PICO VIA

1. Population
25 pediatric SLE patients who follow the clinic.

2. Intervention
No interventions

3. Comparison
to summarize the clinical presentation of pediatric SLE at outpatient
clinic. In addition, we aim to define the pattern of disease expression in
pediatric SLE such as nephropathy, fever, anorexia, and arthralgia

4. Outcome
From 25 patients
Female to male ratio 2.3:1.
Age at diagnosis range from 4 to 15 years with mean of 9 years.
Duration of symptoms before diagnosis established range from one
month to 7 years with mean of 8 months.
Frequency of SLE classification criteria as follows: +ve ANA 95%,
renal disorder: 84%, immunological disorder 60%, photosensitivity
48%, oral ulcers 48%, Hematological disorder 44%, arthritis 36%,
serositis 28%, malar rash 12%, discoid rash 4%, neurological
disorder 0%.
Other clinical manifestation of SLE include fever 80%, arthralgia
and anorexia 84% each, hair fall 40%, abdominal pain 36%, other
skin manifestation 24%, headache 20%,dyspnea and palpitation 16%
each, Reynards phenomena and lymphadenopathy 12% each.
The most frequent hematological abnormality : elevated ESR: 100%
anemia: 72 % ,leucopenia: 44 %, thrombocytopenia : 20 %
,leukocytosis : 12 % ,thrombocytosis 8 %, lymphopenia : 4 %

5. Validity
a. Is the research question well-defined that can be answered
using this study design?
Yes, the research questions were about to define the pattern
of disease expression in pediatric SLE. Those can be
answered using this prospective retrospective observational
descriptive case series report.
 b. Does the author use appropriate methods to answer their
questions?
Yes, all the research questions had been answered in the
results, proved that the methods was appropriate
c. Is the data collected in accordance with the purpose of
research?
Yes, the data was collected by second author during her
residency in Abu Alrich hospital to study rheumatology. The
25 patients randomly selected. She collects medical history
information directly from the patients and their parents and
reviews their files to collect the other information (e.g.:
investigation results and clinical examinations finding during
course of the disease.
d. Was the randomization list concealed from patients,
clinicians and researchers?
Its unclear. Not mentioned whether all the studies selected in
this journal used randomization or not

6. Importance
a. Is this study important?
Yes, the study is important because the presentation and the
clinical course of SLE have wide variability. Nephropathy, fever,
and arthralgia and anorexia were the most common in pediatric
patients as presenting clinical manifestations. There is marked
delay between the starting of the disease manifestation and
diagnosis, so alertness to the possibility of SLE as diagnosis in
patients with variable manifestation should be there.

7. Applicable
 a. Are your patient so different from those studied that the
results may not apply to them?
Yes , because the small number of patients have been
analyzed, the disparity in selection criteria for patient
inclusion, or the definition of the variables, and our study
didnt include all the SLE patients following the clinic make
comparison of findings with previous reports difficult.
b. Is your environment so different from the one in the study
that the methods could not be use there?
No, because the environment of the studies selected in the
review have to fulfill the criteria, and so the method could be
use there

Journal Reading

Clinical Presentation of Pediatric SLE at

Outpatient Clinic
 Oleh:
Elzan Zulqad Maulana, S.Ked 04054821618215
Maya Chandra Dita, S.Ked 04084821618178
Raisa Eunike Oslin, S.Ked 04084821618179

Pembimbing:
Dr Yusmala Helmy SpA (K)

DEPARTEMEN ILMU KESEHATAN ANAK

FAKULTAS KEDOKTERAN UNIVERSITAS SRIWIJAYA
RSUP Dr.MOHAMMAD HOESIN PALEMBANG
2016
HALAMAN PENGESAHAN

Journal Reading
Clinical Presentation of Pediatric SLE at Outpatient Clinic

Oleh:
Elzan Zulqad Maulana, S.Ked 04054821618215
Maya Chandra Dita, S.Ked 04084821618178
 Raisa Eunike Oslin, S.Ked 04084821618179

Telah diterima sebagai salah satu syarat dalam mengikuti Kepaniteraan

Klinik Senior di Departemen Ilmu Kesehatan Anak Fakultas Kedokteran
Universitas Sriwijaya RSUP Dr.Mohammad Hoesin Palembang.

Palembang, April 2016

Pembimbing

Dr. Yusmala Helmy SpA (K)