Professional Documents
Culture Documents
2557
1.1
1.2
1.3 /
1.4
2
-
-
5
6
7
7
3.1
3.2
3.3
16
4
-
-
- (Standard Precaution)
-
-
23
23
24
16
16
20
28
31
36
()
43
5.1
43
5.2
43
5.3
45
5.4
45
5.5
46
14
22
42
53
1. (Protective Equipment)
2.
3. /
4.
5. /
54
55
69
72
94
95
1
2 HIV oPEP HIV oPEP
3 HIV oPEP*
4
5
6
7
8 CIE
(International Commission on Illumination)
9
.. 2549
3
39
40
66
66
67
69
70
71
1.1
289
143 .. 2550 - 2552
27.3
72.7 25-34 40.5 18-24
30.8 35 28.7
21 18.2
33.6 18.9
15.4
77.6
22.4 anti-HIV
67.8 28.7 3.5
anti-HIV anti-HIV
51 45.5 2.1
0.7
anti-HIV 61.5
22.5 13.3 anti-HIV
35.7 21.7
4.2
Zidouvudine + Lamivudine 47.6
Zidovudine + Lamivudine + Indinavir 13.3 Zidouvudine + Lamivudine +
Nelfinavir 10.5 13.3
.. 2547 2549
52.6 17.2 30.2
37.63
19.35 15.05
28.97 72.05
27.951
(Nosocomial Infection)
1.2
1
10,000 *
**
9,000
0.95
67
0.0067
50
0.005-0.032
30
0.0032
10
0.001-0.003
6.5
0.0003-0.0009
0.5
0.13-0.45
0.00001-0.00004
*CDC 2005
**American Academy of Pediatric PEP in Children and Adolescents for Non-occupational
Exposure to Virus 2003
1.3 /
1.3.1
1.3.2
9
1.4
(hepatitis A virus)
(hepatitis B virus) (hepatitis C virus) ( human
immunodeficiency virus, HIV)
1000 1 (Nursing
home) (43%) (28%)
(15%) (41%)
(40%) (15%) 4%
2550
2
(Hospital accreditation)
4
II
, II-1
-
-
/
-
-
- ( root cause)
III III-4.2
(Working environment)
.
25551 14
5
1-4
2557
2 1)
2)
1.
.. 2554
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2556
2557
.. 25497
8
( 2) ..2553
14
(1)
(2)
(3)
(4)
(1) (2) (3) (
)
2.
3
2.1 ..2545 9
..2545 3
..2545 18 (4)
3/2556
..2556
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3
.. 2545
1
11
2.2
.. 254612
.. 254713
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14
( 7) ..255215
10
.. 2546
.. 2547 . 0403/.128 30
2510
2 .. 2537
( 7) ..2552
2.3
2.3
..2540 16
( 2) ..2542 17
( 3) ..255018
11
(1)
1.5
(2) (1)
5
(3) (1)
3
24
72
..2540
2.4 ..2537
..253719 5
.. 2537 14 20
3
... (3)
12
..2537
.. 2537 13
48
21
1.
2. (.44)
2
3. (.44 )
(.16)
1.
2.
(.16)
3. 1
13
4.
5.
(.16) 2
..
.. 2549
( 2) ..2553
..2556
..2537
..2540
..2537
14
CDC Preventing Needlesticks and Other Sharps Injuries Everything You Need to
Know. [Internet]. 2014 [cited 2014 Feb 2]. Available from:
http://www.cdc.gov/sharpssafety/PPT/2PreventingNeedlesticksPartI.ppt
2
( .. 2554)
3
.
, 2554.
4
..
.
[Internet]. 2014 [cited 2014 Feb 2]. Available from
http://www.isosmartpro.com/private_folder/Law_April_pdf55/1502.pdf
5
. (Key Performance Indicator).
[Internet]. 2014 [cited 2013 April 28]. Available from
http://healthdata.moph.go.th/kpi/index.php
6
. ..
. [Internet]. 2014 [cited 2014 Feb 2]. Available from:
http://www.labour.go.th/th/doc/law/safety-statute-2554.pdf
7
15
13
..2547
14
. 0403/.128 30 2510
15
( 7) ..2552
16
..
