Family, Morphology of Genome Culturing Antigenic Routes and Modes Specimen for Immune

genus name virus (models) structures of virus diagnosing; preparations for

transmission diagonostic treatment and
laboratory tests prophylaxis
Hep B ~ ~ double ~ culture in ~ HBs Antigen ~ Parental (a) Specimen Treatment
(HBV) envelope(HBsAg) stranded chimpanzees (envelope (1) Blood (by ~ blood, saliva, ~ no specific
circular DNA but not cultured protein) needle) serum antiviral treatment
F: ~ 42 nm genome in cell culture (2) Sexual through IF use for
Hepadnavirid ~ HBc Antigen intercourse (b) Rapid tests chronic infection
ae ~ spherical capsid ~ virus genome ~ incubation (3) Perinatal from ~ PCR treatment
G: consists of period approx. mother new
~ HBE Antigen
Orthohepadn partially double 90 days born (c) Serological
avirus stranded ~ within core is a examination Immunoprophylaxis
~ sensitive to
circular DNA DNA dependent ~ ~ passive
environment
DNA polymerase immunoprecipitation immunization of
~ ELISA sera from
~ immunized patient
immunoelectrophore
sis ~ vaccine have
~ RIA viral attenuated An
( HBsAn) 3 types of
vaccines for 3 types
of antigens

(1) HBsAn
(2) Polypeptides
(3) Recombinant of
line vaccination
virus and
HBsAn

Hep C ~ envelop ~ single ~ in ~ E1 and E2 An ~ by abscess of (a) Specimen ~ -IF and ribovirin
(HCV) stranded RNA chimpanzee contact ~ blood (but not eliminate
~ 30-60 nm ~ core An (HCD) its carrier state)
F: Floviridae ~ +ve sense ~ may form ~ blood (b) Rapid tests
G: ~ spherical virion calcinoids in cell ~ non structural ~ PCR ~ there is no
Hepacivirus tiss culture protein of capsid ~ by bed bugs vaccine and hyper
(NS2, NS3, NS4, ) (c) Virology Ig
~ incubation examination
period approx. ~ determination of ~ patients with
50 days RNA of these virus in chronic HVC
blood confirming the infection should
acute infection dec. intake of
alcohol and moniter
(d) Serological with -fetoprotein
 examination test and lover
~ use paved sera sonogram to detect
1) 1/3 of carcinoma
infection
2) 10-40 days
later
(together
with 2 sera)
3) Test a rise in
4 fold to
confirm
diagnosis
Hep D ~ envelope ~ single ~ chimpanzee ~ An (in ~ transmit like (a) Specimen ~ recovery from
(HDV) stranded RNA capsid) ( inc HBV ~ blood, serum infection or induced
~ 35nm ~ +/- severity of HBV ; immunity to HBV
F: not ~ +ve sense (hepatoma cell inc. mortality) ~ blood (b) Made by detect most protect
classified ~ spherical virion line) either An or against Hep virus
G: deltavirus ** detect by ~ sex IgM antibody to
~ have capsule **accompy HBV serological test ~ non specific
An in patients
** not occur infection ~ pernatal antiviral therapy
serum
in ~ have nucleic
monoinfectio capsid ~ no vaccine
(c) PCR
n
~ determine RNA in
** must exist
hepatocytes
with hep B
then only will
affect
hepatocytes

Hep E ~ no envelope ~ single ~ in ~ protein of ~ fecal-oral route ~ electron ~ no antiviral

(HEV) stranded RNA chimpanzee capsid microscope
~ 27-34 nm ~ person to person ~ no vaccine
F: ~ +/- hepatoma ~ serological
Caliciviridae ~ icosahedra cell examination
G: virion
Hepatovirus

**not severe ** cause mild

infection infection but can
be fatal in
pregnant female
esp near
trimester of
pregnancy
** viruses are
eliminated on
recovery, not
carrier state