Professional Documents
Culture Documents
(Review)
Teixeira LJ, Soares BGDO, Vieira VP, Prado GF
This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library
2008, Issue 3
http://www.thecochranelibrary.com
TABLE OF CONTENTS
HEADER . . . . . . . . . .
ABSTRACT . . . . . . . . .
PLAIN LANGUAGE SUMMARY .
BACKGROUND . . . . . . .
OBJECTIVES . . . . . . . .
METHODS . . . . . . . . .
RESULTS . . . . . . . . . .
DISCUSSION . . . . . . . .
AUTHORS CONCLUSIONS . .
ACKNOWLEDGEMENTS
. . .
REFERENCES . . . . . . . .
CHARACTERISTICS OF STUDIES
DATA AND ANALYSES . . . . .
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22
[Intervention Review]
of Physiotherapy, Prefeitura Municipal de Balneario Camboriu, Santa Catarina, Brazil. 2 Universidade Federal de So
Paulo, So Paulo, Brazil. 3 Medicina Interna e teraputica, UNIFESP - Universidade Federal de So Paulo, So Paulo, Brazil. 4 So Paulo,
Brazil
Contact address: Lzaro Juliano Teixeira, Department of Physiotherapy, Prefeitura Municipal de Balneario Camboriu, R. Ana Garcia
Pereira, n 167, Balneario Camboriu, Santa Catarina, 88340-000, Brazil. lazarojt@terra.com.br.
Editorial group: Cochrane Neuromuscular Disease Group.
Publication status and date: New, published in Issue 3, 2008.
Review content assessed as up-to-date: 3 February 2008.
Citation: Teixeira LJ, Soares BGDO, Vieira VP, Prado GF. Physical therapy for Bell s palsy (idiopathic facial paralysis). Cochrane
Database of Systematic Reviews 2008, Issue 3. Art. No.: CD006283. DOI: 10.1002/14651858.CD006283.pub2.
Copyright 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
ABSTRACT
Background
Bells palsy (idiopathic facial paralysis) is commonly treated by physical therapy services with various therapeutic strategies and devices.
There are many questions about their efficacy and effectiveness.
Objectives
To evaluate the efficacy of physical therapies on the outcome of Bells palsy.
Search strategy
We searched the Cochrane Neuromuscular Disease Group Trials Register (February 2008), the Cochrane Central Register of Controlled
Trials (The Cochrane Library, Issue 4, 2007), MEDLINE (January 1966 to February 2008), EMBASE (January 1980 to February
2008), LILACS (January 1982 to February 2008), PEDro (from 1929 to February 2008), and CINAHL (January 1982 to February
2008).
Selection criteria
We selected randomised or quasi-randomised controlled trials involving any physical therapy. We included participants of any age with
a diagnosis of Bells palsy and all degrees of severity. The outcome measures were: incomplete recovery six months after randomisation,
motor synkinesis, crocodile tears or facial spasm six months after onset, incomplete recovery after one year and adverse effects attributable
to the intervention.
Data collection and analysis
Titles and abstracts identified from the register were scrutinized. The assessment of methodological quality took into account secure
method of randomisation, allocation concealment, observer blinding, patient blinding, differences at baseline of the experimental
groups, and completeness of follow-up. Data were extracted using a specially constructed data extraction form. Separate subgroup
analyses of participants with more and less severe disability were undertaken.
Physical therapy for Bell s palsy (idiopathic facial paralysis) (Review)
Copyright 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Main results
The search identified 45 potentially relevant articles. Six studies met the inclusion criteria. Three trials studied the efficacy of electrostimulation (294 participants) and three exercises (253 participants). Neither treatment produced significantly more improvement than
the control treatment or no treatment.
There was limited evidence that improvement began earlier in the exercise group.
Authors conclusions
There is no evidence of significant benefit or harm from any physical therapy for idiopathic facial paralysis. The possibility that facial
exercise reduces time to recover and sequelae needs confirming with good quality randomised controlled trials.
