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Handbook of

Clinical Drug Data 10th


Edition
2002.

DOSIS MIMS

AMOKSISILIN

Durasi:
Dosis : Adult 250-500 mg 8 hrly. (amoxillin, mims)Severe renal
impairment Dose should be reduced. Peritoneal dialysis patient Max:
500 mg daily. Gonococcal urethritis 3 g as a single dose (novax, mims)
Kelas : antibiotik golongan penisilin.
Adult Dosage. PO 250500 mg q 8 hr or 500-875 mg bid, to a maximum
of 4.5 g/day. PO for endocarditis prophylaxis 2 g 1 hr before dental or
upper airway procedures.
Dosage Forms. Cap 250, 500 mg; Susp 25, 50 mg/mL; Tab 500, 875
mg.

ALLOPURINOL

Durasi:
Dosis :Adult Initially 100-300 mg daily. Maintenance: 200-600 mg daily.
Max: 900 mg daily (alluric, mims). Adult 100 mg daily. Increase at wkly
intervals by 100 mg until normal serum uric acid level is attained. Max:
800 mg/day (puricemia, mims).
Kelas :Hyperuricemia & Gout Preparations Belongs to the class of
preparations inhibiting uric acid production. Used in the treatment of gout.

AMINOFILIN

Durasi:
Dosis :Adult 250-500 mg/day(aminophyllin indofarma, mims). Adult Awal
1 tab 2 x/hari. Maks: 2 tab 2 x/hari. Pencegahan spasme bronkial 1-2
tab menjelang tidur (phyllocontin,mims).
Kelas :Antiasthmatic & COPD Preparations Belongs to the class of
xanthines. Used in the systemic treatment of obstructive airway diseases.

AMITRIPTILIN

Durasi:
Dosis :Out-patient Initially 2 tab daily. In-patient Initially 1 tab 3-6 times
daily, may be increase up to 8 tabs daily. Max: 12 tab daily. Maintenance:
1-4 tab daily. (trilin,mims)
Elderly :depression: oral: initial: 10-25mg at bedtime, dose should be
increased in 10-25 mg increaments every week if tolerated; dose range :
25-150mg/day (DIF,20TH EDITION).
Kelas :Antidepressants, Belongs to the class of non-selective monoamine
reuptake inhibitors. Used in the management of depression.

AMLODIPINE

Durasi :

Dosis : 5 mg once daily. Max: 10 mg/day. Patients w/ hepatic


insufficiency, elderly Initially 2.5 mg.

Kelas : Belongs to the class of dihydropyridine derivative selective


calcium-channel blockers with mainly vascular effects. Used in the
treatment of cardiovascular diseases. (sanbe,mims)

AMPICILLIN

Durasi :

Dosis : Oral Adult & childn 20 kg 250-500 mg 6 hrly, <20 kg 50-100


mg/kg body wt daily in divided doses 6 hrly. Inj Adult & childn >20
kg 250-500 mg 4 times daily IM/IV, <20 kg 100-200 mg/kg body wt/day
IM/IV in equally divided doses 6 hrly, infant >7 days 75 mg/kg/day IM/IV
in divided doses 8 hrly, <7 days 50 mg/kg/day IM/IV in divided doses 12
hrly. Meningitis Adult & childn >20 kg 8-14 g IV daily 3-4 hrly, <20
kg 150-250 mg/kg/day IV in divided doses 6 hrly, infant >7 days 150200 mg/kg/day IV in divided doses 8 hrly, <7 days 100 mg/kg/day IV in
divided doses 12 hrly.

Kelas : ampicillin ; Belongs to the class of penicillins with extended


spectrum. Used in the systemic treatment of infections.(sanbe,mims).

ANTASID

Durasi:
Dosis : 3-4x (1-2)tablet
Kelas :
Administration and Adult Dosage. PO for symptomatic relief of
indigestion, nonulcer dyspepsia, epigastric pain in PUD, or
heartburn in gastroesophageal reflux disease (GERD) 1030 mL prn
or 1 and 3 hr after meals and hs.1,2 PO for treatment of PUD 100160

mEq of acid-neutralizing capacity per dose, given 1 and 3 hr after meals


and hs for 48 weeks or until healing is complete. Additional doses may be
taken if epigastric pain persists. There is evidence that lower dosages can
heal peptic ulcers.1,2 PO or NG for prevention or treatment of upper
GI bleeding in critically ill patients titrate to maintain intragastric pH
>4.0.3 PO for phosphate binding in renal failure (aluminum
hydroxide) 1.94.8 g tid or qid or (calcium carbonate) 812 g/day; titrate
dosage based on serum phosphate.

ANTASID SYRUP

Durasi:
Dosis : 1-2 sendok suspensi
Kelas :

ASIKLOVIR

Durasi:
Dosis :AdultTreatment of herpes simplex infections 200 mg 5 times
daily 4 hrly.. Suppression of herpes simplex infections 200 mg 4
times daily 6 hrly. Treatment of herpes zoster infections 800 mg 5
times daily 4 hrly for 7 days. (clinovir tablet, mims)
Kelas :Antivirals, Belongs to the class of nucleosides and nucleotides
excluding reverse transcriptase inhibitors. Used in the systemic treatment
of viral infections (clinovir tablet, mims).

