CENTER FOR

CROHNS AND COLITIS

75 Francis Street
Boston, MA 02115
(617) 732-7368
www.brighamandwomens.org

TEACHING AFFILIATE

CROHNS AND COLITIS

AT BRIGHAM AND WOMENS HOSPITAL
AN INTEGRATED AND COLLABORATIVE APPROACH

Optimal care for patients with

Crohns disease and ulcerative
colitis requires a comprehensive,
multi-disciplinary approach. At the
Center for Crohns and Colitis at
Brigham and Womens Hospital, our
team of experts brings together the
latest diagnostic tools, leading-edge
medical therapy, innovative surgical
techniques, and state-of-the-art
nutritional care to improve the
quality-of-life for patients.

TO

CARE

Experts in inflammatory bowel disease (IBD) from the Brigham and

Womens Hospital Division of Gastroenterology, Hepatology and
Endoscopy are committed to partnering with referring physicians to
provide continuous, patient-centered care for complications due to
Crohns disease and ulcerative colitis. Seamless coordination among IBD
specialists, surgeons, nutrition experts, and diagnostic leaders at Brigham
and Womens Hospital enables patients to receive consultation and
treatment from physicians in multiple disciplines during one visit.

Leading services provided by experts at the Center for Crohns

and Colitis include:
Comprehensive, multi-disciplinary evaluation;
Innovative therapy, including novel clinical trials;
Advanced surgical care;
Nutritional treatment plans;
Collaborative partnership with referring physicians;
Patient and family support services and education.

Robert Burakoff, MD, MPH, FACG, FACP

Director, Center for Crohns and Colitis

For 11 years in a row, Brigham and

Womens Hospital has been included
on the U.S. News & World Report
Honor Roll of Americas Best
Hospitals. Brigham and Womens

ABDOMINAL RADIOLOGY
The Gastrointestinal Radiology Service and the CT Interventional Section at
Brigham and Womens Hospital provide pre- and post-operative diagnostic and
therapeutic support, including:
Initial evaluation to determine the extent of disease;
Examination of fistulae using magnetic resonance imaging;

CENTER FOR CROHNS AND COLITIS

C OMPLETE D IAGNOSTIC S ERVICES

CENTER FOR

Drainage of abscesses;
Assessment using CT enteroclysis.

ENDOSCOPY
The Center for Crohns and Colitis works closely with the Endoscopy Center at
Brigham and Womens Hospital. Led by David L. Carr-Locke, MD, FRCP, FACG,
an internationally-renowned expert in endoscopic procedures, the Endoscopy
Center at Brigham and Womens Hospital provides a comprehensive range of
diagnostic and therapeutic procedures for Crohns
disease and ulcerative colitis, their complications
and associated conditions. The Center focuses on
endoscopic and other less invasive methods for
diagnosing and treating aspects of IBD, such as
direct endoscopic dilation of strictures, control
of bleeding, capsule endoscopy for suspected
Crohns disease, endoscopic surveillance for
dysplasia, diagnosis and treatment of biliary
disease, documentation of the extent and
severity of IBD, and diagnosis of malignancy.
Dr. Carr-Lockes research efforts in IBD
include evaluation of new treatment options
for sclerosing cholangitis and new biodegradable
David L. Carr-Locke, MD, FRCP, FAGG,
stents allowing for drug delivery for patients
Director, Endoscopy Center
with Crohn's disease.

Hospital has also been ranked among

the nations top ten hospitals for
treatment of digestive disorders.

75 FRANCIS STREET BOSTON, MA 02115 (617) 732-7368 WWW.BRIGHAMANDWOMENS.ORG

Directed by Robert D. Odze, MD, surgical pathologists at Brigham and Womens

Hospital with research and clinical interest in IBD provide screening and surveillance
guidelines for patients and interpret all endoscopic biopsies using advanced histologic,
immunohistochemical, and molecular techniques. They also perform ongoing research
studies of the natural history, diagnosis, and molecular characteristics of preneoplastic
changes in IBD.

Directed by Ronald Bleday, MD, surgery for IBD at

Brigham and Womens Hospital is performed by a
group of specialized gastrointestinal and colorectal
surgeons. Advanced surgical treatment offered at the
Center for Crohns and Colitis includes:
Laparoscopic-assisted procedures to minimize
abdominal incision;
Bowel-preserving surgical procedures, such as
strictureplasty;

T REATMENT
AN INNOVATIVE APPROACH

CENTER FOR CROHNS AND COLITIS

CENTER FOR CROHNS AND COLITIS

Surgery

PATHOLOGY

TO

TREATMENT

Using multiple modalities, treatment at the Center for Crohns and Colitis incorporates
new clinical trials, advanced medical therapy, and innovative surgical treatment. In
addition, patients have access to leading nutrition and metabolic experts.

Medical Therapy
The Center for Crohns and Colitis provides both conventional and new treatment
plans to produce the best results. Designed to induce and maintain remission of
symptomsas an alternative to or in conjunction with surgerymedical therapy at the
Center for Crohns and Colitis includes expertise in the use of immunomodulatory
drugs and an infusion center for the administration of monoclonal biologic agents,
such as anti-TNF antibody.

Complex anorectal surgery for Crohns disease;

Reconstructive procedures, including Ileoanal
J pouch for ulcerative colitis, to prevent dependence
on a permanent ileostomy bag.
An enterostomal therapy clinical nurse specialist
with advanced clinical skills in wounds and ostomies
provides medical care and emotional support for
patients undergoing surgery requiring an ostomy.

