(mood disorders)

(bipolar disorder)

(anxiety disorders)


(PTSD)
(OCD)
(Schizophrenia)


(depression)

:

Mood disorders :
depression
Depression ():

13%~20%

80%
Prozac ()serotonin(SSRIs: selective
serotonin reuptake inhibitors)
: 60%20%
Unipolar depression:

Bipolar disorder (manic-depressive illness):

 PET study:
depressionfrontal cortexamygdala(
)
Amygdala
depression

antidepressants

amygdala

monoamine hypothesis (
):
Serotonin (; 5HT)
Nor-epinephrine ()

Antidepressant drugs: MAOI

Electroconvulsive shock therapy (ECT) or TMS:

SSRIs (selective serotonin reuptake

inhibitors)Prozac ()
serotonin

stage 3stage 4
(REM)
()
 REM sleep deprivation


Seasonal affective disorder (SAD)

Winter depression ()
depression,
Summertime mania ()

onset time

Light therapy: winter
depression ()

(melatonin)

(anxiety disorders)
temporal lobe
Generalized anxiety disorder ():

Phobic disorders (phobia) ():

PTSD (posttraumatic stress disorder)

Right hippocampus

OCD (obsessive-compulsive disorder)

Orbitofrontal cortex, cingulate cortex, caudate nuclei

(@thalamus )

(Anxiolytics)

Alcohol, barbiturate(), opiate()

Benzodiazepines (GABAA agonist)

Tranquilizer or depressantsmotor sedative effect
Eg., Valium(, )
The benzodiazepin-binding site: orphan receptors (endogenous
ligand still unknown, maybe allopregnanolone
)

New anxiolytics: Buspirone (5-HT agonist)

No motor sedative effect
5-HT1A agonist
D2 partial agonist

(Schizophrenia)

(Schizophrenia)
(ventricular)

(Schizophrenia)
hippocampus

(pyramidal cell)

Hypofrontality hypothesis:

Dopamine () hypothesis:
dopamine
dopamine
Typical neuroleptics()dopamine
D2 receptorChlorpromazine
(delusion,
hallucinations)

Glutamate () hypothesis:
glutamate receptor

PCP

Integrative
psychobiological
model:
(
)

spectrum disorders,
schizotypy,
schizophrenia

(1)
(Schizophrenia)

Shine
A beautiful mind
A tale of two sisters
The machinist
The living and the dead
Shutter island

(2):

(Depressive Disorder)

Prozac nation
The hours

(Bipolar Disorder)

Mr. Jones
Sophies Choice

(3):

(Panic Disorder)
Wanted
(Obsessive Compulsive Disorder)
As good as it gets

Matchstick men

The aviator
(Post-traumatic Stress Disorder)

Reign over me
Waltz with Bashir

Year of the rain

House of Cards

Amy

 (Autistic Disorder)

Rain Man

Mercury Rising

Marathon

Snow cake

Chocolate
Twinkle twinkle little stars

Ocean heaven
(Aspergers Disorder)

Adam

Mary and Max
Dear John

My name is Khan
The girl with dragon tattoo

(Aspergers Disorder)
1.
2.

3.
4.
5.
6.

 (Gender Identity Disorder)

Boys dont cry

Breakfast on Pluto
(Borderline Personality Disorder)
Fatal attraction

Girl, interrupted
(Antisocial personality Disorder)

Gaslight

A clockwork orange

Good will hunting

Catch me if you can

Dark matter

(Dissociative Disorder)
The cabinet of Dr. Caligari

Psycho
()
The shining

Never talk to strangers

Primal fear

Fight club

Me, myself and Irene
ID
Identity

Secret window

The machinist

Hide and seek

The three faces of Eve

The crowded room

The Prince of Tides

 (Mental Retardation)

I am Sam
(Dementia)

Iris
Beautiful memories


The Notebook

Memories of Tomorrow

Summers snow
Do you remember love
(Amnestic Disorder)

Memento
50 first dates

(mood disorders)


(bipolar disorder)

(anxiety disorders)


(PTSD)
(OCD)
(Schizophrenia)