ASIKLOVIR CREAM

Durasi: 5HARI.
Dosis : Apply 5 times daily 4 hrly w/o night dose. Duration of treament: 5
days, may be continued until 10 days (ACIFAR CREM, MIMS)
Kelas : Topical Antivirals, aciclovir ; Belongs to the class of topical
antivirals used in the treatment of dermatological diseases (ACIFAR CREM,
MIMS).

CALCIUM LACTATE

Durasi :
Dosis : 1 cap daily
Kelas : calcium lactate ; Belongs to the class of calcium-containing
preparations. Used as dietary supplements. (graha farma,mims)

CAPTOPRIL

Durasi:
Dosis : HTNAdult Initially 12.5-25 mg 2-3 times daily. May increase to 50
mg 2-3 times daily after 2 wk if BP is not lowered sufficiently. Max: 150 mg
daily. Severe HTN Max: 450 mg daily. Heart failure 12.5-25 mg 3 times
daily (farmoten,mims).
Kelas : ACE Inhibitors/Direct Renin Inhibitors, Belongs to the class of ACE
inhibitors. Used in the treatment of cardiovascular disease
(farmoten,mims).
Adult Dosage. PO for hypertension 12.525 mg bidtid initially,
increasing after 12 weeks to 50 mg bidtid, to a maximum of 450 mg/day.
PO for CHF 6.2525 mg tid initially, increasing over several days based
on the patients tolerance to a dosage of 50 mg tid. Delay further dosage
increases, if possible, for at least 2 weeks to evaluate response. Most
patients respond to 50100 mg tid. For hypertension or CHF use initial
dosages of 6.2512.5 mg bidtid and increase slowly in patients on diuretic
therapy, with sodium restriction, or with renal impairment. PO for left
ventricular dysfunction post-MI 6.25 mg once at 3 or more days postMI and then 12.5 mg tid; increase to 25 mg tid over several days to a
target of 50 mg tid over several weeks as tolerated. PO for diabetic
nephropathy 25 mg tid.

CIPROFLOKSASIN

Durasi:
Dosis :TabUTI Mild/moderate: 250 mg 2 times daily. Severe: 500 mg 2
times daily. Resp tract, bone & joint, skin & soft tissue infections
Mild/moderate: 500 mg 2 times daily. Severe: 750 mg 2 times daily. Acute
gonorrhoea 250 mg single dose. InjAdultUncomplicated kidney
infections & upper & lower UTI 100 mg twice daily. Other infections
200 mg twice daily. Acute gonorrhoea & uncomplicated acute
cystitis in women 100 mg as a single dose (renator,mims).
Kelas : QUINOLON, Belongs to the class of fluoroquinolones. Used in the
systemic treatment of infections.

CTM

Durasi: 4-6 hr.


Dosis :Adult 1 caplet. To be taken 3-4 times daily (orphen,mims).
4-hour allergy tablet - 1 tablet (4 mg) every 4 to 6 hours up to a maximum
of 6 tablets in 24 hours; 8-hour allergy tablet - 1 tablet (8 mg) every 8 to
12 hours up to 3 tablets in 24 hours; 12-hour tablet - 1 tablet (12 mg)
every 12 hours up to 2 tablets in 24 hours .

(Product Information: Chlor-Trimeton(R), chlorpheniramine, Schering-Plough Healthcare Products,


Kenilworth, NJ, 1999. Chlor-Trimeton(R), chlorpheniramine, Schering-Plough Healthcare Products,
Kenilworth, NJ, 1999.)

b) For the prevention of allergic rhinitis symptoms, administer


chlorpheniramine 4 mg (syrup or plain, uncoated tablet) and increase 3
times daily every 3 days as tolerated until reaching 8 mg 3 times daily.
Start before the allergy season (for ragweed - August 1st) and continue
until inhalant allergen is gone (first frost in ragweed areas). Most patients
develop tolerance to the sedative effect if dose is started low and
increased in small increments (only when previous lower dose is tolerated)
(Wong L, Hendeles L, & Weinberger M: Placebo-controlled evaluation of hydroxyzine and
chlorpheniramine for seasonal allergic rhinitis. Presented at American Academy of Allergy, (MAR)
1979, (abstract 236). J Allergy Clin Immunol 1979; 63(3):203.)

Kelas :Antihistamines & Antiallergics, Belongs to the class of substituted


alkylamines used as systemic antihistamines.

COTRIMOXAZOLE

Durasi :
Dosis : sehari 2x2 tab, selama 10-14 hari;shigellosis: selama 5 hari; infeksi
berat dosis dapat dinaikkan 1,5x dalam dosis terbagi 3; gangguan fungsi
ginjal dengan klirensi kreatinin 15-30ml/mnt:1/2 dosis lazim;klirensi
kreatinin ,15ml/mnt; pemberian tidak dianjurkan
Kelas :
PO for UTI 160 mg of TMP and 800 mg of SMZ q 12 hr for 1014 days. PO
for prophylaxis of recurrent UTI 40 mg TMP and 200 of SMZ at
bedtime 3 times a week. PO for shigellosis 160 mg of TMP and 800 of
SMZ q 12 hr for 5 days. IV for severe Gram-negative infections or
shigellosis 810 mg/kg/day of TMP and 4050 mg/kg/day of SMZ, in 24
equally divided doses, q 612 hr for 5 days for shigellosis and up to 14
days for severe UTI. PO or IV for P. carinii pneumonia (PCP) 12.520
mg/kg/day of TMP and 62.5100 mg/kg/day of SMZ, in 24 equally divided
doses, for up to 21 days. PO for PCP infection prophylaxis 160 mg of
TMP and 800 mg of SMZ once daily; intermittent dosage (eg, 3 times a
week) is also used. In patients with HIV infection, the drug is indicated if
there was a previous episode of PCP or CD4 counts are <200 cells/_L.

