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  • Differences in Nitric Oxide levels between depressed and non-depressed ACS patients

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    1) The study aimed to determine differences in nitric oxide levels in depressed patients after an acute coronary syndrome compared to non-depressed patients. 2) The study used an observational cross-sectional design and measured nitric oxide levels in patients at least one month post-ACS between ages 40-60 years old at Dr. Sardjito Hospital from May to August 2015. 3) The results found that nitric oxide levels were lower in depressed patients (32.22) compared to non-depressed patients (32.45), but the difference was not statistically significant. Depressed patients also received organic nitrate treatment less frequently but there was no relationship between nitrate treatment and depression.

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    1) The study aimed to determine differences in nitric oxide levels in depressed patients after an acute coronary syndrome compared to non-depressed patients. 2) The study used an observational cross-sectional design and measured nitric oxide levels in patients at least one month post-ACS between ages 40-60 years old at Dr. Sardjito Hospital from May to August 2015. 3) The results found that nitric oxide levels were lower in depressed patients (32.22) compared to non-depressed patients (32.45), but the difference was not statistically significant. Depressed patients also received organic nitrate treatment less frequently but there was no relationship between nitrate treatment and depression.

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    17 views1 page

    Differences in Nitric Oxide levels between depressed and non-depressed ACS patients

    Uploaded by

    indahprambono
    1) The study aimed to determine differences in nitric oxide levels in depressed patients after an acute coronary syndrome compared to non-depressed patients. 2) The study used an observational cross-sectional design and measured nitric oxide levels in patients at least one month post-ACS between ages 40-60 years old at Dr. Sardjito Hospital from May to August 2015. 3) The results found that nitric oxide levels were lower in depressed patients (32.22) compared to non-depressed patients (32.45), but the difference was not statistically significant. Depressed patients also received organic nitrate treatment less frequently but there was no relationship between nitrate treatment and depression.

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    of 1

    ABSTRACT

    Differences in levels of Nitric Oxide in depressed patients after an acute coronary syndrome
    Hasanah Mumpuni1, Noor Asyiqah Sofia2, Iswandi Darwis3

    Cardiovascular Division, Department of Internal Medicine, Faculty of Medicine Universitas Gadjah

    Mada Dr. Sardjito Hospital


    Cardiovascular Division, Department of Internal Medicine, Faculty of Medicine Universitas Gadjah

    Mada Dr. Sardjito Hospital


    Resident in Department of Internal Medicine, Faculty of Medicine Universitas Gadjah Mada Dr.
    Sardjito Hospital

    Background. Acute coronary syndrome (ACS) is a cardiovascular disease that causes many
    deaths in developed countries. The incidence of depression in patients with ACS are 2-3 times
    higher than the general population. Inflammation and endothelial dysfunction are two things that
    are thought to play an important role in the link between depression and coronary heart disease.
    Elevated levels of inflammatory markers and decrease of endothelial function are found in
    patients with depression. Inflammation plays a role in the synthesis of endothelium Nitric Oxide
    (NO). The aim of this study is to determine the differences in levels of Nitric Oxide in depressed
    patients after an acute coronary syndrome.
    Methods. This was an observational study with cross-sectional design that investigate the
    differences in the levels of NO in depressed patients after acute coronary syndromes and were
    taken at one time. The study was conducted at the Dr. Sardjito Hospital from May to August
    2015. Populations of this study are patients with at least 1 month post-ACS of age 40-60 years
    who went to RSUP Dr. Sardjito and willing to follow the course of the study. The subjects of this
    study are populations that meet the inclusion criteria and without exclusion criteria.
    Results. The amount of nitric oxide in patients with depression is lower 32.22 + 2.38 compared
    to patients with no depression 32.45 + 2.38 with p value of 0.583. It can be concluded that the
    amount of nitric oxide in patients with depression is lower but not significantly different with the
    amount of nitric oxide in patients with no depression. Depressive patients also received fewer
    treatment of organic nitrate 37.5% compared to non-depressed patients 55% (p-value 0.116) but
    there is no relation between organic nitrates with depressive symptoms.
    Conclusions. The amount of nitric oxide in depressed patients is lower than non-depressed
    patients but there is no significant difference.
    Keywords. Acute coronary syndrome, depression, nitric oxide.

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