Asian J. Research Chem.

6 (10): October 2013

ISSN 0974-4169

www.ajrconline.org

REVIEW ARTICLE

A Review on 1,3-Thiazolidin-4-Ones
Kencha Swathi1*, Dr. M. Sreenivasulu2, T. Hari Narayana Reddy1, Y. Pradeep Kumar1,
G. Mahaboob Basha1
1

Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa

(District), Andhra Pradesh.
2
Head of the Department, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New
Boyanapalli, Kadapa (District), Andhra Pradesh.
*Corresponding Author E-mail: kenchaswathi22@gmail.com

ABSTRACT:
1,3-Thiazolidin-4-ones are important group of heterocyclic compounds that are used in the field of medicinal
chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to
these studies. This review aims to review the work reported on the chemistry and biological activities of 1,3thiazolidin-4-ones during the past few years. Since a decade extensive research work is undergoing on the thiazolidine
ring. Researchers have developed number of new compounds related to1,3-thiazolidin-4-ones further they have
screened them for various pharmacological activities to get a molecule with good pharmacological activities and with
least adverse effects. The thiazolidine is not only synthetically important scaffold but also possesses a wide range of
promising biological activities. Some thiazolidine derivatives have better activity than standard drug and could become
a new drug for the market in future. This thiazolidine moiety and its derivatives has shown its importance as antimicrobial, anti-bacterial, anti-tubercular, anti-fungal, anti-inflammatory, analgesic, anti-cancer, anti-proliferative, antiHIV, anti-retroviral,anti-yellowfevervirus,anti-diarrhoeal,anti-arrythmic agent, anti-convulsant, anti-oxidant, antimalarial.

KEYWORDS: Thiazolidinone, biological activities, anti-microbial, anti-malarial, future aspect

INTRODUCTION:
There are numerous biologically active molecules with fivemembered rings, containing two hetero atoms.
Thiazolidinone is an important scaffold known to be
associated with several biological activities. A
comprehensive review has been written on 4thiazolidinones in 19811.1,3-Thiazolidin-4-ones are
heterocycles that have an atom of sulfur at position
1,nitrogen atom at position 3 and a carbonyl group at
position 4. It is a sulfur analogue of oxazolidine.
Thiazolidines may be synthesized by a condensation
reaction between a thiol and an aldehyde or ketone. It is a
reversible reaction.

Received on 14.06.2013
Accepted on 15.07.2013

Modified on 24.06.2013
AJRC All right reserved

Asian J. Research Chem. 6(10): October 2013; Page 879-887

Therefore many thiazolidines are labile towards hydrolysis

in aqueous solution. Hydrolysis of the thiazolidine
generates the thiol and an aldehyde from which it was
synthesized2.
1
S

2
4

N 3
R1

General structure of 1,3-thiazolidin-4-ones

BIOLOGICAL ACTIVITIES OF THIAZOLIDINE

DERIVATIVES:
1. ANTI MICROBIAL ACTIVITY:
Anbalagan et al3., synthesized a series of 2-[(Thiazolidin-4one)phenyl]-1H-phenylbenzimidazole. The synthesized
compounds were screened for anti-bacterial activity and
anti-fungal activity by using gram positive and gram
negative bacterial species and fungal species by using
nutrient agar medium, paper disc diffusion method. The

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Asian J. Research Chem. 6 (10): October 2013

X

synthesized compounds have shown significant antibacterial activity.

N
N

R1

H
N
R2

S
N

N
N

S
R3

CH3

S
O

P. Sudhir Kumar et al ., synthesized some Novel

Thiazolidin-4-one
substituted
1,2,4-Triazoles.The
synthesized compounds were tested on nutrient medium
against gram positive and gram negative bacteria.All the
compounds showed a very good anti-bacterial activity and
the significant compounds like VIIIe and VIIIf were found
to possess broad spectrum activity.
OCH3
N
N
O

SH

N
N

compound 9:X=Br, R=H, compound 10:X=Br, R=OH

Swarup Jyoti Chattarjee et al7., Synthesized some
Thiazolidin-4-one substituted 1, 2, 4-triazoles . The
synthesized compounds were studied for anti-microbial
activities by cup-plate method using various gram stains of
microbes and the standard drugs like ampicillin and
Griseofulvin. The thiazolidine-4-one substituted 1, 2, 4triazole and 3-methoxy benzofuran moieties at 3rd position
might be largely responsible for the marked bactericidal
activity. VIIIe and VIIf showed significant anti-bacterial
activity.
OCH3

