Professional Documents
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SUBJECT: Anatomy
Batch 2018 - A
Transcribers: Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
Trans Subject Head: Jacinto, C. (09157536686)
LECTURE OUTLINE
I.
FUNCTION
V. GLANDS
LECTURE OBJECTIVES
1. Give the functions of epithelial tissue.
2. Enumerate the characteristics of epithelial
tissue,
3. Define cell polarity.
4. Describe the Apical and Lateral
modifications.
5. Differentiate the types of lining and
glandular epithelium
6. Differentiate the types of cell junctions.
7. Describe the organization of an exocrine
gland.
References:
1.
Mescher, A. (2013.) Junquieras Basic
Histology (13th ed.) McGraw-Hill.
2.
CELL
MORPHO.
ECM
Nervous
Impulse
Transmission
Elongated
processes
None
Epithelial
Lining /
Secretion
Aggregate,
polyhedral
Small
amount
Muscle
Movement
Elongated,
contractile
Moderate
amount
Connective
Support,
protection
Various fixed
& wandering
cells
High
amount
Functions of Epithelium
1) Covering and protection, e.g. skin
2) Absorption, e.g. GI tract lining
3) Secretion, e.g. mammary glands, Goblet
cells (lubrication)
4) Contractility (due to actin fibers), e.g.
myoepithelium of lacrimal glands
5) Receptor via transmembrane proteins
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Covering Epithelium
Classified according to:
a) Number of layers
1) Simple only 1 cell layer
Pseudostratified 1 layer but
nuclei are at different levels; all
of the cells are touching the
basal membrane but have
different height
c) Apical/Free-surface
Modification/Specialization
1) Ciliated
2) Non-ciliated
3) Flagellated
4) Microvilli
Brush border uniform of
microvilli
Striated border uneven
length of microvilli
Simple Epithelial Tissues
a) Simple Squamous epithelium
o Surface cell shape: flat and very thin
o Function: exchange, gas diffusion,
secretion, lubrication in pleural
cavity, active transport,**
o Ex: pleural and abdominal cavity
(mesothelium,*) peritoneum, lining
blood vessel walls (endothelium,*)
lining of ventricles and atria of heart
(endocardium*)
Figure 1
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Figure 5
Figure 2
Figure 3
Figure 6
Figure 7
Figure 4
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Figure 8
Figure 10
Figure 9
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Keratinized (dry)
Surface cell shape: flat without nuclei
(dead cells;) like flakes
Function: prevents water loss or
desiccation, barrier
Ex: epidermis of skin (Fig. 13)
Figure 11
Figure 13
Figure 14
Figure 12
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
III.
d) Transitional epithelium/Urothelium*
(ALWAYS stratified)
o Surface cell shape: large dome
shaped/umbrella cells (empty;) flattened
(distended)
o Function: lines organs that are subjected to
changes in pressure or distention; has
minimum of 2 layers even when distended;
specialized to protect underlying tissues
from the hypertonic effects of urine
o Ex: lining renal calyces, renal pelvis,
ureter, urinary bladder
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Functions:
Motile cilia propel substances
Important locations: respiratory tract,
female reproductive tract
2) Microvilli
Structure:
Short finger-like projections
Actin filaments at core which attaches
to terminal web
Striated Border microvilli of same
height; Brush Border microvilli of
different heights
Functions:
Increases surface area 20x 30x for
absorption
Found lining certain tissues such as the
intestines, allowing absorption
3) Stereocilia
Structure:
Actin filament core
Longer than microvilli
Anchored by fibrin and erzin
Functions:
No motility but increases surface area
for concentrated absorption
Located in epididymis
4) Flagellum
Structure:
Similar to cilia but larger and usually
limited to single flagellum per cell
Function:
Movement in whip-like motion to propel
cell
Important locations: sperm cells
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Anatomy | Epithelium and Glands
Figure 19. Various lateral junctions (TJ - Tight junction; ZA Zonula adherens; CJ - Communicating junction; D Desmosome;
HD Hemidesmosome)
Cell-to-Cell Junction
Zonula Occludens/Tight Junction (TJ)
Structure
most superficial to apical surface
(right under microvilli)
fuses adjacent membranes by
transmembrane proteins, claudin
and occluding, arranged in
anastomosing (contact via merging,
see Figure 18) strands (quilt-like
appearance)
reinforced by cadherins (cell
adhesion molecules)
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Anatomy | Epithelium and Glands
Function:
regulates paracellular transport
restrict flow of substances between
cell membranes (reason why it is
very present in storage areas, e.g.
gall bladder.