17
( ) ..
18
(
) .. / / /
19
.. / / /
20
/ / / /
21
[Internet]. 2014 [cited 2014 Mar 24]. Available from:
http://www.sso.go.th/wpr/category.jsp?media=print&lang=th&cat=943
16
3
3.1
(
)
/
3.2
17
3.2.1 (Physical health hazards)
3.2.1.1
3
3
1)
2).
3) ( Direct glare)
(Reflected glare)
18
.. 2549
500
1,000
600 800
3.2.1.2 (Heat)
/
3.2.1.3 (Noise)
/
1)
(Decibel)
Cardiovascular Endocrine Neurological ( Noise)
19
2)
60
85
3.2.2 (Ergonomics)
3.2.3 (Psychosocial health hazards)
(
)
( Work performance) ( Job satistaction)
20
3.3
1)
2)
3)
4)
5) /
6)
7)
8)
9)
.. 255 0
835
21
.. 2556
103
0.1
1,851 2.0 1,365
1.5 Hepatitis B C HIV
22
1.
. 2549
2. /
. 2557
3. ( .. 2554)
23
-
-
-
-
-
-
-
-
1. (Standard Precaution)
( Blood or body fluid) (mucous membrane)
24
1.
1.1
1.1.1
1.1.2
1.1.3
1.1.4
1.1.5
-
1.1.6
1.2
25
1.2.1
1.2.2
1.2.3
1.2.4
Intranet
1.2.5 (
Personal
Protective Equipment: PPE)
PPE
1.2.6
/
/
1.2.7
1.3
1.3.1
1.3.2
1.3.3
1.3.4
/ -
//
1.3.5
1.3.6
26
2.
2.1
Standard
precautions
2.2
/
2.3
27
3 - 5
7
1.
2.
3.
4.
28
5.
6.
7.
2.4
2.5
(Non Touch Technique)
4.3 (Standard Precaution)
(Standard Precautions)
1.
-
- ,
-
-
-
29
(Standard Precautions)
2. 2.1
2.2 -
2.3
-
-
2.4 (Gown)
2.5
3.
4.
30
(Standard Precautions)
4. ()
-
O( ne - handed technique)
(Two - handed technique)
- Clamp Holder
- Syringe
- Mouth piece, Resuscitation Bag
(Resuscitation)
-
5.
6.
7. Respiratory Hygiene/Cough
Etiquette
7.1
-
-
7.2
7.3
7.4 3
- Aseptic technique
- multiple-dose vial or solution container
9. -
Spinal and Epidural
procedure
31
3. /
3.1
3.1.1
3.1.2
Syringe, Suction catheter, Slip joint,
Three- way /
3.1.3
/
3.1.4
/
(Forceps)
3.1.5
3.2
4.4
..2556
26.77
7.2 6.9 7.6
5.1 2,490
466 2,024
19.9 2 103
50,481 75
142 2,352
37,000
32
4
1.
2.
3.
3.1
( medicut, scalp vein)
( blood lancet)
3.2 /
//
4. ( re-cycle)
1. (7 ) /
/
2. -
3.
4.
(ICN)
5.
33
1.
-
- /
- -
-
-
-
-
-
2.
-
-
- /
-
- //
-
-
3. 3 4
4.
34
(: www.pcd.go.th)
1. ( Chemical Disinfection)
(sodium hypochlorite)
0.1-0.5%
2. (Incineration) 90-95 %
600-1,000 C
35
4. (Thermal inactivation)
4.1
4.2
(dry heat)
160 170 C 2-4
5. ( Gas /Vapor Sterilization)
(ethylene oxide) (formaldehyde)
6. ( Microwave)
( Shredder)
95C 20
7. ( Sterilization by irradiation)
1.
1.
2.
2.
3.
3.
4.
4.
36
4.5
(Occupational exposures)
- (percutaneous injury)
- (Contact of mucous membrane)
- (Contact of non - intact skin)
dermatitis
37
- 0.3 ( 95
0.2 - 0.5)
- 0.09 (95 0.006 - 0.5)
- 0.09
-
1.
