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2. Define osmosis and explain the difference between isotonic, hypotonic, and hypertonic fluids
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LECTURE OUTLINE
Introduction
IV lines are started to administer IV fluids and provide access for rapid delivery of emergency
medications
Dehydration
Loss of water from the fluid space inside the cells
As cell dehydrates, it begins to malfunction
Poor function of tissues
Organ failure
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Conditions that quickly develop should be quickly corrected, and conditions that develop
slowly should be corrected slowly
When patient is evaluated at the hospital, the physician calculates the patients free water
deficit
No more than half the free water deficit should be replaced in the 1 st 24 hours
Purpose of prehospital care is to start rehydrating the patient
Choose an IV fluid that provides rehydration to the intracellular space and expands
the volume of fluid within the vascular space
Body fluid compartments
Most of the human body is composed of water
In adults, 45% to 65% of the body
In average man weighing 80 kg = 48 L
Total body water (TBW)
Total amount of water in the body
Intracellular fluid (ICF)
Found inside the cells
Extracellular fluid (ECF)
Found between the cells and inside the blood vessels
2/3 of TBW is in the ICF, 1/3 in the ECF
Of the ECF, is found in the interstitial fluid, in the blood vessels
Interstitial fluid
Space outside the vascular space that is between the cells
Example:
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ECF 1000 mL
Interstitial fluid = 750 mL
Intravascular fluid = 250 mL
Predicting the distribution of various types of IV fluids is possible, to determine the optimal
fluid to administer
Example: patient is dehydrated and has depleted intravascular volume
The fluid this patient receives should provide some expansion of intravascular
volume and fluid in the intracellular space
Good choice of IV fluid would be 0.45% normal saline
For any amount of blood loss, at least 3x the amount of crystalloid is required to increase
the intravascular volume to compensate
Large volume of distribution of IV fluids causes the fluids to shift/leak out of the
vascular space to the interstitial and intracellular spaces
For large amounts of blood loss that produce symptoms of hypovolemia, amount of
required volume replacement is beyond that of most EMS protocols
Rapid transport required
After period of blood loss, body responds by attempting to auto resuscitate
Shift fluid from both the intracellular space and interstitial space into intravascular
space
Cells can become dehydrated and malfunction
Organ failure
Acute blood loss: intravascular fluid replacement needs to occur within minutes to
prevent multiple organ failure
Excessive resuscitation can result in edema and pulmonary complications
Crystalloids
IV fluids in which sodium is the primary particle that controls volume distribution
Most common: Ringers lactate solution and normal saline
Movement of water through fluid compartments is controlled by osmosis
Trapped particles do not attract the movement of water
higher concentration
As water moves into compartment, the concentration of trapped particles
decreases
Diluted by newly added water
Water continues to move down the concentration gradient until a difference in
concentration between the 2 compartments no longer exists
Particles in solution that attract water/exert osmotic pressure are sodium and serum
proteins (albumin)
Isotonic
Fluids that have equal osmotic pressure with the body under normal conditions
Contain sodium and other electrolytes that closely mimic the concentration of the
ECF
Hypotonic
Have less osmotic pressure
Hypertonic
Have greater than normal osmotic pressure
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Bleeding
Burns
Vomiting
Diarrhea
Diabetic ketoacidosis
Bowel obstruction
Healthy individual has capacity to compensate for intravascular volume loss
By the time patient shows signs of hypovolemia, assume significant volume loss
In case of acute blood loss, a 70 kg patient will lose more than 30% of blood
Colloids and hypertonic fluids provide greater volume expansion with less fluid
administered
Albumin can expand the intravascular volume by 80% of the infused volume
After 36 hours, 33% of the infused volume remains in the intravascular space
Hypertonic saline solutions
Have a concentration more than isotonic concentration of 0.9%
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Net effect: intravascular volume is increased by a greater volume than the total
volume infused
Critics argue that pulling fluids from the interstitial and intracellular spaces results in cell
and tissue dysfunction
Research shows that during stress and shock, cells become fat and swell with
additional water
Administration of hypertonic saline results in normalization of cellular water and
volume
Animal research has demonstrated that administration of 7.5% hypertonic solution rapidly
restores both BP and cardiac output in hemorrhagic shock
