Professional Documents
Culture Documents
Muscle Function
Muscle Characteristics
Muscle Tissue Types
Muscle Physiology Skeletal Muscle
General Functions of Skeletal Muscle
Functional Anatomy
Physiology
Skeletal Muscle Types
Energetics
Adaptive Responses
Cardiac Muscle Physiology
Smooth Muscle Physiology
1
Muscle Tissue Types Muscle Comparison Chart
Muscle Special
Tissue Cell Shape Striae Nucleus structures
Skeletal Control
Multi-
Skeletal Cylindrical Yes nucleate & Voluntary none
peripheral
Intercalated
Cardiac Cardiac Cylindrical
& branched
Yes
Uninucleate
& central
Involuntary
discs
May be
Uninucleate
Smooth Fusiform No Involuntary single-unit
& central
or multi-unit
Smooth
Movement Protection
Only have contractility in one direction of underlying structures
Requires multiple muscles abdominal viscera
to create movements from Stronger muscles =
the simple
greater protection,
flexion and extension
To the complex
increased joint stability
Circumduction
2
Skeletal Muscle Skeletal Muscle
General Functions - Involuntary General Functions - Involuntary
3
Skeletal Muscle Skeletal Muscle
Functional Anatomy Functional Anatomy
4
Skeletal Muscle Skeletal Muscle
Functional Anatomy Functional Anatomy
Transmission of force from the sarcomere How does all this functional anatomy
to the tissue at large work?
Sarcomeres linked by 1st synaptic transmission at the
distrophin to sarcolemma, neuromuscular junction
then via membrane nd
2 excitation-contraction coupling
proteins interacting with 3rd contraction-relaxation cycle
cytoskeletal framework
Muscular Dystrophy?
5
Skeletal Muscle Skeletal Muscle
Physiology of Contraction - NMJ Physiology of Contraction Excitation-Contraction Coupling
3. Contraction-Relaxation Cycle
a. Myosin upon attaching to actin is hydrolized
(phosphate coming from the splitting of ATP by
Myosin ATPase)
b. This changes the conformation of myosin causing it
to bend at the neck towards the m-line
c. ADP is released by the conformational change
during the power stroke
d. ATP binding site is now available for another ATP
(along with magnesium Mg2+)
e. Splitting of ATP to ADP + P by myosin detaches
and returns myosin to its active state
f. This single event creates a twitch
6
Skeletal Muscle Skeletal Muscle
Physiology of Contraction Physiology of Contraction
7
Skeletal Muscle Skeletal Muscle
Physiology of Contraction Physiology of Contraction
8
Skeletal Muscle Next Time
Physiology of Contraction