Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing

Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

(
) .


.

Drug Interaction

.


. .

.i

:Outside the body

(.)Precipitation Adsorption Chelation Inactivation
: .

.ii

Inside the body

.a
.b

Pharmacokinetic Interaction
Pharmacodynamic Interaction

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University
)a Pharmacokinetic Interaction
( )ADME
:
Absorption Interaction
-1
Distribution Interaction
-2
Metabolism Interaction
-3
Excretion Interaction
-4
-1 -:

.
-:
-1 .Changes in the pH of the gut
.Ultration of gut motility
-2
Physical or Chemical binding
-3
.
-4 Mal Absorption caused by Drugs
(.)Antiacids .


( )Astringent
.
:

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

,
.
. -2 /:
.


.
. :
.
: .
-3 :
.

.
Induction or Inhibition of Hepatic Microsomal Enzymes.
.
:
.
: .
-4 :
.
3

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

-:
-1 - ( )Urinary Alkalinisers:

.
-2 : : .
-3 : :

.
.
:Pharmacodynamic Interaction
)b



:
-1
-2
-3
-4

. Additive or Synergistic interaction

Antagonism or Opposing Interaction


Interaction due to changes in drug transport

Interaction due to disturbances in fluid and Electrolyte balance.

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University
.
:Additive

.
: ( +).
:Synergistic
.
( : +) ( +).

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Sequential

:Mechanism of synergism*
inhibition of successive steps in
metabolism(TMP + Sulphonamides )

Sequential inhibition of C.Wsynthesis

3
Facilition of drug entry of one antibiotic by another
( beta lactam + aminoglycosides )
4 Inhibition of inactivating enzymes ) Amoxicillin + Clavulinic A.)
5 Prevention of emergence of resistant population
(Erythromycin rifampin)
:Antagonism
.
+ :

.
Mechanism of antagonism
1 Inhibition of bacteriocidal activity of drug by bacteriostatic one.
2 Competition for drug bining sites as chloramphenicol + macrolides.
3 Inhibition of cell permeability as chloramphenicol+ aminoglycoside.
4 Derepression of resistant enzymes as new third generation
cephalosporins + old beta lactam.

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

:
+ = + = + = :
( ) + () = () ( ) .

()

( )

()

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

()
()
()
()

()

()

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

-1

:
To broaden the spectrum of activity against
mixed infection.

( ) Mixed Infection

.
2

To avoid drug toxicity by minimization of dose.

( . ) P.A.S.
- 3 ( Resistant
) Strains

( ) Drug Synergism
( ) 4 = 1 + 1
.

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

( ) Drug Addition ) ( 1 + 1 = 2

. ( Narrow
) Spectrum

.

( Broad Spectrum
) ( ) Drug Addition
( Drug
) Antagonism
.
-4

To avoid induction of bacterial resistance.

5
.

10

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

:
. Super infection. 1
Delay diagnosis. 2
Enhance selection of 3
resistant bacteria
. 4

11