Ch20 Proteins

236
Chapter 20: Proteins
CHAPTER 20
Proteins
1.
2.
Proteins are polymers in which:

a)
Unbranched chains of amino acids are present.
b)
Branched chains of amino acids are present.
c)
Both unbranched and branched chains of amino acids are present.
d)
Alternating amino acid and glucose monomer units are present.
Ans: a
Algorithm: No
Chapter Section: 20.1
Difficulty: Easy
Keyword 2: biochemistry
Keyword 3: proteins and amino acids
Keyword 1: Chemistry
Which of the following statements concerning proteins is incorrect?

a)
ansvara
b)
All proteins contain the elements C, H, O, and N.
c)
ansvarc
d)
ansvard
Ans: d
Algorithm: Yes
Difficulty: Moderate
3.
Which of the following statements concerning standard amino acids is incorrect?

a)
There are four main categories of amino acids.
b)
They are all alpha-amino acids.
c)
None of the standard amino acids are chiral.
d)
ansvard
Ans: c
Algorithm: Yes
4.
How do the standard amino acids differ from one another?

a)
in whether or not the amino group is chiral
b)
in whether or not the carboxyl group is chiral
c)
in the number of chiral carbon atoms between the carboxyl group and the amino group
d)
in the identity of the R group (side chain)
Ans: d
Algorithm: No
5.
Which of the following sets of elements is a possible composition for a standard amino acid?
a)
carbon, hydrogen, oxygen, and sulfur
b)
carbon, hydrogen, nitrogen, and sulfur
c)
carbon, hydrogen, and nitrogen
d)
carbon, hydrogen, oxygen, nitrogen, and sulfur
Ans: d
Algorithm: No
Copyright Cengage Learning. All rights reserved.
237
6.

Which of the following forms of the amino acid alanine (Ala) is the zwitterion form of this amino acid?
a)
b)
c)
d)
Ans: b
Algorithm: No

Keyword 4: zwitterions

7.
238
In a solution that is highly acidic (low pH), which of the following forms of the amino acid alanine (Ala)
would predominate?
a)
b)
c)
d)
Ans: a
Algorithm: No
Keyword 5: ph

Difficulty: Difficult
239
8.

Which of the following amino acids would be classified as a polar neutral amino acid?
a)
b)
c)
d)
Ans: c
Algorithm: No
9.

The joining together of two amino acids to form a dipeptide involves the reaction between
a)
two amide groups
b)
an amino group and an alpha-carbon
c)
an amino group and a carboxyl group
d)
an alpha-carbon and a hydroxyl group
Ans: c
Algorithm: Yes
Keyword 4: peptide

10.
240
Which of the following would be a correct representation of a portion of a protein backbone?

a)
b)
c)
d)
Ans: a
Algorithm: No

Keyword 4: peptide
11.
How many peptide linkages are present in a tripeptide?

a)
two
b)
three
c)
four
d)
five
Ans: a
Algorithm: Yes
Keyword 4: peptide
12.
In the tetrapeptide Phe-Gln-Trp-His, the C-terminal amino acid is

a)
Phe
b)
Gln
c)
Trp
d)
His
Ans: d
Algorithm: Yes
Keyword 4: peptide
13.
How many different tripeptides can be formed from two molecules of leucine (Leu) and one molecule of
glutamic acid (Glu)?
a)
two
b)
three
c)
four
d)
five
Ans: b
Algorithm: No
Keyword 4: peptide
14.
Which of the following biochemically important small peptides functions as an antioxidant?

a)
oxytocin
b)
vasopressin
c)
Met-enkephalin
d)
glutathione
Ans: d
Algorithm: No
241
15.
To which of the following levels of protein structure is the sequence of amino acids in a protein directly
related?
a)
primary
b)
secondary
c)
tertiary
d)
quaternary
Ans: a
Algorithm: No
Difficulty: Easy
Keyword 4: structure
16.
Interactions between amino acid R groups is responsible for which of the following levels of protein
structure?
a)
primary
b)
secondary
c)
tertiary
d)
both secondary and tertiary
Ans: c
Algorithm: No
17.
Quaternary structure is possible for a protein only when:

a)
The amino acid cysteine is present.
b)
All amino acids have nonpolar R groups.
c)
Two or more protein chains are present.
d)
A protein chain bends back on itself.
Ans: c
Algorithm: No
Difficulty: Easy
18.
The non-amino acid portion of a conjugated protein is called a

a)
side chain
b)
prosthetic group
c)
hydrophobic group
d)
hydrophilic group
Ans: b
Algorithm: No
Difficulty: Easy
19.
The complete hydrolysis of a protein produces a mixture of

a)
polypeptides
b)
free amino acids
c)
polypeptides and free amino acids
d)
dipeptides and free amino acids
Ans: b
Algorithm: No
Keyword 4: chemical properties
20.
Which of the following is an incorrect characterization for the protein hemoglobin?