SH

VIIIe: R=2-Hydroxy phenyl , VIIIf: R=2-Methoxy phenyl

N
O

Prasad et al5., synthesized Novel 2-aryl-thiazolidin-4-one

N
derivatives. The synthesized compounds were screened for
S
anti-microbial activities against gram +ve and gram-ve
O
Cl/Br
bacteria and six pathogenic fungal species. Compounds 8a8d displayed significant anti-bacterial efficacy specially
Sudhakar Bhusare and Yeshwant Vibhute et al8.,
against Kiebsiella pneumonia.
synthesized some new 2,3-diaryl-1,3-thiazolidin-4-ones and
tested for anti-bacterial activity against bacterial strains by
R
using nutrient agar disc diffusion method. The compounds
R
have shown effective anti-bacterial activity.
R
4

R2

R1
R1

R
R3

S
O

N
8a, 8b, 8c, 8d: R=
R1=H,R2=H, R4=H R5=H.
8a:R3=H, 8b:R3=CF3,8c:R3=Br,8d:R3=Cl.
Haricharan Lal et al6., synthesized 1,2,4-triazole substituted
thiazolidinone and azetidinone derivatives. The synthesized
compounds were evaluated for their antibacterial and antifungal activities by using cup-plate method.Compounds 9
and 10 shown moderate activity.

Shiradkar et al.9, reported a series of N-{4-[(4- amino-5sulphanyl-4H-1, 2, 4-triazol-3-yl) methyl]-1, 3-thiazol-2yl}-2-substituted amide derivatives. These compounds were
tested for their preliminary in-vitro antibacterial activity
against S. aureus, E. coli, P. aeroginosa and S. typhosa and
then were screened for antitubercular activity against M.
tuberculae H37Rv strain by both micro dilution assay
method. Compound [II] and [III] showed best activity. The
compounds showing more than 90% inhibition were
obtained by S-alkylation with acetonitrile. It was noted that
the cyano group did not have any role in increasing the
activity.

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Asian J. Research Chem. 6 (10): October 2013

Nareshvarma Seelam and S. P. Shrivastava et al12., a series

of thiazolidinone and their 5-arylidenederivatives
O
R
containing 4-(4-methyl benzamido)-benzoyl moiety were
synthesized via the reaction of benzocaine with appropriate
N
chemical reagents. These compounds were screened for
O
HN
S
their antibacterial activity against Gram-positive bacteria
N
S
(Bacillus subtilis and Bacillus thuringiensis), GramN
N
negative bacteria (Escherichia coli, Pseudomonas
H
aeruginosa) and antifungal activity against Botrytis fabae,
N
N
Fusarium oxysporan and Candida albicans. On the other
hand the synthesized compounds were also screened for
[II] R=NHCOCH3, Ar=3-NO2C6H4
their anti tubercular activity. The results revealed that some
[III] R=NHCOC6H5, Ar=3-NO2C6 H4
of these compounds have shown promising antimicrobial
and antitubercular activity in comparison with standard
Upadhyay A. et.al10., Several new N-[(4-oxo-2-substituted drugs.
aryl-1, 3- thiazolidine)-acetamidyl]-5-nitroimidazoles were
synthesized
from N-(arylidene amino acetamidyl)-5O
O
nitroindazoles. The reactions were carried out by both
H
conventional as well as microwave method. The newly
H3C
C
NH
C
NH
N
C
synthesized compounds were evaluated for their
S
antimicrobial activity against bacterial and fungal strains.
O
The compound [IV] and [V] show the maximum
antibacterial activity (MIC 11 and 10 mg/mL) against
Escherichia coli and antifungal activity (MIC 9 and 8
mg/mL) against Fusarium oxysporum.
Br

Dhameliya et al13., Synthesised a series of (Z) n-(5Benzylidene-4-oxo-2 substituted phenylthiazolidin-3-yl)-5((1, 3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzamide

derivatives.

