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Cell biology
Cytology, the study of the structure and function of cells
The human body contains both somatic and sex cells
A typical cell
Is surrounded by extracellular fluid, which is the interstitial fluid of
the tissue
Has an outer boundary called the cell membrane or plasma membrane
Physical isolation
Regulation of exchange with the environment
Structural support
The cell membrane is a phospholipid bilayer with proteins, lipids and
carbohydrates.
Integral proteins
Peripheral proteins
Anchoring proteins
Recognition proteins
Receptor proteins
Carrier proteins
Channels
Glycolipids
Glycoproteins
The Cytoplasm
The cytoplasm contains:
The fluid (cytosol)
The organelles the cytosol surrounds
Organelles
Nonmembranous organelles are not enclosed by a membrane and
always in touch with the cytosol
Cytoskeleton, microvilli, centrioles, cilia, ribosomes, proteasomes
Membranous organelles are surrounded by lipid membranes
Endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes,
mitochondria
Microfilaments
Intermediate filaments
Microtubules
Thick filaments
Microvilli
increase surface area
Centrioles
Direct the movement of chromosomes during cell division
Organize the cytoskeleton
Cytoplasm surrounding the centrioles is the centrosome
Cilia
Is anchored by a basal body
Beats rhythmically to move fluids across cell surface
Ribosomes
Are responsible for manufacturing proteins
Are composed of a large and a small ribosomal subunit
Contain ribosomal RNA (rRNA)
Proteasomes
Remove and break down damaged or abnormal proteins
Require targeted proteins to be tagged with ubiquitin
Endoplasmic reticulum
Intracellular membranes involved in synthesis, storage, transportation and
detoxification
Forms cisternae
Rough ER (RER) contains ribosomes
Forms transport vesicles
Smooth ER (SER)
Involved in lipid synthesis
Golgi Apparatus
Forms secretory vesicles
Discharged by exocytosis
Forms new membrane components
Packages lysosomes
Membrane flow
Continuous movement and recycling of membranes
ER
Vesicles
Golgi apparatus
Cell membrane
Mitochondria
Responsible for ATP production through aerobic respiration
Matrix = fluid contents of mitochondria
Cristae = folds in inner membrane
The Nucleus
The nucleus is the center of cellular operations
Surrounded by a nuclear envelope
Perinuclear space
Communicates with cytoplasm through nuclear pores
Diffusion
Movement of a substance from an area of high concentration to low
Continues until concentration gradient is eliminated
Osmosis
Diffusion of water across a semipermeable membrane in response to
solute differences
Osmotic pressure = force of water movement into a solution
Hydrostatic pressure opposes osmotic pressure
Water molecules undergo bulk flow
Tonicity
The effects of osmotic solutions on cells
Isotonic = no net gain or loss of water
Hypotonic = net gain of water into cell
Hemolysis
Hypertonic = net water flow out of cell
Crenation
transport
Carrier mediated transport
Binding and transporting specific ions by integral proteins
Cotransport
Counter-transport
Facilitated diffusion
Compounds to be transported bind to a receptor site on a carrier
protein
Active transport
Active transport
Consumes ATP
Independent of concentration gradients
Types of active transport include
Ion pumps
Secondary active transport
Interphase
Most somatic cells spend the majority of their lives in this phase
Interphase includes
G1
S
G2
Prophase
Metaphase
Anaphase
Telophase
Differentiation
Process of specialization
Results from inactivation of particular genes
Produces populations of cells with limited capabilities
Differentiated cells form tissues