Professional Documents
Culture Documents
Pancreas
Cystic Fibrosis:
- is a multisystem disease inherited as an autosomal recessive trait due to a
defective gene carried on
chromosome 7
- involves the transport of chloride with a failure to excrete sodium and water
- defective ion permeability leads to viscous epithelial secretions and obstruction
in the ducts of organs
such as the pancreas.
- concentration of chloride, bicarbonate and water low
- net effects: lack of pancreatic amylase and proteases, increased
monosaccharide absorption
- pancreatic lipase, colipase and phospholipase
- causes severe malabsorption and poor nutrition
- 2nd and 12th month of life
- present with malodorous steatorrhea and chronic pulmonary infection
- weakness, weight loss, deficient absorption of the fat soluble vitamins (ADE and
K)
- deficiency of vitamin K leads to bleeding abnormalities
- diagnosis of CF: confirmed or excluded by the sweat test (determination of
chloride concentration;
extremely reliable tool when performed correctly)
- Sweat Test:
- Pilocarpine stimulates sweating when introduced into the skin of the
flexor surface of the
forearm or thigh
- greater than 60 mmol/L consistent with the diagnosis of CF
- infant under 3 months of age, a sweat chloride of >40 mmol/L (highly
suggestive of CF)
- determined on two separate occasions
Endocrine Tumors:
Gastrinoma:
- consists of G cells that secrete gastrin, a potent stimulator of gastric acid by the
stomach
- causes Zollinger-Ellison syndrome (gastric hypersecretion, peptic ulceration,
elevated gastrin levels)
Glucagonoma:
- rare, characterized by migratory erythematous rash, hyperglycemia, anemia
and weight loss
- 80% reduction in plasma amino acids
Insulinoma:
- beta cell tumor leads to hypoglycemia