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9. Where would you expect to find a receptor that binds a non-polar ligand?
Inside the cytoplasm, (intracellular receptors)
Part 3 - Use the Wikipedia article Second Messengers to answer the following
questions. Note the article gives an example using a GPCR, however other receptors
also use second messengers. We will look at some more examples in class.
10. What is the major role of second messengers? How are they related to extracellular
signals?
Second messengers relay messages from a receptor on the cell membrane which
activates physiological changes. The primary messengers are extracellular signals and
generate the second message.
11. Why are second messengers important for signal transduction in light of limitations of first
messenger?
Second messengers can travel downstream to multi-cyclic kinase cascades which can
then spread the extracellular message intracellularly.
12. Where are second messengers located in the cell?
Second messengers are found in the cytosol and cellular membrane.
13. From the Examples chart, what enzyme (primary effector) is involved with releasing the
second messenger calcium?
Phospholipase C
14. From the Examples chart, what enzyme is involved with releasing the second messenger
cAMP?
Adenylyl cyclase