Kimberly P. Lindsey, Ph.D.

Curriculum Vitae

Date Prepared:

Monday, July 07, 2014

Name:

Kimberly Pate Lindsey, Ph.D.

Office Address:

McLean Imaging Center, McLean Hospital, 115 Mill St. Belmont, MA 02478

Home Address:

54 Winsor Ave. Watertown, MA 02472

Work Phone:

617-855-2710

Work Email:

klindsey@mclean.harvard.edu

Work FAX:

801-457-8689

Place of Birth:

Huntsville, AL

Education
1997

B.A.

Psychology

University of Texas

2002

Ph.D.

Biological and Biomedical Sciences, Molecular and

Systems Pharmacology (Leonard L. Howell, Ph.D.)

Emory University

Postdoctoral Training
2002-2004

National Research Service

Award Training Fellow

Neuroimaging
and Drug Abuse

Medical Department,
Brookhaven National Laboratory,
Upton, NY

2004-2005

National Research Service

Award Training Fellow

Drug Abuse

Alcohol and Drug Abuse

Research Center,
McLean Hospital

2005

Research Fellow

Neuroimaging
and Drug Abuse

Behavioral Psychopharmacology
Research Laboratory,
McLean Hospital

Faculty Academic Appointments

2000-2002

Individual Predoctoral
National Research Service
Award (F31) Training Fellow

Neuroscience (Yerkes), and

Pharmacology (Emory)

2005-

Instructor

Department of Psychiatry

Harvard Medical School

2005-

Assistant Research
Pharmacologist

Division of Alcohol and

Drug Abuse

McLean Hospital

Yerkes National Primate

Research Center/Emory
University

Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
Appointments at Hospitals/Affiliated Institutions
2005

Assistant Research
Pharmacologist

Behavioral Psychopharmacology Research

McLean
Laboratory (Division of Alcohol and Drug Abuse) Hospital

2006 -

Director

Pharmacologic Imaging Laboratory (Division of

Alcohol and Drug Abuse)

McLean
Hospital

Committee Service
National and International
2001

Receptors and Cocaine (Session chair)

College on Problems of Drug Dependence

2006-2009

Media Relations Committee (member)

College on Problems of Drug Dependence

2006-2009

Publications Committee (member)

College on Problems of Drug Dependence

Professional Societies
2000-

College on Problems of Drug Dependence

Associate Member

2000-2004

Society for Neuroscience

Member

2000-2004

International Study Group Investigating Drugs as Reinforcers

Member

2007

Society for Research on Nicotine and Tobacco

Member

2007

International Society for Magnetic Resonance in Medicine

Member

Grant Review Activities

2004-

Swiss National Science Foundation

Reviewer

2005-

Neurological Foundation of New Zealand

Reviewer

2007-

National Institutes of Health, National Institute on Drug Abuse

Ad-hoc reviewer

2013

Catalyst, Harvard Medical School

Reviewer

2014

Loan Repayment Award, National Institutes of Health, National

Institute on Allergy, Immunology, and Infectious Disease,

Ambassador,
Reviewer

Editorial Activities
Journal of Neuroscience
Journal of Pharmacology and Experimental Therapeutics
Biological Psychiatry
Psychopharmacology
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
International Journal of Neuropsychopharmacology
Schizophrenia Bulletin
Pharmacology Biochemistry and Behavior
Drug and Alcohol Dependence
Neuropsychiatric Disease and Treatment

Honors and Prizes

1997-2002

Graduate Fellowship

Emory University

Scholastic achievement

2000-2002

Individual Predoctoral
National Research
Service Award (F31)

National Institutes of Health,

National Institute on Drug Abuse

Grantsmanship,
scholarship, service

2001

Short Course
Fellowship

Cellular and Molecular Basis of

Addiction, Cold Spring Harbor
Laboratory

Scholarship

2003

Directors Travel
Award

National Institutes of Health,

National Institute on Drug Abuse

Scholarship

2004-2009

Clinical Loan
Repayment Award

National Instutes of Health,

National Institute on Drug Abuse

Scholarship, service

Report of Funded and Unfunded Projects

Funding Information
Past
2000-2001

Combination Pharmacotherapies for Cocaine Addiction.

