Drug Allergy in Children:

A Three-Years Experience at Dr. Kariadi Hospital Semarang

Wistiani*, Galuh H*
*
Allergy and Immunology Division, Department of Child Health Faculty of
Medicine Diponegoro University/dr. Kariadi Hospital, Semarang, Indonesia
Introduction
Drug allergy (DA) is an immunologically mediated response to specific agent in a sensitized person.
The clinical manifestations of DA are restricted to certain syndromes that are specifically accepted as
allergic in nature, which may present as mild to life threatening reactions.
Objective
To determine the clinical features of DA.
Methods
Patient with clinical history of DA referred to Dr. Kariadi Hospital Semarang between January 2012
to May 2015, under the age of 18 years were retrospectively identified from medical records. Drug
allergy was defined as one of drug-related cutaneous reaction pattern and systemic symptoms of an
immunologically mediated drug hypersensitivity. Statistic analyses was fisher exact test with statistic
significance p < 0.05.
Results
A total of 13 patients, 9 boys (69,2%) and 4 girls (30,8%) were identified. The mean age was 67SD
54 months. The frequency of severe malnutrition and well-nourished were 3 (23,1%) and 10 (76.9%),
respectively. All patients under 60 months of age with DA had neutrophil-lymphocyte count ratio
(NLCR) below 6 (7 cases, 53,8%). The most common type was Fixed Drug Eruption (FDE)
(23,07%). Other type were Steven-Johnson syndrome (SJS), erythema multiforme (EM) and drughypersensitive syndrome (DHS). Antibiotics accounted for more than 50% of all drug implicated in
DA 8 cases (61,5%). Four (30,8%) had a previously history of allergy manifestation and only 2
(15,4%) patient with family history of allergy. Eosinophilia from blood smear examination was found
in 6 cases of DA (46,2%). All patients with FDE showed normal test of liver function 3 (100%), while
non FDE were 10 (40%) with p 0.067. There were no correlation between DA with skin exfoliation
and anemia, and also withhypoalbuminaemia. Clinical features of skin exfoliation had no correlation
with NLCR. All patient of DA except those with FDE received steroid therapy. Mortality in our study
was 7,7%.
Conclusion
Fixed Drug Eruption was the most common type of DA found, with male predominantly affected and
antibiotic was the drug most commonly involved.
Title:
Drug Allergy in Children: A Three-Years Experience at Dr. Kariadi Hospital Semarang Indonesia
Submitter's E-mail Address:
wistiani@yahoo.com
Preferred Presentation Format:
Oral Preferred
Keywords:
Clinical Research: Clinical Trials and Drug Reactions

Prior Publication?
N
Consider for publication?
Yes
Comments to Organizers:
I have no special conflict of interest for this abstract
Date that the Presenting Author completed his/her latest training program in allergy, asthma, clinical
immunology or related field:
0000-00-00
Presenting Author Date of Birth:
0000-00-00
CV:
Topic Selection:
Drug Allergy
Scheduled Date:
Saturday, 17 October 2015
Scheduled Time:
3:30 PM
First Presenting Author
Presenting Author
Ani Wistiani, pediatrician
Dr. Kariadi Hospital
Child Health Department
Semarang,
Indonesia
Email: wistiani@yahoo.com -- Will not be published
Any conflicts of interest? No
Signed on 07/13/2015 by Ani Wistiani
First Additional Contact
Galuh Hardaningsih
Dr. Kariadi Hospital
Child Health Department
Indonesia
Email: glh_Hardaningsih@yahoo.com -- Will not be published