Function:
anchorage points for cytoskeletal
elements, linking the cytoskeletons
of individual cells into a strong
transcellular network (mechanical
attachment to adjacent cells)
Structure:
o 3rd and deepest junction in junctional
complex gap between adjacent
membranes (30 m)
o dense attachment plaques on
cytoplasmic sides (desmoplakin and
plakoglobin)
o intermediate filaments then attach into
the attachment plaque
o Cadherins (desmoglein and
desmocolin) are the transmembrane
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Function:
o provide strong adhesion between
cells, e.g. skin and intestinal lining
o able to withstand the greatest friction
also use cadherins as their
transmembrane proteins
Function:
o serves to stabilize non-epithelial tissue
o similar to the Zonula Adherens of
epithelial cells a broad intercellular
junction in the transversal sections of
an intercalated disc of cardiac muscle
anchoring actin filaments
o helps to transmit contractile forces
Fascia Adherens
Structure:
o mainly found in cardiac muscle
Figure 23. Connexons forming a gap junction patch
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
Function:
o Cell-cell communication (electrically and
metabolically)
o
Focal Adhesion
anchors the actin cytoskeleton to the
extracellular matrix
function: detects and transduces signals
from outside the cell
adhesion process depends on the integrin
receptors embedded in the plasma
membrane
Summary of Junctional Features
Junction Type
Cell-tocell
Occluding
Junction
Classificatio
n
Zonula
Occludens
Major link
proteins
Occludins,
claudins, JAM
Anchoring
Junction
Zonula
Adherens
E-cadherincatenin
complex
Macula
Adherens
Cadherins
(e.g.,
desmogleins,
desmocolins)
Function:
o anchors the epithelial cells to the basement
membrane and the adjacent connective
tissue
Fascia
Adherens
Cell-toextra
cellular
matrix
Communicating
/ Gap Junction
Nexus
Connexin
Anchoring
Junction
Hemi
desmosome
Integrins,
collagen XVII
Focal
adhesion
Integrins
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
IV.
GLANDULAR EPITHELIUM
Glandular Epithelia
Epithelial cells specialized to secrete substances in
membrane-bound secretory granules (vesicles).
Examples of Glandular Epithelia
1) Sebaceous glands (lipid)
2) Pancreatic acini (enzymes)
3) Salivary glands (carbohydrate-protein
complex)
Classifications of Glandular Epithelia
I.
2) EXOCRINE
o releases secretions onto an epithelial
surface either directly or via a duct
o Have ducts that lead to another organ or
body surface
3) PARACRINE
o cells whose secretions target the
immediate extracellular environment,
travels short distances then Endocrine
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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4) AUTOCRINE
o the target cell is on the secreting cell itself
o
II.
III.
3) HOLOCRINE
o Whole cell disintegrates when it secretes
product
o Cell makes and fills with secretion and
ultimately burst and releases secretions
o suicidal glands
o e.g. sebaceous glands of skin
2) APOCRINE
o Secretion accumulates at the cells
apical ends.
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Figure 29. Mucous cells. The lumens (arrows) of mucous tubules are
larger than those of serous acini. Much connective tissue surrounds
the mucous tubules and ducts (D).
Figure 27. Longitudinal section of sebaceous gland with duct (D)
IV.
Figure 30. Serous cells duct (D) Abundant RER (R), a Golgi
complex (G), apical secretory granules (SG) and the small acinar
lumen (L)
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3) Mixed Gland
o With both mucinous and serous glands
o With both serous acini and mucous
tubules capped by groups of serous
cells
o product is a mixture of digestive enzyme
and watery mucus
o e.g. submandibular gland
V.
Based on Morphology
1) Simple (Unbranched) with single duct
(e.g. sebaceous glands)
2) Compound with two or more
branches
VI.
Simple Glands
1) Simple Tubular- Elongated secretory
portion duct usually short or absent
2) Branched tubular- Several long secretory
parts joining to drain 1 duct
3) Coiled Tubular- Secretory portion is very
long and coiled
4) Acinar/Alveolar- Rounded, Saclike
secretory parts entering the same duct
Compound Glands
1) Acinar/Alveolar Several saclike secretory
units with small ducts converge at a larger
duct
2) Tubular Several enlongated, colied
secretory units and their ducts converge to
form larger ducts
3) Tubuloacinar/Tubuloalveolar - Ducts of
both tubular and acinar secretory units
converge at larger ducts
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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Anatomy | Epithelium and Glands
V.
Germ Layer
The primary layer of cells formed during the embryo
stage. Differentiated epithelial cells rise from the
three layers.
1) ENDODERM (innermost layer)
a. Respiratory system epithelium
b. Alimentary canal epithelium
c. Extramural digestive gland epithelium
d. Thyroid, parathyroid, and thymus
glands epithelial components
e. Lining epithelium of the tympanic cavity
and
f. Eustachian tube
2) MESODERM (middle layer)
a. Epithelium of kidney and gonads
b. Mesothelium
c. Endothelium
d. Adrenal cortex
e. Seminiferous and genital duct
epithelium
3) ECTODERM (outer layer)
a. Epidermis
b. Cornea, lens epithelia
c. Components of the inner ear
d. Adenohypophysis
EPITHELIAL CELL RENEWAL
o Achieved through Mitosis
Dependent on epithelial type:
Small intestine: 4-6 days; not easily abraded
Epidermis: 28 days
Stem cells are located along
the walls of the hair follicles
Stratified Epithelium
Mitosis occurs only in the basal layer in
contact with the basal lamina
Baldovino, D., Balgomera, N., Ballesteros, F. (09275457969), Balmaceda, J., Balmaceda, R., Banluta, R.
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