O2N
N
N
CH2CONH

All the newly synthesized compounds were evaluated for

their antibacterial and antifungal activities.
\

OH

O
C

[IV]Ar=2-OHC6H4, [V] Ar=3-OHC6H4

NH

H
C

P. Jaya Preethi et al11., synthesized a series of 4thiazolidinones derivatives. These compounds were
screened for anti-tubercular, antibacterial and anti-fungal
activities.
Anti-Tubercular
activity
mycobacterium
tuberculosis and MIC level of the compounds was less than
6.25 g/ml.

H2C
N

Chandra Kant Belwal et al14., synthesised novel series of

Compound IIIa, IIIc IIId, IVa, IVc and IVd exhibited good thiazolidinone derivatives of 4-(4-oxo-2-phenylthiazolidinantibacterial activity on Gram-positive and Gram-negative 3-yl) benzoic acid. The synthesized compounds were
microorganisms. All the synthesized compounds exhibited screened for their antifungal activity. Antifungal activity
study of the synthesized thiazolidinone derivatives of 4-(4good Antifungal activity.
oxo-2-phenylthiazolidin-3-yl) benzoic acid revealed that all
N
compounds showed moderate activities against selected
microbial strains.
O

HN
N

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Asian J. Research Chem. 6 (10): October 2013

Arun Singh et al17., synthesized a series of3-(2-(5-benzoyl1H-benzo[d][1,2,3]imidazol-1-yl)acetyl)-2-alkylthiazolidin4-one derivatives(5a-d). All the newly synthesized
compounds were evaluated for their antibacterial and
antifungal activities.

R1

N
O
S
N

O
O
R

Ph

N
S

CH2

C
H2

N
R
S

Mukesh C. Patel et al15., synthesised a series of (Z) N-(5Benzylidene-4-Oxo-2-Substituted Phenylthiazolidin-3-yl)5-((1, 3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzamide.

All the newly synthesized compounds were evaluated for
their antibacterial and antifungal activities. In summary,
preliminary results indicate that some of the newly
synthesized title compounds exhibited promising
antibacterial activities and they warrant more consideration
as prospective antimicrobials.
R

OH
O
C

NH

H
C
S

H2C

2. ANALGESIC AND ANTI-INFLAMMATORY

ACTIVITY:
Taranalli AD et al.,18 synthesized a series of thiazolidine-4one derivatives from sulfanilamide and evaluated for antiinflammatory, analgesic activity. Anti-inflammatory
activity was investigated by carrageenan induced rat paw
edema method and analgesic activity by acetic acid induced
writhing and rat caudal immersion method. The antiinflammatory, analgesic activity was performed in 100
mg/kg b.w. rats. The nimesulide was used as standard drug
for comparison. The compound [IX] and compound [X]
with substitution R'-CH3 showed potential activity.
R3

R2

R
HO

R1

Cl

P.M. Ronad et al16., Synthesis and antimicrobial activity of

7-(2-substitutedphenylthiazolidinyl)-benzopyran-2-one
derivatives A series of 7-(2-substituted phenylthiazolidinyl)
-benzopyran-2-one derivatives have been synthesized.
Schiff bases and title compounds were evaluated for
antibacterial and antifungal activities against various
bacterial and fungal strains. The results showed that
compounds 3d, 3f, 4d, 4f and 4i (100 mg/ml) exhibited
good antibacterial and antifungal activity as that of standard
antibiotics Ciprofloxacin and Griseofulvin.

CH3
R

[IX]R=H,R1=H,R2=H,R3=H
[X] R=H,R1=CH3,R2=H,R3=H

Kumar et al.,19 synthesized a series of 3-[4'(p-chlorophenyl)

thiazol-2'-yl]-2-[(substituted
azetidinone/thiazolidinone)aminomethy]-6- bromoquinazolin-4-ones and screened
them for anti-inflammatory and analgesic activities.
Compound [XI] was found to be most active in both the
activities. They found that the presence of thiazolidinone
ring have shown much better anti-inflammatory and
analgesic activity at 50 mg/kg po as compared to their
parent compounds.

