Urdaneta City University

College of Nursing
2nd Semester 2015-2016

Prelim Examination
PHARMACOLOGY

NAME: _________________________________________________ DATE: ______________

COURSE/YEAR AND TIME: _________________________________
SCORE: ______________
I-Multiple- Choice: Choose the correct answer and shade the box that corresponds to
your answer. Strictly No Erasures!
1.

2.

3.

4.

5.

6.

7.

8.

Crushing an enteric-coated tablet before administering it to a client is most

likely to result in:
a. Increased risk of drug toxicity
b. The need to take drug with meals
c. Impaired intestinal absorption of the drug
d. Undesirable interaction between the drug and gastric contents
The nurse would expect to see drug effects most rapidly after which route of
administration
a. Oral capsules
Rectal suppository
b. IM injection
Metered-dose inhaler
Morphine has a large hepatic first-pass effect. Based on this information, the
nurse should anticipate which of the following when a client is switched from
IM to oral morphine?
a. The PO dose will be much larger than the IM dose
b. The PO dose will be much smaller than the IM dose
c. The PO dose will be equal to the IM dose
d. Loading doses must be given first before routine PO dosing begins
Which of the following laboratory results would indicate that a client is at an
unusually high risk for a toxic reaction to a highly protein-bound drug?
a. Serum protein 9.1g/dl
Serum albumin 2.1g/dl
b. Serum calcium 12.1mg/dl
Serum glucose 180mg/dl

A B C D

Miss Thailand began taking fluoxetine (Prozac) for depression 3 days ago.
She tells the nurse, I have taken every pill the way I was told, but I dont
feel any better? Which is the most appropriate action for the nurse to take?
a. Notify the physician that the drug is not having the desired
therapeutic effect
b. Assess Miss Thailand for factors that would impair absorption of the
drugs
c. Explain that is will take at least 10 days for the full therapeutic effect
to appear
d. Check Miss Thailand serum protein levels for excessive protein binding
of the drug
When evaluating whether a client is at high risk for drug cumulation, it is
most important for the nurse to check the results of the following tests?
a. Serum lipids
c. Blood urea nitrogen
b. Serum albumin
d. Liver enzymes
Clients often interpret distressing side effects as allergic responses to drugs.
Which of the following descriptions by a clients is most likely to reflect a
drug side effect rather than allergic reaction?
a. I felt like my throat was closing and I couldnt breathe.
b. I felt nauseated every time I took a pill and sometimes I vomited.
c. I got a fever and my joints were achy.
d. I got a rash that looked like little blisters and was itchy.
When administering a drug, the nurse understands that a drug administered
by which route would be absorbed most rapidly?
a. Oral
b. Intramuscular
c. Intravenous
d. Subcutaneous

ANNALISA A. TELLES, MAN

2016
Page 1
Instructor

2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016
9.

1
0.

1
1.

1
2.

1
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14.

1
5.

1
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1
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Prelim Examination
PHARMACOLOGY

