Protein kinase inhibitors (molecular targeted cancer therapy) are

improvement over traditional cancer therapies target cancer cells more

specifically therefore have less side effects compared to normal therapy.
Traditional Chemotherapy and radiation target cancer cells but also have
undesirable effects on normal cells. Protein kinases are enzymes that
transfers a terminal phosphate (PO4) group from ATP to a hydroxyl group
on protein in a process called phosphorylation leading to a conformational
change and modulation in the function of the protein while protein kinase
inhibitor is an enzyme inhibitor that blocks the action of one or more
protein kinases.