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Purpose of review
Maintenance of adequate tissue oxygenation is an
important task in intensive care units. In this context, venous
oximetry by obtaining mixed venous oxygen saturation or
central venous oxygen saturation has been discussed as
useful monitoring parameters. This review discusses the
physiology and clinical application of these parameters.
Recent findings
No study has so far demonstrated that venous oxygen
saturation monitoring can reduce mortality in critically ill
patients although length of stay has been decreased in
cardiac surgery patients. Furthermore, pulmonary artery
catheter usage does not affect outcome in critically ill
patients. In contrast, early goal directed therapy for patients
with severe sepsis or septic shock, which includes
treatment goals for mean arterial pressure, central venous
pressure, and central venous oxygen saturation, was able to
increase survival in these patients. There is also evidence
that central venous oxygen saturation measurement is
beneficial in other types of shock.
Summary
Early goal directed therapy should be implemented in the
initial resuscitation of septic patients. Measurement of
central venous oxygen saturation can easily be applied in
intensive care unit patients and offers a useful indirect
indicator for the adequacy of tissue oxygenation.
Keywords
central venous oxygen saturation, hemodynamic
monitoring, mixed venous oxygen saturation, oxygen
transport, tissue oxygenation
Curr Opin Crit Care 11:259
263. 2005 Lippincott Williams & Wilkins.
Klinik f. Anasthesiologie und Intensivtherapie, Klinikum der
Friedrich-Schiller-Universitat, Jena, Germany
Correspondence to Prof. Dr. med. K. Reinhart, Klinikum der
Friedrich-Schiller-Universitat Jena, Klinik f. Anasthesiologie und Intensivtherapie,
Erlanger Allee 101, 07747 Jena, Germany
Tel: +49 3647 932 31 01; fax: +49 3641 932 31 02;
e-mail: Konrad.Reinhart@med.uni-jena.de
Current Opinion in Critical Care 2005, 11:259
263
2005 Lippincott Williams & Wilkins.
1070-5295
Introduction
Continuous measurement of the systemic blood pressure
and heart rate are routinely obtained in critically ill
patients. It is a very basic question to what extent the routinely measured cardiorespiratory parameters provide information about the adequacy of oxygen transport and,
more importantly, on the quality of tissue oxygenation.
Recognition, prevention, and treatment of tissue hypoxia
play a key role in intensive care medicine. The aim of
cardiovascular monitoring is the early recognition of impending tissue hypoxia. In some situations, tissue
hypoxia may exist despite normal values obtained by conventional hemodynamic monitoring such as arterial blood
pressure, central venous pressure, heart rate, and urine
output.
Measurement of mixed venous oxygen saturation (SvO2)
from the pulmonary artery has for some time been advocated as an indirect index of tissue oxygenation. In myocardial infarction, decreased SvO2 was found to be
indicative of current or imminent cardiac failure [1]. In
several diseases such as cardiopulmonary disease, septic
shock, cardiogenic shock, and in patients after cardiovascular surgery, a low SvO2 was associated with a poor prognosis [24]. Based on these findings, fiberoptic pulmonary
artery (PA) catheters for continuous SvO2 measurement
have been developed. However, PA catheterization is costly
and includes inherent risks. Furthermore, its usefulness in
various clinical conditions remains under debate due to
a lack of convincing data [5]. In comparison, central venous catheterization via the superior vena cava is part of
standard care for critically ill patients and is easier and
safer to perform. Similar to the SvO2, the measurement
of the central venous oxygen saturation (ScvO2) has been
advocated as a simple method to assess changes in the adequacy of global oxygen supply in various clinical setting
[1]. However, it has been questioned whether this parameter exactly mirrors the SvO2 especially in critically ill
patients. Rivers et al. [6] demonstrated in a recent prospective randomized study in patients with severe sepsis
and septic shock that, in addition to maintaining central
venous pressure above 812 mm Hg, mean arterial pressure
above 65 mm Hg, and urine output above 0.5 mL/kg/h, the
maintenance of a ScvO2 above 70% resulted in an absolute
reduction of mortality by 15%. These findings refueled
the interest in the measurement of ScvO2 in critically
ill patients. The purpose of this review is to discuss the
differences and the similarities between mixed and central
venous oxygen saturation as well as the potential usefulness of measuring ScvO2 in clinical practice.
259
measurement of ScvO2 is not possible. However, more important than the precise prediction of SvO2 is the question
whether changes in SvO2 indicating a hemodynamic derangement or a treatment effect are mirrored by changes
in the ScvO2. In a dog model, various clinical conditions
such as hypoxia and hemorrhagic shock were investigated
regarding their effects on these parameters [14]. This
study confirmed that ScvO2 differed from SvO2 but
changes in SvO2 were accompanied by parallel changes
in ScvO2 (Fig. 2).
This could also be demonstrated in the clinical setting
where 32 critically ill surgical patients were monitored
for a total of 1097 hours. A good agreement between
SvO2 and ScvO2 was shown [11]. The authors concluded
that the continuous measurement of ScvO2 might be a reliable and convenient tool to monitor the adequacy of the
oxygen supply/demand ratio. Figure 3 shows an example of
a septic patient who developed septic shock on day 3. Although the difference between SvO2 and ScvO2 increases
after onset of septic shock, the curves of both parameters
change in parallel.
Conclusion
Measurement of ScvO2 is simple and does not necessitate
additional invasive techniques. There is a good correlation
between ScvO2 and SvO2 under non-shock conditions.
During the state of circulatory shock, however, ScvO2 does
not always exactly mirror SvO2. However, changes of both
parameters occur in a parallel manner. Furthermore,
changes in SvO2 due to therapeutic interventions are well
reflected in changes of ScvO2. This holds true especially
in patients with severe sepsis/septic shock and patients
with cardiac arrest. In critically ill patients, ScvO2 is higher
than SvO2. This implies that a pathologic ScvO2 indicates
an even lower SvO2. As many other parameters in intensive care medicine, ScvO2 should not be used as the only
measure in the assessment of the cardiocirculatory system
but should be combined with standard vital parameters
(heart rate, blood pressure, central venous pressure), lactate measurement, and parameters of organ function (urine
output, gastric tonometry). Combining several parameters
for a goal-oriented therapy should increase the reliability to
achieve stable hemodynamic conditions without evidence
of tissue hypoxia.
of special interest
of outstanding interest
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