BACKGROUND
Idiopathic facial palsy, also called Bells palsy, is an acute disorder
of the facial nerve, which may begin with symptoms of pain in the
mastoid region and produce full or partial paralysis of movement
of one side of the face (Adour 1982; Valena 2001). Its cause is
not known (Peitersen 2002). Increasing evidence suggests that the
main cause of Bells palsy is reactivation of latent herpes simplex
virus type 1 in the cranial nerve ganglia (De Diego 1999; Holland
2004; Valena 2001). How the virus damages the facial nerve is
uncertain (Gilden 2004).
The annual incidence of Bells palsy varies widely, ranging between
11.5 and 40.2 cases per 100,000 population (De Diego 1999;
Peitersen 2002). There are peaks of incidence in the 30 to 50 and
60 to 70 year old age groups (Gilden 2004; Gonalvez 1997).
Bells palsy has a fair prognosis without treatment (Holland 2004).
According to Peitersen (Peitersen 2002), complete recovery was
observed in 71% of all patients. Ninety-four per cent of patients
with incomplete and 61% with complete paralysis made a complete recovery. The main question is whether results would be better if some treatment were given.
About 23% of people with Bells palsy are left with either moderate to severe symptoms, hemifacial spasm, partial motor recovery,
crocodile tears (tears upon salivation), contracture or synkinesis
METHODS
Types of studies
We searched the Cochrane Neuromuscular Disease Group Trials Register in February 2008 using the terms Bells palsy or
idiopathic facial paralysis or facial palsy. We also searched the
Cochrane Central Register of Controlled Trials (The Cochrane
Library, Issue 4, 2007), MEDLINE (January 1966 to February
OBJECTIVES
The objective of this systematic review was to evaluate the efficacy
of physical therapies for Bells palsy (idiopathic facial palsy).
2008), EMBASE (January 1980 to February 2008), LILACS (January 1982 to February 2008), and CINAHL (January 1982 to
February 2008) and PEDro (from 1929 to February 2008).
Electronic searches
See Appendix 1, Appendix 2, Appendix 3, Appendix 4, Appendix
5.
Study selection
Two authors (LJT, VPV) scrutinized titles and abstracts identified
from the register. The full texts of all potentially relevant studies
were obtained for independent assessment by the authors. Two
authors decided which trials fitted the inclusion criteria. Disagreements about inclusion criteria were resolved by consensus and consultation with a third author (BGOS).
Analysis of data
Data were entered and analysed using Review Manager 5.0.5
(RevMan) software. For dichotomous data, relative risks (RR) with
95% confidence intervals (CI) were estimated based on the fixedeffect model or on the random effects model if heterogeneity was
present. The number needed to treat (NNT) and number needed
to harm (NNH) were calculated if possible. For continuous outcomes, weighted mean differences (WMD) between groups were
estimated.
Heterogeneity was assessed by the chi-squared test and was assumed to be present when the significance level was lower than
0.10 (p < 0.10). When significant heterogeneity was present, an
attempt was made to explain the differences based on clinical characteristics of the included studies. A sensitivity analysis was performed, omitting trials which included participants with different
clinical characteristics or trials with lower methodological quality.
If there had been sufficient trials of the same intervention, we
would have constructed a funnel plot (of trial effect versus trial
size) to assess potential publication bias.
Subgroup analysis
Separate subgroup analyses of participants with more severe disability (House Grade III or worse) and less severe disability (House
Grade II or better) were undertaken. We also considered patients
treated before and after two weeks from onset.
RESULTS
Description of studies
Assessment of methodological quality
The assessment of methodological quality took into account secure
method of randomisation, allocation concealment, observer blinding, patient blinding, differences at baseline of the experimental
groups, and completeness of follow-up. These items were assessed
according to the Cochrane Collaboration standard scheme: grade
A: adequate, grade B: unclear, grade C: inadequate or not done.
Two authors (LJT, VPV) assessed quality independently. Disagreement between the authors was resolved by discussion if necessary
with a third author (BGOS).
Data extraction
Two authors independently extracted data on participants, methods, interventions, outcomes and results using a specially constructed data extraction form. Missing data were obtained from
the trial authors whenever possible.
Included studies
The six studies (Beurskens 2003; Flores 1998; Manikandan 2007;
Mosforth 1958; Wang 2004; Wen 2004) (See Characteristics
of included studies) included a total of 547 people. Three trials studied manual therapy and electrostimulation (Flores 1998;
Manikandan 2007; Mosforth 1958) (294 participants), and three
involved exercise (Beurskens 2003; Wen 2004; Wang 2004) (253
participants).
