Family of High Functionality Excipients

The Next Generation of Modern Excipients:

All-in-One Excipient Composite:
Binder/Filler, Glidant, Superdisintegrant, Lubricant

PROSOLV EASYtab SP

Microcrystalline Cellulose, Colloidal Silicon Dioxide,

Sodium Starch Glycolate, Sodium Stearyl Fumarate
ODT Excipient Matrix License and Royalty Free

PROSOLV ODT

Microcrystalline Cellulose, Colloidal Silicon Dioxide,

Mannitol, Fructose, Crospovidone
High Functionality Excipient

PROSOLV SMCC

Silicified Microcrystalline Cellulose

Our Basis:
The wellknown
JRS PHARMA Excipient Family.

Calcium Hydrogen Phosphate Dihydrate

Dibasic Calcium Phosphate Dihydrate

ANHYDROUS

Calcium Hydrogen Phosphate, Anhydrous

Dibasic Calcium Phosphate, Anhydrous

Wide Range of Branded High-Quality Excipients

and Innovative, High-Functionality Specialities.
Backed up by Advanced Technical Support
and Handling Services that Save You Money.

COMPACTROL

Calcium Sulfate Dihydrate

One Stop Shopping for Better Tablets.

And Added Value in Costs and
Patient Compliance.
JRS PHARMA active all over the world. Your tried and
tested, reliable manufacturer of excipients, in possession
of all significant certificates and customer approvals.
We offer a comprehensive range of excipients for all
important functions, with graduated performance profiles:
Branded Excipient Quality, e.g. VIVAPUR, EMCOCEL .
High Quality Original Products (PRUV , EMDEX).
Innovative PROSOLV SMCC High Functionality Excipients.
PROSOLV EASYtab and ODT Ready-to-use Excipient Composites.
Co-Processing Technology for APIs and Extracts.
Cost savings based on Direct Compression (DC).

Lubricants

Our extensive modular system of excipients forms the

basis for perfect conceptual solutions.
In conjunction with you we will develop your individual package
for success, whether it is just a single product or an entire
tablet matrix formulation.
JRS PHARMA Excipients stand for
Perfect product quality, maximum availability and
first-class documentation.
Customised delivery and logistics solutions, all over the world.
One-stop shopping from a massive product range.
Reduced testing requirements based on the possibility of
large batches.
Security of supply as a result of redundant production sites
distributed between continents worldwide.
Currently the world's biggest production capacity for MCC
and powdered cellulose.

VIVA PUR MCC SPHERES

What we offer: problem solution from a single source,

including application consulting and customer-specific formulation
development from three Technical Competence Centres (TCC's)
staffed by experienced specialists in Germany, the USA and India.

Microcrystalline Cellulose Pellets

The ideal partner for Global Players.

Direct access by local contact persons to all services,
documents and data.

Coatings

Comprehensive excipient functions.

Graduated performance profiles.
Individual products or complete systems.
Multiple specialities.

Ready-to-Use Coating System

VIVA PHARM HPMC

Hypromellose

Become Part of the Global

JRS PHARMA Excipient Family

Co-Processing of Actives

Contract
Formulation
Development

an associate of JRS PHARMA

Worli, Mumbai, 400 018.

India

Contract R+D
Contract Manufacturing
for Biotech

CELONIC AG
4051 Basel Switzerland
CHO Cell Line based
Contract Services

Bringing Value Through a

Dedicated Worldwide Sales and Support Network

ProJect Pharmaceutics GmbH

82152 Munich / Martinsried
Germany
www.project-pharmaceutics.com

CELONIC GmbH
52428 Jlich Germany
Bioanalytics

JRS PHARMA - the Family Name for

Customer Advantages

www.szhaveri.com
www.celonic.com

Customer Service:

The new, extended JRS PHARMA FAMILY

New Business Fields:

