1.

KA-3A
Contents

Electrolytes, glucose.

Indications

To supply or replenish water and electrolytes which are needed for

daily maintenance. The composition is based on the average
required amounts of water and electrolytes in normal humans.
For post-surgery use in patients who have difficulties in the oral
intake of water and electrolytes and for hypertonic dehydration
with hypokalemia.
KA-EN 3A is recommended for use in children 3 years because
of its low content of potassium.

Dosage &
Administration

Adults and Children 3 years or 15 kg Body Weight: 50-100

mL/hr. The dosage should be adjusted according to the patient's
condition, age and body weight.

Contraindications

Hyperkalemia, oliguria, Addison's disease, severe burn and

azotemia. Patients with sodium overload, glucose-galactose
malabsorption syndrome, severe hepatic injury and cardiac
arrhythmia.

Special Precautions

The use of KA-EN 3A should be carefully supervised in the

following cases: Congestive heart failure, renal failure, peripheral
and pulmonary edema, preeclampsia, hypertension,
hypoproteinemia, early post-traumatic state, severe sepsis,
acidosis, reduced urinary output due to obstructive urinary tract
disease and diabetes mellitus.
Potassium supplements are particularly dangerous in patients who
are also receiving a potassium-sparing diuretic.
The infusion should not be mixed with whole blood; hemolysis
and clumping have occurred.
The electrocardiogram and serum-potassium concentration should
be monitored frequently and adequate urinary output must be
assured.
During the infusion of KA-EN 3A, the desirable urine output is at
least 500 mL/day or 20 mL/hr.

Adverse Drug
Reactions

Alkalosis.
Cerebral, pulmonary and peripheral edema, water intoxication and
hyperkalemia may occur with a large volume and/or over-infusion.
Thrombophlebitis.
Thrombosis of vein chosen.
Click to view ADR Monitoring Form

Drug Interactions

Since KA-EN 3A solution develops precipitates with calcium ions,

concomitant use and mixing of solution with calcium preparations
should be avoided.

Storage

Store at room temperature, away from direct sunlight.

Description

Each liter solution contains electrolytes (mEq/L): Na+ 60, K+ 10,

Cl- 50, lactate- 20. Glucose: 27 g/L.
Average pH Immediately After Manufacture: About 5.6. pH
Specification: 4-7.5. Specific Gravity (20C): 1.014. Osmotic
Pressure (Ratio to Saline Solution): About 1.;

MIMS Class

Electrolytes

ATC Classification

B05BB02 - electrolytes with carbohydrates ; Belongs to the class

of solutions affecting the electrolyte balance used in I.V. solutions.

Drug Classification

Presentation/Packing

IV infusion (sterile, clear, colorless or slightly yellowish soln) 500

mL x 1's.

2. KA-EN 3B
Contents

Electrolytes, glucose.

Indications

To supply or replenish water and electrolytes which are needed for

daily maintenance. The composition is based on the average
required amounts of water and electrolytes in normal humans.
For post-surgery use in patients who have difficulties in the oral
intake of water and electrolytes and for hypertonic dehydration
with hypokalemia.
KA-EN 3B is recommended in adults as a maintenance solution.

Dosage &
Administration

Adult (3 years or 15 kg Body Weight): Usual Dosage: 500-1000

mL at one time by IV drip infusion. Infusion Rate: Adults: 300500 mL/hr (about 80-130 drops/min). Children: 50-100 mL/hr.
The dosage should be adjusted according to the patient's condition,
age and body weight.

Contraindications

Hyperkalemia, oliguria, Addison's disease, severe burn and

azotemia. Patients with sodium overload, glucose-galactose
malabsorption syndrome, severe hepatic injury and cardiac
arrhythmia.

Special Precautions

The use of KA-EN 3B should be carefully supervised in the

following cases: Congestive heart failure, renal failure, peripheral
and pulmonary edema, preeclampsia, hypertension,
hypoproteinemia, early post-traumatic state, severe sepsis,
acidosis, reduced urinary output due to obstructive urinary tract
disease and diabetes mellitus.
Potassium supplements are particularly dangerous in patients who
are also receiving a potassium-sparing diuretic.
The infusion should not be mixed with whole blood; hemolysis
and clumping have occurred.
The electrocardiogram and serum-potassium concentration should
be monitored frequently and adequate urinary output must be

assured.
During the infusion of KA-EN 3B, the desirable urine output is at
least 500 mL/day or 20 mL/hr.
Use in pregnancy & lactation: Safe use during pregnancy and
lactation has not been assessed, but its use during these periods is
not considered to constitute hazard.