DEKSTROMETHROPAN HBR

Durasi: Oral: Up to 6 hr.


Dosis : 1030 mg q 48 hr, to a maximum of 120 mg/day; SR 60 mg q 12
hr.
Kelas :Cough & Cold Preparations , Belongs to the class of opium alkaloids
and derivatives. Used as cough suppressant.

DEXAMETHASONE

Durasi: 72 hr.
Dosis :Tab 1-4 tab daily in divided dose (corsona, mims). TabAdult 0.5-9
mg in divided doses. Intensive therapy or emergency 2-4 mg 6-8 times
daily. Max daily dose: 50 mg. Shock condition 1-6 mg/kg body wt
(cortidex,mims).
Kelas :Corticosteroid Hormones, Belongs to the class of glucocorticoids.
Used in systemic corticosteroid preparations.
Total daily dosage is variable depending on the clinical disorder and
patient response. Not recommended for alternate-day administration
because of prolonged duration of activity. PO, IM, or IV for acute, selflimited allergic disorders or exacerbation of chronic allergic
disorders 48 mg on the first day in one dose, then taper over 5 days;
give tapering dosage in 2 divided doses for 3 days, once daily for 2 days,
then discontinue. IV for cerebral edema 10 mg (as the sodium
phosphate) initially, followed by 4 mg IM or IV q 6 hr for several days until
maximal response occurs; then decrease the dosage over 57 days and
discontinue.

DIAZEPAM

Durasi:
Dosis :Oral 2-5 mg 3 times daily (stesolid, mims). Anxiety & adjunct in
muscle spasms 2-10 mg 2-4 times daily depending on the severity.
Alcohol w/drawal 10 mg 3-4 times daily in the 1st 24 hr, then 5 mg 3-4
times daily. Elderly & debilitated patients Initial dose: 1-2.5 mg 3-4
times daily (valdimex,mims).
Kelas :Anxiolytics, Belongs to the class of benzodiazepine derivatives
anxiolytics. Used in the management of anxiety, agitation or tension.

DICHLOFENAC POTASSIUM

Durasi :
Dosis :Adult 100-150 mg daily. Milder cases & childn >14 yr 75-100 mg
daily. Daily dose should be given in 2-3 divided doses.
(ARMOXINDOFARMA,MIMS)
Kelas : Belongs to the class of acetic acid derivatives and related
substances of non-steroidal antiinflammatory and antirheumatic products.
(pharos,mims)

DICLOFENAC SODIUM

Durasi :
Dosis :Tab Adult 50 mg 2-3 times daily. Milder cases: 75-100 mg daily. SR
tab Adult Initially 100-150 mg daily. In milder cases, 1 tab is usually
sufficient. Retard tab 100 mg daily or 2 tab of Voltaren SR 75. IM/IV
infusion Adult 1-2 amp (in severe cases) daily for 2 days. Supp Adult Two
50 mg supp or one 100 mg supp at night. More severe cases: Combine w/
25 or 50 mg tab. Max: 150 mg daily.
Kelas : G

EFEDRIN

Durasi: 3-6 hr (oral).


Dosis :
Kelas :

ERGOTAMINE

Durasi:
Dosis : The usual oral dose of ergotamine is 1 to 2 milligrams initially then
1 to 2 milligrams every 30 to 60 minutes. The maximum recommended
dose is 6 milligrams/24 hours and 10 milligrams/week [16]; (Roswell et al,
1973)
Kelas :Antimigraine Preparations
Administration and Adult Dosage. PO for migraine 2 mg initially,
then 1 mg each 1 hr prn, to a maximum of 6 mg/day or 10 mg/week; PR
2 mg initially, may repeat in 1 hr prn, to a maximum of 4 mg/attack or 10
mg/week; SL 2 mg initially, then 2 mg q 30 min as needed, to a maximum
of 6 mg/day or 10 mg/week.7 Titrate the dosage during several attacks
gradually, then administer the minimum effective dosage with subsequent
attacks. Patients who routinely require over 2 mg/headache can be given
the total effective dosage at the onset of the headache.

GLYCERYL GUAICOLATE (GG)

Durasi :
Dosis : 2-4 tab tiap 4 jam maksimum 24 tab perhari (sampharindi,ISO
VOL46,PG496)
Kelas :
Administration and Adult Dosage. PO as an expectorant 100400
mg q 4 hr; SR 6001200 mg q 12 hr, to a maximum of 2.4 g/day.8

Geriatric Dosage. Same as adult dosage.

GLIBENKLAMIDE

Durasi: 24 hr.
Dosis :Initially 2.5-5 mg daily, should be adjusted in stepwise dose of 2.5
mg at about 1 wk interval. Max dosage: 10 mg/day (padonil, mims).
Initially 5 mg daily. Should be adjusted in step of 2.5 mg at intervals of
about 1 wk. Max: 15 mg/day (condiabet,mims).
Elderly initial : 1.25-2.5mg/day, increase by 1.25-2.5mg/day every 1-3
weeks(DIH 20th edition)
Kelas :Antidiabetic Agents, Belongs to the class of sulfonamides, urea
derivatives. Used in the treatment of diabetes.
1.2520 mg in 12 divided doses

HIDROKLORTIAZID (HCT)

Durasi: 6-12 hr.


