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Deadenylases in Malaria
Transmission
Kevin Hart
Lindner Lab
5/21/15
Up: 513
200
0
FPKM
CCR4-1
10
7.22
CCR4
0.56
0
WT
99
WT
Puf2 KO
Deadenylation
CAF 1
200
0
Not1
50
159
151
WT
Puf2 KO
CAF1 0
24
24
WT
Puf2 KO
50
0
Not2
Not7
0.65
25.74
WT
Puf2 KO
Not5
100
NOT 5
57
4
0
CAF16
2
Puf2 KO
Not4
CAF16
100
WT
N OT 2
CAF40
Puf2 KO
221
Ubiquitination
(-/-) H3K4me3 reduction
CAF40
110
159
WT
Puf2 KO
52
0
WT
Puf2 KO
CCR4-2
4
3
2
1
0
3.37
0.02
WT
Puf2 KO
Modified from Collart, M., & Panasenko, O. (2012). The Ccr4Not complex. Gene, 492(1), 42-53.
Conclusions:
KO results in a decrease in proliferation
efficiency
KO results in a severe disruption of merozoite
egress
Premature merozoites bursting RBC
membrane
Attempts to KO in P. berghei unsuccessful
Acknowledgements
Lindner Lab
Scott Lindner
Laura Bowman
Steve Griffin
Brooke Kanaskie
Mark Kennedy
Allen Minns
Elyse Munoz
Amanda Reese
Erin Vrana
Mike Walker
Funding Sources
NIAID: 1K22AI101039-01 (SEL)
Penn State Start Up Finds (SEL)