The first study evaluating physical therapy for facial palsy was one
of the first physical therapy randomised controlled trials described
for any condition. Mosforth (Mosforth 1958) studied 86 people
with acute Bells palsy of less than 14 days duration. Three participants were lost to follow up. Auto-massage of the face, infrared
and interrupted galvanic stimulation (pulse 100 msec) in 44 participants, was compared to massage alone in 42 participants. Treatment was continued until recovery or until the condition seemed
stationary (two to six months). The outcomes were electrical examination and grade of paralysis estimated visually as a percentage
of the function of the normal side, the time to begin improvement
and the time to complete recovery.
Manikandan 2007 assessed the results of 59 participants with acute
facial palsy and compared two groups with physiotherapy interventions. Although the objective of the study was to test a specific
exercise strategy and both groups undertook different exercises,
the regimen adopted was similar (home based exercises) and electrotherapy was the main difference between the groups. One group
of 30 people underwent a fixed protocol with electrostimulation
(galvanic and faradic currents) for the two first weeks, massage and
gross facial exercises. The other 29 people learnt an individualized
exercise program focused on the quality of the exercises and not
on the quantity. The movements were to be symmetrical without
voluntary movement of the uninvolved side. All individuals were
assessed by the Facial Grading Scale (Roos 1996) at the outset and
after three months.
In Flores 1998, there were 149 participants with acute Bells
palsy (onset in one to three days). Twenty-nine people (19.46%)
dropped out without a description of the reason for drop out.
One group of 76 people were treated with infrared treatment and
electrostimulation and were compared to 72 people treated with
prednisone for up to 14 days. Outcomes were time to recover, clinical history and a functional scale (May Scale). Authors analysed
Blinding
Due to the nature of the intervention evaluated in this review,
effective blinding of the participants is problematic. Placebo electrostimulation could have been used but blinding to exercise interventions is impractical or impossible. Blinding of outcome assessors can be achieved but only Beurskens 2003 and Wang 2004
blinded the assessor.
Completeness of follow-up
Beurskens 2003 and Mosforth 1958 assessed outcomes at one year
follow up. Beurskens analysed all the 50 participants (of whom
34 had Bells palsy) at this time. Mosforth did not analyse all the
people after one year because they were discharged when recovered. Despite this, our analyses were not affected. The data of interest (incomplete recovery) were reported by the study and drop
outs were considered to have incomplete recovery in our intention
to treat analysis. Flores 1998 did not describe follow up and 29
people (19.26%) dropped out without description of their allocation groups. The reasons described were that the participants requested another medication or they had not adhered to the treatment. Manikandan 2007 and Wen 2004 followed subjects until
12 weeks and Wang 2004 until 30 days, the end of the treatment
period.
Effects of interventions
The results have been divided by the intervention and described
according to the results for each of our outcome measures.
ELECTRICAL STIMULATION
Subgroup analyses
Flores 1998 undertook a subgroup analysis by severity of the axonal damage. In the group with mild disease or with lesions distal
to the chorda tympani lesion (n = 102) all individuals in both
groups improved at six months. In the most severe group or lesions proximal to the chorda tympani (n = 47) there was no significant difference in recovery, RR = 0.62, 95% CI 0.34 to 1.15 (see
Analysis 2.2). Analysing mean time to recovery of the 149 participants in the study in days, we found significantly faster recovery
with electrical stimulation, (MD -8.38, 95% CI -13.99 to -2.77
Analysis 2.3). However Manikandan 2007 gave opposite results.
Wen 2004 presented data on participants with mild and more severe disease. There was no difference in the proportion of participants that improved in the exercise group and conventional therapy group in the individuals with mild paralysis (Analysis 4.2).
But when we analysed the sub-group with moderate severity, we
observed that the exercise group began (Analysis 4.2) and finished
(Analysis 4.3) improving sooner.