Contract R+D and
Contract Manufacturing
for Small Molecules
and Biotech

Worldwide Headquarters:
+ 49 (0) 7967 / 152 312

USA + Canada:
+ 1 (845) 878 3414

info@jrspharma.de

info@jrspharma.com

www.jrspharma.com

PROSOLV Family of High Functionality Excipients

All-in-One Composite: Binder/Filler, Glidant, Superdisintegrant, Lubricant

ion

Innovat

PROSOLV EASYtab SP

High Functionality Excipient

A homogeneous lubricated high-functionality excipient composite, comprised of binder/filler, glidant, super disintegrant, and lubricant. PROSOLV EASYtab SP
imparts a perfect balance of compaction, flow, disintegration, lubrication, content uniformity and reduces sticking. PROSOLV EASYtab SP for rapid formulation
development, convenient tablet manufacture, significantly higher tabletting speed and output/hour.
Grade

Ingredients

PROSOLV EASYtab SP

Average Particle
Size by Laser
Diffraction (m)

Bulk Density
(g/cm)

Main Application

140

0.30 - 0.42

Ready-to-use excipient composite. Suitable for formulations with

API content up to 65 %, especially for abrasive, bad flowing, and
fluffy actives. High-speed tabletting, superior weight, and
content uniformity, no overmixing, higher yield.

Microcrystalline Cellulose
Colloidal Silicon Dioxide
Sodium Starch Glycolate
Sodium Stearyl Fumarate

PROSOLV SMCC
Silicified Microcrystalline Cellulose, NF
1
(Microcrystalline Cellulose, Ph.Eur., NF, JP and Silica, Colloidal Anhydrous, Ph.Eur. )
A portfolio of high functionality excipients that imparts superior flow, compaction and dispersion to a formulation. When used in direct compression, PROSOLV SMCC
can replace granulations, while significantly reducing excipient numbers and levels. PROSOLV SMCC formulations produce distinctive, uniform, cost effective tablets.

Grade

Average Particle
Size by Laser
Diffraction (m)

Bulk Density
(g/cm)

PROSOLV SMCC 50

60

0.25 - 0.37

Formulas where optimal compaction is required.

PROSOLV SMCC 50 LD

50

0.20 - 0.30

Formulas where optimal compaction is required.

PROSOLV SMCC 90

110

0.25 - 0.37

Formulas where a balance of flow and compaction is required.

PROSOLV SMCC HD 90

110

0.38 - 0.50

Formulas where optimal flow and consolidation is required. This grade shows the best
disintegration times.
*Low moisture grade avaliable on request

PROSOLV SMCC 90 LM

110

0.25 - 0.37

Equal quality to grade SMCC 90, but lower moisture content (< 3 %).

ODT Excipient Matrix License and Royalty Free

tion
a
r
e
n
e
2nd G

PROSOLV ODT

PROSOLV ODT G2 is an orally disintegrating tablet excipient matrix. It allows a rapid formulation development and quality tablet manufacture.
PROSOLV ODT G2 requires no licence and royalty agreement.
Grade

Ingredients

PROSOLV ODT G2

Average Particle
Size by Laser
Diffraction (m)

Bulk Density
(g/cm)

Main Application

52

0.52

PROSOLV ODT G2 is a simple-to-use co-processed composite derived

from JRS PHARMAs patented PROSOLV Technology. Its primary
application is for the development and manufacture of orally
disintegrating tablets allowing the discrete and convenient administering of medicines without water for high patient compliance.

Microcrystalline Cellulose
Colloidal Silicon Dioxide
Mannitol
Fructose
Crospovidone

Main Application

NF = Colloidal Silicon Dioxide; JP = Light Anhydrous Silicic Acid

Lubricants

Binders

VIVA PUR

PRUV

EMCOCEL

Sodium Stearyl Fumarate , Ph.Eur., NF, JPE

Microcrystalline Cellulose , Ph.Eur., NF, JP

Average
Particle Size
by Laser
Diffraction
(m)

Spray
Dried Quality

Air Stream Dried

Quality

VIVAPUR 105

VIVAPUR 101

EMCOCEL 50 M

PRUV is a lubricant with a hydrophilic character. It avoids many problems

associated with magnesium stearate including active incompatibility*, over
lubrication, and film formation in effervescent tablets.

Bulk Density (g/cm3)

Main Application

VIVAPUR EMCOCEL
Very fine grade, which gives a pleasant mouth feeling, masks bitter tastes
and supports flavors.