After 30 min, BP and cardiac output were similar to those treated with normal saline
Research continues to identify a fluid capable of sustained improvement of BP and
cardiac output
Electrolytes
Paramedics must treat electrolyte disorders that have clinical manifestations
Most electrolyte disorders are not immediately life threatening and can wait for lab test
confirmation, except hyperkalemia
Hyperkalemia
May occur with renal failure
Symptoms include:
Burns
Severe infections
Left untreated, can progress to heart block and cardiac arrest
Treatment objectives:
Protect heart from effects of hyperkalemia and hide potassium inside the cells
Administer 1 g 10% calcium gluconate
Does not alter serum level of potassium
To hide potassium, must be shifted from the extracellular space into the intracellular
space
Administer sodium bicarbonate, 50% dextrose, and insulin
Sodium bicarbonate rapidly shifts potassium into cells within minutes of
administration and lasts up to 12 hours
Works by pushing potassium into the cell in exchange for a hyrdrogen ion
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Hypokalemia
Low serum concentration of potassium
Cannot diagnose without lab blood test
Result of chronic medical conditions:
Muscle weakness
Burns
Paramedics must rely on symptoms
Abdominal distention
Constipation
May transport a patient from one facility to another who is receiving a potassium
infusion
Potassium in chronic and nonemergent conditions is provided with oral supplements
IV potassium administration is potentially dangerous
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Once metal needle is removed from the vein, possibility of puncturing the wall of
Between the IV bag and volume chamber controls amount of fluid in the chamber
Administration port
Drip chamber
Compartment immediately below IV bag where IV fluid drips at predetermined
volume
Can control volume and rate of administration
Allow provider to count number of drops over a period and calculate rate of fluid
Drop factor
Number of drops into the chamber required to administer 1 mL of fluid
Microdrip
Administer 60 gtt/mL
Number of drops counter per minute = rate of infusion in mL/hour
Used with adrenergic agents and cardiac antiarrhythmics
Used with children who are sensitive to large amounts of IV fluids
Macrodrip
Variety of sizes
Drip factors of 10, 12, 15 and 20 gtt/mL
Volume-control chambers
Used to control amount of fluids delivered
Can be inserted between drip chamber and IV bag
Can set maximal amount of fluid to be infused by filling the chamber from the
IV
Once emptied, patient cannot receive any more fluid
Y-tubing
Used in patients who require volume expansion and possibly transfusion of blood
products
Also known as blood solution set
For trauma patient, start IV line with Y-tubing and hang normal saline
Transfusion of blood can be started as soon as blood is available
IV fluids infused without an infusion pump use the force of gravity
Must be frequently verified as flowing at the intended rate
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30 to 50 mL/hr
Failure to infuse some fluids slowly can result in the IV line clotting
Vein will not be available in an emergency
Small children
Fluid amounts that seem small and insignificant in an adult could be detrimental to a child
Trauma
IVs are started for rapid administration of fluids or blood to expand the intravascular
volume
Running fluids wide open means opening the roller clamp all the way
To increase rate of delivery, paramedic can place IV bag in a pressure bag or have
someone manually squeeze the bag of fluids
Rate that fluid can flow through a tube is determined by the laws of physics:
(Change in pressure) x radius4/length of the catheter
Increasing the change in pressure by increasing the height of the bag, adding a
pressure bag, or manually squeezing increases rate of delivery
Increasing the length of tubing by adding tubing actually decreases the rate
In helicopters and mobile intensive care units, paramedics may encounter a variety of
infusion pumps
Advantages
Able to directly enter rate of infusion
Allows entry of the patients weight and desired dose of medication
Procedures
IV assembly
Equipment needed:
IV solution
IV tubing
Procedure:
Observe universal precautions
When possible, explain to the patient what procedure you are performing and
why
Select the appropriate fluid
Remove cover from both IV part of the IV bag of fluids and the spike on the IV
tubing drip chamber
Insert the spike of the tubing drip chamber into the IV tubing part of the bag
Open the roller clamp on the IV tubing to flush the IV fluid though the tubing
Once tubing has been flushed, close the roller clamp or set fluid infusion rate as
prescribed
IV assembly with Volutrol
Equipment needed:
IV solution
IV tubing with Volutrol
Procedure:
Observe universal precautions
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Select the appropriate IV fluid and spike the bag in the same way you would for a
regular IV
Connect and hang the drip set