NIH/NIDA F31 DA006042 Predoctoral Individual National Research Service Award
Principal Investigator, $68,844
Goals of this project were to assess three DAT inhibitors, a mixed action
dopamine/serotonin uptake inhibitor, and the combination of a DAT inhibitor
coadministered with an SSRI for their ability to decrease cocaine reinforced responding in
rhesus monkeys. Additionally, neuroimaging using positron emission tomography (PET)
was used to quantify the proportional degree of DAT occupancy associated with this effect
for each drug.

2006-2010

PhMRI of smoked tobacco: Effects of abstinence and dependence.

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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
NIH/NIDA K01 DA021730 Mentored Research Scientist Development Award
Principal Investigator, $397,196
Goals of this project were to use blood oxygen level dependent functional magnetic
resonance imaging to visualize local hemodynamic changes in brain during the smoking of
tobacco or placebo cigarettes and during nicotine and saline infusion.
2007-2010

fMRI of cigarette smoking: Effects of dependence, withdrawal, and conditioned

reinforcers.
NIH/NIDA R03 DA021231 Imaging - Science Track Award for Research Transition
(I/START)
Principal Investigator $228,067
Similar to the K01, goals of this project were to use blood oxygen level dependent
functional magnetic resonance imaging to visualize local hemodynamic changes in brain
during the smoking of tobacco or placebo cigarettes and during nicotine and saline
infusion.

2009-2013

Citicoline-Induced Modulation of Cannabis Effects: Imaging and Mechanism of Action.

NIH/NIDA R01 DA024007 Investigator initiated grant
Investigator
Goals of this project included1) quantifying the acute, chronic and withdrawal effects of
cannabis using brain imaging (EEG/ERP, fMRI and MRS) and 2) using these data to serve
as a foundation for exploring new strategies for cannabis medication development.

2010-2013

Realtime Near Infrared Spectroscopy of the Frontal Lobe for Neurofeedback.

NIH/NIDA R21 DA027877
Investigator
The goals of this project was to: develop and test a real-time near infrared spectroscopic
(NIRS) functional imaging system to allow subjects to directly monitor, and as a result
modulate, their frontal brain activity. The data from this exploratory study will be used to
develop a novel and potentially important tool for training subjects to reduce drug craving
and drug seeking behaviors.

2012-2013

Combining functional near-infrared spectroscopy with transcranial magnetic

stimulation
McGovern Institute for Brain Research at MIT (MINT Project)
Investigator
The goal of this project is to study rapid changes in transcription caused by neural activity
on a genome-wide scale and to use recently developed tools from systems biology to
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
identify and ultimately to manipulate specific functional gene networks that are regulated
by neural activity.
2013-2014

A new multimodal perfusion imaging method using concurrent NIRS and fMRI
NIH/NIDA R21 DA032746
Investigator
Goals of this project include: 1) Compare data quality obtained using NIRS from four
different recording locations; 2) Evaluate the use of RIPTiDe data as input to the Balloon
Model to generate quantitative estimates of blood flow and volume to compare results with
ASL and VASO; 3) Implement a RIPTiDe processing package.

Current Funded Projects

None

Current Unfunded Projects

2014

Near Infrared Video Pyrometry for Puff Topography

Principal Investigator
Goals of this project are to develop and implement a novel video-based non-contact
method for assessing temporal patterns of acute drug administration via smoking.

Report of Local Teaching and Training

Teaching of Students in Courses
1997

Biology 358, Evolutionary Perspectives on

Behavior
30 upper level undergraduate students

Emory University
One full semester, 3 hours contact time, 3
hours prep time per week.

1999 - 2000

MSP 570r Principles of Molecular

Therapeutics and Toxicology Seminar
24 graduate students

Emory University
4 semesters, 2 hours contact time, 2 hours
prep time per week.

2006

BIOS E200 Graduate Research Methods

and Scholarly Writing in the Biological
Sciences
12 undergraduate students

Harvard Extension School

1 hour contact time, 8 hours prep time.

Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
2007

Psych 1201 Psychopharmacology

60 undergraduate students

Harvard University
1.5 hours contact time, 15 hours prep time.

2013-present

SHDH504 Drug Abuse and Public Health

Graduate students

Harvard School of Public Health

Annually 2 hours contact time, 12 hours
preparation.

2015-present

PSYCH 751 Psychopharmacology

Suffolk University, 45 hours contact time,

120 hours preparation.