0.26 - 0.31

65

0.26 - 0.31

Same grade as 101 but very low amount of visable specks and
high degree of brightness.

VIVAPUR 103

65

0.26 - 0.34 0.25 - 0.37

Same quality as grade 101/50M, but very low moisture content

(< 1.5 % resp. 3 %) for processing water-sensitive actives.

VIVAPUR 301

65

0.35 - 0.46

Same quality as grade 101, but increased bulk density and improved
flow properties.

100

0.28 - 0.33 0.25 - 0.37

Medium size standard MCC grade, suited for the majority of directly
compressible actives. Combines good flow and high compactibility.

100

0.28 - 0.33

Same grade as 102 but very low amount of visable specks and
high degree of brightness.

Premium

VIVAPUR 102

EMCOCEL 90 M

VIVAPUR 102
Premium

0.25 - 0.37

VIVAPUR 112

EMCOCEL XLM 90

100

0.30 - 0.36

0.25 - 0.37

Same quality to grades 102/90M, but very low moisture content (< 1.5 %)
for processing water-sensitive actives.

VIVAPUR 302

EMCOCEL HD 90

100

0.35 - 0.50

0.38 - 0.50

Same quality to grade 102/90M, but increased bulk density and improved
flow properties. Especially suited for high speed tableting and processing
high density actives.

* e.g. Azathioprin, Cefaclor, Cilazapril, Clarithromycin, Clopidogrelacetate, Diclofenac,

Fosinopril, Ibuprofen, Ketorolac, Levofloxacin, Nifedipin, Omeprazol, Ramipril, Trandolapril.
1

RO-CEP 2006 - 313

Disintegrants

180

Sodium Starch Glycolate, Ph.Eur., NF, JP

Et-OH based

Me-OH based

VIVAPUR 14

180

EMCOCEL LP 200

190

VIVAPUR 200

VIVAPUR XLM 200

Superdisintegrant with a rapid and high degree of swelling for tablet and capsule formulations.
Especially for poor water soluble actives.

5.5 - 7.5

Superdisintegrant with a rapid and high degree of swelling for tablet and capsule formulations.
Especially for poor water soluble actives and tablet matrixes with higher pH values.

5.5 - 7.5

Special grade with very low methanol content.

Especially suited for alcohol and moisture sensitive actives.

EXPLOTAB CLV

5.5 - 7.5

Special grade with increased number of crosslinkings.

Especially suited for wet granulation applications.

EXPLOTAB Low PH

3.0 - 5.0

Special grade with low pH value. Complies with Typ (B) Ph. Eur, NF.

EXPLOTAB
VIVASTAR PSF

Viscous grades which form a gel in water and chloride reduced types (PCF) complying with Japanes food regulations are available on request.

250

0.31 - 0.37

Large size MCC grade with excellent flow properties for a variety of direct
compression formulations.

250

0.33 - 0.40

Same quality to grades 200/LP200, but very low moisture content (<1.5 %)
for processing water-sensitive actives.

Croscarmellose Sodium, Ph.Eur., NF, JP

Grade

EMDEX

Calcium Hydrogen Phosphate Dihydrate, Ph.Eur.

Dibasic Calcium Phosphate, Dihydrate, USP

Dextrates, NF
Ideal for chewable and soluble tablets, EMDEX is the only compendial
(NF) dextrate that delivers the necessary flow, compaction, taste masking
and flavor carrying capacity.
It is highly water-soluble and gives a cool smooth mouth feel.
EMDEX is also available GMO free.

Calcium Hydrogen Phosphate Dihydrate / Dibasic Calcium Phosphate is a superior

inorganic binder. It has a unique particle size, shape and density to maximize flow in
high speed tablet production.

Grade

Chemical Structure

VIVASOL

cotton floc

max. 10 %

max. 1 % Me-OH

VIVASOL GF

wood pulp

max. 10 %

max. 3 % Et-OH

VIVASOL GF LM

wood pulp

max. 6 %

max. 0.5 % Et-OH

VIVASOL SF

cotton floc

max. 10 %

max. 0.3 % Me-OH Special grade with very low methanol

content. Especially suited for alcohol and
moisture sensitive actives, no interaction
with antibiotics known.

