Professional Documents
Culture Documents
Julin de la Torre-Cisneros.
Hospital Universitario Reina Sofa-IMIBIC,
University of Crdoba.
Crdoba, Spain.
Julian Torre-Cisneros
Reina Sofia University Hospital-IMIBIC, University
of Crdoba, Spain
Disclosure
Consulting Astellas, Roche
Effects of CMV
Inflamation
(citokines, grow factors)
Latent CMV
CMV replication
DIRECT EFFECTS
Viral syndrome
Hepatitis
Carditis
Neumonitis
Pancreatitis
Colitis
Retinitis
INDIRECT EFFECTS
Inmunoactivacin
Inmunosuppression
Guidelines to be reviewed
Indirect effects
T-CELL MEDIATED
IMMUNITY
VIRUS
Risk factors
available.
MMF and gastrointestial disease.
Mechanism?
A open discussion.
PROS
Preemptive Increase CMI.
therapy
Reduce antiviral use
CON
Logistics problems
CMV replication
Indirects effects
Universal
Reduce CMV
prophylaxis replication
CMI (D+/R-)
Late MV disease
T-CELL MEDIATED
IMMUNITY
VIRUS
CID 2012
Monitoring of T-cell
mediated immunity (CMI)
Autologous T cells
(SOT)
SOT
CMV D+/RCMV R+/QFnr
Administer
Vaccine
Time Post-Transplant
Measure Vaccine
Response [CMI]
CMV viral lysate 2x106 PBMCs stimulated with viral lysate
showing significant IFN- production in CD8+ and CD4+ T cells in a
CMV-seropositive renal transplant recipient
No need for
prophylaxis
Give prophylaxis