Cognitive changes and

anesthesia.

general

Character and extent of influence.

Kalashnykova K.S., Dubivska S.S, Bitcuk M.D.,Grigorov J.B.
Kharkiv Medical National University
Department of Critical Care Medicine, Anesthesiology and Intensive Care
ABSTRACT:Persons cognitive functions and a brain in general are one of the most difficult, mysterious and unique creations of the nature, but, unfortunately, are
more vulnerable, because first answer on influence of environmental factors, that often involves development of stressful situations. The disease, surgical and
anesthetical intervention, undoubtedly, leads to an operational stress, and as a result, to distortion of the highest brain functions, depending on effect of anesthetic,
the general condition of an organism and many other factors.

INTRODUCTION:Violations of cognitive functions due to anesthetical and surgical intervention is already recognized as clinical phenomenon for today.
However, many processes, which are happening with a brain of the person at this moment, dont have proper explanation. Statement of fact of violation patients
cognitive functions due to surgical interventions demands of carrying out before and postoperative psychometric tests; their manifestations are thin and very
different and not always are caught in time and it is necessary for development of schemes of correction with the use of a neuroprotection and neurorehabilitation of
the patient.

Methods:The research has been conducted on the basis clinical hospital of ambulance and emergency medical service of the A.I. Meshaninov. 78 patients with

surgical pathology, whom we were observing in preoperative, intraoperative and within 30 days of the postoperative period took part in research. Patients were
divided into 2 age groups: 33 patients of young age and 45 of middle age. For monitoring of the cognitive sphere of the patient: MMS, test of drawing the hours, 10
words of Luriya test, Shulte's method, number of tests for frontal dysfunction (FAB). The monitoring was carried out before operation and for 1, 7, 30 days later.

Results:The difference of average values of psychometric indicators before operation and for the 30th days later of

young age has made from 1% to 10% on

different indicators, and at middle age, respectively: 5%, 7%, 18%, 30%, 10%, it was also more reflected in indicators of a technique of Shulte and "10 words of
Luriya".

Figure1: MMSE dynamic

Figure 2: clock drawing test dynamic; one of the simplest tests to determine memory
impairment

Figure 3:10 words Luriya test; allows to explore processes of memory: storing, preservation and reproduction
Figure 4: Shultes method; it allows to diagnose : attention span , efficiency, mental stability
Figure 5: FAB test; designed to identify dementia with a primary lesion of the frontal lobes and subcortical structures

Discussion:
1. POCD arise at 18-41% of patients, who are more senior than 18 years old;
2. One of major factors of risk is the age; at 10% of patients, who are more than 60
years old, POCD kept for more than 3 months;
3. Risk factors are also the accompanying pathology of cerebral blood circulation, a
disease of cardiovascular system;
4. The leading link of pathogenesis
stress.

is the immune answer to an operational

Conclusions:
The obtained data confirms decrease in cognitive functions on all indicators in the postoperative period of all patients.
The obtained data confirms decrease in cognitive functions on all indicators in the postoperative period of all patients.
The obtained data confirms decrease in cognitive functions on all
The obtained data confirms decrease in cognitive functions on all indicators in the postoperative period of all patients; these changes depend on age, the volume of
surgery and a pre-surgical condition of the cognitive sphere. The age, at this stage of our research, is a major factor of risk of the remote consequences of anesthesia.
The most expressed changes from attention and short-term memory that is important for the people who are engaged in mainly intellectual work.