A cellulose-based superdisintegrant,
providing excellent results in tablet disintegration. Used at a level of 1 - 4 % only, it is
one of the most efficient superdisintegrants
in the pharmaceutical technology. VIVASOL
can be used in all tableting processes.
Especially good for medium soluble actives.

CaHPO4 2 H20
Monoclinic crystal

Standard grade with

excellent flow properties

EMCOMPRESS
PREMIUM

CaHPO4 2 H20
Monoclinic crystal

Complies with JP. High degree

of brightness. Low content of
off white particles.

Carriers

COMPACTROL

Calcium Sulfate Dihydrate, Ph.Eur., NF

COMPACTROL is a specially processed Calcium Sulfate Dihydrate for use as
a filler in tablets made by direct compression or a binder in wet granulation.

Special grade, offers improved

compressibility and moisture
stability in tableting. Ideal flow
enhancer for capsule fillings.

CaHPO4
Triclinic crystal

EMCOMPRESS
ANHYDROUS PREMIUM

Bulk density

0.90 - 1.35 g/cm

Median particle size

120 m

VIVAPUR MCC SPHERES

NON-PAREIL
SEEDS

Microcrystalline Cellulose, Ph.Eur., NF, JP

Sugar Spheres, Ph.Eur., NF

Chemical inert carrier for APIs

Grade

Size

Functional Fillers

ARBOCEL

Powdered Cellulose, Ph.Eur., NF, JP

Powdered cellulose is used as an economic and inert diluent in tableting and capsule filling. Especially in wet granulation it works synergistically with other
economic excipients such as starch or lactose. Combined with these, ARBOCEL improves tablet hardness and disintegration time.
Average Particle
Size by Laser
Diffraction (m)

Bulk Density

ARBOCEL M 80

60

0.20 - 0.24

Fine, fibrous grade of powdered cellulose, suitable for wet granulation.

ARBOCEL P 290

80

0.27 - 0.33

Fine grade with increased density and improved flow. Suitable for wet granulation
and direct compression.

ARBOCEL A 300

250

0.31 - 0.41

Coarse grade with excellent flow properties used in direct compression and for capsule fillings.

VIVAPUR

VIVAPUR

VIVAPUR
VIVAPUR

VIVAPUR
VIVAPUR

VIVAPUR

MCC
MCC
MCC
MCC
MCC
MCC
MCC

SPHERES
SPHERES
SPHERES
SPHERES
SPHERES
SPHERES
SPHERES

100
200
350
500
700
1000
1250

Are used in multiple drug units for improved

content uniformity, consistent and controlled
drug release and high drug stability.

Main Application
(m)

(mesh)

Grade

Grade with less than 6 % of moisture for

food applications (E468).

Main Application

EMCOMPRESS

ANHYDROUS
EMCOMPRESS

Soy Polysaccharides
An all natural superdisintegrant, which
does not contain starch or sugar. Being
a dietary fiber, it has excellent application
in nutritional products.

Raw Material GMO free Loss on drying Solvent Content

RO-CEP 2009 -321

EMCOMPRESS

EMCOSOY

VIVASOL

Coarse grade MCC, combines good compactibility and high binding capacity
with outstanding flow. Provides good content uniformity at low weight
variation even when used with low concentrations of fine actives.

Grade

70 - 140

100 - 200

45 - 60

200 - 350

- Water insoluble carrier

35 - 45

355 - 500

- For organic solvent free API coating

25 - 35

500 - 710

- Small particle sizes available

18 - 25

710 - 1000

- High robustness

14 - 18

1000 - 1400

13 - 15

1250 - 1500

Main Application

(m)
(mesh)
14 - 18 1000 - 1400 - Water soluble carrier for
16 - 18 1000 - 1180 multiple dose formulations.
16 - 20 850 - 1180 - High content uniformity.
18 - 20 850 - 1000
20 - 25 710 - 850 - Consistent and controlled
drug release.
25 - 30 600 - 710
30 - 35 500 - 600 - Multiple drugs combined
35 - 40 425 - 500
in one unit.
40 - 50 300 - 425
40 - 60 250 - 425 - High drug stability.
60 - 80 180 - 250

Main Application
(g/cm)

Thickener + Stabilizer

VIVAPUR MCG
Microcrystalline Cellulose and Carboxymethylcellulose Sodium, Ph. Eur., NF

Coating

Thickener and Stabilizer for Suspensions and Emulsions.

