregnancy. Subsequent to admission, development of pneumothorax, need for admission to the intensive
care unit (ICU), and need for mechanical ventilation are all associated with a poor outcome.4 The severity of PCP is clinically
stratified by the degree of hypoxaemia when breathing room
air, into mild (PaO2 >11.0 kPa, SaO2 >96%), moderate (PaO2
8.0e11.0 kPa, SaO2 91e96%) and severe (PaO2 <8.0, SaO2 <91%).
This grading system is used to guide treatment.
Empirical treatment pending diagnosis is used in those with
typical imaging, CD4 counts less than 200/ml, or clinical stigmata
of immunocompromise (e.g. oral hairy cell leukoplakia, cutaneous Kaposis sarcoma). High-dose co-trimoxazole (sulphamethoxazole 100 mg/kg/day with trimethoprim 20 mg/kg/day, in
two to four divided doses) is the treatment of first choice.5,6 It is
given orally in mild disease or intravenously (IV) in moderate-tosevere disease, and continued for 21 days. Adverse effects are
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be isolated, or occur as part of disseminated disease with meningitis, with or without cryptococcaemia. Chest radiographic
changes include diffuse bilateral infiltrates mimicking PCP, focal
infiltrates, nodules, mass lesions, cavities, pleural effusions, and
lymphadenopathy. Diagnosis is made by identifying of C. neoformans in sputum or BAL. Treatment for disseminated disease is
with amphotericin/flucytosine followed by fluconazole, or with
fluconazole alone in isolated pneumonia.
Histoplasma capsulatum and Coccidioides immitis are
endemic in parts of Africa and The Americas. Both present with
disseminated disease in persons with CD4 counts below 200/ml,
but can cause focal pneumonia in those with CD4 counts greater
than 200/ml. Presentation is often non-specific with fever and
weight loss. Diagnosis requires culture of sputum, BAL fluid, or
transbronchial biopsy for both organisms. Serum (1e3)-b-Dglucan may be elevated in histoplasmosis, but is non-specific.
Treatment requires a prolonged course of antifungal medication
until a sustained improvement in CD4 count and HIV-RNA level
has been achieved.8
Active TB: more than two-thirds of cases of active TB in HIVinfected patients present with pulmonary disease. Extrapulmonary disease is common in patients with CD4 counts
below 150/ml and may involve lymph nodes, bone marrow, liver
and pericardium.
In patients with early HIV disease and maintained CD4
counts, the clinical picture of pulmonary TB is similar to adult
post-primary disease. Symptoms include chronic cough, dyspnoea, haemoptysis, chest pain, fever, sweats, and weight loss.
Chest radiographs may show apical change and cavitation.
Sputum and BAL are often smear and culture positive. In more
advanced disease with low CD4 counts, the presentation is often
atypical and symptoms less specific. Chest radiographs may be
normal but tend to represent primary disease with mediastinal
and hilar lymphadenopathy, miliary patterns, and pleural effusions. Cavitation is less likely, due to a lower grade immune
response to the organism, and sputum and BAL are often smear
negative but culture positive.
As in HIV-negative groups, culture remains the gold standard
for diagnosing active disease. Molecular diagnostic tests can be
used on respiratory samples and provide results within hours.
Although increasingly sensitive, they cannot be used to exclude
the diagnosis if negative. They not only enable rapid identification
of M. tuberculosis versus atypical mycobacteria, but also identify
mutations in the rpoB, inhA and katG genes associated with drug
resistance. The role of IGRA in the diagnosis of active tuberculosis
in HIV-infected persons remains uncertain.
While awaiting species identification, all acid- and alcohol-fast
bacilli, regardless of CD4 count, should be treated empirically as
M. tuberculosis, with standard TB treatment (2 months of rifampicin, isoniazid, ethambutol and pyrazinamide, followed by a
further 4 months of isoniazid and rifampicin). Daily treatment is
preferred over intermittent treatment because of concerns about
development of drug resistance patients with a high mycobacterial
burden. Some authorities advocate extending the continuation
phase to seven months in patients with cavitating pulmonary
disease and where sputum remains smear positive at 2 months. In
central nervous system disease, treatment is for 12 months.
Adverse events, drug reactions and mortality are more frequent
compared with non-HIV-infected individuals. Following treatment, secondary prophylaxis of TB is not given in UK; its role in
areas with high rates of re-infection remains unclear.
Multidrug-resistant and extensively drug-resistant tuberculosis have been epidemiologically associated with HIV infection.
This is probably due to rapid development of active tuberculosis
in HIV co-infected persons exposed to drug-resistant cases, rather
than any predilection to infection with drug-resistant strains.
Viral infections
Influenza A: there is no evidence that influenza A is more
common in HIV-infected persons, but those with lower CD4
counts may experience more severe disease and infection may be
complicated by secondary bacterial pneumonia. Patients with
both seasonal and H1N1 influenza present with coryzal symptoms, myalgia, fever and headache. As for the general population, treatment with neuraminidase inhibitors should be given
if influenza A is suspected or confirmed, and is most effective
if started within 48 hours of symptom onset. Diagnosis is
confirmed when viral antigen or RNA is detected in a nasopharyngeal aspirate or nasal swab. HIV-infected patients may
continue to excrete influenza A in respiratory secretions for
prolonged periods, despite clinical recovery.
