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  • Metabolic Pathway of Diazepam

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    Keshni Devi
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    Diazepam can undergo two metabolic pathways in the body: N-dealkylation, which removes an alkyl group and produces nordiazepam, or 3-hydroxylation, which introduces a hydroxyl group and yields temazepam. Both nordiazepam and temazepam are then further metabolized through additional hydroxylation or dealkylation to form oxazepam.

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    Diazepam

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    Diazepam can undergo two metabolic pathways in the body: N-dealkylation, which removes an alkyl group and produces nordiazepam, or 3-hydroxylation, which introduces a hydroxyl group and yields temazepam. Both nordiazepam and temazepam are then further metabolized through additional hydroxylation or dealkylation to form oxazepam.

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    116 views1 page

    Metabolic Pathway of Diazepam

    Uploaded by

    Keshni Devi
    Diazepam can undergo two metabolic pathways in the body: N-dealkylation, which removes an alkyl group and produces nordiazepam, or 3-hydroxylation, which introduces a hydroxyl group and yields temazepam. Both nordiazepam and temazepam are then further metabolized through additional hydroxylation or dealkylation to form oxazepam.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Metabolic Pathway of Diazepam

    Diazepam undergoes either N-dealkylation, producing nordiazepam, or 3hydroxylation, yielding temazepam. Dealkylation is a chemical process through
    which alkyl groups are removed from a given compound. An alkyl group is a
    functional group on an organic molecule that is derived from an alkane that has
    lost a hydrogen atom. Hydroxylation is a chemical process that introduces a
    hydroxyl group (-OH) into an organic compound. Each of these metabolites is
    converted to oxazepam by 3-hydroxylation or N-dealkylation respectively.

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