VIVAPUR MCG 591 P

Ready-to-Use Coating System

Grade

VIVAPUR MCG 611 P

Main Application

VIVACOAT A

(high) Adhesion

VIVACOAT M

Moisture Barrier

- Highest quality standards - Made in Germany

VIVACOAT X

eXtra Elegance

- Color guarantee

VIVACOAT C

Customer Formulation

- Fully formulated Coating System (powder)

VIVAPUR MCG 811 P

NaCMC (%)

Particle Size

8.3 - 13.8

> 250 m (60 mesh): max. 0.1 %

> 45 m (325 mesh): max. 45 %

39 - 91 (1.2 % solids)

Gelling agent for ready to use applications prepared

with high shear forces.

11.3 - 18.8

> 250 m (60 mesh): max. 0.1 %

> 45 m (325 mesh): max. 50 %

50 - 118 (2.6 % solids)

Gelling agent for reconstituable dry suspensions

requires low shear forces.

2400 - 5600 (2.6 % solids)

High functional gelling agent for all type

of suspensions and emulsions.

11.3 - 18.8 > 250 m (60 mesh): max. 3 %

Viscosity (mPas)

Main Application

All data are subject to changes without notice, errors reserved.

io
Innovat

- Free technical support

www.jrspharma.com

VIVA PHARM HPMC

Hypromellose, Ph.Eur., USP, JP
Grade

Substitution
Type

VIVAPHARM HPMC E3

VIVAPHARM HPMC E5
VIVAPHARM HPMC E6
VIVAPHARM HPMC E15
VIVAPHARM HPMC E50

USP 2910
Methoxy-groups: 28 - 30 %
Hydroxypropoxy-groups:
7 - 12 %

Viscosity (2 %)
(mPas)

Main Application

For high solid content

Typical grade for an excellent coat

Typical grade for an excellent coat

15

For wet granulation (10 % aqueous solution)

50

As a suspension stabilizer

Coating Hotline: Phone: + 49 (0) 7967 / 152 444 filmcoating@jrspharma.de

WORLDWIDE HEADQUARTERS

USA+Canada

JRS PHARMA GMBH & CO. KG

JRS PHARMA LP

73494 Rosenberg (Germany)

Phone: + 49 (0) 7967 / 152 312
Fax: + 49 (0) 7967 / 152 345
info@jrspharma.de www.jrspharma.de www.jrs.de

2981 Route 22, Suite 1 Patterson, NY 12563-2359

TollFree(USA): (800) 431 2457
Phone: + 1 (845) 878 3414 Fax: + 1 (845) 878 3484
info@jrspharma.com www.jrspharma.com

Customer Service: + 49 (0) 7967 / 152 312

Customer Service: + 1 (845) 878-3414

4540_GB_V11_3.51209KE

0.25 - 0.37

Main Application

5.5 - 7.5

Same quality to grade 12, but very low moisture content (<1.5 %) for
processing water-sensitive actives.

0.34 - 0.42

pH Value

VIVASTAR P

Coarse grade MCC, combines good compactibility and high binding capacity
with outstanding flow. Provides good content uniformity at low weight
variation even when used with low concentrations of fine actives.

0.30 - 0.36

STAR
VIVASTAR

EXPLOTAB

The Innovative MCC- Grade for Direct Compression

VIVAPUR 12

LUBRITAB is made from hydrogenated cottonseed oil. As a plant-derived

product it is the ideal lubricant for health supplement and neutraceutical
products. It can also be used as a binder and controlled release matrix.

Fine standard MCC grade, especially suited for wet granulation,

roller compaction and spheronization. Very high compactibility.

65

VIVAPUR 101

Hydrogenated Vegetable Oil, NF, BP

Hydrogenated Oil, JP

0.20 - 0.26

25

LUBRITAB