1.1
4% Chlorhexidine 70% Alcohol 10% Iodophore
1.2
4% Chlorhexidine
70% Alcohol 10% Iodophore
1.3 0.9% NSS
2.
(Anti - HIV)
( CD4)
( HIV RNA)
(Window period)
38
HBsAg)
(
(Anti - HCV)
2.2.
2.2.1.
(1)
(2) Ant - HIV, HBsAg, Anti - HCV
(3)
2.2.2.
39
3.1 (Serology)
Anti - HIV, HBsAgAnti - HCV
Yes
No
Y/ N4
Yes
No
Yes
Y9/N
1
Baseline
4
3
Yes
Yes
Yes
Yes
No
Yes
Yes
Yes
No
Yes
No
No
5
Yes
Yes
No
Y5/N
Yes
No
Y/N7
No
Yes
No
No
Y/N8
No
Yes
No
No
1.
acute HIV infection
2. Anti-HIV 4thgeneration Anti-HIV 3rd generation 6
1 source patient HCV co - infection 12 1
3. 1 2
40
C
AZT TDF A B
estimated
glomerular filtration rate (eGFR)
< 60./
41
:
TDF
= 300 1
AZT
= 200-300 12 ()
3TC
= 300 1 150 12
Rilpivirine
= 25 1
Raltegravir = 400 12
Lopinavir/ritonavir = 400 Lopinavir/100 ritonavir 12
Atazanavir/ritonavir = 300 Atazanavir/100 ritonavir 1
Darunavir/ritonavir = 800 Darunavir/100 ritonavir 1
600 Darunavir /100 ritonavir 12
* source patient HIV drug - resistant
42
1. Kuhar DT, Henderson DK, Kimberly KA, et al. Updated US Public Health Service
Guidelines for the Managementof Occupational Exposures to Human
Immunodeficiency Virusand Recommendations for Postexposure Prophylaxis. Infect
Control Hosp Epidemiol 2013;34(9):875-892.
2. New YorkState Department of Health AIDS Institute. HIV prophylaxis following
occupational exposure. 2012 [cited 2014, May 16]. Available from
http://www.hivguidelines.org/clinical-guidelines/post-exposure-prophylaxis/hivprophylaxis-following-occupational-exposure
3. Landovitz RJ, Currier JS. Postexposure Prophylaxis for HIV Infection. N Engl J Med
2009; 361:1768-1775.
4. Cardo DM, Culver DH, Ciesielski CA, et al.A case-control study of HIV
seroconversion in health care workers after percutaneous exposure. Centers for
Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med.
1997;337(21):1485-90.
5. Ippolito G, Puro V, De Carli G.The risk of occupational human immunodeficiency
virus infection in health care workers. Italian Multicenter Study. The Italian Study
Group on Occupational Risk of HIV infection. Arch Intern Med 1993;153(12):1451-8.
6. Henderson DK, Fahey BJ, Willy M, et al. Risk for occupational transmission of
human immunodeficiency virus type 1 (HIV-1) associated with clinical exposures. A
prospective evaluation.Ann Intern Med. 1990;113(10):740-6.
7. Postexposure Prophylaxis to Prevent Hepatitis B Virus Infection. MMWR 2006: 55
(RR16);30-31.
8. Updated U.S. Public Health Service Guidelines for the Management of
Occupational Exposures to HBV, HCV, and HIV and Recommendations for
Postexposure Prophylaxis. MMWR 2001: 50(RR11);1-42
43
5.1
( Collection of Data)
1. ( Consolidation)
2. (Interpretation)
3. ( Dissemination) (
)
4.
5.2
.. 1987
Zidovudine (AZT)
.. 1990 Center of Diseases Control and Prevention(CDC)
(Guideline for Occupational Post Exposure Prophylaxis)
.. 1995 Morbidity and Mortality Weekly Report (MMWR)
.. 1996
( Non-occupational Post Exposure Prophylaxis)
(sexual assault and consensual sex)
US Public Health Service (PHS) PEP
()
44
.. 1998 CDC
2-3
72 28
.. 2000
.. 1998 CDC
.. 1999
.. 2001 US PHS
( 2)
.. 2003
.. 2004
(Refugees)
.. 2005 CDC
.. 2005 US PHS
( 3)
.. 2005 US PHS
PEP Food and Drug Administration (FDA)
.. 2013 US PHS
( 4)
45
5.3
/
5.4
1.