Adverse Drug
Reactions

Alkalosis.
Cerebral, pulmonary and peripheral edema, water intoxication and
hyperkalemia may occur with a large volume and/or over-infusion.
Thrombophlebitis.
Thrombosis of vein chosen.
Click to view ADR Monitoring Form

Drug Interactions

Since the solution develops precipitates with calcium ions,

concomitant use and mixing of KA-EN 3B solution with calcium
preparations should be avoided.

Storage

Store at room temperature, away from direct sunlight.

Description

Each liter solution contains electrolytes (mEq/L): Na+ 50, K+ 20,

Cl- 50, lactate- 20. Glucose: 27 g/L.
Average pH Immediately After Manufacture: About 5.6. pH
Specification: 4-7.5. Specific Gravity (20C): 1.014. Osmotic
Pressure (Ratio to Saline Solution): About 1.;

MIMS Class

Electrolytes

ATC Classification

B05BB02 - electrolytes with carbohydrates ; Belongs to the class

of solutions affecting the electrolyte balance used in I.V. solutions.

Drug Classification

Presentation/Packing

IV infusion (sterile, clear, colorless or slightly yellow soln) 500 mL

x 1's.

3. KA-EN 4A
Contents

Electrolytes, glucose.

Indications

Supply of water and electrolytes in the early phase after surgery

and operations in infants, neonates and children <3 years or with
body weight of <15 kg.

Dosage &

For infants and neonates, dosage should be adjusted according to

Administration

the patient's conditions, age and body weight.

Contraindications

Patients with sodium overload, severe hepatic injury, glucosegalactose malabsorption syndrome.

Special Precautions

Use with caution in patients with congestive heart failure (CHF),

peripheral and pulmonary edema, impaired renal function,
preeclampsia, hypoproteinemia, early post-traumatic state, severe
sepsis, acidosis, reduced urinary output due to obstructive urinary
tract disease and diabetes mellitus.

Adverse Drug
Reactions

Cerebral, pulmonary and peripheral edema, water intoxication may

occur with over infusion. Thrombophlebitis and thrombosis of vein
chosen.
Click to view ADR Monitoring Form

Description

Each liter of solution contains electrolytes (mEq/L): Sodium 30,

chloride 20 and lactate 10. Glucose: 40 g/L (160 kCal/L).;

MIMS Class

Electrolytes

ATC Classification

B05BB02 - electrolytes with carbohydrates ; Belongs to the class

of solutions affecting the electrolyte balance used in I.V. solutions.

Drug Classification

Presentation/Packing

Soln for infusion 500 mL.

4. KA-EN 4B
Contents

Electrolytes, glucose.

Indications

Supply of water and electrolytes in the early phase after surgery

and operations in infants, neonates and children <3 years or with
body weight <15 kg, and in condition of potassium retention.

Dosage &
Administration

For infants and neonates, dosage should be adjusted according to

the patient's conditions, age and body weight.

Contraindications

Patients with sodium overload, severe hepatic injury, glucosegalactose malabsorption syndrome, cardiac arrhythmia,
hyperkalemia, oliguria, Addison's disease, severe burn and
azotemia.

Special Precautions

Use with caution in patients with congestive heart failure (CHF),

peripheral and pulmonary edema, impaired renal function,
preeclampsia, hypoproteinemia, early post-traumatic state, severe
sepsis, acidosis, reduced urinary output due to obstructive urinary
tract disease and diabetes mellitus.
Potassium supplement is particularly dangerous in patients who are
receiving potassium-sparing diuretics. ECG and serum
concentration should be monitored frequently and urinary output
must be assured.

Adverse Drug

Cerebral, pulmonary and peripheral edema, water intoxication may

Reactions

occur with over infusion. Thrombophlebitis, thrombosis of vein

chosen and hyperkalemia.
Click to view ADR Monitoring Form

Description

Each liter of solution contains sodium chloride 1.17 g, potassium

chloride 0.6 g, sodium lactate 1.12 g and anhydrous dextrose 37.5
g.
Electrolytes (mEq/L): Sodium 30, potassium 8, chloride 28 and
lactate 10. Glucose: 37.5 g/L (150 kCal/L).;

MIMS Class

Electrolytes

ATC Classification

B05BB02 - electrolytes with carbohydrates ; Belongs to the class

of solutions affecting the electrolyte balance used in I.V. solutions.

Drug Classification

Presentation/Packing

Soln for infusion 500 mL x 1's.

5. KA-EN 1B
Contents

Electrolytes, glucose.

Indications

To supply or replenish water and electrolytes in the following

conditions: Dehydration in patients whose carbohydrate store may
be depleted, disease due to unknown causes and before and after
surgery.