R ESEARCH
PIONEERING RESEARCH: FROM BENCH

Metabolic Support Service

The multidisciplinary team of Metabolic Support Service (MSS) experts at Brigham
and Womens Hospital, led by Malcolm K. Robinson, MD, assist referring physicians
and gastroenterologists in developing comprehensive nutrition treatment plans. MSS
also provides:
Metabolic cart studies (indirect calorimetry)
to more accurately determine calorie needs;
Feeding tube management and support;

Ronald Bleday, MD, Section Chief,

Division of Colorectal Surgery

TO

BEDSIDE

The Center for Crohns and Colitis at Brigham and Womens Hospital conducts advanced
basic science, translational, and clinical research studies to develop innovative treatment
approaches. A member of the Clinical Research Alliance of the Crohns and Colitis
Foundation of America, the Center is actively involved in ongoing clinical trials
and innovative techniques, as well as
physician-initiated trials, for new
treatments designed to improve the
quality-of-life for patients.

Current areas of research at the

Center include:

Total parenteral nutrition (TPN)

management and support;

Studies in cellular immunity and

pathways in IBD;

Minimally invasive laparoscopic surgery to

establish enteral access as needed.

Study of new anti-inflammatory

therapies for the treatment of
Crohns disease and ulcerative colitis;
Study of new biologic therapies for
the treatment of Crohns disease and
ulcerative colitis.
Malcolm K. Robinson, MD, Director,
Metabolic Support Service

Sonia Friedman, MD, Director of Clinical Trials, Center for Crohns and Colitis;
Richard S. Blumberg, MD, Chief, Division of Gastroenterology, Hepatology
and Endoscopy

The Center for Crohns and Colitis is committed to serving patients individual needs. As the
medical needs of patients with Crohns disease and ulcerative colitis are often complex, the
Center works closely with referring physicians to ensure continuity of care through treatment,
consultation, and ongoing communication with referring physicians.
In conjunction with a wide range of womens health experts at Brigham and Womens
Hospital, the Center is working to meet the specific needs of women with Crohns disease and
ulcerative colitis, including women who are pregnant or in the process of planning a family.
Committed to patient education and support, the Center also works with the New England
Chapter of the Crohns and Colitis Foundation to deliver the latest research and treatment
information to patients.

CARE FOR YOUNG ADULTS

The Center for Crohns and Colitis at Brigham and Womens Hospital works closely with the
Center for Inflammatory Bowel Disease at Childrens Hospital Boston to ensure a smooth
transition to adult care for older teens and young adults with Crohns disease and ulcerative
colitis. Researchers at Brigham and Womens Hospital and Childrens Hospital Boston also
collaborate on clinical trials and new treatment options.

THE CENTER FOR

CROHNS AND COLITIS
AT BRIGHAM AND WOMENS HOSPITAL
CENTER STAFF
Department of Medicine
Division of Gastroenterology, Hepatology and Endoscopy
Richard S. Blumberg, MD, Division Chief

CENTER FOR CROHNS AND COLITIS

CENTER FOR CROHNS AND COLITIS

ADDRESSING PATIENTS INDIVIDUAL NEEDS

Robert Burakoff, MD, MPH, FACG, FACP,

Clinical Chief and Director for the Center for Crohns and Colitis
Sonia Friedman, MD, Director,
Clinical Trials, Center for Crohns and Colitis
David L. Carr-Locke, MD, FRCP, FACG, Director, Endoscopy Center
Peter A. Banks, MD
Frederick L. Makrauer, MD

YOUR CONNECTION TO THE CENTER FOR CROHNS

AND COLITIS AT BRIGHAM AND WOMENS HOSPITAL
The central access practitioner at the Center for Crohns and Colitis manages inquiries
regarding patient appointment scheduling, consultation requests, patient care, and clinical
trials. To refer a patient to the Center for Crohns and Colitis at Brigham and Womens
Hospital, or for information regarding current clinical trials, please contact (617) 732-7368,
and our experienced physician assistant will provide you with the information and resources
you need.

Sarathchandra I. Reddy, MD, MPH

McKenzy Carlton, MS, PA-C, Physician Assistant,
Center for Crohns and Colitis
Department of Surgery
Division of General and Gastrointestinal Surgery
Michael J. Zinner, MD, Surgeon-in-Chief
Ronald Bleday, MD, Chief, Section of Colon & Rectal Surgery
Malcolm K. Robinson, MD, Director, Metabolic Support Service
Elizabeth L. Breen, MD
Stanley W. Ashley, MD
Department of Pathology
Robert D. Odze, MD, FACP, Director, Gastrointestinal Pathology Service
Jonathan N. Glickman, MD, PhD
Jason L. Hornick, MD, PhD
Mark S. Redston, MD
Department of Radiology
John M. Braver, MD, Director, Gastrointestinal Radiology
Stuart G. Silverman, MD, Director, CT and Interventional Radiology
Koenraad J. Mortele, MD

(From left to right) Frederick L. Makrauer, MD; Robert Burakoff, MD, MPH, FACG, FACP, Clinical Chief and Director,
Center for Crohns and Colitis; Richard S. Blumberg, MD, Division Chief; Sonia Friedman, MD, Director of Clinical Trials,
Center for Crohns and Colitis; McKenzy Carlton, MS, PA-C, Physician Assistant, Center for Crohns and Colitis