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Topicupdatedon02/17/1512:52pm
11
OverviewofByMechanism
FatEmbolismSyndrome
Thromboembolism(PE&DVT)
Anticoagulation
NeurologicDiseases
MultipleSclerosis
AmyotrophicLateralSclerosis
(ALS)
ComplexRegionalPain
Syndrome(CRPS)
SystemicDiseases
RheumatoidArthritis
SystemicLupusErythematosus
(SLE)
LymeDisease
AcuteRheumaticFever
MetabolicDisease
Hypercalcemia
OTHER
Hypocalcemia
Hypoparathyroidism
Natrual
Firstgeneration
Hyperparathyroidism
Ciprofloxacin(Cipro)
Amikacin
Ertapenem
Azithromycin
Levofloxacin
Gentamicin
Aztreonam
Imienem
Clarithromycin Rifampin
Vancomycin
Meropenem
PenicillinG
Cephalothin
(Levaguin)
Kanamycin
Dirithromycin
Doxycycline
PenicillinVK
Cefazolin(Ancef,
Moxifloxacin(Avelox)
Neomycin
Erythromycin
Linezolid
Pseudohypoparathyroidism
Kefzol)
Norfloxacin
Tobramycin
Clindamycin Tetracycline
Scurvy
Cephapririn
Trimethoprim/
Cephalexin(Keflex)
sulfamethoxacole
Hypophosphatasia
other
Medications&Toxicity
Penicillinase
Medications
Bisphosphonates
SecondGeneration
Resistant
Methicillin
Cefacor
Nafcillin
Cefotetan(Cefotan)
AntibioticClassification&
Mechanism
Oxacillin
other
AntiinflammatoryMedications
Aminopenicillins
AnalgesicMedications
Ampicillin
ProphylaxisAntibiotics
other
(Rocephin)
Anesthesia
PlateletRichPlasma
other
Toxicology
LeadToxicity
ThirdGeneration
Ceftriaxone
FourthGeneration
Cefpirome
Cefepime
ClinicalScience
ClinicalStudies
AntibioticGroupingByMechanism
CellWallSynthesis
StatisticDefinitions
LevelofEvidence
ClinicalTrialDesign
OutcomeMeasureTools
HealthcareWorplace
OccupationalHealth
Penicillins
Cephalosporins
Vancomycin
BetalactamaseInhibitors
Carbapenems
Aztreonam
Polymycin
Bacitracin
ProteinSynthesisInhibitors
LegalandEthics
JobBank
http://www.orthobullets.com/basicscience/9059/antibioticclassificationandmechanism
Inhibit30sSubunit
Aminoglycosides(gentamicin)
Tetracyclines
Inhibit50sSubunit
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Inhibit50sSubunit
Macrolides
Chloramphenicol
Clindamycin
Linezolid
Streptogramins
DNASynthesisInhibitors
Fluoroquinolones
Metronidazole
RNAsynthesisInhibitors
Rifampin
MycolicAcidsynthesisinhibitors
Isoniazid
FolicAcidsynthesisinhibitors
Sulfonamides
Trimethoprim
AntibioticClassification&Indications
InhibitsCellWallSynthesis
Penicillins
(bactericidal:blockscrosslinkingviacompetitiveinhibitionofthetranspeptidaseenzyme)
Class/Mechanism
Drugs
Indications(**Drugof
Choice)
Toxicity
Penicillin
PenicillinG
AqueouspenicillinG
ProcainepenicillinG
BenzathinepenicillinG
PenicillinV
Aminopenicillins
Ampicillin
Amoxicillin
Penicillinaseresistant
penicillins
Methicillin
Nafcillin
Oxacillin
Cloxacillin
Dicloxacillin
Above+
PCNase
producingStaph.
