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PancreaticpolypeptideWikipedia,thefreeencyclopedia

Pancreaticpolypeptide
FromWikipedia,thefreeencyclopedia

Pancreaticpolypeptide(PP)isapolypeptidesecretedbyPPcellsintheendocrinepancreaspredominantlyin
theheadofthepancreas.Itconsistsof36aminoacidsandhasmolecularweightabout4200Da.[1]

Pancreaticpolypeptide

ThefunctionofPPistoselfregulatepancreaticsecretionactivities(endocrineandexocrine)italsohaseffects
onhepaticglycogenlevelsandgastrointestinalsecretions.
Itssecretioninhumansisincreasedafteraproteinmeal,fasting,exercise,andacutehypoglycemiaandis
decreasedbysomatostatinandintravenousglucose.
PlasmaPPhasbeenshowntobereducedinconditionsassociatedwithincreasedfoodintakeandelevatedin
anorexianervosa.Inaddition,peripheraladministrationofPPhasbeenshowntodecreasefoodintakein
rodents.[2]PPissecretedbyPPpancreaticcellsofLangerhansislets.Itstimulatesthegastricjuicesecretion,but
inhibitsthegastricsecretioninducedbypentagastrine.Itistheantagonistofcholecystokininandinhibitsthe
pancreaticsecretionwhichisstimulatedbycholecystokinin.Onfasting,PPsericconcentrationis80pg/mlafter
themeal,itrisesupfrom8to10timesmoreglucoseandfatsalsoinducePP'slevelincrease,butonparenteral
introductionofthosesubstances,thelevelofhormonesdoesn'tchange.Theadministrationofatropine,the
vagotomy,blocksthePP'saftermealsecretion.Theexcitationofthevagusnerve,theadministrationofgastrin,
secretinorcholecystokinininducePPsecretion.
TheaugmentationofPPsecretionhasbeenobservedinhormonalactivepancreatictumors(insulin,glucagon),
inVernerMorrisonsyndrome,andingastrinomas.

Identifiers
Symbol PPY
Entrez 5539(https://www.ncbi.nlm.nih.gov/gen
e?cmd=retrieve&dopt=default&list_uids=
5539&rn=1)
HUGO 9327(http://www.genenames.org/data/hgn
c_data.php?hgnc_id=9327)
OMIM 167780(http://www.omim.org/167780)

ThePPYgeneencodesanunusuallyshortproteinprecursorthatiscleavedtoproducePP,aswellaspancreatic
icosapeptideanda5to7aminoacidoligopeptide.[3]

RefSeq NM_002722(https://genome.ucsc.edu/cgi
bin/hgTracks?Submit=Submit&position=
NM_002722&rn=1)

References

UniProt P01298(http://www.uniprot.org/uniprot/P
01298)

1.LonovicsJ,DevittP,WatsonLC,RayfordPL,ThompsonJC(Oct1981)."Pancreaticpolypeptide".ArchSurg.116
Otherdata
(10):125664.doi:10.1001/archsurg.1981.01380220010002.PMID7025798.
Locus Chr.17p11.1qter(http://omim.org/searc
2.Batterham,RLLeRoux,CWCohen,MAPark,AJEllis,SMPatterson,MFrost,GSGhatei,MABloom,SR
h?index=geneMap&search=17p11.1)
(Aug2003)."Pancreaticpolypeptidereducesappetiteandfoodintakeinhumans".TheJournalofClinical
EndocrinologyandMetabolism.88(8):398992.doi:10.1210/jc.2003030630.PMID12915697.
3.Boel,E.Schwartz,T.W.Norris,K.E.Fiil,N.P.(April1984)."AcDNAencodingasmallcommonprecursorforhumanpancreaticpolypeptideandpancreatic
icosapeptide".EMBOJournal.3(4):909912.PMC557446 .PMID6373251.
https://en.wikipedia.org/wiki/Pancreatic_polypeptide

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PancreaticpolypeptideWikipedia,thefreeencyclopedia

Externallinks
Physiology:6/6ch2/s6ch2_25(http://humanphysiology.tuars.com/program/section6/6ch2/s6ch2_25.htm)Essentials
ofHumanPhysiology
Pancreaticpolypeptide(https://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=Pancreatic+polypeptide)at
theUSNationalLibraryofMedicineMedicalSubjectHeadings(MeSH)
BBCHopeover'obesitybustinggum'(http://news.bbc.co.uk/1/hi/health/6262347.stm)15January2007
http://library.usmf.md/downloads/ebooks/Endocrinology_Anestiadi_en_2003/Lecture_11_p.(167200).pdf
Retrievedfrom"https://en.wikipedia.org/w/index.php?title=Pancreatic_polypeptide&oldid=723731845"

IHCforPancreaticpolypeptideina
mousepancreas,200

Categories: Genesonhumanchromosome17 Pancreatichormones

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