Dosis :hipertensi : initial, 25 mg ORALLY once daily; may increase to 50 mg
ORALLY daily in single or 2 divided doses. Edema 25 to 100 mg ORALLY daily
in single or divided dose (Product Information: hydrochlorothiazide oral
tablets, hydrochlorothiazide oral tablets. Mylan Pharmaceuticals Inc (per
FDA), Morgantown, WV, 2011).
Kelas : diuretik, Belongs to the class of low-ceiling thiazide diuretics.

HYDROCORTISONE

Durasi:
Dosis:

Kelas: hydrocortisone ; Belongs to the class of weak (group I)


corticosteroids. Used in the treatment of dermatological diseases. (indo
farma,mims)

IBUPROFEN

Durasi: 4-6 hr (oral). (MIMS)


Dosis : Adult 400 mg 3-4 times daily. Analgesia 200-400 mg 3-4 times
daily. (arefen,mims).
Kelas :Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) / Other
Cardiovascular Drugs (MIMS)

ISDN

Durasi: 2 hrs (sublingual); 4-6 hr (oral as conventional tab).


Dosis :Angina pectoris 1 tab sublingually. Prevention of anginal
attacks 3-4 tab daily (isorbid,mims).5-mg SL tab 1-2 tab 2-3 hrly as
required. 10-mg tabAdult 1 tab 4 times daily or 1 tab before sleeping for
prophylaxis (farsorbid,mimms).AdultCedocard 5 tabAngina acute attack

1 tab. Prophylaxis: 1-2 tab 3-4 times daily. Prevention of nocturnal


attacks 1-2 tab before sleep. Cedocard 10 tab 1-3 tab 4 times daily.
Cedocard 20 tabPrevention of expected attack or of nocturnal
angina 1 tab. General dose: 30-160 mg/day, taken 3-4 times daily. CHF
Initially tab. Effective dose: 40-160 mg daily, in severe cases up to 240
mg daily. Cedocard IV infusion 2-10 mg/hr. Cedocard Retard tab 1 tab 2
times daily.(cedocard,mims).
Kelas :Anti-Anginal Drugs, Belongs to the class of organic nitrate
vasodilators. Used in the treatment of cardiac disease.

KETOKONAZOLE

Durasi:
Dosis :Adult 1 tab once daily. Severe infection: 2 tab daily
(formyco,mims). Adult 1 tab daily. Childn 50-100 mg daily. Vag
candidosis 2 tab once daily for 5 days (funet,mims). Adult1 tab daily;
may be increased to 2 tab daily if response is insufficient. Vag
candidiasis 2 tab once daily for 5 days(mycoderm).
Kelas :Antifungals, Belongs to the class of imidazole derivatives. Used in
the systemic treatment of mycotic infections.

KLORAMFENIKOL

Durasi: Typhoid: 8-10 days; meningitis: 7-10 days; brain abscess: Up to 4


wk.
Dosis :CapAdult 1-2 cap 3-4 times daily. SyrAdult 3 tsp 3-6 times daily.
Childn 6-15 yr 2 tsp 3-4 times daily, 1-5 yr 1 tsp 3-4 times daily. Infant
tsp 3 times daily. (colsancetine, mims).
Kelas :Chloramphenicols, Belongs to the class of amphenicols. Used in the
systemic treatment of infections.

KLORAMFENIKOL TETES MATA

Durasi:
Dosis : Eye drops Instill 2 drops 3-4 times daily. Eye oint Apply a sufficient
amount 3-4 times daily (reco,mims).
Kelas : Eye Anti-Infectives & Antiseptics, Belongs to the class of
antibiotics. Used in the treatment of eye infections.

KLORAMFENIKOL SALEP

Durasi:
Dosis : Apply 3-4 times daily.

Kelas :Topical Antibiotics, Belongs to the class of other topical antibiotics


used in the treatment of dermatological diseases.

LORATADINE

Durasi:>24 hr.
Dosis :Adult & childn >12 yr 1 tab or 2 tsp once daily.(LESIDAS,MIMS).
Kelas :Antihistamines & Antiallergics, Belongs to the class of other
antihistamines for systemic use.

LUMINAL/PHENOBARBITAL

Durasi :
Dosis :
Kelas :phenobarbital ; Belongs to the class of barbiturates and derivatives
antiepileptics.

METFORMIN

Durasi:
Dosis :1 tab 2-3 times daily (diafac, mims). 500 mg tab 1 tab 3 times
daily. 850 mg tab 1 tab twice daily. Max: 3 g/day. Combination therapy: 1
500-mg tab or -1 850-mg tab, may be increased a wkly intervals
(glucophage, mims).
Kelas :Antidiabetic Agents , Belongs to the class of biguanides. Used in
the treatment of diabetes.

