Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing

Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Antibiosis

Waksman 1889

Vuillemin 1945

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

1899 Metchnikoff


Lactobacillus

1910 Emmerich and
low

P.aeruginosa

Gratia and Dath

1924

Pasteur and joubert

1875

1928 Alexander fleming

staphylococcus aures

()Penicillium notatum

1940 Waksman

1939 Dubos

Bacillus

:
Anti
Antibody

Antigen
Antitoxin
Antiserum

(/ )


2

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Antimicrobial

Antibacterial
Antifungal
Antiparasitic
Antiviral
Antiseptic

Disinfectants

Sanitizer

Antibiotics

( )

(
)

:
.

:

3

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Antibiotic
. Streptomycin
.
antibiotic

.

:
Antibiotic

Microorganism

-1
Bacitracin

Bacillus licheniformis

-2 (
)
Chioramphenicol
Fusidic acid

Streptomyces venzuelae
Fusidium ceccineum
Streptomyces griseus
4

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Streptomycin
-3
Penicillin

Penicillium notatum

Selective toxicity

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

:
)1
)2
)3
)4
)5
)6
)7 normal flora
)8

:
-1
-2

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Baceteriostatc

Bacetriocidal

Bacteriolytic

:
Measuring Antibiotic activity

** :

Technological
Methods

:Microbiogical Methods

, :

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

,
:
-1
Turbidimetry

-2

Nephelometry

-3
Enzym Actity Method
-4 CO2

-5
Impedance

-
-
)(MIC
: sensitivity test
:

plate

diffusion test

:
.
MIC
-1
:
: disc test
-1

serial

dilution

24 37 : test .



-2
streak test

:
24 -18
37







24 37 .
MIC

Minimum
Bacteriocid
al
concentrati
: on




.

MBC



MIC
0.1
24
37

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

-2

Agar
dilution
: test








.

. MBC

10

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

MBC MIC
.
( ) .
.
( . ) pH
:
.

The activity of antibiotic combination

, ( )

.
G ,

G .

11

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

** ( synergy
: ) combination
-1 .
-2 .
-3 .
-4 .
-5 .
-6 .
-7 .

**
:

-1
Indefference

-2
Antagonism

.


.

-3 Addition

12

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

-4 Synergism
.

: :

Indifference
-1
-2 Antagonism
Addition
-3
-4 Synergism

13

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

**
:
. bactericidal -1
. bacteriostatic -2
-3

14

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

Streptomycin Bactericidal
Sisomicin

Neomycins
) Resting (
Penicillins
Bacitracin Proliferating
Fosfomycin
Tetracyclines

Carbomycin

Novobiocin

Bactericidal
D-Cycloserine
Capreomycn
.
Viomycin

:
15

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

( )

-1 :
.
( -
) -
.

,
, (
) !!!

-2 :
:

16

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

. ( (
)

.

.
. :
( )
,
,
.

. :
,

.


.

17

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

(
)

-3

18

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

- 4

:
-1 -2 3
-4 -5 -6

19

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

-5 :

.

:
-1 .
-2 Transaminases

-1

:
-1

-2

:
.

20

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

:
.

:
: :

.
.

. .
. .

pH .
.
.

.
.
Bengal red
,alone .

21

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

: :

-2
-1
.

E.coli Staphylococcus aureus ( )5-6

.
.

22

Mohamed Hossany Negm

Senior Technical Support Specialist and Marketing
Masters Degree, Poultry Science
TEL:00201123223874
Faculty of Agriculture Zagazig University

: :

23