aureus
Above+
Interstitialnephritis
Antipseudomonal
penicillins
Carbenicillin
Ticarcillin
Piperacillin
Above+
Pseudomonas
aeruginosa**
Above
Hypersensitivity
Strep.pyogenes
reaction
(Grp.A)**
Hemolyticanemia
Step.agalactiae
(Grp.B)**
C.perfringens(Bacilli)**
Above+
Gramnegative:
E.faecalis**
E.Coli**
Above
Cephalosporins
(bactericidal:inhibitsbacterialcellwallsynthesisviacompetitiveinhibitionofthetranspeptidaseenzyme)
1stgeneration
Cefazolin
Cephalexin
Staph.aureus**
Allergicreaction
Staph.epidermidis**
Coombspositive
SomeGramnegatives: anemia(3%)
E.Coli
Klebsiella
2ndgeneration
Cefoxitin
Cefaclor
Cefuroxime
Above+
Gramnegative
AllergicReaction
ETOHDisulfiram
reaction
3rdgeneration
Ceftriaxone
Cefotaxime
Ceftazidime
Cefepime(4thgeneration)
Above+
Gramnegative
Pseudomonas
AllergicReaction
ETOHDisulfiram
reaction
Vancomycin
(bactericidal:disrupts
peptioglycancrosslinkage)
Vancomycin
BetalactamaseInhibitors
(bactericidal:blockingcross
linking)
ClavulanicAcid
Sulbactam
Tazobactam
Carbapenems
Imipenem(+cilastatin)
Meropenem
OtherCellWallInhibitors
http://www.orthobullets.com/basicscience/9059/antibioticclassificationandmechanism
MRSA**
PCN/Cephallegies**
S.aureus
S.epidermidis
Saureus**
Sepidermis**
E.Coli**
Klebsiella**
Broadestactivityof
anyantibiotic
Redmansyndrome
Nephrotoxicity
Ototoxicity
Hypersensitivity
Reaction
Hemolyticanemia
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Meropenem
Doripenem
Ertapenem
anyantibiotic
(exceptMRSA,
Mycoplasma)
Aztreonam
Aztreonam
Gramnegativerods
Aerobes
Hospitalacquired
infections
Polymyxins
PolymyxinB
PolymyxinE
TopicalGramnegative
infections
Bacitracin
Bacitracin
TopicalGrampositive
infections
ProteinSynthesisInhibition
Anti30Sribosomalsubunit
Aminoglycosides
(bactericidal:irreversible
bindingto30S)
Gentamicin
Neomycin
Amikacin
Tobramycin
Streptomycin
Tetracyclines
Tetracycline
(bacteriostatic:blockstRNA) Doxycycline
Minocycline
Demeclocycline
AerobicGram
negatives
Enterobacteriaceae
Pseudomonas
Rickettsia
Mycoplasma
Spirochetes(Lyme's
disease)
Nephrotoxicity
Ototoxicity
Hepatotoxicity
Toothdiscoloration
Impairedgrowth
Avoidinchildren<
12yearsofage
Anti50Sribosomalsubunit
Macrolides
(bacteriostatic:reversibly
binds50S)
Erythromycin
Azithromycin
Clarithromycin
Streptococcus
H.influenzae
Mycoplamsa
pneumonia
Coumadin
Interaction
(cytochromeP450)
Chloramphenicol
(bacteriostatic)
Chloramphenicol
Hinfluenzae
BacterialMeningitis
Brainabsces
AplasticAnemia
GrayBaby
Syndrome
Lincosamide
(bacteriostatic:inhibits
peptidyltransferaseby
interferingwithaminoacyl
tRNAcomplex)
Clindamycin
Bacteroidesfragilis
Saureus
Coagulasenegative
Staph&Strep
ExcellentBone
Penetration
Pseudomembranous
colitis
Hypersensitivity
Reaction
Linezolid
(variable)
Linezolid
ResistantGram
positives
Streptogramins
Quinupristin
Dalfopristin
VRE
GASandS.aureus
skininfections
DNASynthesisInhibitors
Fluoroquinolones
(bactericidal:inhibitDNAgyraseenzyme,inhibitingDNAsynthesis)
1stgeneration
Nalidixicacid
Steptococcus
Mycoplasma
AerobicGram+
Phototoxicity
Achillestendon
rupture
Impairedfracture
healing
2ndgeneration
Ciprofloxacin
Norfloxacin
Enoxacin
Ofloxacin
Levofloxacin
AsAbove
+Pseudomonas
asabove
3rdgeneration
Gatifloxacin
Asabove+Gram
positives
asabove
4thgeneration
Moxifloxacin
Gemifloxacin
Asabove+Gram
asabove
positives+anaerobes
Metronidazole
(bacteridical:metabolic
biproductsdisruptDNA)
Metronidazole(Flagyl)
OtherDNAInhibitors
Anaerobics
Seizures
Crebelardysfunction
ETOHdisulfram
reaction
RNASynthesisInhibitors
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RNASynthesisInhibitors
