Date: 30-11-2016

From
Mr. Vara Prasad Saka,
Department of pharmacology,
Vignan pharmacy college, Vadlamudi.

To
The coordinator,
Scientific committee,
Nirmala College of Pharmacy,
Mangalagiri.

Dear Sir,
Sub: Covering letter for the abstract of my students to the conference regarding.
I, Vara Prasad Saka, Assistant professor, Department of Pharmacology, Vignan
College of Pharmacy, Vadlamudi forwarding the abstract of myself and B. Pharm students
Nihitha. S, Apoorva. K for oral and e-poster. Please, kindly consider for acceptance.
I humbly request you for the kind consideration of the abstract.
Thanking you, sir,
Yours sincerely,
Vara Prasad Saka.

Abstract for oral Presentation.

Effect of Avena sativa (oats) on fluoride induced infertility in male albino rats.
*Vara Prasad Saka, P. Srinivasa Babu
Vignan Pharmacy College, Vadlamudi 522212
*Corresponding author: Email: vara.visionary@gmail.com
ABSTRACT
Infertility is one of the major health problems faced by many couples due to lack of
pregnancy during a year of unprotected intercourse and 30% was due to low sperm
concentration, motility, viability, and morphology. Various factors like pollution, drug
treatment,

stress,

life

style

changes,

toxicants,

insufficient

nutrition

effect

the

spermatogenesis and reproductive health in men. Fluorine is one such potent toxicant to
which humans are exposed and the problem of fluorosis was known for long in India,
especially in Andhra Pradesh. It was reported in several studies that fluorine interferes with
the structural and functional integrity of the male reproductive system resulting in male factor
infertility. Because of the wide range of chemical and mineral constituents Avena sativa has
been used in the present study to evaluate its effectiveness against the fluoride induced
infertility at a dose of 10 mg/kg body weight. Fluoride caused damage to histoarchitecture of
the testis there by decreasing the hormones such as serum testosterone, F.S.H, L.H whereas
hydroalcholic extract of Avena sativa significantly reversed the effects of fluorine and hence
Form the present study it was reported that Avena sativa have the ability to decrease the toxic
effect of fluorine.
Key words: Avena sativa, reproductive toxicity, male factor infertility, Fluoride toxicity

Abstract for e-poster:

Evaluation of behavioral and neuroprotective activity of Curcuma amada against cell

phone radiation induced brain damage in rats.
*Nihitha. S, Vara Prasad Saka, P. Srinivasa Babu
Vignan Pharmacy College, Vadlamudi 522212
*Corresponding author: Email: nihithasanka145@gmail.com
ABSTRACT
Cell phone radiation is a well-known neurotoxic agent and neurodamage induced by cell
phone radiation (Frequency range of 900 MHz) is one of the model systems for the screening
of neuroprotective activity of plant extracts. Damage begins with the changes in behaviour,
loss of enzymes. The present study was focused to evaluate the behavioural and
neuroprotective activity of Curcuma amada (100, 200, 300 mg/kg) against cell phone
radiation. Behavioural study were analysed by using Y maze. Hydro alcoholic extract of
Curcuma amada were compared for its neuroprotective activity with control group. Curcuma
amada 300mg/kg had shown significant behavioural and neuroprotective activity on par with
100 mg/kg. Curcuminoids and flavonoids responsible for neuroprotective activity of
Curcuma amada.
KEY WORDS: Cell phone radiation, Neurodamage, Curcuma amada, Neruoprotective
activity, Y-maze.

Abstract for e-poster:

Blood purification by magnetic separation- A promising approach

*K. Apoorva, P. Durga Nithya, Vara Prasad Saka, P. Srinivasa Babu
Vignan Pharmacy College, Vadlamudi 522212
*Corresponding author: Email: nihithasanka145@gmail.com
ABSTRACT
The direct removal of disease-causing compounds is an inherently attractive treatment
modality for a range of pathological conditions, including intoxications and blood stream
infections. While low molecular weight compounds (potassium, urea, etc.) are routinely
removed from blood circulation by membrane-based processes, such as hemodialysis and
hemofiltration, high molecular weight targets are only accessible by sorption-based processes
e.g. hemoadsorption and hemoperfusion, where blood is pushed at high flow rates through
adsorbent cartridges. In spite of promising initial findings, the practical use of hemoperfusion
is still controversial and concerns have been raised due to potential side effects such as
unspecific protein adsorption, loss of blood cells (e.g. platelets) and possible activation of
coagulation and inflammation pathways during operation. Compared to porous membranes,
the use of free-floating nanosized particles exhibits significant benefits in terms of surface
accessibility (no pore diffusion, shorter contact times), but this comes at a price: the
pathogen-loaded particles need to be removed from the blood. Recently, it has been
demonstrated that magnetic (nano-)particles can be employed to bind pathogenic substances
on their surface, followed by a re-collection by magnetic separation. In magnetic separationbased blood purification, capturing agents attached to tiny magnetic nanoparticles are injected
into an extracorporeal blood circuit This article discusses the promising future of magnetic
separation-based purification while keeping important safety considerations in mind.
Keywords: Blood purification, Intoxication, Magnetic separation, Magnetic nanoparticles,
Sepsis

Abstract for e poster

SNA- A Promising Psoriasis Therapy
Arjun kolagani, Vara Prasad Saka, Srinivasa Babu Puttagunta.
Vignan Pharmacy College, Vadlamudi 522213
Corresponding Author: arjunkolagani@gmail.com
Abstract
Psoriasis is an auto-immune disease, triggered when the body creates normally healthy
protein, tumour necrosis factor- (TNF-) in higher concentration. When human cells
activate genes, their DNA codes are translated into snippets of single-stranded RNA called
messenger RNA (mRNA). This mRNA then transfers to protein factories called ribosomes,
which convert the code into amino acids. Seldom, diseased cells build too many copies of
tumor necrosis factor- (TNF-), which overstimulates the immune system in people with
psoriasis, leading to red, scaly skin lesions. To interrupt that process, antisense RNA therapies
inject cells with RNA strands that bind to specific mRNA snippets, effectively blocking them
from being read by ribosomes. This removes them from circulation before they can be
converted into proteins. Traditional antisense RNA drugs usually doesnt work as they are
digested by the enzymes before they reach the target. Contrasting to conventional mRNAs,
which are short linear sequences, SNAs are tiny spheres with 100 or so identical RNA
snippets attached to a central particle, often made of fatty molecules called lipids. This allows
SNAs to get into cells and prevents them from being digested up by enzymes. In theory, they
should enable therapies for dozens of genetic diseases. This could be helpful in developing
therapies for auto immune disorders.
Keywords: Psoriasis, mRNA, SNA, Snippets.