Close the flow clamp at the bottom of the volume-control changer
Evaluate the patient for desired effects of the medication and any adverse effects
Continued reevaluation should occur throughout transport
Peripheral IV access
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Equipment needed:
Alcohol or Betadine prep
Tourniquet
IV catheter
IV tubing
IV solution
Adhesive tape or dressing to secure IV line
Sharps
PPE
Procedure:
Observe universal precautions
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Position the patient to stabilize the extremity where the IV is to be inserted with
pillows or a cot that is easily accessible
Ensure all IV tubing and equipment are assembled and flushed, and all materials
required for securing and dressing the catheter are immediately available
Determine the location for IV catheter placement
Apply the tourniquet several inches proximal to the proposed IV site
Prepare the area
Hold the needle in your dominant hand at a 30 angle, with the needle bevel up
Insert the needle through the skin approximately to 1 inch distal to the site
where it will enter the vein
As you slowly advance the needle through the skin, reduce the angle to
approximately 15 while advancing through the soft tissues into the vein
Once the needle has entered into the vein, blood will flow back into the hub of
the needle
Holding the needle still, slowly advance the catheter over the needle and into the
vein
Discard the needle immediately into a sharps container
While securing the catheter with 1 hand, release the tourniquet and connect the
hub of the catheter to the preassembled tubing set
Secure the catheter in place with tape or adhesive dressings
Document the medication, dose, route, needle size, and time in the PCR
Evaluate the patient for desired effects of the medication and any adverse effects
Continued reevaluation should occur throughout transport
Once IV line has been established, providers can deliver medications directly into the
circulatory system
IV push
Involves using a syringe connected to the injection port of an IV line
Injection ports
Areas placed along the IV tubing where the provider can inject the contents of a
Must assemble the syringe by removing the yellow caps on the ends of the 2
pieces, then screwing the 2 pieces together
Prefilled tubes
Glass syringes or tubes that are rapidly screwed in a plastic or metal Tubex
Medications not supplied in preloaded syringes are provided in vials or ampoules
Must transfer medication into a syringe
Vials
Glass bottles with a sealed opening, rubber diaphragm, aluminum rim and
cover
Ampules
Small glass containers that contain a single dose of medication
Alcohol prep
Vial of medication
Syringe
Needle for syringe
Sharps
Procedure:
Observe universal precautions
Verify drug order
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Peel back the aluminum lid of the vial to expose the rubber diaphragm
When withdrawing a medication from a vial for use by the IM or Sub-Q routes,
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Ampule of medication
2 pieces of 4 x 4 gauze
Syringe
Filtered needle for drawing the medication into the syringe
Needle for injection
Sharps
Procedure:
Verify drug order
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Shift all the medication into the lower portion of the ampule by tapping the top
With a filtered needle to prevent any glass shards from being drawn up, draw the
medication up into the syringe
Discard this needle and switch to a different needle if using a needle to
administer medication
IV drug administration
Equipment needed:
Alcohol prep
Medication loaded in a syringe
Needle for the syringe
Sharps
PPE
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Procedure:
Observe universal precautions
Verify drug order
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Locate the medication port of the IV line and wipe it clean with alcohol
Clamp or pinch the IV tubing above the site of the medication port
Insert the needle of the syringe through the diaphragm of the medication port
If using a needleless system, 1st unscrew needle
Gently pull back plunger on the syringe until you see a small flow of blood in the
IV tubing
Ensure catheter is in the vein and prevents infiltration of the medication into
the soft tissues
Inject the medication into the IV line at the rate appropriate for medication
Once all the medication has been injected, remove the needle from the
medication port, unclamp the IV tubing, and dispose of the needle and syringe
into the sharps container
Document the medication, dose, route, needle size, and time in the PCR
Evaluate the patient for desired effects of the medication, and any adverse
effects
Continued reevaluation should occur throughout transport
IV piggyback
Secondary infusions attached to the primary infusion line
Medication is added to a smaller bag of IV fluid and slowly infused through the
medication port of the main IV line
Many IV medications are administered over a projected period of 30 min to hours
Smaller IV bag containing the medication is then connected by an injector port into