2.
3. (
) ( )
46
4.
5.
6.
5.5
/ /
1
/ /
- ()
........................................................................................................
........................
1. B ()
2. // (//)
3. 08.30 16.30 . 16.30 24.00 . 00.01 08.30 .
1. .............................................. HN.HIV
5. ( ) ( .. Staff Resident Intern Extern)
( ) ( ) (..RN TN) ( ) . ( )
( ) .......................................... .................................................
6. ()...........................................................................................
7.
1.
2.
47
8. P( PE)
( )
( )
( ) /
(1
( )
2 ( ) ( ) mask ( ) ( )
( ) ( ) ( ) () ....................................................
9 17, 27 29
15
29
9. (, ,............... )................................................................
10. ...................................................................................................................................
11.
1.
2.
3.
4.
5. ..................................................
12. ().......................................................
...................................................................................................................................................................
13. ().......................
14.
( )
( 5 , )
( ) ( 5 , )
( ) ( 50 )
15. /
( )
( )
( )
( ) //
( ) /
( )
( )
( ) /
( ) ...................................................................................................................................
48
/
( ) /ward ( )
( ) LR & Delivery room
( ) Treatment
OR
( ) ER
( ) ICU
( ) OPD
( ) .....................................................................
16.
( )
( ) ( )
17. ............................................................
18. /
( )
( )
( )
( )
( ) IV catheter
( ) ......................................................................................................................................
19.
( )
1.
( ) 2.
19.1
( )
1.
( ) 2.
20. (, )....................................................................
21. (, , )....................
...................................................................................................................................................................
22. ()..................................................................
23.
(Safety Design)
( ) 1.
( ) 2.
24.
( ) 1.
( ) 2. ( ) 3.
25.
( ) 1. 1 ( ) 2. 2 ( ) 3.
26.
( ) 1.
) 2.
49
27. /
28. /
.................................................................................................................................................................................
.................................................................................................................................................................................
.................................................................................................................................................................................
.................................................................................................................................................................................
.................................................................................................................................................................................
...............................................................................................................................................................................
..
.................................................................................................................................................................................
29. : ( ) ( )
( ) stat dose ............. ...............
( ) TDF 300 mg + 3TC 150 mg
( ) .....................................................................................................
( ) stat dose 72 .........................................................
..
..
..
...........................................
(.............................................................)
......................................................
(..............................................................)
. ............./................../.....................
50
2
........./........../.......... ..................... .
/
(* : expose /
)
Percutaneous
// /
1
injury*
/(mucous membrane /(non-intact skin
exposure)*2
exposure)*3
( ) Less severe
( ) Small volume
( ) Small volume
( ) More severe ( ) Large volume
( ) Large volume
1 =
2 = Mucous
Percutaneous injury membrane exposure
0.3% 0.9%
3 = Non-intact skin
exposure
< 0.9%
( )
( )
( ) (
28 ) ..
Vaccine Hepatitis B
( ) ......................................................................
( )
( )
HBIG ...... / ...... / .......( ) Hepatitis B VaccineDay 0 ...... /........ / .......
1 ....... /......../ .......
6 ....... /......../........
( )
( )
( )
( ) Anti HIV ( ) HBsAg ( ) Anti-HBs
( ) CBC, UA ()
( ) SGOT, SGPT, BUN, Cr ()
/ .............................................
..
(............................................)
.... / ............ / ..........
51
3 ICN
( ) ( ) ( )
( ) ( ) ( )
( )
( ) S/E ( )
( ) ( )
( )
( ) :
( ) ( )
(Day 0)
Hemoglobin .mg% Hematocrit mg% Neutrophil .%
Anti-HIV ( )
Lymphocyte %
Red cell morphology ..
WBC count . Per cu.mm.