Rifampin
Rifampin
(bactericidal:inhibitsRNA
transcriptionbyinhibitingRNA
polymerase)
Staphylococcus
Mycobacterium(TB)
Bodyfluid
discoloration
Hepatoxicity(with
INH)
MycolicAcidsSynthesisInhibitors
Isoniazid
Isoniazidz
TB
LatentTB
FolicacidSynthesisInhibitors
Trimethoprim/Sulfonamides Trimethoprim/Sulfamethoxazole UTIorganisms
(bacteriostatic:inhibitionwith (SMX)
Proteus
PABA)
Sulfisoxazole
Enterobacter
Sulfadiazine
Pyrimethamine
Pyrimethamine
Malaria
T.gondii
Thrombocytopenia
Avoidinthird
trimesterof
pregnancy
BacteriaOverview
GramPostiveCocci
Staphylococcus
Staph.aureus
MSSA
MRSA
Staph.epidermis
Staphsaprophyticus
Streptococcus
Streppneumoniae
Streppyogenes(GroupA)
Strepagalacticae(GroupB)
Strepviridans
StrepBovis(GroupD)
Enterococci
E.faecalis(GroupDstrep)
GramPositiveBacilli
SporeForming
Bacillusanthracis
Bacilluscereus
Clostridiumtetani
Clostridiumbotulinum
Clostridiumperfringens
Clostridiumdifficile
NonSporeForming
Corynebacteriumdiphtheriae
Listeriamonocytogenes
Neisseria
Neisseriameningitidis
Neisseriagonorrhoeae
GramNegativeCocci
GramNegativeBacilli
Enterics
Escherichiacoli
Salmonellatyphi
Salmonellaenteridis
Shigelladysenteriae
Klebsiellapneumoniae
Serratia
Proteus
Campylobacterjejuni
Vibriocholerae
Vibrioparahaemolyticus/vulnificus
Helicobacterpylori
Pseudomonasaeruginosa
Bacteroidesfragilis
Respiratorybacilli
Haemophilusinfluenzae
Haemophiliusducreyi
Bordatellapertussis
Zoonoticbacilli
Yersiniaenterocolitica
Yersiniapestis
Brucella
Francisellatularensis
Pasteurellamultocida
Bartonellahenselae
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Other
Gardnerellavaginalis
Mycobacteria
Mycobacteriumtuberculosis
Mycobacteriumleprae
MOTTS
Spirochetes
Borreliaburgdorferi
Leptospirainterrogans
Treponemapallidum
Chlamydiaceae
Chlamydiatrachomatis
Chlamydophila
Rickettsia
Ehrlichia
Mycoplasmataceae
Mycoplasmapneumoniae
Ureaplasmaurealyticum
FunguslikeBacteria
Actinomycesisraelii
Nocardia
OtherBacteria
AntibioticResistanceMechanisms
Bacteriadevelopabilitytohydrolyzethesedrugsusinglactamase
confersresistancetopenicillin
e.g.E.coli,Staphepidermidis,Pseudomonasaeruginosa,Klebsiellapneumoniae
addlactamaseinhibitore.g.clavulanicacidinamoxicillinclavulanate(Augmentin)
GeneticmutationofmecA
abacterialgeneencodingapenicillinbindingprotein.NewPBPhasreducedaffinityfor
antibiotics
confersresistancetomethicillin,oxacillin,nafcillin
e.g.MRSA
Alteredcellwallpermeability
confersresistancetotetracyclines,quinolones,trimethoprimandlactamantibiotics
Creationofbiofilmbarrier
providesanenvironmentwhereoffendingbacteriacanmultiplysafefromthehosteimmune
system
Salmonella
Staphepidermidis
Activeeffluxpumps
confersresistancetoerythromycinandtetracycline
e.g.msrAgeneinStaph
Alteredpeptidoglycansubunit(alteredDalanylDalanineofNAM/NAGpeptide)
confersresistancetovancomycin
e.g.vancomycinresistantenterococcus(VRE)
Ribosomealteration
ermgeneconferinducibleresistancetoMLS(macrolidelincosamidestreptogranin)agents
viamethylationof23srRNA
demonstrateusingDzonetest
forinducibleclindamycinresistanceinStaphandbetahemolyticStrep
Penicillins
Mechanism
interferwithbacterialcellwallsynthesis
Subclassificationandtestedexamples
natural
penicillinG
penicillinaseresistant
methicillin(Staphcillin)
aminopenicillins
ampicillin(Omnipen,Polycillin)
Cephalosporins
Overview
bactericidal
Mechanism
disruptsthesynthesisofthepeptidoglycanlayerofbacterialcellwalls
doessothroughcompetitiveinhibitiononPCB(penicllinbindingproteins)
peptidoglycanlayerisimportantforcellwallstructuralintegrity.