FACIAL EXERCISES
DISCUSSION
Electrical stimulation
Almost all the outcomes reported failed to show any statistically
significant difference between either electrotherapy or exercises
and conventional or no treatment. Mosforth 1958 concluded that
it is not possible to recommend electrostimulation and questions
its cost-effectiveness. The results of Manikandan 2007 are in agreement as the group with electrical stimulation had worse quality
of movement and functional recovery after three months. Flores
1998 found no differences in the proportion of participants with
recovery after six months. The time to recovery in the Flores study
was less in the electrostimulation group but the study had some
methodological restrictions such as comparing physiotherapy with
prednisone, an active treatment, and almost 20% participant drop
outs. No statistical differences were found in synkineses or other
complications in any of the trials.
Exercise
Neither Wen 2004 studying acute cases nor Beurskens 2003 studying chronic cases found differences in the proportion recovering
after three and six months. Significantly less synkinesis was observed by Wen 2004 after three months. The evidence was limited
by the restrictions of reported outcomes to continuous data. The
assessment was blinded in two studies (Beurskens 2003; Wang
2004).
AUTHORS CONCLUSIONS
Implications for practice
There is no evidence of significant benefit or harm from the limited
trials of electrical stimulation or facial exercises for Bells palsy.
ACKNOWLEDGEMENTS
The staff of the Brazilian Cochrane Centre, Cochrane Neuromuscular Desease Group, Dr David Allen for his important contribution reviewing the protocol and a special thanks to Professor Richard Hughes for all the comments during all the editorial process. Rachel Barton for the search strategy and the
database searches. To Dr Zhannat Idrissova, Dr Hitoshi Nukada
and Yuquian Ma for the translations. Kate Jewitt, Janice Fernandes
and Jane Batchelor for all the support. Special thanks to my wife,
Cinira Gomes, and our daughter Rafaela for the patience and love
all the time.
REFERENCES
Additional references
10
Adour 1982
Adour KK. Current concepts in neurology: diagnosis and
management of facial paralysis. The New England Journal of
Medicine 1982;307(6):34851.
Adour 2002
Adour KK. Decompression for Bells palsy: why I dont do
it. European Archives of Otorhinolaryngology 2002;259(1):
407.
Allen 2004
Allen D, Dunn L. Aciclovir or valaciclovir for Bells palsy
(idiopathic facial paralysis). Cochrane Database of Systematic
Reviews 2004, Issue 3.
Beurskens 2004
Beurskens CHG, Burgers-Bots IAL, Kroon DW,
OOstendorp RAB. Literature review of evidence based
physiotherapy in patients with facial nerve paresis. Journal
of the Japanese Physical Therapy Association 2004;7:359.
Beurskens 2004b
Beurskens CHG, Heymans PG. Physiotherapy in patients
with facial nerve paresis: description of outcomes. American
Journal of Otolaryngology 2004;25(6):394400.
Danielidis 1999
Danielidis V, Skevas A, Van Cauwenberge P, Vinck B.
A comparative study of age and degree of facial nerve
recovery in patients with Bells palsy. European Archives of
Otorhinolaryngology 1999;256(10):5202.
Roos 1996
Ross BG, Fradet G, Nedzelski JM. Development of a
sensitive clinical facial grading system. Otolaryngology Head
and Neck Surgery 1996;114:3806.
De Diego 1999
De Diego JI, Prim MP, Madero R, Gaviln J. Seasonal
patterns of idiopathic facial paralysis: a 16-year study.
Otolaryngology and Head and Neck Surgery 1999;120(2):
26971.
Salinas 2004
Salinas RA, Alvarez G, Ferreira J. Corticosteroids for Bells
palsy (idiopathic facial paralysis). Cochrane Database of
Systematic Reviews 2004, Issue 4.[Art. No.: CD001942.
DOI: 10.1002/14651858.CD001942.pub3]
Gilden 2004
Gilden DH. Clinical Practice. Bells palsy. The New England
Journal of Medicine 2004;351(13):132331.
Sullivan 2007
Sullivan FM, Swan IR, Donnan PT, Morrison JM, Smith
BH, McKinstry B, et al.Early treatment with prednisolone
or acyclovir in Bells palsy. New England Journal of Medicine
2007;357(16):1598607.
Gonalvez 1997
Gonalvez-Colho TD, Pinheiro CN, Ferraz EV, AlonsoNieto JL. Clusters of Bells palsy. Arquivos de NeuroPsiquiatria 1997;55(4):7227.
