Mechanically stirred tanks and airlift bioreactors and are widely used in bioprocessing . Airlift bioreactors are applicable for relatively less viscous fluids and when there is a need for gentle agitation and low-cost oxygen transfer. In comparison, conventional stirred fermenters have a broader range of applications but they perform poorly in highly viscous non-Newtonian media, have a poorly defined mixing pattern relative to airlift reactors, and cannot be aerated at a high rate because of impeller flooding. A mechanically agitated hybrid airlift bioreactor with one or more downward pumping axial flow impellers located in the draft-tube and aeration confined to the annular zone, potentially overcomes some of the limitations of both the conventional stirred and the airlift vessels. This hybrid bioreactor has a highly directional flow pattern similar to that of an airlift device but it can achieve greater rates of fluid circulation than are possible in conventional airlift reactors. Highly directional and enhanced circulation of fluid means an improved capability for suspending solids and reduced axial gradients of concentration of nutrients and oxygen. Such gradients are known to occur in tall airlift reactors and affect performance adversely. Furthermore, in the hybrid configuration, the gas is sparged in the annular riser zone and not beneath the impeller; therefore, flooding becomes less of a concern. In some cases By employing an impeller in the riser, the volumetric mass transfer coefficient can be enhanced up to four times compared with a classical internal airlift. Whereas the stirred hybrid airlift reactor has been shown to perform well, little is known about such devices compared to the knowledge base for the design of normal stirred and airlift bioreactors the required field of study in this subject covers: 1- the influence of different types of impellers on hydrodynamics and mass transfer in an internal loop contactor. 2- An influence of the gas flow rate and the stirrer speed on the riser and downcomer gas hold-up difference and on the liquid circulation velocity. 3- Study the performance of the system using fermentation systems like fermentations of the mycelia micro fungus and antibiotic erythromycin production. REFERENCES
Srgio S. de Jesus, Aline Santana, and Rubens Maciel Filho Hydrodynamic
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