METRONIDAZOLE

Durasi :
Dosis :Tab Trichomoniasis 250 mg 3 times/daily for 7-10 days. If required,
2nd dose after 4-6 wk. Childn >10 yr 200-250 mg 3 times/daily for 7 days,
5-10 yr 375 mg/daily, 3-5 yr 250 mg/daily, <3 yr 150 mg/daily. Doses to be
taken for 7 days. Amoebiasis Adult 750 mg 3 times/daily for 7-10 days or 2
g once daily for 2 days. Childn 35-50 mg/kg/day in 3 divided doses for 10
days. Anaerobic infections Prevention: Adult 1 g as a single dose pre-op,
then 250-500 mg 3 times/day or as a single dose. Childn 30 mg/kg as a
single dose 24 hr pre-op, then 4 mg/kg 3 times/daily for 5 days. Treatment:
Adult 500 mg 3 times/daily for 7 days. Childn 7.5 mg/kg 3 times/daily.
Infusion Rate: 5 mL/min. Adult Treatment 500 mg IV infusion. Childn 7.5
mg/kg body wt 8 hrly. Anaerobic infections Prevention: Adult 500 mg IV
infusion followed by 500 mg oral administration. Childn 7.5 mg/kg body wt
8 hrly. Supp Treatment of identified anaerobic bacterial infection Adult 1
supp 8 hrly. Childn 7.5 mg/kg body wt 8 hrly. Prevention of post-op
infection due to anaerobic bacteria Adult 1 supp 2-4 hr pre-op then 8 hrly
post-op. Childn or of 500-mg supp 8 hrly. (SANBE,MIMS)

Trichomoniasis Adult 2 g daily in a single dose or 500 mg twice daily for 7


days. To prevent re-infection, the partner should be treated simultaneously
w/ the same dose. Childn 15 mg/kg body wt/day in 3 divided doses for 710 days. Intestinal amoebiasis Adult 750 mg 3 times daily for 5-10 days.
Hepatic amoebiasis 500-750 mg 3 times daily for 5-10 days. Childn 35-50
mg/kg body wt/day in 3 times daily for 10 days. Giardiasis Adult 2 g once
daily for 3 days or 250-500 mg 3 times daily for 5-7 days. Childn 15 mg/kg
body wt in 3 divided doses for 5-7 days. Anaerobe infection Adult 7.5
mg/kg body wt 6 hrly, (Max: 4 g daily) for 7-10 days. (PHAROS,MIMS)

Kelas : G
(SANBE,MIMS)

MEFENEMIC ACID

Durasi :
Dosis :Adult Initially 500 mg then 250 mg 6 hrly.
Kelas : G

MOLAGIT

Durasi :
Dosis: Adult & childn >12 yr 2 caplet after each subsequent bowel
movement. Max: 12 caplet/day.
Kelas : attapulgite, combinations ; Belongs to the class of other intestinal
adsorbents.(antidiarrheal[mims class]) (armoxindofarma,mims)

NIFEDIPINE

Durasi:
Dosis :5-10 mg 3 times daily (calcianta,mims). Stable, variant &
unstable angina pectoris, cardiac infarction Initially 1 tab 3 times
daily. May increase up to 9-12 tab in divided doses daily in patients w/
angina. HTN, Raynaud's syndrome May increase up to 2 tab 3 times
daily (nifedin,mims). Chronic heart diseaseAdult 5-10 mg 3 times daily.
Dose may be gradually increased to 20 mg 3 times daily. Coronary
spasms (unstable & Prinzmetal's angina, angina at rest) 20 mg 4-6
times daily. HTN 10 mg 3 times daily. Max: 20 mg 3 times daily (farmalat).
Kelas :Calcium Antagonists, Belongs to the class of dihydropyridine
derivative selective calcium-channel blockers with mainly vascular effects.
Used in the treatment of cardiovascular diseases.

PAPAVERIN

Durasi:
Dosis :

Kelas :

PARACETAMOL

Durasi
: 4-6 hr (analgesia). IV: 6 hr (antipyretic).
Dosis : Tab Adult. To be taken 3-4 times daily. Max daily dose: 4 g. Doses
should be given w/ at least 4 hr interval. (farmadol, mims)
Kelas : analgesik (non opiodida) & antipiretik.
Administration and Adult Dosage. PO for pain or fever (non-SR)
3251000 mg q 46 hr, to a maximum of 4 g/day; (SR Tab) 1300 mg q 8 hr.
PR for pain or fever 650 mg q 46 hr, to a maximum of 4 g/day.
Administration and Adult Dosage.
PO for pain or fever (non-SR) 3251000 mg q 46 hr, to a maximum of 4
g/day; (SR Tab) 1300 mg q 8 hr. PR for pain or fever 650 mg q 46 hr, to
a maximum of 4 g/day.

PIROXICAM

Durasi:
Dosis :RA, OA (arthrosis, generative joint disease, ankylosing
spondylitis) Initially 20 mg daily as a single dose. Acute gout Initially 40
mg daily as a single dose, followed by 40 mg daily on the next 4-6 days in
single or divided doses. Acute musculoskeletal disorders Initially 40
mg daily for the 1st 2 days in single or divided doses. For the remainder of
7-14 days treatment period, reduce dose to 20 mg daily (fleroxi,mims).
Adult 20 mg daily as a single dose (campain).
Kelas :Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Belongs to the
class of non-steroidal antiinflammatory and antirheumatic products,
oxicams.