H
C
S

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Asian J. Research Chem. 6 (10): October 2013

Cl

CO O H

O
N

Cl

R
N

S
N

S
O

[XI]

Vaidya et al.,20 synthesized a series of 4-thiazolidinone

derivatives . The synthesized compounds were screened for
anti-inflammatory activity. Among the entire test
compounds, III have shown promising anti-inflammatory
activity as compared to the rest. All the experimental results
were statistically significant.
R1

R2

R3

3.ANTI CANCER AND ANTI-PROLIFERATIVE

ACTIVITY
Arun M. Isloor et al.,23 Synthesised a new series of 2-(3substituted-1H-pyrazol-4-yl)-3-(3-substituted-5-sulfanyl1,2,4-triazol-4-yl)-1,3-thiazolidin-4-one
(4ao).
The
compounds exhibited dose-dependent cytotoxic effect in
MTT assay in human breast cancer (MCF-7) cells.
Apoptotic degradation of DNA due to action of potent
thiazolidin-4-ones was analysed by agarose gel
electrophoresis and visualized by ethidium bromide staining
(comet assay). A concentration-dependent increase in tail
length and olive tail moment was observed when treated
with thiazolidin-4-ones.
N

SH

O
R

O
N

IIIa: R=4-SCH3,R2=4-OCH3,R3=H.
O

Anbalagan et al.,21synthesized a new series of

2NH
[(thiazolidin-4-one)-phenyl]-1H-Phenylbenzimidazoles.The
N
synthesized compounds were tested for analgesic activity
S
by writhing reflex method and anti-inflammatory activity
R1
by carrageenen induced paw edema method. The
synthesized compounds have shown significant activity of
24
analgesic and anti-inflammatory activity comparable to that Gududuru et al., described the synthesis and biological
evaluation of new 2-aryl-4-oxo-thiazoilidin-3-yl amides
of standard.
R1
against prostate cancer cells. The antiproliferative effects of
synthesized compounds were examined in five human
N
prostate cancer cell lines (DU-145, PC- 3, LNCaP, PPC-1
R2
and TSU). Three potent compounds have been identified
N
(VI, VII and VIII), which are effective in killing prostate
N
H
cancer cells with improved selectivity compared to serine
S
R3
amide phosphates (SAPs).
O

O
O

Sugumaran Murugesan et al.,22 a series of 4- thiazolidinone

derivatives were synthesized from 4-amino benzoic acid.
The two synthesized compounds SS5 and SS6 were
screened for anti-inflammatory and analgesic activity. Antiinflammatory activity was evaluated by carrageenaninduced paw edema test and analgesic activity by Eddys
hot plate method. Both the compounds showed good
activity. All the experimental results were statistically
significant. The anti-inflammatory and analgesic activity
confirmed that the test compound SS6 showed superior
activity than SS5. However, the test compounds were found
to be less active than the standard drugs used.

883

C18H37

N
H

VI

Asian J. Research Chem. 6 (10): October 2013

O

A. ANTI HIV ACTIVITY

Jan Balzarini et al.,27 synthesized a series of novel
thiazolidin-4-ones bearing a lipophilic adamantyl
substituent at position 2, and versatile substituents on the
nitrogen atom of the thiazolidine ring, the compound (+)-2adamantan-1-yl-3-(4,6-dimethyl-pyridin-2-yl)- thiazolidin4-one [XIV] was endowed with a remarkable antiviral
potency (EC50 0.35 mM). The adamantane moiety
played an important role in the eventual antiviral activity of
the compound. This compound behaved as a typical nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI)
with non-competitive inhibition against RT with respect to
the substrate(ki1/4 12 mM).

O
C18H37

N
H

VII

O
O

C18H37

N
H

CH3

VIII
R=
25

Gududuru et al., described the synthesis and biological

evaluation against prostate cancer cells of new 2-aryl-4oxo-thiazolidin-3-yl amides. The antiproliferative effects of
synthesized compounds were examined in five human
prostate cancer cell lines (DU-145, PC-3,LNCaP, PPC-1,
and TSU). Three potent compounds have been detected (43,
44 and 45), which are effective in killing prostate cancer
cells with improved selectivity compared to serine amide
phosphates (SAPs) [37].The compound 46 was screened
against nine types of human cancer cells and showed
significant cytotoxic activity in the case of lung cancer,
melanoma and renal cancer, where the reduction in growth
was found to be 75%, 97% and 84%, respectively, at the
concentration of 1.0 x 10-4M [38].