Mycobacterial infections
Mycobacterium tuberculosis: TB occurs between 20 and 40 times
more frequently in HIV-infected persons, can occur at any stage
of HIV, is an AIDS-defining illness regardless of CD4 count, and is
a notifiable disease in the USA, the UK and most European
countries. Worldwide about 15% of new TB cases occur in HIVinfected persons, and TB is the cause of about 25% of all adult
HIV-related deaths.
Latent TB infection (LTBI): the annual risk of progression from
latent to active disease is high in HIV-positive individuals,
estimated at 10% per annum, and is greater with lower CD4
counts. Long-term treatment with cART significantly decreases
this risk, but does not restore it to that of an HIV-negative
person. Acutely, cART may increase the risk of TB, so-called
unmasking disease. HIV-positive individuals who have a high
risk of latent TB due to their country of origin, and a high risk
of reactivation of disease due to a low CD4 count or limited
time on cART, should therefore be screened and treated for
LTBI. Interferon-g release assays (IGRA) are more specific than
the tuberculin skin test for screening for LTBI, and retain
sensitivity at low CD4 counts. Chemoprophylaxis regimens
include isoniazid for 6 months, and rifampicin with isoniazid
for 3 months.
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Tuberculosis: BCG is a live vaccine, and its efficacy in HIVinfected patients is unknown. Given the risk of disseminated
disease it is not recommended in HIV-infected persons.
Malignant disease
Pulmonary Kaposis sarcoma
Kaposis sarcoma (KS) is the most common HIV-associated
malignancy. General aspects are discussed elsewhere (see AIDSrelated malignant disease on pages 430e434 of this issue). Pulmonary involvement with KS is almost always accompanied by
cutaneous or lymphadenopathic KS, and palatal disease strongly
predicts the presence of pulmonary disease. Presentation is with
progressive dyspnoea and non-specific cough; haemoptysis is
uncommon. Pulmonary KS may affect the airways, parenchyma,
pleura, or intra-thoracic lymph nodes. Radiological abnormalities
include nodular or interstitial infiltrates, pleural effusion (up to
40%), and mediastinal/hilar lymphadenopathy (w25%). Diagnosis is confirmed on bronchoscopy where multiple, red or purple,
flat or raised endotracheal or endobronchial lesions may be seen in
up to 50% (Figure 3). Biopsy has a low yield and is rarely performed. Pleural biopsy or cytology is rarely diagnostic. cART may
induce remission of lesions. Chemotherapy is given for symptomatic or extensive parenchymal disease at presentation, or disease that progresses despite cART. Kaposis sarcoma-associated
pleural effusions are difficult to treat, medical pleurodesis is
seldom successful, and repeat thoracocentesis is often required.
Lymphoma
High-grade non-Hodgkins B cell lymphoma is the most common
intra-thoracic lymphoma. Hodgkins lymphoma also occurs with
increased frequency among HIV-infected individuals. Lung parenchyma, pleura (effusion or mass), and mediastinal/hilar
lymph nodes may be involved. Extra-thoracic disease is usually
evident at diagnosis. Outcome from chemotherapy is better if
cART is also given.
Lung cancer
Lung cancer is the most common non-AIDS-defining cancer
among HIV-infected persons in the developed world.16 The
incidence is higher among the HIV-infected than the general
population, an effect only partially explained by tobacco smoking. In the cART era the incidence appears to be increasing.17
Clinical presentation is often with extensive local or metastatic
disease with a poor prognosis, which is not improved by starting
cART.
Initiation of cART
<100
100e350
As soon as practicable
As soon as practicable
Can wait until 8/52, especially
if difficulties with drug interactions,
drug adherence, and drug toxicities
At physicians discretion
>350
Non-malignant disease
Airways disease
The prevalence of fixed airway obstruction and diffusion impairment is higher in the HIV-infected population.18 HIV-infected
Table 3
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Pneumothorax
Pneumothorax occurs more commonly in HIV-infected persons
than in the general population. Risk factors include cigarette
smoking and nebulised pentamidine. PCP should be excluded in
any patient presenting with a pneumothorax.
Conclusions
Among HIV-infected populations with access to cART, the spectrum of HIV-associated lung disease has changed, such that PCP is
less commonly seen, but patients with undiagnosed/declared HIV
infection continue to present with respiratory symptoms, to both
primary care and to emergency departments. Among this population a wide differential diagnosis exists. Any adult presenting with
severe or atypical respiratory disease should be offered an HIV test,
irrespective of the presence/absence of stigmata of immune suppression, in keeping with UK British Association for Sexual Health
and HIV (BASHH)/British HIV Association (BHIVA) national
guidelines.
A
b
(a) Chest radiograph showing multiple, nodular infiltrates in a
patient with pulmonary Kaposis sarcoma. (b) Endobronchial
lesions of pulmonary Kaposis sarcoma.
Figure 3
REFERENCES
1 Morris A, Crothers K, Beck JM, Huang L, American Thoracic Committee
on HIV Pulmonary Disease. An official ATS workshop report:
emerging issues and current controversies in HIV-associated pulmonary diseases. Roc Am Thorac Soc 2011; 8: 17e26.
2 Crothers K, Thompson BW, Burkhardt K, et al. International HIV
associated opportunistic pneumonias (IHOP) study; lung HIV study.
HIV-associated lung infections and complications in the era of combined antiretroviral therapy. Proc Am Thorac Soc 2011; 8: 275e81.
3 Huang L, Cattamanchi A, Davis JL, et al. International HIV associated
opportunistic pneumonias (IHOP) study; lung HIV study.
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