Professional Documents
Culture Documents
Name of Defect
1. Chipping
Description
Defect where the film becomes
chipped and dented, usually at the
edges of the tablet
Reason
It may be due to sticking or
to damaged punches or
incorrectly
to
tablet
machine.
Remedy
- Increase hardness of the
film by increasing the
molecular weight grade of
polymer
2. Mottling
3. Capping
Entrapment of gases in or
underneath the film due to
overheating either during
spraying or at the end of the
coating run.
Use of
condition.
4. Orange
Peel
(Roughn
ess)
5. Blisterin
g
6. Binding
7. Craterin
g
8. Laminati
on
It is generally due
insufficient lubrication
to
The
coating
solution
penetrates the surface of the
tablet, often at the crown
where the surface is more
porous, causing localized
disintegra-tion of the core
and disruption of the coating
It is caused by the same
factors as capping but by
exaggerated conditions at
high speed. Its also due to
poorly cohesive or oily
granules.
9. Cracking
Small, fine cracks observed on the
upper and lower central surface of
tablets, or very rarely on the
sidewall are referred to as cracks
It is due to expansion to
expansion as distinguished
from
capping
and
laminating. It may be also
due to binding or sticking.
mild
drying
10.Picking