N
CH3

[XIV]

The anti-HIV activity of several series of 2, 3- diaryl-1, 3thiazolidin-4-ones [XV] has been studied by Chavan, Y.B.
et al.,28,29,30 Which are reported as a new family of antiviral
agents acting as NNRTIs with minimal cytotoxicity.

R1

Ar
N

Me

N
H

NO2

Bhushan M. Panchabunde et al.,26 synthesized a series of

new thiazolidin-4-ones by the reaction of different
substituted acetophenones with thiourea in presence of
propanol to give 2-amino-4-aryl thiazol (1) which react
with chloroacetyl chloride to produce the corresponding 2chloro acetamido-4-arylthiazoles (2).The latter was treated
with potassium thiocyanate in refluxing acetone to afford
the related 2-imino-3-(-4-aryl thiazol-2-yl)-thiazolidin-4ones (3).The synthesized compounds showed significant
inhibition of cell by in-vitro method using MTT assay.
4. ANTI VIRAL ACTIVITY

B. ANTI RETROVIRAL ACTIVITY

There are several works in the literature describing the
thiazolidinones highly active as non-nucleoside reverse
transcriptase inhibitor(NNRTI) with minimal cytotoxicity.
The biological activity of 1,3-thiazolidin-4-ones is
associated with the ability to assume a conformation
butterfly-like shape. From the SAR point of view, the
anti-HIV activity is strongly influenced by the nature of the
substituent at 2 and 3 position of the thiazolinone nucleus.
The presence of the two halogen atoms at 2 and 6 position
restricted the rotation of the phenyl ring (at 2-position on
thiazolidinone ring) and allowed the molecules to assume
the characteristic butterfly-like conformation.
The rings 2-pyridinyl and 2-pyrimidinyl attached at N-3
atom enhances the HIV activity. The replacement of these
heterocycles for a phenyl [25], a furfuryl [26], a thiazol or a
thiadiazol [27], moiety reduce the HIV-RT inhibitory

884

Asian J. Research Chem. 6 (10): October 2013

O

activity. The replacement of the carbonyl group with the

isostere thiocarbonyl group negatively influences the
activity with appreciably decreases [28].

Me

C. ANTI YELLOWFEVER VIRUS ACTIVITY

Sriram et al.,31 described the synthesis of 1,3-thiazolidin-4ones bearing diaryl ring at C-2 and N-3 positions. The
compounds were evaluated for their inhibitory effects on
the replication on yellow fever virus in green monkey
kidney, by means of a cytopathic effect reduction assay.
Among these compounds, the 2-(4-chlorophenyl)-3-(4fluorophenyl)-1,3-thiazolidin-4-one (40) emerged as the
most promissory anti-yellow fever virus agent with EC50 of
6.9 M and CC50 more than 100 M making it more potent
than standard ribavirin.

MeO

41
Me
Me

42
N

Me

Me
F

Cl

(40)

5. ANTI DIARRHOEAL ACTIVITY

Several 1,3-thiazolidin-4-ones were synthesized and
screened for antidiarrhoeal activity in mice. Although the
results showed that the compounds were 15- to 80-fold less
active than the reference loperamide, they were much less
toxic, 1000 mg/Kg and 108.8 mg/Kg, respectively. The
most active compound was the 2-phenyl-3-{2-[(4-phenyl-4cyano)piperidino]ethyl}-1,3-thiazolidin-4-one (39).

6. ANTI CONVULSANT ACTIVITY

Amin et al.,33 reported some new substituted coumarinyl
thiazolines, coumarinyl thiazolidin-4-ones and substituted
chromenothiazoles and evaluated for the anticonvulsant
activity. Compounds [XVII] and [XVIII] were the most
active against PTZ induced seizures.
N
S
N
O