Grogan 2001
Grogan PM, Gronseth GS. Practice parameter: steroids,
acyclovir and surgery for Bells palsy (an evidence based
review): report of the Quality Standards Subcommittee of
the American Academy of Neurology. Neurology 2001;56
(7):8306.
Hato 2007
Hato N, Yamada H, Kohno H, Matsumoto S, Honda N,
Gyo K, et al.Valacyclovir and prednisolone treatment for
Valena 2001
Valena MM, Valena LP, Lima MC. Idiopathic facial
paralysis (Bells palsy): a study of 180 patients [Paralisia
facial perifrica idioptica de Bell]. Arquivos de NeuroPsiquiatria 2001;59(3-B):7339.
VanSwearingen 1996
VanSwearingen J, Brach J. The Facial Disability Index:
reliability and validity of a disability assessment instrument
for disorders of the facial neuromuscular system. Physical
Therapy 1996;76(12):128898.
11
CHARACTERISTICS OF STUDIES
Participants
N = 50 peripheral facial nerve paresis (34 idiopathic). 2 dropped out in each group.
Diagnosis: people with sequelae of facial paralysis, House-Brackmannn IV, for at least 9 months; no nerve
or muscle reconstruction; absence of complete, partial, or central facial paralysis; absence of congenital
facial paralysis; and sufficient knowledge of the Dutch language.
Gender: both sexes (21 males and 29 females), including the participants with other causes of facial palsy.
Race: not mentioned.
Age: median 44 years (20 to 73, SD 14) including the participants with other causes of facial palsy.
Setting: Physiotherapy outpatient department
Interventions
1. Exercises (mime therapy) on a individual basis in sessions of 45 minutes, once weekly, over 3
months (10 sessions) and home program of exercises. N = 16
2. Control group (waiting list). N =18
Outcomes
Stiffness of the face. Lip mobility (both lip and pout length).
Physical and social index of the Facial Disability Index (VanSwearingen 1996 )
Sunnybrook Facial Grading System.
House-Brackmann Facial Grading System.
Notes
This study description is the pool of three publications by the author about the same population and
groups
Risk of bias
Item
Authors judgement
Description
Allocation concealment?
No
12
Flores 1998
Methods
Participants
N = 149
Diagnosis: acute Bells palsy of onset within 1 to 3 days. EMG 8 days after onset. Excluded other causes
of facial paralysis.
Gender: both sexes (males 61 and females 88)
Race: not mentioned
Age: median 33 (3 to 60) years.
Setting: clinic.
History/Comorbidities: normal glycemia and arterial pressure
Interventions
Outcomes
Clinical history and May Scale (grade I - complete recovery, II - complete recovery with facial asymmetry
with movements between 2 to 6 months, and III - incomplete recovery with asymmetry, synkinesis for
more than 6 months)
Drop out: 29 people (19.26%) without describing the exact reason for drop out or the groups they were
allocated to. Reasons: participants requested another medication or they did not adhere to the treatment
Notes
We are waiting for the authors answer about details of the study
Risk of bias
Item
Authors judgement
Description
Allocation concealment?
Unclear
Manikandan 2007
Methods
Blinding: no.
Analysis: the authors used Wilcoxon signed-rank test and Mann Whitney U-test to compare the Facial
Grading Scale scores within each group.
Duration: three months of therapy.
Follow up: three months. Until the end of the therapy.
Center: Kasturba Hospital, Manipal, Karnataka, India.
Design: Randomised clinical trial.
13
Manikandan 2007
(Continued)
Participants
N = 59 participants.
Diagnosis: unilateral Bells palsy with a mean duration of two weeks.
Excluded people with diseases of the central nervous system, sensory loss over the face, recurrence of facial
paralysis and who were uncooperative during the study.
Gender: both sexes (males 24 and females 37).
Race: not mentioned.
Age: median of 35 years old.
Setting: Neurorehabilitation unit.
History/Comorbidities: non described
Interventions
Outcomes
Facial Grading Scale (facial symmetry at: rest, movement and synkinesis) before and after 3 months
Notes
Risk of bias
Item
Authors judgement
Description
Allocation concealment?
Yes
Mosforth 1958
Methods
Blinding: none.