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)

2007-2008

Preclinical Studies of Human Drug Abuse,

Seminar Series on Drug Abuse
PGY3/4 Residents in Psychiatry

McLean Hospital
1 hours contact time, 8 hours prep time.

Laboratory and Other Research Supervisory and Training Responsibilities

2005-2007

Elizabeth T. Ryan, M.A., Ph.D. Coauthored one publication.

Research assistant continued studies of psychoactive drugs and behavior, and went on to
complete a Ph.D. program in Psychology at Ohio State University, and is currently a
postdoctoral fellow in Clinical Psychology at Brown University.

2007-2009

R. Ross MacLean, B.A. Coauthored manuscripts both published and in preparation.

Research assistant continues studies of neuroimaging of cigarette smokers as a Doctoral
Candidate at Pennsylvania State University.

Formally Supervised Trainees

2009-2010

Bethany Bracken Ph.D., Scientist III, Charles River Analytics

A postdoctoral fellow with whom I coauthored one abstract, one publication, one
manuscript in preparation, and who now works in industry.

2010-present

Yunjie Tong, Ph.D., Instructor in Psychiatry, Assistant Biomedical Engineer

A postdoctoral fellow who was awarded a Mentored Quantitative Research Career
Development Award (K25) entitled Multimodal neuroimaging of cigarette smoking
(mentors, B. Frederick, and K. Lindsey, PhDs), and with whom I have coauthored two
papers, and two abstracts.

Formal Teaching of Peers (e.g., CME and other continuing education courses)
2008

Pharmacologic MRI of Smoked Tobacco: Research

Highlights for Technologists
6

Brigham and Womens Hospital,

Boston, MA.

Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
Northeastern Regional Meeting of the Society for
Magnetic Resonance Technologists.

Local Invited Presentations

2001

Selective Dopamine Transporter Blockers as Potential Pharmacotherapies for Cocaine

Addiction. Molecular and Systems Pharmacology Seminar. Dept. of Pharmacology, Emory
University
Atlanta, GA.

2014

Behavioral pharmacology and neuroimaging of the effects of acute smoking. MIC Seminar
Series. McLean Imaging Center, McLean Hospital
Belmont, MA

Report of Regional, National and International Invited Teaching and

Presentations
Invited Presentations and Courses
Regional
2007

Pharmacological MRI of Tobacco Smoking.

Pharmaceutical Sciences Colloquium. Department of Pharmaceutical Sciences,
Northeastern University, Boston, MA.

2007 - present

PSC G226 Imaging in Medicine and Drug Discovery

12-18 graduate students
Northeastern University, Boston, MA
3 hours contact, 15 hours preparation.

2010 - present

CAS PS 333 Drugs and Behavior

30-100 undergraduate students
Boston University

1-3 hours contact, 8-15 hours preparation.

National
2001

Preclinical investigations of monoamine transport blockers as potential pharmacotherapies for

cocaine addiction. Department of Psychiatry, University of Pennsylvania
Philadelphia, PA.

2001

Monoamine transporter inhibitors in cocaine medications development. Postdoctoral Seminar.

Behavioral Pharmacology Research Unit, Johns Hopkins University
Baltimore, MD
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
2001

Preclinical investigations of monoamine transport blockers as potential pharmacotherapies for

cocaine addiction.
Department of Psychiatry Treatment Research Center Seminar Series. University of Pennsylvania
Philadelphia, PA

2001

Monoamine transporter inhibitors: Potential pharmacotherapies for cocaine addiction? ,

Brookhaven National Laboratory
Upton, NY

2001

Monoamine transporter inhibitors and behavior: Relation to dopamine transporter occupancy as

determined by PET in rhesus monkeys. Neuropsychiatric Institute, University of California, Los
Angeles, CA.

2001

Monoamine transporter inhibitors in cocaine medications development.

Behavioral Pharmacology Research Unit Special Seminar, Johns Hopkins University
Baltimore. MD.

2004

Neuroimaging of the effects of monoamine transporter blockers in nonhuman and human

primates. Weekly Seminar, Alcohol and Drug Abuse Research Center, McLean Hospital Belmont
MA.

2007

BOLD fMRI studies of the acute effects of nicotine or placebo smoking. NIDA Early Career
Investigator Poster Session, American Psychological Association Annual Meeting
San Francisco, CA.

2008

Pharmacologic MRI of cigarette and placebo smoking

National Institutes on Drug Abuse Annual Mentored Scientist Award (K) meeting
Bethesda, MD.

