DEV SAMAJ MODERN

SCHOOL
Chemistry
Investigatory Project
Session 2016-17

Study of the given

sample of Antacid
Made by:-

Furquan Haidar
th

of class 12 A1
Roll no.:-17

Acknowledgements
I am extremely grateful to Mrs. Meha, Teacher of
Department of Chemistry for her able guidance
and useful suggestions, which helped me in
completing the project work, in time.
I would also like to thank all the teaching and nonteaching staff of Chemistry department who helped
me directly or indirectly in the completion of this
project.
Finally, yet importantly, I would like to express my
heartfelt thanks to my beloved parents for their
blessings, my friends/classmates for their help and
wishes for the successful completion of this project.
-Furquan Haidar

Contents
Acknowledgements 2
Certificate4
Aim ...............5
Introduction6
Apparatus Required8
Procedure .
9
Observation ...11
Conclusion....14

Certificate
Thi s i s to ce r ti f y t ha t Furquan Haidar
ha s s a ti sfa c to r il y co mp l et e d th e c ou r se
o f Chemistry I n ve s ti ga t o ry Pro ject
prescribed by the CBSE in the laboratory of
Dev Samaj Modern School in the year of 2016-17.

Signatures
CHEMISTRY TEACHER

PRINCIPAL

AIM:-

To analyze th e given samples of

commercial antacids by determining the
amount of hydrochloric acid they can
neutralize.

INTRODUCTION:ANTACIDS
An Antacid is any substance, generally a base or basic salt,
which neutralizes stomach acidity. They are used to relieve
acid indigestion, upset stomach, sour stomach, and
heartburn.

ACTION MECHANISM
Antacids perform a neutralization reaction, i.e. they
buffer gastric acid, raising the pH to reduce acidity in the
stomach. When gastric hydrochloric acid reaches the
nerves in the gastrointestinal mucosa, they signal pain to
the central nervous system. This happens when these
nerves are exposed, as in peptic ulcers. The gastric acid
may also reach ulcers in the esophagus or the duodenum.
Other mechanisms may contribute, such as the effect of
aluminium ions inhibiting smooth muscle cell contraction
and delaying gastric emptying.

INDICATIONS

Antacids are taken by mouth to relieve heartburn, the

major symptom of gastro esophageal reflux disease, or
acid indigestion. Treatment with antacids alone is
symptomatic and only justified for minor symptoms.
Peptic ulcers may require H2-receptor antagonists or
proton pump inhibitors.

Some famous antacid brands:1. Alka-Seltzer NaHCO3 and/or KHCO3

2. Equate Al(OH)3 and Mg(OH)2
3. Gaviscon Al(OH)3
4. Maalox (liquid) Al(OH)3 and Mg(OH)2
5. Maalox (tablet) CaCO3
6. Milk of Magnesia Mg(OH)2
7. Pepto-Bismol HOC6H4COO
8. Pepto-Bismol Childrens CaCO3
9. Rolaids CaCO3 and Mg(OH)2

DRUG NAMES
Some drugs used as antacids are :
1. Aluminium hydroxide
2. Magnesium hydroxide
3. Calcium carbonate
4. Sodium bicarbonate
5. Bismuth subsalicylate
6. Histamine
7. Cimetidine
8. Ranitidine
9. Omeprazole
10.

Lansoprazole

APPARATUS REQUIRED:-

Burettes, pipettes, titration flasks,

measuring flasks, beakers, weight box,
fractional weights, sodium hydroxide,
sodium carbonate, hydrochloric acid,
phenolphthalein, methyl orange.

PROCEDURE :1.Prepare 1 litre of approximately

HCl
solution by diluting 10 ml of the concentrated
acid for one litre.
2.Similarly, make 1 litre of approximately NaOH
solution by dissolving 4.0g of NaOH to prepare
one litre of solution.
3. Prepare Na2CO3 solution by weighing
exactly
1.325 g of anhydrous sodium carbonate and
then dissolving it in water to prepare exactly
0.25 litres (250 ml) of solution.
4.Standardize the HCl solution by titrating it
against the standard Na2CO3 solution using
methyl orange as indicator.
9

5.Similarly, standardize NaOH solution by

titrating it against standardized HCl
solution using phenolphthalein as
indicator.
6.Powder the various samples of antacid tablets
and weigh 1.0 g of each.
7.Add a specific volume of standardised HCl to
each of the weighed sample is taken in conical
flasks. The acid should be in slight excess, so
that it can neutralize all the alkaline
component of the tablet.
8.Add 2 drops of phenolphthalein and warm the
flask till most of powder dissolves. Filter of
the insoluble material.
9.Titrate this solution against the standardized
NaOH solution, till a permanent pinkish tinge
is obtained. Repeat this experiment with
diferent antacids.
1
0

OBSERVATIONS AND CALCULATIONS :1. Standardization of HCl solution :Volume of Na2CO3 solution taken = 20.0 ml

S. No.

Burette
reading
s (ml)
Initial
Final

Volume
of acid
used
(ml)

1.

15

15.0 ml

2.

15

30

15.0 ml

3.

30

45.1

15.1 ml

4.

15

15.0 ml

Concordant reading = 15.0 ml

Applying molarity equation, N1V1 =
N2V2 N1 x 15.0 = 1 x 20
Normality of HCl, N1 = 0.133 N
1
1

2. Standardization of NaOH solution

:Volume of the given NaOH solution
taken = 20.0 ml

S. No.

Burette
reading
s (ml)
Initial
Final

Volume
of acid
used
(ml)

1.

26.5

26.5 ml

2.

26.8

26.8 ml

3.

26.6

26.6 ml

4.

26.6

26.6 ml

Concordant volume = 26.6 ml

Applying normality equation,
N1V1 (ACID)= N2V2 (BASE)
0.133 x 26.6 = 2 x 20
Normality of NaOH, N2 =0.176N
12

Analysis of antacid tablet :

Weight of antacid tablet powder = 1.0
g Volume of HCl solution added = 20.0
ml

S.No.

Antacid

VOL. OF
NaOH
USED TO
NEUTRALI
SE HCl
(ml)

VOL. OF HCl
USED TO
NEUTRALISE
1.0gm
ANTACID (ml)

1.

Gelusil

12.1 ml

12.0 ml

2.

Digene

16.0 ml

16.2 ml

3.

Aludrose

19.3 ml

18.9 ml

4.

Ranitidine

21.4 ml

21.7 ml

5.

Ocid 20

22.7 ml

21.9 ml

13

CONCLUSION :The antacid which has maximum volume of

HCl is used for neutralizing i.e.
OCID 20 is more efective.
BIBLIOGRAPHY
1. WEBSITES :
www.wikipedia.org www.google.com
www.ask.com
www.pharmaceuticaldrugmanufacturers.com
2.BOOKS :
Comprehensive Practical Manual for class
XII Pradeeps New Course Chemistry
NCERT Class XII Part
14