J Comp Path Compilation 2010

Expression of Vascular Endothelial Growth Factor in Canine Inflammatory and

Non-inflammatory Mammary Carcinoma. J. Comp. Path. 2010, Vol. 142, 36e42.
VEGF was strongly expressed in all IMCs and the percentage of VEGF-immunoreactive
tumour cells was significantly higher in IMC than in non-IMC (P ¼ 0.02). There was no
difference in HER-2 receptor expression between IMC and non-IMC, and no IMC
expressed ER or PR. These results suggest that VEGF may contribute to the high
angiogenic phenotype of canine IMC and that this expression may underlie the tendency
towards local and systemic metastasis of these tumours.

Immunohistochemical Detection of Aetiological Agents of Proliferative and

Necrotizing Pneumonia in Italian Pigs. J. Comp. Path. 2010, Vol. 142, 74e78.
Proliferative and necrotizing pneumonia (PNP) is a form of interstitial pneumonia that
occurs in weaning and post-weaning pigs. PNP is characterized by hypertrophy and
hyperplasia of type II pneumocytes and coagulative necrosis and granular debris within
alveolar spaces. The principle aetiological agent of PNP in Italy therefore appears to be
PRRSV (11 of 28 pigs). Coinfection with PRRSV and PCV2 (8 pigs) is characterized by
more severe microscopical changes in affected lungs.

Chondro-osteoblastic Metaplasia in Canine Benign Cutaneous Lipomas. J. Comp.

Path. 2010, Vol. 142, 89e93. Mechanical stress, tropic disturbances, contact with
periosteum and other unknown factors may contribute to this transformation.

Increased Derlin-1 Expression in Metastases of Canine Mammary

Adenocarcinomas. J. Comp. Path. 2010, Vol. 142, 79e83. Derlin-1 (Derl-1) is a
transporter protein for the export of misfolded proteins from the endoplasmic reticulum
(ER) and an inhibitor of ER stress-induced apoptosis. There is greater expression of
Derl-1 mRNA in laser mi-
crodissected lymph node metastases of mammary adenocarcinomas than in non-
neoplastic mammary gland
tissue from the same dog. Neoplastic mammary gland cells therefore appear to have an
increased stress-associated unfolded protein response, and this is highest in
intralymphatic tumour cells.

Distribution of Lesions in Red and Fallow Deer Naturally Infected with

Mycobacterium bovis. J. Comp. Path. 2010, Vol. 142, 43e50. Fallow deer were
significantly more likely to have thoracic lesions than red deer. Lesions were observed in
the retropharyngeal lymph nodes. There were no microscopical differences in the lesions
in the lymph nodes of the red and fallow deer. Prevalence was 22%-28% in Fallow and
red deer respectively.