Juxtacapillary (J) receptors - Wikipedia, the free encyclopedia

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Juxtacapillary (J) receptors

From Wikipedia, the free encyclopedia

J (juxtacapillary) receptors (or pulmonary C-fiber receptors) are sensory nerve endings located within the
alveolar walls in juxtaposition to the pulmonary capillaries of the lung and are innervated by fibers of the vagus
nerve.[1] Although their functional role is unclear, J-receptors respond to events such as pulmonary edema,
pulmonary emboli, pneumonia, congestive heart failure and barotrauma, which cause a decrease in oxygenation
and thus lead to an increase in ventilation/respiration.[2] They may be also stimulated by hyperinflation of the
lung as well as intravenous or intracardiac administration of chemicals. The stimulation of the J-receptors
causes a reflex increase in breathing rate, and is also thought to be involved in the sensation of dyspnea, the
subjective sensation of difficulty breathing.[3][4] The reflex response that is produced is apnea followed by rapid
breathing, bradycardia, and hypotension (pulmonary chemoreflex). The physiologic role of this reflex is
uncertain, but it probably occurs in pathologic states such as pulmonary congestion or embolization.[5] These
receptors were discovered by Dr. A.S. Paintal.[6]
Because these receptors have been found in the walls of bronchi, the larynx, and the nose, they appear to be part
of a widespread population of nociceptors found in most tissue. For this reason, they are now usually referred to
as pulmonary C-fiber receptors.[7]

References
1. Sircar, Sabyasachi. Principles of Medical Physiology. pp. 35051. ISBN 1-58890-572-1.
2. Guyton (2011). "Regulation of Respiration". Textbook of Medical Physiology. Saunders Elsevier. ISBN 978-1-41604574-8.
3. A.A. Majid, A.N.Kingsworth, Fundamentals of Surgical Practice. Cambridge, MA: Cambridge University Press, 2006.
ISBN 0-521-67706-8.
4. J.C. Bennett, F.Plum ed. Cecil Textbook of Medicine, 20th ed., W.B. Saunders, Philadelphia PA, 1996. ISBN 0-72163574-1
5. Ganong, WF (2005). "Regulation of Respiration". Review of Medical Physiology 22nd ed. McGraw Hill.
6. "A.S. Paintal a celebrated physiologist" (http://www.hindu.com/seta/2006/01/19/stories/2006011900181500.htm). The
Hindu (Chennai, India). 19 January 2006.
7. Widdicombe, J. (2006). Reflexes from the lungs and airways: Historical perspective. Journal of Applied Physiology, 101.
628-634.

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Categories: Nervous system
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