When researching information about a drug, the nurse finds that the drug
tightly binds to protein. The nurse would interpret this to mean which of the
following?
a. The drug will be released fairly quickly
b. The drug will have a long duration of action
c. The drug will be excreted quickly
d. The drug will lead to toxicity when given
A drug that binds to receptor and initiates a response is called a(n):
a. Agonist
b. Competitive antagonist
c. Noncompetitive antagonist
d. Ligand
An organ that is commonly affected by drug toxicities is the:
a. Bone marrow
b. Heart
c. Brain
d. Kidney
The drug cimetidine blocks gastric acid secretion, raising e pH of the
stomach. In monitoring the effects of other medications taken by a client
who receives cimetidine, it would be most important for the nurse to assess
for:
a. Increased side effects of weakly acidic drugs
b. Decreased therapeutic effects of weakly acidic drugs
c. Decreased therapeutic effects of weakly alkaline drugs
d. Increased gastric distress caused by all types of drugs
John has been taking theophylline to control asthma for 2 years.
Theophylline is inactivated by the microsomal enzymes in the liver. John is
now schedules to begin taking rifampin, which induces enzymes. Based on
this information, the nurse should observe John closely for:
a. Theophylline toxicity
b. Rifampin toxicity
c. An increase in asthma symptoms
d. Hepatotoxicity
Which of the following statements by a client would support a nursing diagnosis of
noncompliance with drug therapy?
a. I dont understand why I have to keep taking the pills when Im not coughing any
more.
b. I cant see the lines on the syringe very well, but I can tell the dose is right by how
far I pull up the plunger.
c. My pulse was only 50, so I didnt take my digoxin today.
d. When I get headaches I know my blood pressure is up, so I take the medicine for a
few days.
During a phase II study a drug may be removed from testing for which
reason?
a. Greater than anticipated effectiveness
b. Low risk for toxicity
c. High benefit-to-risk ration
d. Unacceptable adverse effects
During which stage of drug development is the drug tests to animals?
a. Preclinical trial
b. Phase I
c. Phase II
d. Phase III
Which phase of drug development is associated with continual evaluation of
the drug?
a. Phase I study
b. Phase II study
c. Phase III study
ANNALISA A. TELLES, MAN
2016
Page 2
Instructor

2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016

Prelim Examination
PHARMACOLOGY

d. Phase IV study

1
8.

1
9.

2
0.

2
1.

2
2.
2
3.
2
4.
2
5.

2
6.

27.

Male volunteers are usually selected for drug testing during a phase study
for which reason?
a. Women are more unreliable in terms adhering to the terms of the
study
b. Men are typically have a greater consistency in body-build and makeup
c. The risk of damaging or destroying ova is too great
d. Men are less likely to develop toxic effects related to the drug
A nurse is administering a drug to a patient who had the disease for which a
drug is designed to treat. The nurse is most likely participating in which of
the following?
a. Preclinical trial
b. Phase I study
c. Phase II study
d.
Phase III study
Which of the following would be a key element associated with
pharmacodynamics?
a. Enzyme systems
b. Critical concentration
c. Dynamic equilibrium
d. Protein binding
Which of the following most commonly occurs first when an oral drug is
being absorbed?
a. Liver enzymes breakdown the drug into metabolites
b. The drug is delivered to the circulatory system for transport
c. The drug moves from the small intestine directly into the portal
venous system
d. A portion of the drug reaches the tissues before getting to the liver
When describing biotransformation to a group of students, which of the
following would the instructor include as part of phase II biotransformation?
a. Oxidation
b. Reduction
c. Hydrolysis
d.
Conjugation
Which of the following plays the largest role in drug excretion?
b. Skin
b. Feces
c. Kidneys
d. Lungs
A patient is receiving 250mg of a drug that has a half-life of 8 hours. How
much drug would remain after 24 hours?
a. 125mg
b. 31.25mg
c. 62.5mg
d.
15.6256mg
A nurse administers a prescribed loading dose of digoxin based on the
understanding that doing so will result in which of the following?
a. Critical concentration being reached more quickly
b. Enhanced absorption for effectiveness
c. Prevention of drug breakdown by stomach acid
d. Prolonged half-life of the administered drug
Which mechanism is primarily responsible for drug absorption in the body?
a. Active transport
b. Passive diffusion
c. Protein binding
d. Filtration
A nurse is preparing to administer prescribed drug to a patient who has liver
disease. The nurse expects a reduction in dosage based on the
understanding that which of the following might be altered?
a. Absorption
b. Distribution
c. Metabolism
d.
Excretion

ANNALISA A. TELLES, MAN

2016
Page 3
Instructor

2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016
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8.

2
9.

3
0.
3
1.

3
2.

3
3.

3
4.

3
5.

3
6.
3
7.