C2H5

H3CO

XVII
O

N
S

C2H5O

C2H5

H3CO

NC

XVIII
39

Wilson Cunico et al., have been synthesized Several 5-[(2phenyl-4-oxo-thiazolidin-3-yl) amino]-2-oxo-thio barbituric
Thiazolidinone with anti-diarrhoeal activity
acids derivatives [XIX and XX]34 and 3-({4-[2alkylphenyl)-4- oxo-1,3-thiazolidin-3-yl]-1,3,4-thiadiazol6. ANTI- ARRYTHMIC ACTIVITY
2-yl}methylamino)-2-methyl-6monosubstituted-quinazolinAtrial flutter and atrial fibrillation are the most common
4(3H)-one derivatives [XXI]35 and screened in-vivo for their
cardiac arrhythmias and they are associated with an increase
anticonvulsant activity.
in heart failure, stroke, and mortality. Blockade of the
Kv1.5 ion channel is potentially atrial-selective avenue for
O
the treatment of atrial fibrillation and atrial flutter. Jackson
O
et al.,32 described the synthesis and biological evaluation of
N
S
HN
N
thiazolidinone-based blockers of Kv1.5. The 3,4-dimethyl
H
derivatives 41 (IC50 = 0.069M) and 42 (IC50 = 0.270M)
S
N
O
were the most potent compounds of this series .
H
R

[X IX ] R = p -O C H 3
[X X ] R = m -O C H 3 ,p - O H

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Asian J. Research Chem. 6 (10): October 2013

3,

O
N

Me

H3C

C6H5

HN
N
Br

N
N

N
H

N
N+

N
N

ON
O

XXI

(XXII)
OMe
OH

P. Jaya Preethi et al.,36 synthesized a series of 4thiazolidinones and 2-azetidinone derivatives by refluxing
Schiff bases with different aromatic aldehydes. Schiff bases
were synthesized by reaction of nicotinamide with
hydrazine hydrate. The chemical structures of the
synthesized compounds were confirmed by means of IR,
1H-NMR, mass spectroscopy and elemental analysis.
Compound IIIa, IIId, IVa and IVd exhibited good Anticonvulsant activity.

Arun M. Isloor et al.,39Synthesised a new series of 2-(3substituted-1H-pyrazol-4-yl)-3-(3-substituted-5-sulfanyl1,2,4-triazol-4-yl)-1,3-thiazolidin-4-one (4ao) by cyclocondensation reaction of 5-substituted-4-[(3-substituted-1Hpyrazol-4ylmethylidene)amino]-2H-1,2,4-triazole-3-thione
(3ao) and thioglycolic acid. The synthesized compounds
were screened for anti-oxidant activity. In vitro antioxidant
studies like DPPH and ABTS-free radical scavenging
assays-indicated moderate activity of thiazolidin-4-ones.
N
N
R

SH

O
N

NH
N
S

HN

R1

N
S

Velmurugan. V et al.,37 synthesized Thiazolidinone

derivatives from thiourea. The syntesized Thiazolidinone
derivatives was undertaken to investigate the anticonvulsant
activity by using maximal electroshock-induced seizure
(MES) in mice. All the compounds were evaluated for their
anticonvulsant activity by maximal electroshock seizure
(MES) method. Some of the compounds showed more
activity than the standard and some are equally active to
standard drug phenytoin.

8. ANTI MALARIAL ACTIVITY

Solomon et al.,40 reported the synthesis of chloroquine
analogues having a 1, 3- thiazolidin-4-one nucleus at the
terminal side chain amino group of 4-aminoquinoline
[XVI]. All compounds were evaluated for their antimalarial
activity against P. falciparum in-vitro and some compounds
that have shown their activity comparable to standard drug
were also evaluated against P. yoelli in-vivo. The best
compound (IC50 = 0.039M) posses superior in-vitro
activity compared to chloroquine.
O

HN

HN

S
Cl

CH

Cl

HN
Cl

2(a-f)
XVI

CONCLUSION:
7. ANTIOXIDANT ACTIVITY
Shih et al.,38 synthesized a series of sydnonyl substituted
thiazolidinone and thiazoline derivatives and evaluated for
their antioxidant activity. The antioxidant activity of
compound [XXII] have been found to exhibit the significant
DPPH (1, 1-diphenyl-2- picrylhydrazyl) radical scavenging
activity, comparable to that of vitamin E.

In this article, we reviewed the literature data of biological

activities of thiazolidinone. The thiazolidinone is not only
synthetically important scaffold but also possesses a wide
range of promising biological activities. Some
thiazolidinone derivatives have better activity than standard
drugs and could become a new drug for the market in

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Asian J. Research Chem. 6 (10): October 2013

future. In thiazolidinone substitution at nitrogen yielded

potent compounds with good pharmacological activities.

19.

FUTURE ASPECT:

20

Future Research and investigation could give some

interesting results on substitution at various position of

21

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