PHENYTHOIN

Durasi :
Dosis :Oral Adult Initially 100 mg 3 times daily. Childn 5 mg/kg body
wt/day in 2 or 3 divided doses. Max: 300 mg daily. Inj Max: 50 mg/min IV.
Status epilepticus 10-15 mg/kg body wt slow IV (approx 20 min in a 70 kg
patient), followed by a maintenance dose of 100 mg orally or IV every 6-8
hrly. Neurosurgery 100-200 mg IM 4 hrly & post-op. Cardiac arrhythmia
3.5-5 mg/kg body wt, repeated once if necessary. Total daily dosage: 7001000 mg.
Kelas : phenytoin ; Belongs to the class of hydantoin derivatives
antiepileptics. (Pfizer,mims)

PREDNISONE

Durasi:
Dosis : sehari 1-4 tab. maks sehari 2x tab (berliko mulia farma, ISO VOL
46,PG 297)
Kelas :Corticosteroid Hormones, Belongs to the class of glucocorticoids.
Used in systemic corticosteroid preparations.

RANITIDINE

Durasi:
Dosis :Active duodenal ulcer 150 mg 2 times daily or 300 mg once daily
at bedtime for 4-8 wk. Active benign gastric ulcer 150 mg 2 times daily
for 4-8 wk. Reflux oesophagitis 150 mg 2 times daily for 8 wk.
Prevention of peptic ulcer relapse 150 mg at bedtime for 12 mth.
Pathological hypersecretory conditions Initially 150 mg 3 times daily
& may increase to 6 g/day in divided doses. Impaired renal function,
CrCl 50 mL/min 150 mg 24 hrly (ranin,mims). tab/CapletPeptic ulcer
150 mg 2 times daily. Zollinger-Ellison syndrome 150 mg 2 times daily.
Severe cases Up to 6 g/daily. AmpIM 50 mg/2 mL 6-8 hrly. IV intermittent
bolus 50 mg (2 mL) 6-8 hrly (acran, mims).
Kelas :Antacids, Antireflux Agents & Antiulcerants, Belongs to the class of
H2-receptor antagonists. Used in the treatment of peptic ulcer and gastrooesophageal reflux disease (GERD).

RESERPINE

Durasi:
Dosis :hipertensi, initial, 0.5 mg/day ORALLY for 1 to 2 wk; maintenance,
0.1 to 0.25 mg/day ORALLY. Psychotic, usual dose, 0.5 mg/day ORALLY;
range 0.1 to 1 mg/day (Product Information: reserpine oral tablets,
reserpine oral tablets. Eon Labs,Inc, Laurelton, NY, 2004).
Kelas :Other Antihypertensives, Belongs to the class of rauwolfia alkaloids,
centrally-acting antiadrenergic agents. Used in the treatment of
hypertension.

SALBUTAMOL

Durasi: oral: 8 hr; modified-release preparation: 12 hr.


Dosis :TabAdult 2-4 mg, SyrAdult 5-10 mL. All doses are to be taken 3-4
times daily( astharol,mims)
Kelas :Antiasthmatic & COPD Preparations, Belongs to the class of
adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in
the treatment of obstructive airway diseases.

Administration and Adult Dosage. Inhal for asthma (metered-dose


inhaler) 90180 _g (12 puffs) q 46 hr prn and just before exercise;
(inhalation solution) 2.5 mg by nebulization tidqid; (inhalation capsule) 1
2 inhalation capsules q 46 hr or 1 capsule 15 min before exercise. Inhal
for severe bronchospasm nebulized by compressed air or oxygen 2.55
mg (0.51 mL of 0.5% in 23 mL NS) q 46 hr prn (q 12 hr under medical
supervision).
PO for asthma 24 mg q 68 hr, increase as tolerated to a maximum of
32 mg/day; SR Tab 48 mg q 12 hr, to a maximum of 32 mg/day.

SIMVASTATIN

Durasi:
Dosis :Initially 5 or 10 mg once daily in the evening. Adjust dosage at 4
wk intervals to max of 40 mg daily (detrovel,mims). Adult Initially 10
mg/day. Max: 40 mg/day. Mild to moderate hypercholesterolemia 5
mg/day. All doses to be taken as a single dose in the evening. Adjust dose
at 4 wkly interval as required (valemia,mims).
Kelas :Dyslipidaemic Agents, Belongs to the class of HMG CoA reductase
inhibitors. Used in the treatment of hyperlipidemia.

SULFACETAMIDE

Durasi :
Dosis :
Kelas :

SODIUM BICARBONATE 500mg

Durasi:
Dosis : usual dose is between 1-5gr. Maximum daily dose is 5gr
Kelas : antacids (focuspharmaceuticals)

TETRACYCLINE

Durasi :
Dosis :1 cap 4 times daily. Brucellosis 500 mg 4 times daily for 3
wk. Syphilis 30-40 g in equally divided doses for 15 days.
Kelas : Belongs to the class of tetracyclines. Used in the systemic
treatment of infections.(Armoxindo Farma,mims)

TRIHEKSIPHENIDYL

Durasi :

Dosis : 1st day: 1 mg. 2nd day: 2 mg w/ further increase of 2 mg daily at 35 days interval, up to 6-10 mg daily in 3-4 divided doses. Some patients
may require total dose of 12-15 mg daily. Drug-induced parkinsonism 5-15
mg daily, advisable to initiate therapy w/ single 1 mg dose. Patient >65 yr
Smaller doses required.(pyridam,mims)
Initially 1-2 mg/day then 2 mg/day at 3-5 days interval, may increase up to
6-10 mg or 12-15 mg daily in 3-4 divided doses, until clinical effect is
obtained. (harsen,mims)

Kelas : trihexyphenidyl ; Belongs to the class of tertiary amines


anticholinergic agents. Used in the management of Parkinson's disease.