samemechanicsmofactionasbetalactamantibiotics(suchaspenicillins)
Subclassificationandtestedexamples
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Subclassificationandtestedexamples
firstgeneration
cefazolin(Ancef,Kefzol)
secondgeneration
cefaclor(Ceclor)
thirdgeneration
cefriazone(Rocephin)
fourthgeneration
cefepime(Maxipime)
Fluoroquinolones
Mechanism
blocksDNAreplicationviainhibitionofDNAgyrase
Sideeffects
inhibitearlyfracturehealingthroughtoxiceffectsonchondrocytes
increasedratesoftendinitis,withspecialpredilectionfortheAchillestendon.
tenocytesintheAchillestendonhaveexhibiteddegenerativechangeswhenviewed
microscopicallyafterfluoroquinoloneadministration.
recentclinicalstudieshaveshownanincreasedrelativeriskofAchillestendonrupture
of3.7.
Subclassificationandtestedexamples
ciprofloxacin(Cipro)
levofloxacin(Levaquin)
Aminoglycosides
Mechanism
bactericidal
inhibitionofbacterialproteinsynthesis
workbybindingtothe30sribosomesubunit,leadingtothemisreadingofmRNA.This
misreadingresultsinthesynthesisofabnormalpeptidesthataccumulateintracellularly
andeventuallyleadtocelldeath.Theseantibioticsarebactericidal.
Subclassificationandtestedexamples
gentamicin(Garamycin)
Vancomycin
Coverage
grampositivebacteria
Mechanism
bactericidal
aninhibitorofcellwallsynthesis
Resistance
increasingemergenceofvancomycinresistantenterococcihasresultedinthedevelopment
ofguidelinesforusebythe(CDC)
indicationsforvancomycin
seriousallergiestopenicillinsorbetalactamantimicrobials
seriousinfectionscausedbysusceptibleorganismsresistanttopenicillins(MRSA,
MRSE)
surgicalprophylaxisformajorproceduresinvolvingimplantationofprosthesesin
institutionswithahighrateofMRSAorMRSE
Rifampin
MosteffectiveagainstintracellularphagocytizedStaphylococcusaureusinmacrophages
Linezolid
Linezolidbindstothe23Sportionofthe50Ssubunitandactsbypreventingtheformationof
theinitiationcomplexbetweenthethe30Sand50Ssubunitsoftheribosome.
Splenectomy
Splenectomypatientsorpatientswithfunctionalhyposplenismrequirethefollowingvaccines
and/orantibiotics
Pneumococcalimmunization
HaemophilusinfluenzatypeBvaccine
MeningococcalgroupCconjugatevaccine
Influenzaimmunization
Lifelongprophylacticantibiotics(oralphenoxymethylpenicillinorerythromycin)
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(OBQ12.53)WhatmechanismallowsStaphylococcusepidermidistoadheretosurfacesandresistphagocytosis?
ReviewTopic
1.
2.
3.
4.
5.
Creationofactiveeffluxpumps
Methylationof23srRNA
Biofilmproduction
Alterationofcellwallpermeability
Betalactamaseproduction
PREFERREDRESPONSE
Evidence
Tested(/Site/EFootprints/ViewForTopic/9059?mode=Tested)
All(/Site/EFootprints/ViewForTopic/9059?mode=All)
evidenceFootprint
100%
CostEffectiveness(more)
80%
60%
40%
20%
0.0
0%
ClinicalImpact(increase)
Key
SHOWEVIDENCE
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