Prelim Examination
PHARMACOLOGY

When assessing a patient for possible factors that may affect the
pharmacokinetics of a drug, a patient with a history of which of the following
would lead the nurse to suspect that the patient may experience an
alteration in the distribution of a drug?
a. GI disease
b. Kidney disease c. Liver disease
d.
Vascular disease
An instructor is describing a specific area on a cell membrane where most
drugs are thought to act. The students demonstrate understanding of this
information when they identify this area which of the following?
a. Lock
b. Receptor site
c. Enzyme system
d.
Agonist
Penicillin causes bacterial cell death without disrupting normal human cell
functioning. This is an example of which of the following?
a. Critical concentration
c. First -pass effect
b. Selective toxicity
d. Enzyme interaction
Chemotherapeutic agents are drugs that:
a. Are used only to treat cancers
b. Replace the normal body chemicals that are missing because of
disease
c. Interfere with foreign cell functioning such as invading
microorganisms or neoplasm
d. Stimulate the normal functioning of a cell
During assessment, a nurse asks a patient about any chronic conditions that
might have an impact on the patients prescribed drug therapy. Which of the
following, if reported by the patient, would alert the nurse to a possible
problem?
a. Two episodes of pneumonia over the last 5 years
b. Kidney disease diagnosed 2 years ago
c. Nearsightedness for the past 10 years
d. Episode of gastroenteritis last month
Receptor sites
a. Are normal part of enzyme substrates
b. Are protein areas on cell membranes that react with specific
chemicals
c. Can usually be stimulated by many different chemicals
d. Are responsible for all drug effects in the body
Selective toxicity is
a. The ability of a drug to seek out a specific bacterial species or
microorganism
b. The ability of the drug to cause only specific adverse effects
c. The ability of a drug to cause fetal damage
d. The ability of a drug to attack only those systems found in foreign
or abnormal cells
The half-life a drug
a. Is determined by a balance of all pharmacokinetic processes
b. Is a constant factor for all drugs taken by a patient
c. Is influenced by the fat distribution of the patient
d. Can be calculated with the use of a body surface nomogram
A nurse is gathering information about a patient. The nurse is participating in
which step of the nursing process?
a. Assessment
b. Implementation
c. Nursing diagnosis
d. Evaluation
Which of the following would the nurse expect to during implementation?
a. Develop statements about a patients actual problem
b. Obtain baseline information about the patients pattern of health
care
c. Identify the patients social support
d. Provide patient teaching about a drug therapy regimen
ANNALISA A. TELLES, MAN
2016
Page 4
Instructor

2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016
3
8.

3
9.

4
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41.

4
2.

4
3.

4
4.

4
5.

4
6.
4
7.

Prelim Examination
PHARMACOLOGY

Which of the following would be least important to include when teaching a

patient about drug therapy?
a. Alternative therapies to avoid
b. Drug toxicity warning signs
b. Timing of administration
d. How to report a medication
error
The nurse obtains a medical history from a patient before beginning drug
therapy based on an understanding of which of the following?
a. Medical conditions can alter a drugs pharmacodynamics and
pharmacokinetics
b. A medical history is a key component of any nursing protocol
c. A baseline information is necessary to evaluate a drugs effects
d. The medical history is the first step in the nursing process
A patient is receiving a drug to lower his blood glucose level. Which of the
following would lead the nurse to suspect that his blood glucose level was
too low?
a. Cold, clammy skin
b. Increased urination
c. Fruity breath odor
d. Increased hunger
The nurse writes a nursing diagnosis for which reason?
a. Directs medical care
b. Help to increase patient compliance
c. Identify actual or potential alteration in patient function
d. Determine insurance reimbursement in most cases
A patient receiving an antihistamine complains of dry mouth and nose. An
appropriate comfort measure for this patient would be to:
a. Suggest that the patient use a humidifier c. Have the patient
avoid sun exposure
b. Encourage voiding before taking the drug d. Give the patient a
back rub
Which of the following instructions would be most appropriate for the nurse
to teach the patient to reduce the risk of medication errors in the home
setting?
a. Keep a written record of all prescription medication taken
b. Store the medications in the bathroom medicine cabinet
c. Take the medications according to what works best with the
patients schedule
d. Know what each drug is being used for as treatment
When instructing a patient who is taking an antibiotic about the possibility of
nausea, diarrhea, the nurse understands that these effects are examples of
which of the following?
a. Primary actions
b. Drug allergy
c. Secondary actions
d. Hypersensitivity
A patient develops a cytotoxic reaction to a drug. Which of the following
would the nurse expect to do?
a. Administer prescribed epinephrine subcutaneously
b. Encourage the use of Medic-alert identification
c. Discontinue the drug immediately as ordered
d. Administer antipyretics as ordered
When assessing a patient who has developed a serum sickness reaction,
which of the following would the nurse expects to find?
a. Hives
b. Decrease WBC count
c. Difficulty breathing
d. Facial edema
A patient develops stomatitis from drug therapy. Which measure would be
most appropriate for the nurse to suggest?
a. Consumption of three large meals per day
b. The use of an astringent mouthwash
c. Frequent rinsing with cool liquids
ANNALISA A. TELLES, MAN
2016
Page 5
Instructor

2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016

Prelim Examination
PHARMACOLOGY

d. Brushing of teeth with a firm toothbrush

4
8.
4
9.

5
0.

The nurse would assess a patient receiving which medication for possible
superinfection?
a. Antibiotics
b. Antihypertensive
c. Antihistamine
d.
Antineoplastic
Which of the following is an example of a secondary action?
a. Anticoagulant that leads to excessive and spontaneous bleeding
b. Dizziness and weakness with a recommended dose of
antihypertensive
c. An antihistamine causes the patient to experience drowsiness
d. Urinary retention develops in a patient with an enlarged prostate
who is taking an anticholinergic
The nurse expect the following to asses a patient experiencing anaphylactic
reaction except:
a. Dilated pupil
b. Feeling panic
c. High fever
d. Swollen joints
e. Difficulty breathing

II. DEFINITION OF TERMS: Define the following terms. Each item is equivalent to three
(3) points.
1. PASSIVE DRUG DIFFUSION =
2. FIRST PASS EFFECT =
3. THERAPEUTIC USE OF SELF =
4. HEALTH CARE PROCESS=
5. BODY MECHANICS =
III. ESSAY/DISCUSSION: Answer/discuss/explain the following. Write your answer in your
test booklet.

PREPARED BY:
ANNALISA A. TELLES RN, MAN
Instructor

NOTED BY:

ANNALISA A. TELLES, MAN

2016
Page 6
Instructor

2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016

Prelim Examination
PHARMACOLOGY

ZOSIMA C. GARIN, Ed. D.

Dean, College of Nursing

APPROVED BY:
JOSEPHINE S. LAMBINICIO, Ed. D.
Vice President for Academic Affairs

M100: FUNDAMENTALS OF
MIDWIFERY PRACTICE
PRELIM EXAM
ANSWER KEY
TEST I. Multiple Choice:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.

B
C
A
D
B
B
A
C
A

26.
27.
28.
29.
30.
31.
32.
33.
34.

A
B
D
C
C
B
A
C
B

TEST II. Definition of Terms

D
C
B

1. Midwife a healthcare practitioner that

assists women in childbearing and birth.
2. Disease alteration in body functions which
results in reduction of capacities or a
shortening of the normal life span.
3. Human Needs physiologic or psychologic
conditions that an individual must meet
to achieve state of health or well being.
4. Man is a human being considered to be
35. D
individualized, holistic, humane and
36. D
ethical.
37. A
5. Illness a personal state in which the

38. C

person
13.

ANNALISA A. TELLES, MAN

2016
Page 7
Instructor

feels unhealthy.
2ND Semester 2015-

Urdaneta City University

College of Nursing
2nd Semester 2015-2016
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.

A
D
C
B
C
B
D
A
C
C
B
C

39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.

ANNALISA A. TELLES, MAN

2016
Page 8
Instructor

A
B
A
D
B
C
D
A
B
C
D
B

Prelim Examination
PHARMACOLOGY

Test III. Essay/ Discussion:

= Two (2) items for 35 points

2ND Semester 2015-