a)
multimeric protein
b)
globular protein
c)
simple protein
d)
conjugated protein
Ans: c
Algorithm: No
Keyword 4: shape/function
21.
Which of the following statements concerning protein structure is correct?

a)
Amino acids are connected to each other through peptide bonds.
b)
At least one unit of each of the 20 standard amino acids musts be present.
c)
More than one chain of amino acids may be present.
d)
More than one correct response.
e)
No correct response.
Ans: d
Algorithm: No
Chapter Section: 20.2; 20.6
Difficulty: Easy
Keyword 4: peptide
242
22.
Which of the following elements is present in some of the standard amino acids but not all of them?
a)
oxygen
b)
sulfur
c)
phosphorus
d)
more than one correct response
e)
no correct response
Ans: d
Algorithm: No
Difficulty: Easy
23.
Glycine, the simplest amino acid, is different from all of the other standard amino acids in that it
a)
does not have a chiral center
b)
has a side chain that does not contain carbon
c)
occurs naturally as a D-isomer rather than as a L-isomer
d)
e)
no correct response
Ans: d
Algorithm: No
Difficulty: Easy
24.
In a solution of high pH, all of the acidic and basic sites in an amino acid are
a)
protonated
b)
deprotonated
c)
negatively charged
d)
e)
no correct response
Ans: b
Algorithm: No
Keyword 4: ph values
25.
Which of the following types of standard amino acids exist as zwitterions in the solid state?
a)
polar neutral amino acids
b)
polar acidic amino acids
c)
nonpolar amino acids
d)
e)
no correct response
Ans: d
Algorithm: No
26.
Which of the following statements concerning the tripeptide ValAlaGly is correct?

a)
The C-terminal amino acid residue is Val.
b)
The N-terminal amino acid residue is Gly.
c)
Three peptide linkages are present.
d)
e)
Ans: e
Algorithm: No
Keyword 4: peptide
27.
Which of the following tripeptides is a possible product from the partial hydrolysis of AlaValGlyGly
AlaVal?
a)
GlyGlyAla
b)
AlaValAla
c)
AlaValVal
d)
e)
no correct response
Ans: a
Algorithm: No
243
28.
A total of six isomeric tetrapeptides can be made from which of the following combinations of amino acids?
a)
Ala, Ala, Val, and Val
b)
Val, Val, Val, and Ala
c)
Ala, Ala, Val, and Gly
d)
e)
no correct response
Ans: a
Algorithm: No
Keyword 4: peptide
29.
Which of the following terms describes a protein secondary structure?

a)
alpha helix
b)
globular shape
c)
fibrous shape
d)
e)
no correct response
Ans: a
Algorithm: No
30.
Parallel polypeptide chains in a beta-pleated sheet conformation are held together by

a)
R-group interactions
b)
covalent bonding
c)
hydrogen bonding
d)
e)
no correct response
Ans: c
Algorithm: No
31.
Which of the following types of interactions contribute to protein tertiary structure?

a)
hydrophobic interactions between nonpolar R groups
b)
hydrogen bonds between polar neutral R groups
c)
hydrogen bonds between C=O and NH groups
d)
e)
no correct response
Ans: d
Algorithm: No
32.
R-group interaction between which of the following pairs of amino acids produces a disulfide bond?
a)
cysteine-cysteine
b)
proline-proline
c)
alanine-glycine
d)
e)
no correct response
Ans: a
Algorithm: No
Difficulty: Easy
33.
Which of the following levels of protein structure is not disrupted when protein hydrolysis occurs?
a)
primary structure
b)
secondary structure
c)
tertiary structure
d)
e)
no correct response
Ans: e
Algorithm: No

34.
In which of the following pairs of proteins are both members of the pair fibrous proteins?
a)
alpha-keratin and collagen
b)
collagen and hemoglobin
c)
hemoglobin and myoglobin
d)
e)
no correct response
Ans: a
Algorithm: No
Difficulty: Easy
Keyword 4: shape/function
35.
Which of the following statements concerning proteins is correct?

a)
Some, but not all, multimeric proteins are also conjugated proteins.
b)
All monomeric proteins are also simple proteins.
c)
Some, but not all, globular proteins are also multimeric proteins.
d)
e)
Ans: d
Algorithm: No
244
Use the following to answer questions 36-45:

In each of the following multiple-choice questions, characterize EACH of the three given statements as
being TRUE or FALSE and then indicate the collective true-false status of the statements using the choices:
a) All three statements are true.
b) Two of the three statements are true.
c) Only one of the statements is true.
d) None of the statements is true.
36.
Statements:
(1) In pure form, amino acids are white crystalline solids with limited solubility in water.
(2) In an alpha-helix structure, all of the amino acid side chains lie outside the helix.
(3) Protein denaturation affects all four levels of protein structure.
a)
All three statements are true.
b)
Two of the three statements are true.
c)
Only one of the statements is true.
d)
None of the statements is true.
Ans: b
Algorithm: No
Chapter Section: 20.10; 20.16; 20.2
Keyword 4: chemical properties; structure
37.
Statements:
(1) Some tertiary-structure interactions involve covalent bonding.
(2) Nonpolar amino acids contain one amino group, one carboxyl group, and a nonpolar side chain.
(3) The two amino acids present in a dipeptide are linked via an amide linkage.
a)
b)
c)
d)
Ans: a
Algorithm: No
Keyword 4: peptide; structure
245
38.
Statements:
(1) The major force responsible for protein secondary structure is hydrogen bonding.
(2) Amino acids found in proteins are almost always L-isomers.
(3) Conjugated proteins always contain one or more prosthetic groups.
a)
b)
c)
d)
Ans: a
Algorithm: No
39.
Statements:
(1) Partial hydrolysis of the tripeptide Ala-Gly-Cys produces three different dipeptides.
(2) The number of standard amino acids is 23.
(3) Enkephalins are peptides that bind at receptor sites in the brain to reduce pain.
a)
b)
c)
d)
Ans: c
Algorithm: No
40.
Statements:
(1) In a peptide, the number of amino acids and the number of peptide bonds are always equal.
(2) HDL and LDL are examples of lipoproteins.
(3) Tertiary structure interactions in proteins always involve amino acid R groups.
a)
b)
c)
d)
Ans: b
Algorithm: No
Keyword 4: Lipoprotein; peptide; structure
41.
Statements:
(1) In the tripeptide Gly-Ala-Ser, the amino acid at the N-terminal end is Ser.
(2) More than one polypeptide chain may be present in a conjugated protein but not in a simple protein.
(3) In solution at physiological pH, the side chain of a polar basic amino acid bears a negative charge.
a)
b)
c)
d)
Ans: d
Algorithm: No
Keyword 4: peptide; ph values; structure
42.
246
Statements:
(1) Collagen, the most abundant protein in humans, is both a fibrous protein and a glycoprotein.
(2) Quaternary structure, the highest level of protein organization, is found in all proteins in which 80 or
more amino acids are present.
(3) A protein chain lacks directionality because its two ends always involve the same amino acid.
a)
b)
c)
d)
Ans: c
Algorithm: No
Keyword 4: peptide; shape/function; structure
43.
Statements:
(1) For a tripeptide in which the three amino acids are different, six isomeric forms are possible.
(2) The backbone of a protein is an alternating sequence of C and N atoms.
(3) Both alpha-helix and beta-pleated sheet configurations can be present in the same protein.
a)
b)
c)
d)
Ans: b
Algorithm: No
Chapter Section: 20.10; 20.6
Keyword 4: peptide; structure
44.
Statements:
(1) For neutral amino acids, three different forms can exist, with the form found dependent of solution pH.
(2) Hydrophobic interactions are the strongest of the tertiary-structure interactions.
(3) Protein digestion is an enzyme-catalyzed hydrolysis reaction.
a)
b)
c)
d)
Ans: b
Algorithm: No
Keyword 4: chemical properties; ph values; structure
45.
Statements:
(1) The antirejection drug cyclosporine is structurally a small cyclic peptide.
(2) The chemical basis for a hair permanent is reversible denaturation in which peptide linkages are broken
and reformed.
(3) Among the standard amino acids, there are more nonessential ones than essential ones.
a)
b)
c)
d)
Ans: b
Algorithm: No
Chapter Section: 20.2; chemical connections
247

Aspartic acid, an acidic amino acid, can have four different forms in solution. These four forms are given in
the response list. For each of the conditions or characterizations, select from the response list the form of
aspartic acid that will be dominant. Responses may be used more than once or need not be used at all.
a) H2N
CH
_
COO
CH2
+
b) H3N
COO
CH
COOH
CH2
+
c) H3N
COOH
CH
COO
CH2
COOH
d) H3N
CH
COO
CH2
COO
46.
47.
Zwitterion form
Ans: c
Algorithm: No