VITAMIN B1

Durasi:
Dosis :1-2x 1tab 50mg (Trifa,ISO VOL 46, PG 558)
Kelas :Multivitamins, plain ; Used as dietary supplements (nycomed,mims)

VITAMIN B12

Durasi:
Dosis :
Kelas :multivitamins and other minerals, incl. combinations ; Belongs to
the class of multivitamins with minerals. Used as dietary supplements
(nufarindo,mims).

VITAMIN B6

Durasi:
Dosis :SEHARI 3X1 TAB 10MG (Trifa,ISO VOL 46 PG 558)

Kelas :pyridoxine (vit B6) ; Belongs to the class of other plain vitamin
preparations. Used as dietary supplements (kimia farma,mims).

VITAMIN B KOMPLEKS

Durasi:
Dosis : 3x sehari satu tablet

Kelas : Vitamin B-complex, plain ; Used as dietary supplements (kimia


farma,mims).

VITAMIN C

Durasi:
Dosis :Adult 100-250 mg 1-2 times daily for several days. Severe cases,
1,000-2,000 mg daily could be administered
Kelas : Belongs to the class of ascorbic acid (vitamin C). Used as dietary
supplements (sanbe,mims)

VITAMIN K

Durasi:
Dosis : 10-40mg per hari
Kelas : menadione ; Belongs to the class of vitamin K. Used in the
treatment of hemorrhage (kimia farma,mims).

ZINC

Durasi:
Dosis :
Kelas :

CEFIXIME

Durasi :
Dosis : Adult & childn weighing 30 kg 50-100 mg twice daily. Severe
or intractable infections May be increased up to 200 mg twice daily.
Kelas : cefixime ; Belongs to the class of third-generation cephalosporins.
Used in the systemic treatment of infections. (kimia farma,mims).

CIMENTIDINE

Durasi :
Dosis : Adult 1 tab 3 times daily & 2 tab at bedtime. For higher doses, 2
tab 4 times daily. Childn 20-40 mg/kg/day in divided doses. Treatment
should be given for at least 4 wk.

Kelas : cimetidine ; Belongs to the class of H2-receptor antagonists. Used


in the treatment of peptic ulcer and gastro-oesophageal reflux disease
(GERD) (armoxindo farma,mims).

DIGOXIN

Durasi :
Dosis : Rapid digitalization (24-36 hr) Adult 4-6 tab followed at
adequate interval by 1 tab until compensation is achieved. Childn 25
mcg/kg, increasing at interval until compensation achieved. Maintenance:
10-20 mcg/kg daily. Slow digitalization (3-5 days) 2-3 tab daily in
divided doses. Maintenance: 1-3 tab daily. Inj 0.5-1 mg/day.
Elderly : dose is based on lean body weight and normal renal function for
age.
Heart failure: if patient is > 70 years, low doses,(0.125mg daily or every
other day) should be used. (DIF,20 TH EDITION, PG 511).
Kelas : Belongs to the class of digitalis glycosides. Used in the treatment of
heart failure (Fahrenheit, mims).

DOXYCYCLINE

Durasi :
Dosis : Adult & childn >8 yr w/ >45 kg body wt 1st day: 100 mg twice
daily followed by 100 mg daily. Childn >8 yr w/ <45 kg body wt 1st
day: 4.4 mg/kg body wt/day in 2 divided doses, then 2.2 mg/kg body
wt/day. Severe infections 2.2 mg/kg body wt/12 hr. Streptococcal
infection Duration of treatment min 10 days. Acute gonorrhea 1st day:
200 mg & 100 mg at bedtime, then followed by 100 mg twice daily for 3
days.
Kelas : Belongs to the class of tetracyclines. Used in the systemic
treatment of infections (ifars,mims).

ERYTHROMYCIN

Durasi :
Dosis : Adult & childn >20 kg Cap/chew tab 1 cap or 2 chew tab 4 times
daily. Caplet 1 caplet 2 times daily.Syr 10 mL 4 times daily. Childn 20
kg 30-50 mg/kg body wt daily in 4 divided doses.
Kelas : Belongs to the class of macrolides. Used in the systemic treatment
of infections.(sanbe, mims).

FUROSEMIDE

Durasi :
Dosis : Tab Edema Adult Initially 20-80 mg as a single daily dose. Dose
may be carefully titrated up to 600 mg/day (except in advanced renal
failure). Childn 1-2 mg/kg body wt as a single dose. Max: 40

mg. InjAdult Initially 20-40 mg as a single dose IV/IM. Acute pulmonary


edema Initially 40 mg single dose IV. Max: 80 mg. Cerebral edema 2040 mg 3 times daily IV. Forced diuresis 20-40 mg in addition to infusion
of electrolyte soln. Childn 1 mg/kg body wt IM/IV. Max: 20 mg.
Kelas : Belongs to the class of high-ceiling sulfonamide diuretics.(Sanofi
Aventis,mims).