Monocyte %
( )
HBsAg
( )
Basophil %
( )
Eosinophil%
Anti-HB ( )
( )
( ) 1* ( 2 ) ......./......../.........
( ) 2* ( 4 ) ......./........./.........
* CBC, SGOT, SGPT,
BUN, Cr, UA
( ) 3 ( 6) ......../......../..........
( ) 4 ( 3 ..... .../......./..........
( ) 5 ( 6 .... ..../......../.........
52
( ) ..... /
4
) (
..............................................................................................................................................................................
( ) 4
( )
( )
/
/ ..............................
Monocyte %
Basophil %
Eosinophil%
Band form ..%
Anti-HIV ( )
( )
3
Anti-HIV ( )
( )
6
Anti-HIV ( )
Hematocrit mg% Neutrophil .%
( )
Lymphocyte %
Monocyte %
Basophil %
Eosinophil%
Band form ..%
53
54
1. (Protective Equipment)
2.
3. /
4.
5. /
55
1. (Protective Equipment)
1.
2.
3.
4.
5.
1. (cap)
2. (eye - ware)
3. - (mask)
4. (glove)
5. (gown)
6. (apron)
7. (foot - ware)
1.
-
-
1.
2.
3.
56
2.
1.
2.
3.
4
1.
2.
3.
4. (face shield)
3. -
-
1.
2.
3.
1.
(bronchoscopy)
2.
57
(fit check)
4.
2
1.
2.
2
1. ( sterile glove) ( disposable)
(reusable) 2
1.1
1.2
2. (non-sterile glove)
2.1 (examination glove)
2.2 ( heavy-duty glove)
1.
2.
1.
1.1 3-5 (surgical
hand washing)
1.2
1.3
58
1.4
1.5 30
(hygienic hand washing)
1.
2.
3. ()
2.
2.1
2.2
2.3
2.4
1.
2.
3.
5.
1.
2.
59
6.
-
7.
1.
2. ()
1.
2.
3.
4.
1.
2.
1) Gown
2) Mask
3) Goggles/face shield
4)
5) Gloves
6) (Booth)/Apron
60
1)
2)
3) (Face shield or goggles)
4) (Gown)
5) Mask
1.
61
2.
3.
62
4.
5.
63
1.
2.
64
3.
4.
65
5.
66
1.
2.
3. -
4.
5.
6.
7.
8.
-/+
+
+
+
+
+
-
+
+
+
-
+
+
+
-
1.
2.
3.
4.
5.
6. Cut Down
7. Ambu bag
8. (CPR)
9.
10.
11.
12.
13.Blood Exchange
14.Hemodialysus
15.
16.
17.
18.
19.
20.
+
-
+
+
+
+
+
+
+
+
+
-
+
+
+
+
-
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
+
+
-
+
+
+
+
-
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
+
+
+
-
+
+
-
+
+
+
+
+
+
+
+
+
+
-
+
-/+
-
67
1.
2.
3.
4.
+
+
+
+
+
-/+
+
+
-/+
+
+
-/+
-/+
-
+
-/+
-/+
+
-
1.
1.
2.
3. Body fluids
4.
5.
2.
2.1
2.2
.
non-infectious material
68
2.3 3-5
20 20-30
Clostridium
difficile
nonenveloped virus
3.
3.1
3.2
2 2-5
3.3
Chlorhexidinegluconate
6
2
4.
4.1
4.2
4.3
4.4
4.5
4.6
69
70
8 CIE
(International Commission on Illumination)
71
9
.. 2549
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
Occupational Safety and Health Administration
(OSHA) .. 1971
.. 1972 OSHA " national consensus"
( Federal Standards)
OSHA .. 1991
( blood-borne pathogens) HIV
.. 2001 OSHA
CFR1910.1030
standard precautions
CDC guideline
OSHA 300 Log
( EU Commission for Employment, Social Affairs and Inclusion, 2010)
(Council of
the EU, 2010) .. 2013
( Needle
stick injuries)
(safety-engineered medical devices ; SEMDs)
95
. ..
. .
. .
. .
. ...
. ..
. .
/
.
.
. .
. .
. .
. .
. .
. .
.
.
. .
/
. ..
/
.
96