the main IV line
IV infusion (piggyback)
Equipment:
Alcohol prep
Medication
Syringe
Needle
Small bag of compatible IV fluids (100 or 250 mL)
IV tubing
Medication label
Sharps
Procedure:
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
To prepare the medication for piggyback infusion, draw it into a syringe by the
techniques previously explained
Wipe the injection port of the smaller bag of IV fluids being used for the
piggyback infusion with alcohol
Inject the medication into the IV bag
effects
Continued reevaluation should occur throughout transport
Attaching infusion solution to primary IV line
Equipment needed:
Alcohol prep
Medication
Syringe
Needle
Small bag of compatible IV fluids
IV tubing
Medication label
Sharps
Procedure:
Verify drug order
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Wipe clean the medication port of the IV line with alcohol
Infuse the medication into the primary IV line at the rate appropriate for the
particular medication
Hang the smaller IV bag containing the medication given by piggyback infusion
at a level higher than the bag used for the primary IV infusion
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Once the infusion of the medication is complete, remove the piggyback infusion
and unclamp the tubing of the primary IV line
Document the medication, dose, route, needle size, and time in the PCR
Evaluate the patient for desired effects of the medication and any adverse effects
Continued reevaluation should occur throughout transport
Intraosseous infusions
Placement of a needle set into the highly vascular intramedullary space of the bone
and infusion of fluids or medications into this space
In cases of hypovolemic shock, veins often collapse, making access with IV catheters
difficult or impossible
Intramedullary cavity of the bone remains open
Fluids, blood, and medications administered through an IO line can be delivered to
the central circulation by this route as rapidly as through peripheral or central venous
catheters
Most common site: proximal tibia
Flat nature and lack of extensive overlying muscle and soft tissue
To locate, palpate the proximal tibia immediately below the knee and feel for a
marked bump in the bone
Tibial tuberosity
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IV tubing
PPE
Procedure:
Verify drug order
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Identify the site of insertion
Document the medication, dose, route, needle size, and time in the PCR
Evaluate the patient for desired effects of the medication, and any adverse
effects
Continued reevaluation should occur throughout transport
IO infusion sterna approach for fast1 IO
Equipment needed:
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PPE
Procedure:
Observe universal precautions
Verify drug order
Confirm right patient, right medication, right dose, right route, and right time
Confirm the patient has no allergies to the medication
Document allergies to other medications
When possible, explain to the patient what procedure you are performing and
why
Locate the patients manubrium and prepare the site with aseptic solution
Use the index finger to align the target patch with the patients sternal notch
Place the target patch
Place the introducer into the target zone on the patch, perpendicular to the skin
Firmly push on the introducer to insert the infusion tube into the correct site and
to the right penetration depth
Pull the introducer straight back, exposing the infusion tube and a two-part
support sleeve, which falls away
Verify correct placement by observing marrow entering the infusion tube
Connect the IV solution and tubing to the infusion tube on the patch, and adjust
the flow rate
Place the protective dome over the site by pressing firmly over the target patch to
engage the Velcro fastening
Document the medication, dose, route, needle size, and time in the PCR
Evaluate the patient for desired effects of the medication, and any adverse
effects
Continued reevaluation should occur throughout transport
Complications of intravenous therapy
IV therapy has potential complications
Infiltration
Occurs when the tip of the catheter dislodges from the lumen of the vein
Fluid then delivered to soft tissues around the vein
Can result in tissue destruction and necrosis at the site of infiltration
Signs:
Fluid no longer freely drips
Pain and swelling at the IV site
Treatment
Discontinue IV
Start new IV either proximal to infiltration or in another extremity
Hand and foot infiltration can cause damage to the underlying and adjacent
structures
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Document communication
Document findings, time of incident, treatment rendered
Catheter shear
Occurs when a segment of the catheter breaks off
Is either retained in the vein or embolizes through the venous system
Can occur when provider tries to pull a catheter back over a needle
Typically when blood return appears while starting an IV
While attempting to advance the catheter into the vein over the needle,
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