Dosage &
Administration

Adults: Usual Dosage: 500-1000 mL at one time by IV drip

infusion.
Infusion Rate: Adults: 300-500 mL/hr (about 80-130 drops/min).
Children 3 years or 15 kg Body Weight: 50-100 mL/hr.
The infusion should not be acutely (>100 mL/hr) infused in
newborn and premature babies.
The dosage should be adjusted according to the patient's condition,
age and body weight.

Contraindications

Patients with hyponatremia and comatose patients due to insulin.

Special Precautions

The use of KA-EN 1B should be carefully supervised in the

following cases: Renal failure due to renal diseases, cardiac
failure; reduced urinary output due to obstructive urinary tract
diseases, diabetes mellitus. Administration of sodium chloride
solution to patients with potassium deficiency may increase the
degree of deficiency.
Use in pregnancy & lactation: Safe use in pregnancy and
lactation has not been established, but its use during these periods
is not considered to constitute hazard.

Adverse Drug
Reactions

Cerebral, pulmonary and peripheral edema and dilution acidosis,

and water intoxication may occur with a large volume and/or acute
infusion.

Water intoxication may occur with acute infusion (>100 mL/hr) in

newborn babies and neonates.
Click to view ADR Monitoring Form
Storage

Store at room temperature, away from direct sunlight.

Description

Each liter solution contains electrolytes (mEq/L): Na+ 38.5, Cl38.5. Glucose: 37.5 g/L.
Average pH Immediately After Manufacture: About 4.6. pH
Specification: 4-7.5. Specific Gravity (20C): 1.014. Osmotic
Pressure (Ratio to Saline Solution): About 1.;

MIMS Class

Electrolytes

ATC Classification

B05BB02 - electrolytes with carbohydrates ; Belongs to the class

of solutions affecting the electrolyte balance used in I.V. solutions.

Drug Classification

Presentation/Packing

IV infusion (clear, colorless or slightly yellowish, sterile and

pyrogen-free) 500 mL x 1's.

6. KA-EN MG3
Contents

Electrolytes, glucose.

Indications

To supply or replenish water and electrolytes which are needed for

daily maintenance. The composition is based on the average
required amounts of water and electrolytes in normal humans.
As a maintenance solution for patients with difficulties in the oral
intake of water and electrolytes after surgery, or for hypertonic
dehydration with hypokalemia.
Patients with carbohydrate and electrolyte imbalances in the
following cases: Insufficient oral intake eg, unconsciousness at
cerebral stroke, anorexia due to malignant tumors, general
marasmus, meningitis, encephalitis, malnutrition and pneumonia.
Surgery procedure, neonatology, diabetic acidosis.

Dosage &
Administration

Usual Dosage: 500-1000 mL at one time by gradual IV drip

infusion.
The dosage should be adjusted according to the patient's condition
(loss amounts of body water and electrolytes, etc).
KA-EN MG3 500 mL solution in 1000-mL bottle can be admixed
with eg, amino acid infusion.

Contraindications

Hyperkalemia, oliguria, Addison's disease, severe burns and

azotemia.
Cardiac arrhythmia.

Special Precautions

The use of this solution should be carefully supervised in the

following cases: Renal failure without complicating hyperkalemia;
cardiac failure; severe hepatic injury; reduced urinary output due
to obstructive urinary tract diseases; diabetes mellitus.

During infusion of KA-EN MG3, the desirable urine output is at

least 500 mL/day or 20 mL/hr.
Use in pregnancy & lactation: The safety of this solution during
pregnancy and lactation has not been assessed, but its use during
these periods is not considered to constitute hazard.
Adverse Drug
Reactions

Cerebral, pulmonary and peripheral edema, water intoxication,

hyperkalemia and thrombophlebitis may occur with a large volume
and/or acute infusion.
Click to view ADR Monitoring Form

Storage

Store at room temperature, away from direct sunlight.

Description

Each liter solution contains electrolytes (mEq/L): Na+ 50, K+ 20,

Cl- 50, lactate- 20. Glucose: 100 g/L.
Average pH Immediately After Manufacture: About 5. pH
Specification: 3.5-7. Specific Gravity (20C): 1.042. Osmotic
Pressure (Ratio to Saline Solution): About 2.;

MIMS Class

Electrolytes

ATC Classification

B05BB02 - electrolytes with carbohydrates ; Belongs to the class

of solutions affecting the electrolyte balance used in I.V. solutions.

Drug Classification

Presentation/Packing

IV infusion (clear, colorless or slightly yellowish, sterile, pyrogenfree soln) 500 mL x 1's.