Analysis: The participants were divided, for purposes of analysis, into those with and those without
electromyographic evidence of denervation
Duration: the treatment was given daily until the active contractions returned and then thrice weekly
until recovery was virtually complete or the condition seemed stationary (2 to 6 months).
Follow up: one year.
Center: Department of Electromyography Leeds General Infirmary
Design: controlled randomised trial.
Participants
14
Mosforth 1958
(Continued)
1. Auto-massage of the face plus infrared for 10 min plus interrupted galvanic stimulation of 11
muscles of the face for 3 times of 30 contraction (pulse 100 msec). N = 44
2. Massage. N = 42
Outcomes
Electrical examination.
Grade of paralysis estimated visually as a percentage of the function of the normal side
Notes
One patient from group 1 and two from group 2 dropped out before the completion of the study with
reasons
Risk of bias
Item
Authors judgement
Description
Allocation concealment?
Yes
Wang 2004
Methods
Blinding: no.
Analysis: Improvement Index = (Scores After Treatment - Scores Before Treatment)/ Scores After Treatment
Duration: one month (30 days).
Follow up: one month. Until the end of the therapy.
Center: Neurology Department of West China Hospital.
Design: randomised clinical trial.
Participants
Interventions
1. Drug plus physical treatment plus massage plus acupuncture plus functional exercise. N = 43
1-7 days - drug treatment and physical treatment.
8-14 days - drug treatment, physical treatment, functional exercise and massage and acupuncture
treatment.
14-30 days - physical treatment, functional exercise and massage and acupuncture treatment.
2. Drug plus physical treatment plus massage plus acupuncture. N = 31
1-7 days - drug treatment and physical treatment.
15
Wang 2004
(Continued)
Scores of facial muscular function: Potmann Scores (frowning, eyes closing, moving nose, smiling,
whistling, and plumping the face, each movement graded 3 scores, adding 2 scores for the impression of
quiet state).
There was no exact criterion to measure the symptoms.
Notes
Risk of bias
Item
Authors judgement
Description
Allocation concealment?
Yes
Wen 2004
Methods
Blinding: none.
Analysis: each group has patients with three different severities: mild, moderate and severe. The degree of
recovery, time to recovery and complications were used to evaluate the results.
Follow up: during the treatment = 12 weeks (between 10/2000 and 11/2003).
Center: central Hospital of Nanyanz, Manyang, Henan Province, China.
Design: controlled randomised trial.
Participants
Interventions
1. Conventional therapy plus facial rehabilitation exercises (movements using facial muscles, exercises
performed daily under the tutoring of clinicians). N = 85
2. Conventional therapy only. N = 60.
Both groups received the same pharmacological treatment (no information about the dosage that was
used)
Outcomes
Grade of paralysis estimated visually as a percentage of the function of the normal side.
The outcome measures were times when the patient started to recover and completely recovered; the
percentage of completely recovered patients within 12 weeks.
The measurements took place once a week by clinicians but the results were presented as standard mean
differences. No baseline level was indicated
16
Wen 2004
(Continued)
Notes
Facial muscle synkineses were reported in one case in the mild and one in the moderate group. In the
severe patient group, 12 cases of complications reported in the control group and 4 cases in the training
group were reported
Risk of bias
Item
Authors judgement
Description
Allocation concealment?
