Self-Assessment
1. The human genome contains
A. 20 00022 000 genes
B. 100 000150 000 genes
C. 500600 genes
D. ~ 1 million genes
2. The genetic basis of Huntingtons disease is
A. Chromosome 4 trisomy
B. A trinuceotide repeat disorder
C. A missense single nucleotide polymorphism
(SNP)
D. A DNA translocation
3. An DNA intron is defined as
A. An alternative form of a gene
B. The coding region of a gene
C. The non-coding region of a gene
D. The promoter region of a gene
4. In genetics the term sequencing refers to
A. Establishment of the nucleotide (base) order of
the almost complete genome
B. Quantification of tagging SNPs
C. Rearrangement of the nucleotide (base) order of
the almost complete genome
D. Creation of a clone
5. In a monogenic autosomal recessive disorder, which
of the following is correct?
A. Occurs only in females
B. The gene defect is always in an intron region of
DNA
Answers to Multiple-Choice Questions: 1(A), 2(B), 3(C), 4(A), 5(D) and 6(C).
Nutrition Research Methodologies, First Edition. Edited by Julie A Lovegrove, Leanne Hodson, Sangita Sharma and Susan A Lanham-New.
2015 John Wiley & Sons, Ltd. Published 2015 by John Wiley & Sons, Ltd.
www.wiley.com/go/nutritionsociety
NRM Ch 15 web questions.indd 1
C. The inheritance of one mutated copy of the defective
gene is sufficient to cause disease
D. The disease only occurs in those with two defective
copies of the gene
6. Mutations in the amyloid precursor protein, p reselin-1
and preselin-2 genes are associated with the familial
form of
A. Osteoporosis
B. Cardiovascular disease
C. Alzheimers disease
D. Hypertension
Short answer questions
1. Describe the various types of genetic variation.
2. Discuss the terms dominant, recessive and X-linked
monogenic disorders, providing an example of each.
3. Provide a brief description of the candidate-gene
genetic approach.
4. Outline briefly the principles of GWAS and whole
genome sequencing.
Essay titles
1. Outline the basic design elements of a GWAS study,
and discuss the strength and limitations of this
genetic tool.
2. Explain the term nutrigenetics and provide an over-
view of the approaches commonly used to investigate
genotypephenotype associations.
1/10/2015 1:44:36 PM