Professional Documents
Culture Documents
Received: 02-03-2013
Accepted: 03-04-2013
2.
University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur-208024, Uttar Pradesh,
India.
[E-mail: saushi123@rediffmail.com; Tel: 9838095777]
Associate Professor, Department of Pharmaceutical Sciences, Faculty of Health Sciences,
SHIATS, Allahabad, UP, India.
Objective: The aim of the proposed work was to formulate and characterize fast dissolving tablets of ibuprofen for
rapid dissolution of drug and absorption, which may produce rapid onset of action. These dosage forms rapidly
disintegrate and/or dissolve to release the drug as soon as they come in contact with saliva, thus obviating the need
for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients.
Method: The fast dissolving tablets of ibuprofen were prepared by two methods named melt technology and super
disintegrant addition method. Comparatively evaluation parameters with respect to various physical parameters
(weight variation, hardness, friability, etc.) were evaluated and drug release profile was analyzed. The concentration
of sucrose and ac-di-sol were optimized for desired rapidly disintegrating formulations.
Result and conclusion: Both the methods of rapidly disintegrant tablets showed desirable results. The formulations
prepared by super disintegrant addition were having lesser wetting time, disintegration time, invitro dispersion time
and better drug release as compared to the formulations prepared by melt technology.
Keyword: Rapidly Disintegrating, Ibuprofen, Super Disintegrant Addition, Melt technology, ac-di-sol.
1. Introduction
Fast release tablets can disintegrate and dissolve
rapidly once placed into the oral cavity. These
tablets are prepared by using either of
effervescent melt technology, addition of super
disintegrant or melt technology[1]. All the
technologies formulate rapidly disintegrate tablet
and release desired drug concentration at the end
of 10 minutes. There are various patented
technologies such as Zydis, WOW TABS,
FLASH DOSE, CEFORM and ORAQUICK[2]. In
zydis technology tablets are prepared by
lyophilization process thats why it becomes
highly porous in nature which on contact with
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Table 1: Composition of fast disintegrating formulations of ibuprofen prepared by addition of super disintegration (S1S3) and melt technology method (M1-M3)
Ingredients
S1
(mg)
S2
(mg)
S3
(mg)
M1
(mg)
M2
(mg)
M3
(mg)
Ibuprofen
50
50
50
50
50
50
Mannitol
65
65
65
36
36.85
36.85
Microcrystalline
cellulose
65
60
62
30
20
32
15.5
20
18
Sucrose+glucose
45
55
40
Sorbitol
35
35
35
Talc
3.68
3.68
3.68
3.68
3.68
3.68
Magnesium
stearate
1.8
1.8
1.8
1.8
1.8
1.8
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Fig 1: Comparative drug release profile of fast disintegrating formulations of ibuprofen prepared by addition of super
disintegrant
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The
was
Fig 2: Comparative drug release profile of fast disintegrating formulations of ibuprofen prepared by melt technology
method
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4. References
1.
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