HEPATITA D

V defectiv, necesita prez unei anvelope, AgHBs

36 nm, ARN monocatenar circ
nvelit n AgHBs, se fixeaza, patr n hepatocit?ef citopatogen dir prin (-) si
ntezei prot prin hibridizarea ARN v cu cel celular + ef indir prin mec imun
Transmitere: sg/derivate, sex, toxicomani,
Coinf HBV-HDV: n per de remisie a HBV, reapar semnele clinice de b?IHA/vi
ndec. Paracl: evol bifazica a TGP
Suprainf: survine pe portaj de AgHBs/hep cr; evol severa, cu forme fulmi
nans, IHA, >70% cr
Dg +: Ag VHD evid n hepatocit, ser; PCR- .v ARN-HDV
Coinf: AcVHD IgM+IgMHBc
Suprainf: Ac IgM VHD+markeri de inf cr-AgHBs, AgHBe/ AcHBe, IgG AcHBc