Positively-charged form
Ans: b
Algorithm: No

48.
Form in a solution of pH 13
Ans: a
Algorithm: No
49.
Form in a solution of pH 1
Ans: b
Algorithm: No
50.

Form in which no net charge is present

Ans: c
Algorithm: No

For each of the amino acids, choose a correct classification from the response list. Responses may be used
more than once or need not be used at all.
a) nonpolar amino acid
b) polar neutral amino acid
c) polar acidic amino acid
d) polar basic amino acid
248
COO
51.
H3N CH CH2 OH
Ans: b
Algorithm: No


COO
52.
H3N CH CH2 COO

Ans: c
Algorithm: No
COO
53.
H3N CH (CH2)2 C NH2

Ans: b
Algorithm: No



COO
54.
H3N CH CH3
Ans: a
Algorithm: No
COO
55.
H3N CH (CH2)4 NH3

Ans: d
Algorithm: No

Use the response list to answer the following questions concerning the pentapeptide GlyAlaGlyGlyAla.
Responses may be used more than once or need not be used at all.
a) zero
b) two
c) three
d) four
56.
Number of peptide linkages present

Ans: d
Algorithm: No
Keyword 4: peptide
57.
Number of different amino acids produced by complete hydrolysis

Ans: b
Algorithm: No
58.
Number of possible different dipeptides produced by partial hydrolysis

Ans: c
Algorithm: No
59.
Number of possible different tripeptides produced by partial hydrolysis

Ans: c
Algorithm: No
249
60.
Number of possible different tripeptides produced by denaturation

Ans: a
Algorithm: No

Determine the structural level (primary, secondary, etc.) associated with each of the protein characteristics
using the response list. Responses may be used more than once or need not be used at all.
a) primary structure
b) secondary structure
c) tertiary structure
d) quaternary structure
61.
Sequence of amino acids in a protein chain

Ans: a
Algorithm: No
Difficulty: Easy
62.
Three-dimensional shape resulting from R-group interactions

Ans: c
Algorithm: No
63.
Hydrogen bonding between amide hydrogen atoms and carbonyl oxygen atoms
Ans: b
Algorithm: No
64.
Alpha-helix configuration
Ans: b
Algorithm: No
65.

Beta pleated-sheet configuration

Ans: b
Algorithm: No

Identify the standard amino acid with each of the characteristics using the response list. Responses may be
used more than once or need not be used at all.
a) proline
b) cysteine
c) glycine
d) alanine
66.
67.
68.
69.
Only standard amino acid whose side chain does not contain carbon
Ans: c
Algorithm: No
Only standard amino acid with a cyclic side chain

Ans: a
Algorithm: No
Only standard amino acid that is achiral

Ans: c
Algorithm: No
Only standard amino acid that participates in disulfide bonds

Ans: b
Algorithm: No
70.
Only standard amino acid with a methyl group attached to its alpha carbon atom
Ans: d
Algorithm: No
250

Ch20 Proteins

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Ch20 Proteins

Uploaded by

Copyright:

Available Formats

236

Chapter 20: Proteins

Proteins are polymers in which:

Which of the following statements concerning proteins is incorrect?

Which of the following statements concerning standard amino acids is incorrect?

How do the standard amino acids differ from one another?

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Chapter Section: 20.4

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Chapter Section: 20.4

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Chapter Section: 20.2

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Which of the following would be a correct representation of a portion of a protein backbone?

Chapter Section: 20.6

How many peptide linkages are present in a tripeptide?

In the tetrapeptide Phe-Gln-Trp-His, the C-terminal amino acid is

Which of the following biochemically important small peptides functions as an antioxidant?

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Quaternary structure is possible for a protein only when:

The non-amino acid portion of a conjugated protein is called a

The complete hydrolysis of a protein produces a mixture of

Which of the following is an incorrect characterization for the protein hemoglobin?

Which of the following statements concerning protein structure is correct?

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Which of the following statements concerning the tripeptide ValAlaGly is correct?

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Which of the following terms describes a protein secondary structure?

Parallel polypeptide chains in a beta-pleated sheet conformation are held together by

Which of the following types of interactions contribute to protein tertiary structure?

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Which of the following statements concerning proteins is correct?

Use the following to answer questions 36-45:

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Use the following to answer questions 46-50:

Chapter Section: 20.4

Chapter Section: 20.4

Chapter Section: 20.4

Form in which no net charge is present

Use the following to answer questions 51-55:

Copyright Cengage Learning. All rights reserved.

Chapter 20: Proteins

Chapter Section: 20.4

Chapter Section: 20.4

H3N CH CH2 COO

H3N CH (CH2)2 C NH2

Chapter Section: 20.4

Chapter Section: 20.4

Chapter Section: 20.4

H3N CH (CH2)4 NH3

Use the following to answer questions 56-60: