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Penicillin
()
Penicillin
Amoxicillin
Ampicillin
Cephalosporin
()
1st generation
2nd generation
2.5th generation
Cefamycin
*Flumarin
2.
Cefamycin NMTT side chain GPC coveragecover GNB and Anaerobe better
GPC Cefuroxime cover SASP (SA/SP)(SA)
GNB 2nd Cefacover PECK+HM
Anaerobes( Bacteroides Metronidazole B. fragilis )
Intra-abdominal Infection(IAI)Pelvic inflammatory disease(PID)
3rd generation
3.5th generation
Cefamycin
4th generation
5th generation
Carbapenem
()
PsA
Seizure
Ertapenem
Invanz
IF
Imipenem
Tienam
+++
IF
Meropenem
Mepem
IVIF
Doripenem
Finibax
++
+/-
IF
FQ
FQ TB masking TB () CAP
PNA, IAI, Soft tissue/bone, UTI, prostatitis, STD, Mycobacteria infection
2+, 3+(), QT prolongation side effect
2nd FQCiproxinGPC Cover GNB PsA Ana
3rd FQCravitGPC PsA Ana
4th FQAveloxFactive PsA GPC ( SP ) Ana GNB
GPC
GNB
PsA
Ana
Ciprofloxacin(2nd)
Ciproxin
+/-
++
Levofloxacin(3rd)
Cravit
Moxifloxacin(4th)
Avelox
++
Gemifloxacin(4th)
Factive
++
++
AG
Aminoglycoside Resistance
Amikacin
Gentamicin
Streptomycin
Macrolide
Erythromycin
Azithromycin
Clarithromycin
Monobactam
Aztreonam
MRSA
Glycopeptide
Vancomycin
1.
2.
3.
4.
Teicoplanin
1.
kidney function
2.
(Loading dose )
Daptomycin
MRSA
GPC GNB(-)PsA(-)Anerobics(-)
1. Vancomycin serious, invasive infection
2. IndicationMRSA, VISA, VRSA, VRE, PRSP
3.
4.
5.
myopathy CK
Linezolid(Zyvox)
Anti-HA-MRSA
Tigecycline
3.
Tigecycline Ceftazidime(Fortum)
Volume of distribution morbidity combine
4.
5.
Clindamycin
Baktar
PJP
1.
Trimethorpim/Sulfamethoxazole (TMP/SMX)
2.
3.
Indication: Simple UTI, PJP, Salmonella infection, Travelers diarrhea, Toxoplasmosis, Norcardiosis
A.
B.
C.
Colistine
Burkholderia cepacia
Burkholderia pseudomallei(melioidosis)
Stenotrophomonas maltophilia
4.
D. Norcardiosis
E. PJP(Pneumocystitis jirovecii pneumonia)
GI upset, Skin rash, neutropenia, hyperkalemia, psychosis
1.
2.
3.
4.
(1947 )/MDRABMDRPA
QQ
Proteus spp.ProvidenciaBurkholderiaSerretia speciesS.mElizabethChryseobacteriumMoraxella
(neuromascular blockade)
Anti-TB
Rifampin
GPCGNBMycobacteriaRickettsia
1. Anti-TB (deep infection, prosthetic joint infection, biofilm )
2. biofilm Teicoplanin Deep infection of SA
3. Combine therapy
4. SA Rifampim Baktar Clindamycin
5. ( 36%)
6. (Hepatocellular hepatitisGOT/GPTCholestatic hepatitisALP/GGTT-BIL)()
Tetracycline
Tetracycline
Minocycline
Doxycycline
4.
A. Chlamydial infection
B. Rickettsail infection
C. Vibrio infection()
Doxycycline
5.
A. Malaria
B. Mycoplasma pneumoniae Macrolide Doxycycline
C. Tetra Mino Tetra Doxycycline
(Esp. Doxycycline)(Esp. MinoN/V)
SA
Staphylococcus aureus
PNA
Pneumonia
SP
Streptococcus pneumoniae
BTI
PsA
Pseudomonas aeruginosa
IAI
Intra-abdominal infection
Ana
AB
Anaerobes
Acinetobacter baumannii
N/V
CA
Nausea/Vomiting
Community-Acquired
Steno
Stenotrophomonas maltophilia
HCA
Health-Care-Aquired
PJP( PCP)
HA
Hospital-Acquired
Antifungal
Polyene
Amphotericin B
Liposomal
Amphotericin-B
(Ambisome)
Triazole
Itraconazole
CandidiasisAspergillosisDermatophytoses
1.
2. Aspergillosis Voriconazole Voriconazole Itraconazole Aspergillosis
3. CNS fungal meningitis candidal UTI
4. (negative inotropic effect)
Fluconazole
3.
4.
5.
Voriconazole
2.
3.
4.
96% IV IV
A. ( Neutropenic fever)
B.
C.
Voriconazole
CSF 30~68% fungal meningitis Candidal UTI
5.
Posaconazole
CandidiasisAspergillosisMucormycosisFusariosisZygomycosis
1.
2.
Sertaconazole
Echinocandin
Caspofungin
Micafungin
Anidulafungin
()histamine-mediated symptoms()LFTN/V
Echinocandin
Caspofungin 10000 NTD/dayMicafungin 4000 NTD/dayAnidulafungin 4500 NTD/day
1.
2.
3.
4.
5.
1.
2.
1.
2.
3.
Flucytosine(5-FC)
2.
1.
2.
3.
4.
5.
6.
7.
8.
9.
Serratia, "Indole-positive" PsA, "Indole-positive" Providencia, "Indole-positive" Proteus vulgaris, Citrobacter, and Enterobacter species
(Cefamycin)NMTT side chain effectNMTT chain vitamin K dependent carboxylase vitamin K 2,3-epoxide reductase
(competitive antagonist) prolonged PT & PTT liver function
A. Bactericidal
B. Bacteriostatic
A. S(Sensitive)
B. I(Intermediate)
C. R(Resistant)
10.
A. Peak level()Peak level 30
B. Trough level()Trough level
11. Liver doseRenal dose CCRT dose Loading dose Maintenance dose
Loading dose Maintenance dose
12. IV form AmoxicillinIV=1.25*PO
Streptococcus Pneumonia
PSSP(Penicillin sensitive Streptococcus Pneumoniae) : Penicillin or Ampicillin or Cefazolin
PRSP(Penicillin resistant Streptococcus Pneumoniae) : Vancomycin or Ceftriaxone(Rocephin)
PRSP meningits Vanco+Rocephin
Staphylococcus Aureus
MSSA ( Methicillin Sensitive Staphylococcus Aureus )Oxacillin(1st)Cefazolin(2nd)Vancomycin(3rd)
MRSA ( Methicillin Resistant Staphylococcus Aureus )Vancomycin or Teicoplanin DaptomycinLinezolidTigecycline
VRSA ( Vancomycin Resistant Staphylococcus Aureus )DaptomycinLinezolid
Enterococcus(E. faecalis E. faecium Vancomycin Ampicillin )
ASE(Ampicillin Susceptible Enterococcus) Ampicillin PCN OxacillinUnasyn Penicillin
ARE(Ampicillin Resistance Enterococcus)Vancomycin or Teicoplanin
VRE(Vancomycin Resistance Enterococcus)DaptomycinLinezolidTigecycline
Anaerobes(Bacteroides Clostridium )
CefamycinCefoxitinCefmetazoleFlumarinBrosym
-lactam+-lactamase inhibitorUnasynAugmentinTazocin
CarbapenemErtapenemImipenemMeropenemDoripenem
Other agent: MetronidazoleTigecyclinClindamycin
IAI(Intra-Abdominal Infection)
Cefa Cefamycin(CefoxitinCefmetazole)FlumarinBrosym
FQ AveloxFactive
ESBL
CarbapenemTigecyclineColistin
AmpC CarbapenemTigecyclineFQ AG Cefepime
CRAB ColistinSulbactam ( BrosymUnasyn)Tigecycline
GPC
Staphylcocci
Coagulase(+):
Staphylcoccus aureus
Coagulase(-):
CONS Staphylcoccus epidemis ()
GNC
Nesseria
N. meningitis
N. gonorrhea
Moraxella
-hemolytic()
GASS. pyogenes ( pharyngitis &
GNB
Enterobacteriaceae
Fermenting GNB
1. PECK(Proteus, E.coli, Klebsiella spp.)
Streptococci
S. pneumonia
S. bovis (Group D, endocarditis)
Enterococcus faecalis()
() Enterococcus faecium( VRE)
Enterococcus
GPB
Aerobes
()
Listeria ()
Corynebacterium dipheriae()
Nocardia (, )
Acinetobacter baumannii
Burkholderia spp.
Pseudomonas aureus
Stenotrophomonas maltophilia
Fastidious GNB
Atypical
H. influenza
Mycoplasma, Chlamydia, Legionella
Rickettsia, scrub typhus
Mycobacteria
Mycobacterium tuberculosis(tuberculosis)
Mycobacterium leprae(leprosy)
Anaerobes
peptostreptococcus
Bacteroides fragilis
Bacillus anthracis ()
Anaerobes
Clostridium (, )
C. difficile()
C. perfringens()
C. botulinum()
C. tetani()
Ocillina
Oxacillin
1st Penicillin
Amikin
Amikacin
Aminoglycoside
Cefa
Cefazolin
1st Cephalosporin
Gentamycin
Gentamicin
Aminoglycoside
Keflex/Cephalexin/Ulex
Cephalexin()
1st Cephalosporin
Rulid
Erythromycin
Macrolide
Furoxime
Cefuroxime
2nd
Zithromax
Azithromycin
Macrolide
Ceflour
Cefuroxime()
2nd Cephalosporin
Targocid
Teicoplanin
Glycopeptide
Cetazone
Cefmetazole
2.5th Cephalosporin
Cubicin
Daptomycin
Lipopeptides
Cexitin
Cefoxitin
2.5th
Zyvox
Linezolid
Oxazolidinones
Flumarin
Flomoxef
2.5th Cephalosporin
Tygacil
Tigecycline
Glycylcycline
Rocephin
Ceftriaxone
3rd Cephalosporin
Clincin/Lindacin
Clindamycin
Lincosamide
Claforan
Cefotaxime
3rd
Baktar/Sevatrim
Trimethoprim-sulfamethoxazole
Co-trimoxazole
Sulfonamide
Fortum/Tatumcef
3rd Cephalosporin
Borymycin
Monocycline
Tetracycline
Cefspan
Ceftazidime
Cefixime()
3rd
Colimycin
Colistin
Polymixin
Seftem
Ceftibuten()
3rd Cephalosporin
Anegyn/Flagyl
Metronidazole
Nitroimidazole
Brosym
CPZ+sulbactam
3.5th Cephalosporin
Fungizone
Amphotericin B
Polyene
Maxipime
Cefepime
4th
Ambisome
Amphotericin B, Liposomal
Polyene
Ciproxin
Ciprofloxacin
Quinolone
Diflucan
Fluconazole
Triazole
Cravit
Levofloxacin
Quinolone
Sporanox
Itraconazole
Triazole
Avelox
Moxifloxacin
Quinolone
Posanol
Posaconazole
Triazole
Factive
Gemifloxacin
Quinolone
Vfend
Voriconazole
Triazole
Invanz
Ertapenem
Carbapenem
Zalain
Sertaconazole
Triazole
Tienam
Imipenem
Carbapenem
Cancidas
Caspofungin
Echinocandin
Mepem
Meropenem
Carbapenem
Mycamine
Micafungin
Echinocandin
Finibax
Doripenem
Carbapenem
Eraxis
Anidulafungin
Echinocandin
Azactam
Aztreonam
Monobactam
Flusine
Flucytosine
Pyrimidine
Cephalosporin
Cephalosporin
Cephalosporin
Cephalosporin
Cephalosporin