RTK Pathway

Receptor Tyrosine Kinase Pathway

Integral membrane protein

Extracellular [binding] domain
Intracellular/cytosolic domain- tyrosine
residues

Autophosphorylation of tyrosine residues of

the cytosolic domain

Mechanism

The binding of a ligand to RTK, which

causes dimerization of two RTK
monomers, activates crossphosphorylation that can stimulate signal
transduction cascades leading to changes
in physiological processes or gene
expression.

Function
Regulation of cell proliferation and
differentiation
Survival
ECM attachment
Cancer

Ligands
EGF
Fibroblast Growth Factor (FGF)
Platelet Derived Growth Factor (PDGF)
Stem Cell Factor (SCF)
Hormones

Overview

1.

Receptor dimerization

2.

1 RTK monomer+ 1RTK monomer= RTK dimer

Cross- phosphorylation
Phosphotyrosine residue

3.

Phosphotyrosine-dependent protein-protein
interaction

4.

SH2 domain- containing

proteins+phosphotyrosine

Activation of [other] signalling pathways

MEK/ERK pathway
STAT pathway

RTK-Ras Pathway