2008

Pathways to Careers in Behavioral Pharmacology. Emory University Molecular and Systems

Pharmacology Alumni Symposium, Department of Pharmacology, Emory University
Atlanta, GA.

2009

Puffing on air or tobacco smoke produces BOLD signal change in smoking-related brain regions
without widespread alteration of the BOLD response to visual stimulation. Frontiers in Addiction
Research - NIDA 2009 Mini-Convention Society for Neuroscience Annual Meeting,
Chicago, IL.

International
2000

Attenuation of cocaine self-administration by RTI-113: Relation to dopamine transporter

occupancy determined by PET in rhesus monkeys. (Selected Oral Abstract)
College on Problems of Drug Dependence Annual Meeting.
San Juan, Puerto Rico

Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
2001

Attenuation of cocaine self-administration by GBR12909: Relation to transporter occupancy

measured by PET in rhesus monkeys. (Selected Oral Abstract)
College on Problems of Drug Dependence Annual Meeting.
Scottsdale, AZ.

2002

Attenuation of cocaine self-administration by substituted tropanes: Relation to dopamine

transporter occupancy determined by PET in rhesus monkeys. (Selected Oral Abstract) College on
Problems of Drug Dependence Annual Meeting.
Quebec City, Quebec, Canada

2007

fMRI Imaging of the effects of smoked tobacco and placebo tobacco.

Joint meeting of the Society for EEG and Clinical Neuroscience with the International Society for
Neuroimaging in Psychiatry.
Montreal, Canada

2007

Pharmacological MRI of Smoked Tobacco. (Selected Oral Abstract)

Nicotine & Tobacco Research Vol 10:S2. p.S106 and Society for Research on Nicotine and
Tobacco 13th Annual Meeting.
Austin, TX.

2008

Pharmacologic MRI of Cigarette and Placebo Smoking. (Selected Oral Abstract)

Organization for Human Brain Mapping 14th Annual Meeting
Melbourne, Australia.

2009

Air puffing, smoking, and nicotine effects on BOLD response to visual stimulation.
Weekly Seminar, Oxford Centre for Functional MRI of the Brain
Department of Clinical Neurology, John Radcliffe Hospital
Oxford, UK.

Report of Technological and Other Scientific Innovations

Lindsey KP, Lukas SE, MacLean RR, Ryan ET, Reed KR, Frederick BdeB. Design and
validation of an improved nonferrous smoking device for self-administration of
smoked drugs with concurrent fMRI neuroimaging, Clinical EEG &
Neuroscience, 2009 Jan;40(1):21-30.
Frederick B, Lindsey KP, Nickerson LD, Ryan ET, Lukas SE. (2007) An MR-compatible
device for delivering smoked marijuana during functional imaging.
Pharmacology, Biochemistry, and Behavior May;87(1):81-9. Epub 2007 Apr 13.
This apparatus allowed the very first fMRI studies of smoked drugs with concurrent smoking
and neuroimaging. Local investigators have proposed to use the device in upcoming studies, and
inquiries from national investigators at Duke, Penn State, and Yale have been received.
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
Report of Scholarship
Publications
Peer reviewed publications in print or other media
Research Investigations
Stout SC, Owens MJ, Lindsey KP, Knight DL, Nemeroff CB. (2001) Effects of sodium valproate on
corticotropin-releasing factor systems in rat brain. Neuropsychopharmacology, 24(6):62431.
Wilcox KM, Lindsey KP, Votaw JR, Goodman MM, Martarello L, Carroll FI, Howell LL. (2002) Selfadministration of cocaine and the cocaine analog RTI-113: relationship to dopamine
transporter occupancy determined by PET neuroimaging in rhesus monkeys. Synapse,
43(1):78-85.
Howell LL, Hoffman JM, Votaw JR, Landrum AM, Wilcox KM, Lindsey KP. (2002) Cocaine-induced
brain activation determined by positron emission tomography neuroimaging in conscious
rhesus monkeys. Psychopharmacology, 159(2):154-60.
Votaw JR, Howell LL, Martarello L, Hoffman JM, Kilts CD, Lindsey KP, Goodman MM. (2002)
Measurement of dopamine transporter occupancy for multiple injections of cocaine using a
single injection of [F-18]FECNT. Synapse, 44(4):203-10.
Lindsey KP, Gatley SJ, and Volkow ND. Neuroimaging in drug abuse (2003) Current Psychiatry
Reports, 5(5):355-61.
Lindsey KP, Wilcox KM, Votaw JR, Goodman MM, Plisson C, Carroll FI, Rice KC, Howell LL. (2004)
Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus
monkeys: relationship to transporter occupancy determined by positron emission
tomography neuroimaging. Journal of Pharmacology and Experimental Therapeutics,
309(3):959-69.
Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. (2005) In vivo
Comparison of the Reinforcing and Dopamine Transporter Effects of Local Anesthetics in
Rhesus Monkeys. Synapse, 58(4):220-8.
Howell LL, Wilcox KM, Lindsey KP, Kimmel HL. (2006) Olanzapine-Induced Suppression of Cocaine
Self-Administration in Rhesus Monkeys. Neuropsychopharmacology, 31(3):585-93.
Lindsey KP, Gatley SJ. (2006) Applications of clinical dopamine imaging. Neuroimaging Clinics of
North America, 16(4):553-73, vii-viii.
Frederick B, Lindsey KP, Nickerson LD, Ryan ET, Lukas SE. (2007) An MR-compatible device for
delivering smoked marijuana during functional imaging. Pharmacology, Biochemistry, and
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
Behavior, 87(1):81-9.
Lindsey KP, Lukas SE, MacLean RR, Ryan ET, Reed KR, Frederick BdeB. (2009) Design and validation
of an improved nonferrous smoking device for self-administration of smoked drugs with
concurrent fMRI neuroimaging. Clinical EEG & Neuroscience, 40(1):21-30.
Howell LL, Votaw JR, Goodman MM, Lindsey KP. (2010) Cortical activation during cocaine use and
extinction in rhesus monkeys. Psychopharmacology (Berl). 208(2):191-9
Tong Y, Lindsey KP, Frederick, B. (2011) Partitioning of physiological noise signals in the brain with
concurrent near-infrared spectroscopy (NIRS) and fMRI. Journal of Cerebral Blood Flow
and Metabolism, 31(12):2352-62.
Penetar DM, Lindsey KP, Peters EM, Juliano TM, and Lukas, SE. (2012) Decreasing Nicotine Content
Reduces Subjective and Physiological Effects of Smoking. Tobacco Use Insights, 2012:5
1-9.
Lindsey KP, Bracken BK, Maclean RR, Ryan ET, Lukas SE, Frederick BD. (2013) Nicotine content and
abstinence state have different effects on subjective ratings of positive versus negative
reinforcement from smoking. Pharmacology Biochemistry, and Behavior, 103(4):710-6.
Tong Y, Hocke LM, Nickerson LD, Licata SC, Lindsey KP, Frederick Bd. (2013) Evaluating the effects
of systemic low frequency oscillations measured in the periphery on the independent
component analysis results of resting state networks. Neuroimage, 76:202-15.
Lukas SE, Lowen SB, Lindsey KP, Conn N, Tartarini W, Rodolico J, Mallya G, Palmer C, Penetar DM.
(2013) Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues
in alcohol-dependent volunteers: A bold FMRI study. Neuroimage, 78:176-85.

Non-peer reviewed scientific or medical publications/materials in print or other media

Reviews, chapters, monographs and editorials
Lindsey KP, Glaser ST, and Gatley SJ. (2005) Imaging the Brain Cannabinoid System. Handbook of
Pharmacology, RG Pertwee. Ed. Heidelberg, Springer-Verlag. Heidelberg, Germany, 42543.
Lindsey KP, Gatley SJ. (2006) Applications of clinical dopamine imaging. Neurologic Applications of
PET: An Issue of PET Clinics. B. Dudlick. (Hardcover) Elsevier, Philadelphia, PA, 2: 4566.