Unclear
Study
Aleev 1973
Balliet 1982
Not a randomised controlled trial. Four people with traumatic facial paralysis
Bernardes 2004
Not a -randomised controlled trial. It is a retrospective study to delineate the contribution of myofunctional
exercises during the flaccid phase of the facial paralysis between participants with traumatic and spontaneous
paralysis
Beurskens 2004c
Brach 1999
Not a randomised controlled trial. It is a case study that proposed a treatment-based category based on signs
and symptoms
Brown 1978
Not a randomised controlled trial. It is a case study that described two participants treated with biofeedback in
both clinic and home environment
Casler 1990
Coulson 2006
Coulson 2006b
Not a randomised controlled trial. It is a study of 2 cases following removal of a vestibular schwannoma
Cronin 2003
Not a randomised controlled trial. This is a retrospective case review. There are others causes of facial palsy
including Ramsay Hunt. There were only 3 participants with idiopathic facial palsy. The groups were not
comparable at baseline. Twenty-four participants received neuromuscular facial retraining and the other 6 were
the control group
Dalla-Toffola 2005
Danile 1982
Not a randomised controlled trial. Iontophoresis was applied in 50 participants with idiopathic facial palsy
without a comparison group
17
(Continued)
Dubravica 1996
It was unclear how the groups were divided and if the participants were randomised. The two groups undertook
kinesiotherapy plus electrostimulation 5 weeks before the study and it could have interfered with the results
Goulart 2002
Klingler 1982
This controlled trial is about therapy with cortisone, anti-rheumatics and diuretics to treat facial palsy
Koyama 2005
Lobzin 1989
Not a randomised controlled trial. This is two studies with 32 participants with neuritis and neuropathy of the
facial nerve treated with an electromyography feedback device without a comparison group
Manca 1997
Not a randomised controlled trial. It is a study of 20 participants with facial paralysis treated with EMG
biofeedback
Murakami 1993
Not a randomised trial. One group of people treated with low reactive-level laser therapy (11) compared with
one group treated with stellate ganglion block (26) and another group with a combination of both (15)
Nakamura 2003
There were only 10 participants with idiopathic facial palsy. 27 people with complete facial nerve palsy who had
no response to electrical stimulation were randomly allocated into 2 groups: 12 treated with training method
of biofeedback rehabilitation to prevent synkinesis and 15 as a control without treatment
Romero 1982
Not a randomised controlled trial. Biofeedback training was applied in ten participants with at least one-year
evolution selected in 957 facial paralyses. Only six of them had idiopathic facial palsy
Ross 1991
This study describes a randomised controlled trial with 31 people with long standing facial paresis (minimum
of 18 months) but there were only four participants with idiopathic facial palsy
Segal 1995a
Segal 1995b
Not a randomised controlled trial. It was a study of 25 people (5 with idiopathic paralysis) that proposed an
exercise program based on home exercises and weekly 50 to 60 minute sessions at the clinic. Reassessment was
made at 2.5 month intervals for up to 10 months with the House scale and synkinesis measure. All idiopathic
participants changed from House grade 4 to 3 in 5 to 10 months
Shiau 1995
Not a randomised controlled trial. The assessment was randomised and not the participants
Taverner 1966
Zhao 2005
* EMG = Electromyography
18
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
Guo 2006
Methods
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
Li 2005
Methods
Randomised design. Sample size = 94 (withdrawals: unclear). Experimental Group: 48 acupuncture. Control Group:
46 manipulation. Treatment follow up: after the fourth treatment session.Treatment duration: 7 x 4 days
Participants
Inclusion: participants with Bells palsy defined according to clinical diagnostic criteria of all degrees of severity. Aged
from 6 to 65, mean age: unclear.Male 43, female 51
Interventions
Experimental group: treatment with acupuncture, five days per week with two rest days. Control group: treatment
with manipulation, five days per week. Size of needles: unclear.Total number of sites: 11. Length of application: 20
minutes. Length of session: 1 week.Total number of treatment sessions: 4.
Outcomes
Cured (disappearance of all signs and symptoms, the facial symmetry and the function of mimetic muscle were
fully restored after treatment). Markedly effective (the facial symmetry was normal in repose, however, during
movement, low-grade paralysis persisted after treatment). Improved (the facial symmetry was improved, however,
during movement, paralysis persisted after treatment). No effect (signs and symptoms unchanged after treatment).
Notes
Experimental group: Cured: 30; Markedly effective:12; Improved:6; No effect:0. Control group: Cured: 29; Markedly
effective: 13; Improved: 4; No effect:0
These data were extracted from He 2007.
19
Pan 2004
Methods
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
Qu 2005
Methods
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
Wang 2004b
Methods
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
Yang 2001
Methods
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
20
Zhang 2005
Methods
Not known
Participants
Not known
Interventions
Not known
Outcomes
Not known
Notes
Not known
21
No. of
studies
No. of
participants
Statistical method
Effect size
1
1
1
Not estimable
Not estimable
Totals not selected
1
1
1
Not estimable
Not estimable
Not estimable
No. of
studies
No. of
participants
Statistical method
Effect size
Not estimable
Not estimable
149
102
47
22