GENTAMYCIN

Durasi:
Dosis: Apply 3-4 times daily
Kelas:Belongs to the class of other topical antibiotics used in the treatment
of dermatological diseases.(sanbe,mims)

NYSTATIN

Durasi :
Dosis : Adult 1-6 mL. Childn 1-2 mL. To be taken 4 times daily.
Kelas : Belongs to the class of antibiotics. Used in the treatment of
intestinal infections (PHAROS,MIMS)

PHENYTOIN

Durasi :
Dosis :Oral Adult Initially 100 mg 3 times daily. Childn 5 mg/kg body
wt/day in 2 or 3 divided doses. Max: 300 mg daily. Inj Max: 50 mg/min
IV. Status epilepticus 10-15 mg/kg body wt slow IV (approx 20 min in a
70 kg patient), followed by a maintenance dose of 100 mg orally or IV
every 6-8 hrly. Neurosurgery100-200 mg IM 4 hrly & post-op. Cardiac
arrhythmia 3.5-5 mg/kg body wt, repeated once if necessary. Total daily
dosage: 700-1000 mg.
Kelas :Belongs to the class of hydantoin derivatives antiepileptics
(Pfizer,mims)

VENTOLIN

Durasi :
Dosis :Adult & childn Initially 2.5 mg, then may be increased to 5 mg.
May be repeated 4 times daily. Severe airways obstruction Adult Up to
40 mg/day.
Kelas : Belongs to the class of adrenergics for systemic use, selective beta2-adrenoreceptor agonists. Used in the treatment of obstructive airway
diseases.(GlaxoSmithKline Indonesia,mims)

CIMETIDINE

Durasi :

Dosis : Duodenal ulcer Adult 1-2 tab 3-4 times daily. Min 4 wk. ZollingerEllison syndrome & gastric hyperacidity 1 tab 4 times daily. Max: 2,400 mg
daily. Oesophagitis 2 tab 4 times daily for 4-8 wk. Inhibition of gastric acid
secretion in childn 20-40 mg/kg body wt/day in divided doses.
Kelas : Belongs to the class of H2-receptor antagonists. Used in the
treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD)
(sanbe,mims).

PROPRANOLOL

Durasi :
Dosis : Adult & childn >12 yr Angina pectoris 20 mg 3-4 times daily,
increase gradually to 40 mg 3-4 times daily. Max: 200-280 mg daily.
Cardiac arrhythmia 10-30 mg 3-4 times daily. HTN 20 mg 3 times daily,
increasing to 40 mg 3-4 times daily after 3 days. Migraine (prophylaxis) 40
mg 2-3 times daily. Hypertrophic obstructive cardiomyopathy 10-20 mg 34 times daily. Childn <12 yr adult dose.
Kelas : beta-blockers (
Fahrenheit,mims)

FERROUS FUMERATE

Durasi :
Dosis : lower doses (15-50mg elemental iron/day) may have similar
efficacy and less GI adverse events as compared to higher doses (150mg
elemental iron/day)
Kelas : iron salt (DIF, 20th edition pg 711)

GRISEOFULVIN

Durasi :
Dosis :Adult 500 mg daily. Max: 1 g daily. Childn 10 mg/kg/day. Recalcitrant
infections Up to 12 mth treatment.
Kelas : G

PAPAVERIN

Durasi
Dosis:
Kelas :

DOSIS DATA LIZA


AMINOFILIN 1X1 3X1
ANTASID 2X1
ASAM MEFENAMAT 2X1 3X1
Adult Initially 500 mg then 250 mg 6 hrly.

B1 3X1
1-2x 1tab 50mg

B6 2X1 1x1
SEHARI 3X1 TAB 10MG

B COMP 2X1 1X1


CTM 2X1
Adult 1 caplet. To be taken 3-4 times daily

DIAZEPAM 1X1
Oral 2-5 mg 3 times daily

GG 2X1 3X1
GLIBENKLAMIDE 2x1 3x1

Dosis :Initially 2.5-5 mg daily, should be adjusted in stepwise dose of 2.5


mg at about 1 wk interval. Max dosage: 10 mg/day (padonil, mims).
Initially 5 mg daily.
1.2520 mg in 12 divided doses

IBUPROFEN 2X1
400 mg 3-4 times daily. Analgesia 200-400 mg 3-4 times daily

HIDROKLORTIAZID (HCT) 3x1

Durasi: 6-12 hr.


Dosis :hipertensi : initial, 25 mg ORALLY once daily; may increase to 50
mg ORALLY daily in single or 2 divided doses.

KOTRIMOKSAZOLE 2X1 3X1


LAKTAS 3X1 2X1
LORATADIN 2X1
METFORMIN 1X1
1 tab 2-3 times daily (diafac, mims). 500 mg tab 1 tab 3 times daily. 850 mg tab
1 tab twice daily. Max: 3 g/day

NIFEDIPIN 1X1 2x1


5-10 mg 3 times daily

PCT 2X1
To be taken 3-4 times daily. Max daily dose: 4g

PIROXICAM 2x1 1x1 3x1


RA, OA (arthrosis, generative joint disease, ankylosing spondylitis)
Initially 20 mg daily as a single dose. Acute gout Initially 40 mg daily as a single
dose, followed by 40 mg daily on the next 4-6 days in single or divided doses.

RANITIDIN 1X1 3X1


Active benign gastric ulcer 150 mg 2 times daily for 4-8 wk.

SALBUTAMOL 1X1 2X1


TabAdult 2-4 mg, SyrAdult 5-10 mL. All doses are to be taken 3-4 times daily

TETRASIKLIN 3X1
1 cap 4 times daily. Brucellosis 500 mg 4 times daily for 3 wk.

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