Thesis
Effects of Monoamine Transporter Blockers on Cocaine Self-administration: Relation to Dopamine
Transporter Occupancy Measured By Pet in Rhesus Monkeys: An Investigation of Substitute Agonist
Therapeutic Strategies for Cocaine Addiction. (2002) Emory University, Atlanta, GA.
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings
Tong Y, Lindsey KP, Frederick BB. (2011) Partitioning of physiological noise signals in the brain using
concurrent near-infrared spectroscopy (NIRS) and fMRI. In: Proceedings of the 17th
Annual Meeting of the Organization for Human Brain Mapping; 6/26/10-6/30/10; Quebec
City, Quebec, Canada.
Tong Y, Hocke L, Nickerson L, Licata S, Lindsey K, Frederick B. (2012) Low frequency peripheral
hemodynamic oscillations are correlated with cerebral signals. In: Proceedings of the 18th
Annual Meeting of the Organization for Human Brain Mapping; 6/10/12-6/14/12; Beijing,
China.
Frederick B, Tong Y, Strother M, Nickerson L, Lindsey K, Donahue M. (2013) Derivation of flow
information from a hypercarbia challenge study using time delay correlation processing.
ISMRM 21st Annual Meeting & Exhibition, 4/21/13-4/26/13; Salt Lake City, UT.

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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
Narrative Report
(Background shapes goals) My interest in neuropharmacology arose approximately while attending an
undergraduate course on Biopsychology at the University of Texas at Austin. My interest in biology was
life-long and this course enabled me to unify this passion with a newfound interest in psychology.
Admission to the Interdisciplinary Molecular and Systems Pharmacology Program at Emory University in
Atlanta provided cross training in neuroscience and enlightened me to the idea of using drugs as tools to
probe both normal and abnormal brain function in a quantitative manner. There, I became a behavioral
pharmacologist under the mentorship of Dr. Leonard Howell. My investigations of the relationship
between monoamine transporter inhibitor binding in brain and cocaine self-administration behavior
earned my doctorate in Biological and Biomedical Sciences with emphasis in Molecular and Systems
Pharmacology from Emory University in the Fall of 2002. Since then, my scientific interests have been
focused on answering questions about relationships between behavior and health using behavioral
pharmacology, acute drug administrations, and neuroimaging in various combinations. This array of
techniques allows me to investigate an extremely broad range of outcomes from events that take place
on an organismal level (behavior) to molecular events such as ligand-binding, receptor activation, and
changes in global and/or regional blood flow in brain.
(My position within the field) Addiction is primarily a behavioral phenomenon and as such, is ideally
suited for study and for intervention using behavioral methods. It is the dysregulation of behavior, in
which animals or humans substitute drug-taking behavior for adaptive behaviors, which defines drug
addiction. In contrast, molecular events such as drug binding to receptor are the events that initiate this
maladaptive cascade that culminates ultimately in the behavioral outcome. In vivo neuroimaging is a
method that can be used to visualize a number of different types of events occurring at the molecular level
within the living brains of both human and animal subjects. My preferred strategy has been, and continues
to be, to combine these powerful techniques to simultaneously study phenomena from both ends of this
broad spectrum of addiction-related events. Combined experience in behavioral pharmacology and
neuroimaging have made me uniquely suited to performing experiments combining behavioral
pharmacology with neuroimaging and acute drug administrations to investigate questions relating to drug
abuse, motivation, learning, and reinforcement.
(Accomplishments and achievements) I have authored 17 research publications establishing my expertise
in behavior, pharmacology, brain imaging and physiology. An unusual amount of firsthand experience
with cigarette dependence combined with my formal training to allow me to develop an MRI compatible
smoking device that does not alter the amount of nicotine delivered per cigarette, and can be used for selfadministration of smoked drugs during functional neuroimaging. My association with the Optical
Magnetic Group reinforces my interest in physiology, quantitative biology, and sensors and provides me
an opportunity to mentor Dr. Yunjie Tong, a young biomedical engineer with aspirations to become a
drug abuse researcher. Very few groups are performing neuroimaging studies of nicotine and even fewer
(perhaps none) are performing neuroimaging studies during smoking. The lack of neuroimaging studies of
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Kimberly P. Lindsey, Ph.D.

Curriculum Vitae
nicotine, the most commonly abused drug in the world, using smoking, the most commonly used route,
creates a gap in the literature that we can fill.
(Future Directions) It has increasingly apparent that for most individuals, behavior is the primary
determinant of health, and also the factor most amenable to self-directed change. The advent of
inexpensive wearable microelectronics for sensing behavior, physiology, and environment positions
biomedicine on the cusp of both an avalanche of data and unprecedented opportunity to understand
interactions between these variables both inside and outside the lab. My experiences, training, and
expertise position me well to continue to draw attention to behavior as a critical, yet underappreciated
topic for medical research.

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